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WO2001087190A2 - Bioprothese cardiaque deux pieces - Google Patents

Bioprothese cardiaque deux pieces Download PDF

Info

Publication number
WO2001087190A2
WO2001087190A2 PCT/US2001/015495 US0115495W WO0187190A2 WO 2001087190 A2 WO2001087190 A2 WO 2001087190A2 US 0115495 W US0115495 W US 0115495W WO 0187190 A2 WO0187190 A2 WO 0187190A2
Authority
WO
WIPO (PCT)
Prior art keywords
outer frame
valve
heart valve
bioprosthetic
bioprosthetic heart
Prior art date
Application number
PCT/US2001/015495
Other languages
English (en)
Other versions
WO2001087190A3 (fr
Inventor
Eric S. Buchanan
Original Assignee
St. Jude Medical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/572,827 external-priority patent/US7722667B1/en
Application filed by St. Jude Medical, Inc. filed Critical St. Jude Medical, Inc.
Publication of WO2001087190A2 publication Critical patent/WO2001087190A2/fr
Publication of WO2001087190A3 publication Critical patent/WO2001087190A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2427—Devices for manipulating or deploying heart valves during implantation

Definitions

  • Implantable heart valves are used for replacement of defective valves in hearts of patients.
  • the valves are typically sutured to a tissue annulus that is left when the surgeon removes the existing valve from the patient's heart.
  • the sutures are tied snugly, thereby securing the valve to the heart .
  • a bioprosthetic heart valve includes an inner bioprosthetic valve and an outer frame configured to attach to a tissue annulus of a heart.
  • An inner bioprosthetic valve has an exterior shape which substantially matches an interior shape of the outer frame .
  • the exterior shape of the inner valve mates in substantial alignment with the interior shape of the outer frame.
  • An outer frame-inner valve attachment mechanism is configured to couple the inner valve to the outer frame .
  • FIG. 1 is a perspective view of a bioprosthetic valve.
  • FIG. 2 is an exploded view of the valve of
  • FIG. 1 and an outer frame.
  • FIG. 3 is a side cross-sectional view of an implantation device and the outer frame of FIG. 2.
  • FIG. 1 is a perspective view of such a stentless bioprosthetic heart valve 510, such as the Toronto SPV ® valve from St. Jude Medical.
  • Valve 510 includes a covering 512 and is adapted for implantation in the aortic position.
  • Valve 510 includes three leaflets 516,518 and 520 which meet along coaptation surfaces 522.
  • Covering 512 can comprise a flexible or fabric sheath which is contoured to the external surf ce of the valve 510.
  • covering 512 consists of a generally annular base 524 and three axially projecting and circumferentially-spaced commissure supports 526, 528 and 530. Sutures 534 along inflow edge 536 and outflow edge 538 are used to attach covering 512 to valve 510.
  • Covering 512 can be a biocompatible polymer such as polyester or polytetrafluoroethylene (PTFE) .
  • FIG. 2 shows an exploded view of valve 510 and outer frame 550.
  • Outer frame 550 has a shape which substantially matches the outer shape of valve 510 such that valve 510 fits securely within outer frame 550.
  • Outer frame 550 can be secured to the native tissue annulus using any appropriate technique such as sutures, staples or screws, or other techniques.
  • outer frame 550 does not include the valve structure, it provides improved access to and visibility of the annular and sub-annular regions for the surgeon during the implantation procedure such that the orientation and location of the valve is more accurate.
  • Outer frame 550 is a substantially flexible structure.
  • it is relatively thin, on the order of about 0.01 to about 0.05 inches (about 0.25 mm to about 1.27 mm) , and is made from a flexible biocompatible polymer such as polyester or PTFE in a molded or fabric form.
  • the wall of outer frame 550 can be continuous, meshed, or have perforations.
  • valve 510 is attached to frame 550. This attachment can also be through suturing or other attachment techniques .
  • an adhesive is used to secure valve 510 to frame 550.
  • a chemically activated adhesive can be used in which the activating chemical is applied to outer frame 550 or valve 510 separately or combined together on either the frame 550 or valve 510 just prior to implantation.
  • a holder can be provided to hold the valve against frame 550 during the adhesion process.
  • the holder has a shape which substantially matches the shape of outer frame 550.
  • the holders can include an inflatable membrane similar to a balloon such that a force can selectively be applied from the valve 510 to the outer frame 550 while the adhesive cures.
  • valve 510 abuts ridge 552 when valve 510 has been accurately placed, and commissure supports 526, 528, 530 are in vertical alignment with the corresponding features of outer frame 550.
  • Valve 510 can be rotated to the correct alignment before the adhesive cures.
  • the inner valve 510 mates in substantial alignment with outer frame 550.
  • FIG. 3 is a side cross sectional view showing tool 211 carrying outer frame 550 at distal end 218.
  • Screws 214 extend through outer frame 550 and can be used to attach outer frame 550 to the native tissue annulus as discussed above.
  • FIG. 3 illustrates screws 214 located in a single plane near the inflow edge of outer frame 550, additional screws can be positioned at other locations on frame 550 to provide improved attachment.
  • additional flexible shafts can be provided to simultaneously actuate additional screws.
  • Screws 214 are actuated by actuating handle 224 and shaft 222 relative to housing 220.
  • a gearing mechanism can turn flexible shafts 262 and thereby rotate screws 214.
  • valve 510 Once the valve 510 is coupled to outer frame 550, the heads of screws 214 are covered by valve 510 and secured in place. Sutures or staples can also be used to implant outer frame 550. In one aspect, any type of surgical attachment mechanism can be used to implant outer frame 550.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)

