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WO2001088156A3 - 33428, membres de la famille des metalloproteases humaines et utilisations associees - Google Patents

33428, membres de la famille des metalloproteases humaines et utilisations associees Download PDF

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Publication number
WO2001088156A3
WO2001088156A3 PCT/US2001/015766 US0115766W WO0188156A3 WO 2001088156 A3 WO2001088156 A3 WO 2001088156A3 US 0115766 W US0115766 W US 0115766W WO 0188156 A3 WO0188156 A3 WO 0188156A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
metalloprotease family
expression vectors
family member
Prior art date
Application number
PCT/US2001/015766
Other languages
English (en)
Other versions
WO2001088156A2 (fr
Inventor
Rosana Kapeller-Libermann
William James Cook
Inmaculada Silos-Santiago
Original Assignee
Millennium Pharm Inc
Kapeller Libermann Rosana
William James Cook
Silos Santiago Inmaculada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Kapeller Libermann Rosana, William James Cook, Silos Santiago Inmaculada filed Critical Millennium Pharm Inc
Priority to AU2001261651A priority Critical patent/AU2001261651A1/en
Priority to EP01935570A priority patent/EP1290195A2/fr
Publication of WO2001088156A2 publication Critical patent/WO2001088156A2/fr
Publication of WO2001088156A3 publication Critical patent/WO2001088156A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des molécules d'acide nucléique isolées, appelées molécules d'acide nucléique 33428, codant pour des nouveaux membres de la famille des métalloprotéases. L'invention porte également sur des molécules d'acide nucléique antisens, sur des vecteurs d'expression recombinés contenant lesdites molécules d'acide nucléique 33428, sur des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits et sur des animaux transgéniques non humains dans lesquels un gène 33428 a été introduit ou dissocié. L'invention se rapporte encore à des protéines 33428 isolées, à des protéines de fusion, à des peptides antigéniques et à des anticorps anti-33428. Elle concerne enfin des méthodes de diagnostic utilisant des compositions de l'invention.
PCT/US2001/015766 2000-05-15 2001-05-15 33428, membres de la famille des metalloproteases humaines et utilisations associees WO2001088156A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001261651A AU2001261651A1 (en) 2000-05-15 2001-05-15 33428, a novel human metalloprotease family member and uses thereof
EP01935570A EP1290195A2 (fr) 2000-05-15 2001-05-15 33428, membres de la famille des metalloproteases humaines et utilisations associees

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20415900P 2000-05-15 2000-05-15
US20416000P 2000-05-15 2000-05-15
US60/204,160 2000-05-15
US60/204,159 2000-05-15

Publications (2)

Publication Number Publication Date
WO2001088156A2 WO2001088156A2 (fr) 2001-11-22
WO2001088156A3 true WO2001088156A3 (fr) 2002-03-28

Family

ID=26899237

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/015527 WO2001088155A2 (fr) 2000-05-15 2001-05-15 33428, un nouveau membre de la famille des metalloproteases humaines et ses utilisations
PCT/US2001/015766 WO2001088156A2 (fr) 2000-05-15 2001-05-15 33428, membres de la famille des metalloproteases humaines et utilisations associees

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015527 WO2001088155A2 (fr) 2000-05-15 2001-05-15 33428, un nouveau membre de la famille des metalloproteases humaines et ses utilisations

Country Status (3)

Country Link
EP (1) EP1290195A2 (fr)
AU (2) AU2001261570A1 (fr)
WO (2) WO2001088155A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055643A1 (fr) * 1997-06-03 1998-12-10 Kureha Chemical Industry Co., Ltd. Proteine adamts-1 humaine, gene codant pour cette proteine, composition pharmaceutique et procede de dosage immunologique de proteine adamts-1 humaine
JP2001008687A (ja) * 1999-06-25 2001-01-16 Yamanouchi Pharmaceut Co Ltd 新規金属プロテアーゼ及び該金属プロテアーゼ遺伝子
WO2001011074A2 (fr) * 1999-08-06 2001-02-15 The Cleveland Clinic Foundation Acides nucleiques codant des metalloproteases de zinc
WO2001023561A2 (fr) * 1999-09-27 2001-04-05 Curagen Corporation Nouveaux polynucleotides codant des proteines contenant des sequences repetees de thrombospondine type 1 (tsrx)
DE10107360A1 (de) * 2000-02-18 2001-09-06 Hoffmann La Roche Neue Metalloproteasen mit Thrombospondin-Domänen und Nucleinsäure- Zusammensetzungen , die diese codieren

