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WO2001078765A3 - Prophylaxe und therapie von diabetes mellitus 1 mit hilfe proteolytischer enzyme - Google Patents

Prophylaxe und therapie von diabetes mellitus 1 mit hilfe proteolytischer enzyme Download PDF

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Publication number
WO2001078765A3
WO2001078765A3 PCT/EP2001/004346 EP0104346W WO0178765A3 WO 2001078765 A3 WO2001078765 A3 WO 2001078765A3 EP 0104346 W EP0104346 W EP 0104346W WO 0178765 A3 WO0178765 A3 WO 0178765A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteolytic enzymes
prophylaxis
treatment
diabetes mellitus
proteolytic
Prior art date
Application number
PCT/EP2001/004346
Other languages
English (en)
French (fr)
Other versions
WO2001078765A2 (de
Inventor
Karl Ransberger
Gerhard Stauder
Original Assignee
Mucos Pharma Gmbh & Co
Karl Ransberger
Gerhard Stauder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mucos Pharma Gmbh & Co, Karl Ransberger, Gerhard Stauder filed Critical Mucos Pharma Gmbh & Co
Publication of WO2001078765A2 publication Critical patent/WO2001078765A2/de
Publication of WO2001078765A3 publication Critical patent/WO2001078765A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die vorliegende Erfindung betrifft die Verwendung proteolytischer Enzyme zur Prophylaxe bzw. Therapie von Diabetes mellitus vom Typ 1. Dabei erfolgt der Einsatz der proteolytischen Enzyme vorzugsweise im prädiabetischen Stadium.
PCT/EP2001/004346 2000-04-17 2001-04-17 Prophylaxe und therapie von diabetes mellitus 1 mit hilfe proteolytischer enzyme WO2001078765A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10018980.6 2000-04-17
DE10018980A DE10018980A1 (de) 2000-04-17 2000-04-17 Prophylaxe und Therapie von Diabetes mellitus I mit Hilfe proteolytischer Enzyme

Publications (2)

Publication Number Publication Date
WO2001078765A2 WO2001078765A2 (de) 2001-10-25
WO2001078765A3 true WO2001078765A3 (de) 2002-04-11

Family

ID=7639036

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/004346 WO2001078765A2 (de) 2000-04-17 2001-04-17 Prophylaxe und therapie von diabetes mellitus 1 mit hilfe proteolytischer enzyme

Country Status (3)

Country Link
US (1) US20020015698A1 (de)
DE (1) DE10018980A1 (de)
WO (1) WO2001078765A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040028675A1 (en) * 2001-12-07 2004-02-12 Zarlink Semiconductor Ab Compositions for the treatment of lupus
US20060101084A1 (en) * 2004-10-25 2006-05-11 International Business Machines Corporation Policy based data migration in a hierarchical data storage system

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000082A1 (en) * 1994-06-24 1996-01-04 Cortecs Limited Medical use of bromelain
WO1997024138A2 (en) * 1995-12-29 1997-07-10 Cortecs (Uk) Limited Medical use of proteases
DE19726255A1 (de) * 1997-06-20 1998-12-24 Mucos Pharma Gmbh & Co Beeinflussung von Cytokinen durch proteolytische Enzyme
DE19847114A1 (de) * 1998-10-13 2000-04-20 Mucos Pharma Gmbh & Co Beeinflussung von hyperaktiven T-Zellen durch proteolytische Enzyme

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000082A1 (en) * 1994-06-24 1996-01-04 Cortecs Limited Medical use of bromelain
WO1997024138A2 (en) * 1995-12-29 1997-07-10 Cortecs (Uk) Limited Medical use of proteases
DE19726255A1 (de) * 1997-06-20 1998-12-24 Mucos Pharma Gmbh & Co Beeinflussung von Cytokinen durch proteolytische Enzyme
DE19847114A1 (de) * 1998-10-13 2000-04-20 Mucos Pharma Gmbh & Co Beeinflussung von hyperaktiven T-Zellen durch proteolytische Enzyme

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
TARGONI OLEG S ET AL: "Prevention of murine EAE by oral hydrolytic enzyme treatment.", JOURNAL OF AUTOIMMUNITY, vol. 12, no. 3, May 1999 (1999-05-01), pages 191 - 198, XP002181698, ISSN: 0896-8411 *
WIEST-LADENBURGER U ET AL: "Protease treatment delays diabetes onset in diabetes-prone nonobese diabetic (NOD) mice.", INTERNATIONAL JOURNAL OF IMMUNOTHERAPY, vol. 13, no. 3-4, 1997, pages 75 - 78, XP001031147, ISSN: 0255-9625 *

Also Published As

Publication number Publication date
US20020015698A1 (en) 2002-02-07
DE10018980A1 (de) 2001-11-08
WO2001078765A2 (de) 2001-10-25

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