Abstract

L'invention concerne une bioprothèse cardiaque (510) comportant un châssis extérieur (550) conçu pour être fixé à un anneau de tissu d'un coeur et une bioprothèse intérieure (150) dont la forme extérieure épouse sensiblement la forme intérieure du châssis extérieur (550). La forme extérieure de la bioprothèse cardiaque (510) s'emboîte de manière sensiblement alignée dans la forme intérieure du châssis extérieur.
PCT/US2001/015495 2000-05-17 2001-05-14 Bioprothese cardiaque deux pieces WO2001087190A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/572,827 2000-05-17
US09/572,827 US7722667B1 (en) 1998-04-20 2000-05-17 Two piece bioprosthetic heart valve with matching outer frame and inner valve

Publications (2)

Publication Number Publication Date
WO2001087190A2 true WO2001087190A2 (fr) 2001-11-22
WO2001087190A3 WO2001087190A3 (fr) 2002-03-07

Family

ID=24289511

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/015495 WO2001087190A2 (fr) 2000-05-17 2001-05-14 Bioprothese cardiaque deux pieces

Country Status (1)

Country Link
WO (1) WO2001087190A2 (fr)

Cited By (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007009117A1 (fr) * 2005-07-13 2007-01-18 Arbor Surgical Technologies, Inc. Valves cardiaques prothetiques percutanees presentant deux parties et methodes de fabrication et d'utilisation associees
US7513909B2 (en) 2005-04-08 2009-04-07 Arbor Surgical Technologies, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
US7717955B2 (en) 2005-02-28 2010-05-18 Medtronic, Inc. Conformable prosthesis for implanting two-piece heart valves and methods for using them
US8083793B2 (en) 2005-02-28 2011-12-27 Medtronic, Inc. Two piece heart valves including multiple lobe valves and methods for implanting them
US8460373B2 (en) 2002-12-20 2013-06-11 Medtronic, Inc. Method for implanting a heart valve within an annulus of a patient
US8747463B2 (en) 2003-08-22 2014-06-10 Medtronic, Inc. Methods of using a prosthesis fixturing device
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9017399B2 (en) 2010-07-21 2015-04-28 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9681952B2 (en) 2013-01-24 2017-06-20 Mitraltech Ltd. Anchoring of prosthetic valve supports
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
USD800908S1 (en) 2016-08-10 2017-10-24 Mitraltech Ltd. Prosthetic valve element
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
USD841812S1 (en) 2017-08-03 2019-02-26 Cardiovalve Ltd. Prosthetic heart valve element
US10245143B2 (en) 2011-08-05 2019-04-02 Cardiovalve Ltd. Techniques for percutaneous mitral valve replacement and sealing
US10376361B2 (en) 2011-08-05 2019-08-13 Cardiovalve Ltd. Techniques for percutaneous mitral valve replacement and sealing
US10390952B2 (en) 2015-02-05 2019-08-27 Cardiovalve Ltd. Prosthetic valve with flexible tissue anchor portions
US10492908B2 (en) 2014-07-30 2019-12-03 Cardiovalve Ltd. Anchoring of a prosthetic valve
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
US10548726B2 (en) 2009-12-08 2020-02-04 Cardiovalve Ltd. Rotation-based anchoring of an implant
US10575948B2 (en) 2017-08-03 2020-03-03 Cardiovalve Ltd. Prosthetic heart valve
US10856975B2 (en) 2016-08-10 2020-12-08 Cardiovalve Ltd. Prosthetic valve with concentric frames
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
US11109964B2 (en) 2010-03-10 2021-09-07 Cardiovalve Ltd. Axially-shortening prosthetic valve
US11246704B2 (en) 2017-08-03 2022-02-15 Cardiovalve Ltd. Prosthetic heart valve
US11291545B2 (en) 2011-08-05 2022-04-05 Cardiovalve Ltd. Implant for heart valve
US11382746B2 (en) 2017-12-13 2022-07-12 Cardiovalve Ltd. Prosthetic valve and delivery tool therefor
US11633277B2 (en) 2018-01-10 2023-04-25 Cardiovalve Ltd. Temperature-control during crimping of an implant
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
US11793633B2 (en) 2017-08-03 2023-10-24 Cardiovalve Ltd. Prosthetic heart valve
US12029646B2 (en) 2017-08-03 2024-07-09 Cardiovalve Ltd. Prosthetic heart valve
US12053379B2 (en) 2016-08-01 2024-08-06 Cardiovalve Ltd. Minimally-invasive delivery systems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK124690D0 (da) * 1990-05-18 1990-05-18 Henning Rud Andersen Klapprotes til implantering i kroppen for erstatning af naturlig klap samt kateter til brug ved implantering af en saadan klapprotese
US5855597A (en) * 1997-05-07 1999-01-05 Iowa-India Investments Co. Limited Stent valve and stent graft for percutaneous surgery
US5935163A (en) * 1998-03-31 1999-08-10 Shelhigh, Inc. Natural tissue heart valve prosthesis

