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WO2001077353A3 - Proteines therapeutiquement actives dans des vegetaux - Google Patents

Proteines therapeutiquement actives dans des vegetaux Download PDF

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Publication number
WO2001077353A3
WO2001077353A3 PCT/EP2001/003788 EP0103788W WO0177353A3 WO 2001077353 A3 WO2001077353 A3 WO 2001077353A3 EP 0103788 W EP0103788 W EP 0103788W WO 0177353 A3 WO0177353 A3 WO 0177353A3
Authority
WO
WIPO (PCT)
Prior art keywords
plastids
expression
plants
pollen allergens
host
Prior art date
Application number
PCT/EP2001/003788
Other languages
English (en)
Other versions
WO2001077353A2 (fr
Inventor
Peter Bernard Heifetz
Stephen Arthur Goff
Annmarie Bloom Tuttle
Monika Else Griot-Wenk
Original Assignee
Syngenta Participations Ag
Peter Bernard Heifetz
Stephen Arthur Goff
Annmarie Bloom Tuttle
Griot Wenk Monika Else
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag, Peter Bernard Heifetz, Stephen Arthur Goff, Annmarie Bloom Tuttle, Griot Wenk Monika Else filed Critical Syngenta Participations Ag
Priority to AU2001252246A priority Critical patent/AU2001252246A1/en
Publication of WO2001077353A2 publication Critical patent/WO2001077353A2/fr
Publication of WO2001077353A3 publication Critical patent/WO2001077353A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
    • C12N15/8214—Plastid transformation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Botany (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Peptides Or Proteins (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

La présente invention concerne des plantes transgéniques exprimant des protéines thérapeutiquement actives, de préférence à partir de leur génome plasmidique ou ciblées sur le vacuole. Cette invention concerne aussi l'administration de ces plantes transgéniques à un hôte dans le cadre de la prévention ou du traitement de maladies. Dans un mode de réalisation préféré de l'invention, ces plantes ou ces matières dérivées de ces plantes sont administrées à cet hôte par voie orale.
PCT/EP2001/003788 2000-04-05 2001-04-03 Proteines therapeutiquement actives dans des vegetaux WO2001077353A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001252246A AU2001252246A1 (en) 2000-04-05 2001-04-03 Therapeutically active proteins in plants

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54361900A 2000-04-05 2000-04-05
US09/543,619 2000-04-05

Publications (2)

Publication Number Publication Date
WO2001077353A2 WO2001077353A2 (fr) 2001-10-18
WO2001077353A3 true WO2001077353A3 (fr) 2002-04-11

Family

ID=24168804

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/003788 WO2001077353A2 (fr) 2000-04-05 2001-04-03 Proteines therapeutiquement actives dans des vegetaux

Country Status (2)

Country Link
AU (1) AU2001252246A1 (fr)
WO (1) WO2001077353A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU783800B2 (en) 1999-09-21 2005-12-08 Rutgers, The State University Of New Jersey Site-specific recombination system to manipulate the plastid genome of higher plants
US7186560B2 (en) 1999-09-21 2007-03-06 Rutgers, The State University Of New Jersey High level expression of immunogenic proteins in the plastids of higher plants
US7534936B2 (en) 2001-03-29 2009-05-19 Rutgers, The State University Of New Jersey Transgenic plants having transformed plastid genomes and progeny thereof
CA2517856A1 (fr) 2003-03-03 2004-09-16 Rutgers, The State University Of New Jersey Elimination de sequences de plastides a l'aide de recombinases specifiques de sites, a expression transitoire
WO2007121467A2 (fr) 2006-04-18 2007-10-25 Rutgers, The State University Of New Jersey Compositions et procédés destinés à augmenter l'expression de transgènes dans les plastes des plantes supérieures

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001486A1 (fr) * 1987-08-11 1989-02-23 New York University Fragments de proteines bactericides/augmentant la permeabilite, biologiquement actifs
WO1994005790A1 (fr) * 1992-09-10 1994-03-17 Immulogic Pharmaceutical Corporation Clonage et sequençage d'allergenes de dermatophagoides (acariens de la poussiere)
WO1994010314A1 (fr) * 1992-10-30 1994-05-11 The University Of Melbourne Peptides et proteines allergenes obtenus a partir du pollen du sorgho d'alep
EP0770681A2 (fr) * 1992-04-09 1997-05-02 Immulogic Pharmaceutical Corporation Epitopes de lymphocytes T des principaux allergènes d'Ambrosia artemisiifolia
WO1998004274A1 (fr) * 1996-07-31 1998-02-05 University Of Manitoba Allergenes salivaires du moustique
WO1998006861A2 (fr) * 1996-08-15 1998-02-19 Agrivax Incorporated Administration d'antigenes tolerogeniques via des plantes comestibles ou des produits derives de plantes
WO2000020612A2 (fr) * 1998-10-07 2000-04-13 Syngenta Participations Ag Proteines vegetales a action therapeutique

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989001486A1 (fr) * 1987-08-11 1989-02-23 New York University Fragments de proteines bactericides/augmentant la permeabilite, biologiquement actifs
EP0770681A2 (fr) * 1992-04-09 1997-05-02 Immulogic Pharmaceutical Corporation Epitopes de lymphocytes T des principaux allergènes d'Ambrosia artemisiifolia
WO1994005790A1 (fr) * 1992-09-10 1994-03-17 Immulogic Pharmaceutical Corporation Clonage et sequençage d'allergenes de dermatophagoides (acariens de la poussiere)
WO1994010314A1 (fr) * 1992-10-30 1994-05-11 The University Of Melbourne Peptides et proteines allergenes obtenus a partir du pollen du sorgho d'alep
WO1998004274A1 (fr) * 1996-07-31 1998-02-05 University Of Manitoba Allergenes salivaires du moustique
WO1998006861A2 (fr) * 1996-08-15 1998-02-19 Agrivax Incorporated Administration d'antigenes tolerogeniques via des plantes comestibles ou des produits derives de plantes
WO2000020612A2 (fr) * 1998-10-07 2000-04-13 Syngenta Participations Ag Proteines vegetales a action therapeutique

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BREITENEDER H ET AL: "THE GENE CODING FOR THE MAJOR BIRCH POLLEN ALLERGEN BETVL, IS HIGHLY HOMOLOGOUS TO A PEA DISEASE RESISTANCE RESPONSE GENE", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 8, no. 7, 1 July 1989 (1989-07-01), pages 1935 - 1938, XP000050673, ISSN: 0261-4189 *

Also Published As

Publication number Publication date
WO2001077353A2 (fr) 2001-10-18
AU2001252246A1 (en) 2001-10-23

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