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WO2001079467A3 - Identification d'une nouvelle nadph-oxydase renale - Google Patents

Identification d'une nouvelle nadph-oxydase renale Download PDF

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Publication number
WO2001079467A3
WO2001079467A3 PCT/US2001/010866 US0110866W WO0179467A3 WO 2001079467 A3 WO2001079467 A3 WO 2001079467A3 US 0110866 W US0110866 W US 0110866W WO 0179467 A3 WO0179467 A3 WO 0179467A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
renal
invention includes
mammalian renal
treating
Prior art date
Application number
PCT/US2001/010866
Other languages
English (en)
Other versions
WO2001079467A2 (fr
Inventor
Thomas L Leto
Miklos Geiszt
Original Assignee
Us Health
Thomas L Leto
Miklos Geiszt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Health, Thomas L Leto, Miklos Geiszt filed Critical Us Health
Priority to AU2001253123A priority Critical patent/AU2001253123A1/en
Publication of WO2001079467A2 publication Critical patent/WO2001079467A2/fr
Publication of WO2001079467A3 publication Critical patent/WO2001079467A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Cette invention se rapporte à des acides nucléiques et à leurs polypeptides codés correspondant à de nouvelles NADPH-oxydases rénales mammaliennes, et à des utilisations de ces acides nucléiques et polypeptides. Cette invention concerne des compositions thérapeutiques correspondant à ces nouvelles NADPH-oxydases rénales mammaliennes, des vecteurs d'expression contenant ces acides nucléiques et des lignées cellulaires transformées contenant ces vecteurs d'expression, ainsi que des procédés de traitement de patients à l'aide de compositions thérapeutiques correspondant à ces nouvelles NADPH-oxydases rénales mammaliennes et des procédés pour produire les polypeptides faisant l'objet de cette invention. Cette invention concerne en outre des dosages permettant de découvrir des composés qui ont la fonction de protéines codées par des acides nucléiques de ces nouvelles NADPH-oxydases rénales mammaliennes, un procédé pour traiter ou prévenir le cancer, l'hypertension, les maladies rénales inflammatoires et les infections des voies urinaires, et un procédé pour traiter des patients souffrant de polycythémie, ainsi qu'un procédé pour déterminer la séquence d'un gène de NADPH-oxydases rénales mammaliennes dans un échantillon.
PCT/US2001/010866 2000-04-12 2001-04-03 Identification d'une nouvelle nadph-oxydase renale WO2001079467A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001253123A AU2001253123A1 (en) 2000-04-12 2001-04-03 Identification of a renal nadph oxidase

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19634100P 2000-04-12 2000-04-12
US60/196,341 2000-04-12
US21262900P 2000-06-19 2000-06-19
US60/212,629 2000-06-19

Publications (2)

Publication Number Publication Date
WO2001079467A2 WO2001079467A2 (fr) 2001-10-25
WO2001079467A3 true WO2001079467A3 (fr) 2003-01-23

Family

ID=26891837

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/010866 WO2001079467A2 (fr) 2000-04-12 2001-04-03 Identification d'une nouvelle nadph-oxydase renale

Country Status (2)

Country Link
AU (1) AU2001253123A1 (fr)
WO (1) WO2001079467A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1399565A2 (fr) * 2000-11-16 2004-03-24 Emory University Regulateurs d'oxygenase mitogeniques

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053312A1 (fr) * 1999-12-23 2001-07-26 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001053312A1 (fr) * 1999-12-23 2001-07-26 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 15 March 2000 (2000-03-15), YANG S. ET AL.: "Mus musculus superoxide-generating oxidase mRNA, complete cds.", XP002209503, retrieved from EBI Database accession no. AF218723 *
DATABASE GENESEQ [online] 22 January 2002 (2002-01-22), "WO200153312 ,Human polypeptide SEQ ID NO 3483", XP002209504, retrieved from EBI Database accession no. AAM40338 *
DATABASE GENESEQ [online] 22 October 2001 (2001-10-22), "WO0153312 SEQ ID NO 3484", XP002209505, retrieved from EBI Database accession no. AAM40339 *
GEISZT MIKLOS ET AL: "Identification of Renox, an NAD(P)H oxidase in kidney.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 97, no. 14, 5 July 2000 (2000-07-05), July 5, 2000, pages 8010 - 8014, XP002209502, ISSN: 0027-8424 *
YANG S ET AL: "Nicotinamide adenine dinucleotide phosphate oxidase in the formation of superoxide in osteoclasts.", CALCIFIED TISSUE INTERNATIONAL, vol. 63, no. 4, October 1998 (1998-10-01), pages 346 - 350, XP001097147, ISSN: 0171-967X *
YANG SU ET AL: "A new superoxide-generating oxidase in murine osteoclasts.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 8, 23 February 2001 (2001-02-23), pages 5452 - 5458, XP002209501, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU2001253123A1 (en) 2001-10-30
WO2001079467A2 (fr) 2001-10-25

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