Cited By (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8460373B2 (en) 2002-12-20 2013-06-11 Medtronic, Inc. Method for implanting a heart valve within an annulus of a patient
US8747463B2 (en) 2003-08-22 2014-06-10 Medtronic, Inc. Methods of using a prosthesis fixturing device
US7717955B2 (en) 2005-02-28 2010-05-18 Medtronic, Inc. Conformable prosthesis for implanting two-piece heart valves and methods for using them
US8083793B2 (en) 2005-02-28 2011-12-27 Medtronic, Inc. Two piece heart valves including multiple lobe valves and methods for implanting them
US10226331B2 (en) 2005-02-28 2019-03-12 Medtronic, Inc. Conformable prostheses for implanting two-piece heart valves and methods for using them
US7513909B2 (en) 2005-04-08 2009-04-07 Arbor Surgical Technologies, Inc. Two-piece prosthetic valves with snap-in connection and methods for use
WO2007009117A1 (fr) * 2005-07-13 2007-01-18 Arbor Surgical Technologies, Inc. Valves cardiaques prothetiques percutanees presentant deux parties et methodes de fabrication et d'utilisation associees
US10660751B2 (en) 2009-12-08 2020-05-26 Cardiovalve Ltd. Prosthetic heart valve with upper skirt
US11351026B2 (en) 2009-12-08 2022-06-07 Cardiovalve Ltd. Rotation-based anchoring of an implant
US10548726B2 (en) 2009-12-08 2020-02-04 Cardiovalve Ltd. Rotation-based anchoring of an implant
US11839541B2 (en) 2009-12-08 2023-12-12 Cardiovalve Ltd. Prosthetic heart valve with upper skirt
US12167963B2 (en) 2010-03-10 2024-12-17 Cardiovalve Ltd. Method for use at a heart valve
US11109964B2 (en) 2010-03-10 2021-09-07 Cardiovalve Ltd. Axially-shortening prosthetic valve
US11653910B2 (en) 2010-07-21 2023-05-23 Cardiovalve Ltd. Helical anchor implantation
US11969163B2 (en) 2010-07-21 2024-04-30 Cardiovalve Ltd. Valve prosthesis configured for deployment in annular spacer
US10925595B2 (en) 2010-07-21 2021-02-23 Cardiovalve Ltd. Valve prosthesis configured for deployment in annular spacer
US9763657B2 (en) 2010-07-21 2017-09-19 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US9017399B2 (en) 2010-07-21 2015-04-28 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US11426155B2 (en) 2010-07-21 2022-08-30 Cardiovalve Ltd. Helical anchor implantation
US10531872B2 (en) 2010-07-21 2020-01-14 Cardiovalve Ltd. Valve prosthesis configured for deployment in annular spacer
US10512456B2 (en) 2010-07-21 2019-12-24 Cardiovalve Ltd. Techniques for percutaneous mitral valve replacement and sealing
US11517429B2 (en) 2011-08-05 2022-12-06 Cardiovalve Ltd. Apparatus for use at a heart valve
US9387078B2 (en) 2011-08-05 2016-07-12 Mitraltech Ltd. Percutaneous mitral valve replacement and sealing
US11690712B2 (en) 2011-08-05 2023-07-04 Cardiovalve Ltd. Clip-secured implant for heart valve
US11951005B2 (en) 2011-08-05 2024-04-09 Cardiovalve Ltd. Implant for heart valve
US10226341B2 (en) 2011-08-05 2019-03-12 Cardiovalve Ltd. Implant for heart valve
US11517436B2 (en) 2011-08-05 2022-12-06 Cardiovalve Ltd. Implant for heart valve
US11864995B2 (en) 2011-08-05 2024-01-09 Cardiovalve Ltd. Implant for heart valve
US11291545B2 (en) 2011-08-05 2022-04-05 Cardiovalve Ltd. Implant for heart valve
US10376361B2 (en) 2011-08-05 2019-08-13 Cardiovalve Ltd. Techniques for percutaneous mitral valve replacement and sealing
