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WO2001088124A3 - Method and reagent for the inhibition of erg - Google Patents

Method and reagent for the inhibition of erg Download PDF

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Publication number
WO2001088124A3
WO2001088124A3 PCT/US2001/015866 US0115866W WO0188124A3 WO 2001088124 A3 WO2001088124 A3 WO 2001088124A3 US 0115866 W US0115866 W US 0115866W WO 0188124 A3 WO0188124 A3 WO 0188124A3
Authority
WO
WIPO (PCT)
Prior art keywords
erg
inhibition
reagent
nucleic acid
acid molecules
Prior art date
Application number
PCT/US2001/015866
Other languages
French (fr)
Other versions
WO2001088124A2 (en
Inventor
Thale Jarvis
Carlowitz Ira Von
James A Mcswiggen
Fiona Mclaughlin
Anna Maria Randi
Original Assignee
Ribozyme Pharm Inc
Glaxo Group Ltd
Thale Jarvis
Carlowitz Ira Von
James A Mcswiggen
Fiona Mclaughlin
Anna Maria Randi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribozyme Pharm Inc, Glaxo Group Ltd, Thale Jarvis, Carlowitz Ira Von, James A Mcswiggen, Fiona Mclaughlin, Anna Maria Randi filed Critical Ribozyme Pharm Inc
Priority to AU2001261676A priority Critical patent/AU2001261676A1/en
Publication of WO2001088124A2 publication Critical patent/WO2001088124A2/en
Publication of WO2001088124A3 publication Critical patent/WO2001088124A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
    • C12N2310/121—Hammerhead
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/317—Chemical structure of the backbone with an inverted bond, e.g. a cap structure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/332—Abasic residue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Nucleic acid molecules, including antisense and enzymatic nucleic acid molecules, such as hammerhead ribozymes, DNAzymes, and GeneBlocs, which modulate the expression of ERG (Ets-related gene).
PCT/US2001/015866 2000-05-16 2001-05-16 Method and reagent for the inhibition of erg WO2001088124A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001261676A AU2001261676A1 (en) 2000-05-16 2001-05-16 Method and reagent for the inhibition of erg

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57202100A 2000-05-16 2000-05-16
US09/572,021 2000-05-16

Publications (2)

Publication Number Publication Date
WO2001088124A2 WO2001088124A2 (en) 2001-11-22
WO2001088124A3 true WO2001088124A3 (en) 2003-01-23

Family

ID=24286013

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015866 WO2001088124A2 (en) 2000-05-16 2001-05-16 Method and reagent for the inhibition of erg

Country Status (2)

Country Link
AU (1) AU2001261676A1 (en)
WO (1) WO2001088124A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7416842B2 (en) * 2004-04-05 2008-08-26 The Rockefeller University DNA virus microRNA
CA2992180C (en) 2004-05-07 2021-02-23 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer
US7482158B2 (en) 2004-07-01 2009-01-27 Mathison Brian H Composite polynucleic acid therapeutics
US7718369B2 (en) 2005-09-12 2010-05-18 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
US9957569B2 (en) 2005-09-12 2018-05-01 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
WO2007131280A1 (en) * 2006-05-12 2007-11-22 The Walter And Eliza Hall Institute Of Medical Research HEMATOPOIESIS AND REGULATION THEREOF BY ETS RELATED GENE (Erg)
US9303291B2 (en) 2007-07-06 2016-04-05 The Regents Of The University Of Michigan MIPOL1-ETV1 gene rearrangements
WO2009020521A2 (en) 2007-08-03 2009-02-12 The Brigham And Women's Hospital, Inc. Identification and treatment of estrogen responsive prostate tumors
CA2774349C (en) 2009-09-17 2019-03-19 The Regents Of The University Of Michigan Recurrent gene fusions in prostate cancer
US8945556B2 (en) 2010-11-19 2015-02-03 The Regents Of The University Of Michigan RAF gene fusions
WO2014172434A1 (en) * 2013-04-16 2014-10-23 The Johns Hopkins University Diagnostic and prognostic test for sturge-weber syndrome, klippel-trenaunay-weber syndrome, and port-wine stains (pwss)
EP4213838A4 (en) * 2020-09-17 2024-08-28 Oklahoma Medical Research Foundation INHIBITION OF ENDOTHELIAL ETS FAMILY TRANSCRIPTION FACTORS PROMOTING FLOW-DEPENDENT OCULAR VESSEL REGRESSION

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054459A2 (en) * 1998-04-20 1999-10-28 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
WO2001088122A2 (en) * 2000-05-16 2001-11-22 Glaxo Group Limited Erg modulators

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999054459A2 (en) * 1998-04-20 1999-10-28 Ribozyme Pharmaceuticals, Inc. Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
WO2001088122A2 (en) * 2000-05-16 2001-11-22 Glaxo Group Limited Erg modulators

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HART A H ET AL: "HUMAN ERG IS A PROTO-ONCOGENE WITH MITOGENIC AND TRANSFORMING ACTIVITY", ONCOGENE, vol. 10, no. 7, 6 April 1995 (1995-04-06), pages 1423 - 1430, XP008000432, ISSN: 0950-9232 *
MCLAUGHLIN FIONA ET AL: "Characterisation of the tumour necrosis factor (TNF)-alpha response elements in the human ICAM-2 promoter.", JOURNAL OF CELL SCIENCE, vol. 112, no. 24, December 1999 (1999-12-01), pages 4695 - 4703, XP002201821, ISSN: 0021-9533 *
MCLAUGHLIN FIONA ET AL: "Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation", BLOOD, vol. 98, no. 12, 1 December 2001 (2001-12-01), pages 3332 - 3339, XP002189946, ISSN: 0006-4971 *
YI HO-KEUN ET AL: "Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias.", ONCOGENE, vol. 14, no. 11, 1997, pages 1259 - 1268, XP008004101, ISSN: 0950-9232 *

Also Published As

Publication number Publication date
WO2001088124A2 (en) 2001-11-22
AU2001261676A1 (en) 2001-11-26

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