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WO2001081586A3 - 21657, deshydrogenase humaine a chaine courte et ses utilisations - Google Patents

21657, deshydrogenase humaine a chaine courte et ses utilisations Download PDF

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Publication number
WO2001081586A3
WO2001081586A3 PCT/US2001/013789 US0113789W WO0181586A3 WO 2001081586 A3 WO2001081586 A3 WO 2001081586A3 US 0113789 W US0113789 W US 0113789W WO 0181586 A3 WO0181586 A3 WO 0181586A3
Authority
WO
WIPO (PCT)
Prior art keywords
scdr
nucleic acid
acid molecules
molecules
chain dehydrogenase
Prior art date
Application number
PCT/US2001/013789
Other languages
English (en)
Other versions
WO2001081586A2 (fr
Inventor
Rachel E Meyers
Original Assignee
Millennium Pharm Inc
Rachel E Meyers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc, Rachel E Meyers filed Critical Millennium Pharm Inc
Priority to AU2001257407A priority Critical patent/AU2001257407A1/en
Priority to EP01930918A priority patent/EP1280917A2/fr
Publication of WO2001081586A2 publication Critical patent/WO2001081586A2/fr
Publication of WO2001081586A3 publication Critical patent/WO2001081586A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne des molécules d'acides nucléiques isolées, désignées molécules d'acide nucléique SCDR, qui codent des molécules de déshydrogénase à chaîne courte se rapportant aux SCDR de l'invention. L'invention concerne également des molécules d'acide nucléique antisens, des vecteurs d'expression de recombinaison contenant les molécules d'acide nucléique SCDR, des cellules hôtes dans lesquels ont été introduits les vecteurs d'expression, et des animaux transgéniques non humains dans lesquels un gène SCDR a été introduit ou interrompu. L'invention concerne en outre des protéines SCDR isolées, des protéines de fusion, des peptides antigènes, et des anticorps anti-SCDR. L'invention concerne enfin des procédés de diagnostic utilisant les compositions de l'invention.
PCT/US2001/013789 2000-04-26 2001-04-25 21657, deshydrogenase humaine a chaine courte et ses utilisations WO2001081586A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001257407A AU2001257407A1 (en) 2000-04-26 2001-04-25 21657, a human short-chain dehydrogenase and uses thereof
EP01930918A EP1280917A2 (fr) 2000-04-26 2001-04-25 21657, deshydrogenase humaine a chaine courte et ses utilisations

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19993700P 2000-04-26 2000-04-26
US60/199,937 2000-04-26

Publications (2)

Publication Number Publication Date
WO2001081586A2 WO2001081586A2 (fr) 2001-11-01
WO2001081586A3 true WO2001081586A3 (fr) 2002-07-18

Family

ID=22739631

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/013789 WO2001081586A2 (fr) 2000-04-26 2001-04-25 21657, deshydrogenase humaine a chaine courte et ses utilisations

Country Status (3)

Country Link
EP (1) EP1280917A2 (fr)
AU (1) AU2001257407A1 (fr)
WO (1) WO2001081586A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003052087A2 (fr) * 2001-12-14 2003-06-26 Bayer Healthcare Ag Regulation de la deshydrogenase/reductase humaine a chaine courte
CA2632675A1 (fr) * 2005-12-08 2007-07-05 Lionel J. Coignet Strategies diagnostiques et therapeutiques pour des pathologies associees au gene flj13639

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1074617A2 (fr) * 1999-07-29 2001-02-07 Helix Research Institute Amorces pour la synthèse de cADN de pleine longueur et leur utilisation
WO2001055364A2 (fr) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Acides nucléiques, protéines et anticorps
WO2001057190A2 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Acides nucleiques et polypeptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1074617A2 (fr) * 1999-07-29 2001-02-07 Helix Research Institute Amorces pour la synthèse de cADN de pleine longueur et leur utilisation
WO2001055364A2 (fr) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Acides nucléiques, protéines et anticorps
WO2001055301A2 (fr) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps
WO2001057190A2 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Acides nucleiques et polypeptides

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 14 September 1999 (1999-09-14), "Homo sapiens cDNA, similar to TR:O53613 Oxidoreductase, mRNA sequence", XP002194834, Database accession no. AW025219 *
DATABASE EMBL 2 August 1999 (1999-08-02), "Homo sapiens cDNA, similar to WP:C01G8.3 CE07803 Oxidoreductase, mRNA", XP002194833, Database accession no. AI921843 *
DATABASE EMBL 28 May 1999 (1999-05-28), "Homo sapiens cDNA clone, similar to SW:OXIR_STRAT Q03326 Probable Oxidoreductase", XP002194835, Database accession no. AI688167 *
DATABASE EMBL 30 November 1999 (1999-11-30), "Homo sapiens cDNA, similar to TR:Q9ZAU1 Daunorubicin C-13 Ketoreductase, mRNA sequence", XP002194832, Database accession no. AW 194384 *
DATABASE GENESEQ "cDNA encoding novel human enzyme polypeptide #102", XP002195015, Database accession no. AAS40886 *
DATABASE GENESEQ 12 November 2001 (2001-11-12), "Human endocrine polypeptide SEQ ID No 323", XP002195009, Database accession no. AAU18368 *
DATABASE GENESEQ 18 December 2001 (2001-12-18), "novel human enzyme polypeptide #117", XP002195014, Database accession no. AAU23031 *
DATABASE GENESEQ 21 November 2001 (2001-11-21), "human endocrine polypeptide encoding cDNA SEQ ID No 97", XP002195011, Database accession no. AAS29597 *
DATABASE GENESEQ 21 November 2001 (2001-11-21), "human endocrine polypeptide encoding cDNA SEQ ID No 98", XP002195012, Database accession no. AAS29598 *
DATABASE GENESEQ 21 November 2001 (2001-11-21), "human endocrine polypeptides SEQ ID No 324", XP002195010, Database accession no. AAU18369 *
DATABASE GENESEQ 6 November 2001 (2001-11-06), "Human polynucleotide SEQ ID NO 796", XP002195013, Database accession no. AAK52251 *
JOERNVALL H ET AL: "SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR)", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 34, no. 18, 9 May 1995 (1995-05-09), pages 6003 - 6013, XP000929805, ISSN: 0006-2960 *
JORNVALL H ET AL: "SDR and MDR: completed genome sequences show these protein families to be large, of old origin, and of complex nature", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 445, no. 2-3, 26 February 1999 (1999-02-26), pages 261 - 264, XP004259268, ISSN: 0014-5793 *
KROZOWSKI Z: "THE SHORT-CHAIN ALCOHOL DEHYDROGENASE SUPERFAMILY: VARIATIONS ON A COMMON THEME", JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, ELSEVIER SCIENCE LTD., OXFORD, GB, vol. 51, no. 3/4, November 1994 (1994-11-01), pages 125 - 130, XP001008512, ISSN: 0960-0760 *

Also Published As

Publication number Publication date
EP1280917A2 (fr) 2003-02-05
WO2001081586A2 (fr) 2001-11-01
AU2001257407A1 (en) 2001-11-07

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