US10702385B2 (en) 2011-08-05 2020-07-07 Cardiovalve Ltd. Implant for heart valve
US11369469B2 (en) 2011-08-05 2022-06-28 Cardiovalve Ltd. Method for use at a heart valve
US11291546B2 (en) 2011-08-05 2022-04-05 Cardiovalve Ltd. Leaflet clip with collars
US10245143B2 (en) 2011-08-05 2019-04-02 Cardiovalve Ltd. Techniques for percutaneous mitral valve replacement and sealing
US10695173B2 (en) 2011-08-05 2020-06-30 Cardiovalve Ltd. Techniques for percutaneous mitral valve replacement and sealing
US8852272B2 (en) 2011-08-05 2014-10-07 Mitraltech Ltd. Techniques for percutaneous mitral valve replacement and sealing
US11344410B2 (en) 2011-08-05 2022-05-31 Cardiovalve Ltd. Implant for heart valve
US11291547B2 (en) 2011-08-05 2022-04-05 Cardiovalve Ltd. Leaflet clip with collars
US10631982B2 (en) 2013-01-24 2020-04-28 Cardiovale Ltd. Prosthetic valve and upstream support therefor
US9681952B2 (en) 2013-01-24 2017-06-20 Mitraltech Ltd. Anchoring of prosthetic valve supports
US10835377B2 (en) 2013-01-24 2020-11-17 Cardiovalve Ltd. Rolled prosthetic valve support
US11701225B2 (en) 2014-07-30 2023-07-18 Cardiovalve Ltd. Delivery of a prosthetic valve
US11872130B2 (en) 2014-07-30 2024-01-16 Cardiovalve Ltd. Prosthetic heart valve implant
US12053380B2 (en) 2014-07-30 2024-08-06 Cardiovalve Ltd. Anchoring of a prosthetic valve
US10492908B2 (en) 2014-07-30 2019-12-03 Cardiovalve Ltd. Anchoring of a prosthetic valve
US10864078B2 (en) 2015-02-05 2020-12-15 Cardiovalve Ltd. Prosthetic valve with separably-deployable valve body and tissue anchors
US10390952B2 (en) 2015-02-05 2019-08-27 Cardiovalve Ltd. Prosthetic valve with flexible tissue anchor portions
US10849748B2 (en) 2015-02-05 2020-12-01 Cardiovalve Ltd. Prosthetic valve delivery system with independently-movable capsule portions
US10888422B2 (en) 2015-02-05 2021-01-12 Cardiovalve Ltd. Prosthetic valve with flexible tissue anchor portions
US9974651B2 (en) 2015-02-05 2018-05-22 Mitral Tech Ltd. Prosthetic valve with axially-sliding frames
US10918481B2 (en) 2015-02-05 2021-02-16 Cardiovalve Ltd. Techniques for deployment of a prosthetic valve
US10758344B2 (en) 2015-02-05 2020-09-01 Cardiovalve Ltd. Prosthetic valve with angularly offset frames
US10973636B2 (en) 2015-02-05 2021-04-13 Cardiovalve Ltd. Prosthetic valve with tissue anchors free from lateral interconnections
US10736742B2 (en) 2015-02-05 2020-08-11 Cardiovalve Ltd. Prosthetic valve with atrial arms
US10357360B2 (en) 2015-02-05 2019-07-23 Cardiovalve Ltd. Prosthetic valve with aligned inner and outer frames
US10722360B2 (en) 2015-02-05 2020-07-28 Cardiovalve Ltd. Prosthetic valve with radially-deflectable tissue anchors
US10695177B2 (en) 2015-02-05 2020-06-30 Cardiovalve Ltd. Prosthetic valve with aligned inner and outer frames
US10682227B2 (en) 2015-02-05 2020-06-16 Cardiovalve Ltd. Prosthetic valve with pivoting tissue anchor portions
US10426610B2 (en) 2015-02-05 2019-10-01 Cardiovalve Ltd. Prosthetic valve with radially-deflectable tissue anchors
US10667908B2 (en) 2015-02-05 2020-06-02 Cardiovalve Ltd. Prosthetic valve with S-shaped tissue anchors
US11801135B2 (en) 2015-02-05 2023-10-31 Cardiovalve Ltd. Techniques for deployment of a prosthetic valve