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998055643A1 (fr) * 1997-06-03 1998-12-10 Kureha Chemical Industry Co., Ltd. Proteine adamts-1 humaine, gene codant pour cette proteine, composition pharmaceutique et procede de dosage immunologique de proteine adamts-1 humaine
EP1004674A1 (fr) * 1997-06-03 2000-05-31 Kureha Chemical Industry Co., Ltd. Proteine adamts-1 humaine, gene codant pour cette proteine, composition pharmaceutique et procede de dosage immunologique de proteine adamts-1 humaine
JP2001008687A (ja) * 1999-06-25 2001-01-16 Yamanouchi Pharmaceut Co Ltd 新規金属プロテアーゼ及び該金属プロテアーゼ遺伝子
WO2001011074A2 (fr) * 1999-08-06 2001-02-15 The Cleveland Clinic Foundation Acides nucleiques codant des metalloproteases de zinc
WO2001023561A2 (fr) * 1999-09-27 2001-04-05 Curagen Corporation Nouveaux polynucleotides codant des proteines contenant des sequences repetees de thrombospondine type 1 (tsrx)
DE10107360A1 (de) * 2000-02-18 2001-09-06 Hoffmann La Roche Neue Metalloproteasen mit Thrombospondin-Domänen und Nucleinsäure- Zusammensetzungen , die diese codieren

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_EST EMBL; 17 September 1999 (1999-09-17), NCI-CGAP: "wv74h06.x1 Soares_thymus_NHFTh Homo sapiens cDNA clone IMAGE:2535323 3' similar to TR:O60345 O60345 KIAA0605 PROTEIN. ;, mRNA sequence.", XP002186998 *
DATABASE EM_EST EMBL; 19 May 1999 (1999-05-19), NCI-CGAP: "we60a01.x1 Soares_thymus_NHFTh Homo sapiens cDNA clone IMAGE:2345448 3' similar to TR:O54768 O54768 A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS ;contains TAR1.t1 TAR1 repetitive element ;, mRNA sequence.", XP002187000 *
DATABASE EM_EST EMBL; 23 September 1998 (1998-09-23), NCI-CGAP: "qb82f12.x1 Soares_fetal_heart_NbHH19W Homo sapiens cDNA clone IMAGE:1706639 3' similar to WP:F25H8.3 CE05729 THROMBOSPONDIN LIKE ;contains TAR1.t1 TAR1 repetitive element ;, mRNA sequence.", XP002186999 *
DATABASE WPI Section Ch Week 200130, Derwent World Patents Index; Class B04, AN 2001-285362, XP002187001 *
FRANCISCA VÁZQUEZ ET AL: "METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 33, 13 August 1999 (1999-08-13), pages 23349 - 23357, XP002141414, ISSN: 0021-9258 *
HURSKAINEN TIINA L ET AL: "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases: General features and genomic distribution of the Adam-TS family", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 36, 3 September 1999 (1999-09-03), pages 25555 - 25563, XP002158991, ISSN: 0021-9258 *
NAGASE TAKAHIRO ET AL: "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vivo", DNA RESEARCH, vol. 5, no. 1, 1998, pages 31 - 39, XP000878819, ISSN: 1340-2838 *
PROCKOP DARWIN J ET AL: "Procollagen N-proteinase and procollagen C-proteinase: Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling.", MATRIX BIOLOGY, vol. 16, no. 7, February 1998 (1998-02-01), pages 399 - 408, XP001042352, ISSN: 0945-053X *
TANG BOR L ET AL: "ADAMTS: A novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats", FEBS LETTERS, vol. 445, no. 2-3, 26 February 1999 (1999-02-26), pages 223 - 225, XP004259261, ISSN: 0014-5793 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7034132B2 (en) 2001-06-04 2006-04-25 Anderson David W Therapeutic polypeptides, nucleic acids encoding same, and methods of use

Also Published As

Publication number Publication date
WO2001088156A2 (fr) 2001-11-22
EP1290195A2 (fr) 2003-03-12
AU2001261570A1 (en) 2001-11-26
WO2001088155A3 (fr) 2002-04-04
AU2001261651A1 (en) 2001-11-26
WO2001088155A2 (fr) 2001-11-22

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