US11793638B2 (en) 2015-02-05 2023-10-24 Cardiovalve Ltd. Prosthetic valve with pivoting tissue anchor portions
US11793635B2 (en) 2015-02-05 2023-10-24 Cardiovalve Ltd. Prosthetic valve with angularly offset frames
US10449047B2 (en) 2015-02-05 2019-10-22 Cardiovalve Ltd. Prosthetic heart valve with compressible frames
US10524903B2 (en) 2015-02-05 2020-01-07 Cardiovalve Ltd. Prosthetic valve with aligned inner and outer frames
US10507105B2 (en) 2015-02-05 2019-12-17 Cardiovalve Ltd. Prosthetic valve with tissue anchors free from lateral interconnections
US11534298B2 (en) 2015-02-05 2022-12-27 Cardiovalve Ltd. Prosthetic valve with s-shaped tissue anchors
US10463487B2 (en) 2015-02-05 2019-11-05 Cardiovalve Ltd. Prosthetic valve delivery system with independently-movable capsule portions
US11672658B2 (en) 2015-02-05 2023-06-13 Cardiovalve Ltd. Prosthetic valve with aligned inner and outer frames
US10463488B2 (en) 2015-02-05 2019-11-05 Cardiovalve Ltd. Prosthetic valve with separably-deployable valve body and tissue anchors
US11298117B2 (en) 2016-02-16 2022-04-12 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
US10531866B2 (en) 2016-02-16 2020-01-14 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
US11937795B2 (en) 2016-02-16 2024-03-26 Cardiovalve Ltd. Techniques for providing a replacement valve and transseptal communication
US12053379B2 (en) 2016-08-01 2024-08-06 Cardiovalve Ltd. Minimally-invasive delivery systems
USD800908S1 (en) 2016-08-10 2017-10-24 Mitraltech Ltd. Prosthetic valve element
US11779458B2 (en) 2016-08-10 2023-10-10 Cardiovalve Ltd. Prosthetic valve with leaflet connectors
US10856975B2 (en) 2016-08-10 2020-12-08 Cardiovalve Ltd. Prosthetic valve with concentric frames
USD841812S1 (en) 2017-08-03 2019-02-26 Cardiovalve Ltd. Prosthetic heart valve element
US11793633B2 (en) 2017-08-03 2023-10-24 Cardiovalve Ltd. Prosthetic heart valve
US10537426B2 (en) 2017-08-03 2020-01-21 Cardiovalve Ltd. Prosthetic heart valve
US11246704B2 (en) 2017-08-03 2022-02-15 Cardiovalve Ltd. Prosthetic heart valve
US12232958B2 (en) 2017-08-03 2025-02-25 Cardiovalve Ltd. Prosthetic heart valve
US11571298B2 (en) 2017-08-03 2023-02-07 Cardiovalve Ltd. Prosthetic valve with appendages
US12090048B2 (en) 2017-08-03 2024-09-17 Cardiovalve Ltd. Prosthetic heart valve
USD841813S1 (en) 2017-08-03 2019-02-26 Cardiovalve Ltd. Prosthetic heart valve element
US12064347B2 (en) 2017-08-03 2024-08-20 Cardiovalve Ltd. Prosthetic heart valve
US12029646B2 (en) 2017-08-03 2024-07-09 Cardiovalve Ltd. Prosthetic heart valve
US10575948B2 (en) 2017-08-03 2020-03-03 Cardiovalve Ltd. Prosthetic heart valve
US10888421B2 (en) 2017-09-19 2021-01-12 Cardiovalve Ltd. Prosthetic heart valve with pouch
US11382746B2 (en) 2017-12-13 2022-07-12 Cardiovalve Ltd. Prosthetic valve and delivery tool therefor
US11872131B2 (en) 2017-12-13 2024-01-16 Cardiovalve Ltd. Prosthetic valve and delivery tool therefor
US11633277B2 (en) 2018-01-10 2023-04-25 Cardiovalve Ltd. Temperature-control during crimping of an implant
US11872124B2 (en) 2018-01-10 2024-01-16 Cardiovalve Ltd. Temperature-control during crimping of an implant

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