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WO2001077169A3 - Methodes et materiaux relatifs a de nouveaux polypeptides et polynucleotides du type facteur de croissance des cellules-souches - Google Patents

Methodes et materiaux relatifs a de nouveaux polypeptides et polynucleotides du type facteur de croissance des cellules-souches Download PDF

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Publication number
WO2001077169A3
WO2001077169A3 PCT/US2001/011208 US0111208W WO0177169A3 WO 2001077169 A3 WO2001077169 A3 WO 2001077169A3 US 0111208 W US0111208 W US 0111208W WO 0177169 A3 WO0177169 A3 WO 0177169A3
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WO
WIPO (PCT)
Prior art keywords
polynucleotides
polypeptides
growth factor
stem cell
cell growth
Prior art date
Application number
PCT/US2001/011208
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English (en)
Other versions
WO2001077169A9 (fr
WO2001077169A2 (fr
Inventor
Tom Y Tang
Ivan Labat
Radoje T Drmanac
Nancy K Mize
Mitsuo Nishikawa
Cheng-Chi Chao
Original Assignee
Kirin Brewery
Tom Y Tang
Ivan Labat
Radoje T Drmanac
Nancy K Mize
Mitsuo Nishikawa
Cheng-Chi Chao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery, Tom Y Tang, Ivan Labat, Radoje T Drmanac, Nancy K Mize, Mitsuo Nishikawa, Cheng-Chi Chao filed Critical Kirin Brewery
Priority to EP01932523A priority Critical patent/EP1268543A2/fr
Priority to AU5904101A priority patent/AU5904101A/xx
Priority to JP2001575639A priority patent/JP2003530124A/ja
Priority to CA002405104A priority patent/CA2405104A1/fr
Publication of WO2001077169A2 publication Critical patent/WO2001077169A2/fr
Publication of WO2001077169A3 publication Critical patent/WO2001077169A3/fr
Publication of WO2001077169A9 publication Critical patent/WO2001077169A9/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne de nouveaux polynucléotides et polypeptides codés par ces polynucléotides et des mutants ou variants de ceux-ci qui correspondent à un nouveau polypeptide sécrété humain du type facteur de croissance de cellules souches. Ces polynucléotides comprennent des séquences d'acide nucléique isolées à partir de bibliothèques d'ADNc préparées à partir de cellules de testicules humains (numéros d'identification de clone Hyseq 2880984 et 2881695), de peau de foetus humains (numéro d'identification de clone Hyseq 15375176), de rates d'adulte (numéro d'identification de clone Hyseq 14856094) et de cellules endothéliales humaines (numéros d'identification de clone Hyseq 13804756, 13687487, 13804756). D'autres aspects de l'invention concernent des vecteurs contenant des processus pour produire de nouveaux polypeptides humains du type facteur de croissance de cellules souches, ainsi que des anticorps spécifiques de ces polypeptides.
PCT/US2001/011208 2000-04-05 2001-04-05 Methodes et materiaux relatifs a de nouveaux polypeptides et polynucleotides du type facteur de croissance des cellules-souches WO2001077169A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01932523A EP1268543A2 (fr) 2000-04-05 2001-04-05 Methodes et materiaux relatifs a de nouveaux polypeptides et polynucleotides du type facteur de croissance des cellules-souches
AU5904101A AU5904101A (en) 2000-04-05 2001-04-05 Methods and materials relating to novel stem cell growth factor-like polypeptides and polynucleotides
JP2001575639A JP2003530124A (ja) 2000-04-05 2001-04-05 新規幹細胞成長因子様ポリペプチドおよびポリヌクレオチドに関する方法および物質
CA002405104A CA2405104A1 (fr) 2000-04-05 2001-04-05 Methodes et materiaux relatifs a de nouveaux polypeptides et polynucleotides du type facteur de croissance des cellules-souches

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US54377400A 2000-04-05 2000-04-05
US09/543,774 2000-04-05
US21573300P 2000-06-28 2000-06-28
US60/215,733 2000-06-28
US75756201A 2001-01-09 2001-01-09
US09/757,562 2001-01-09
US26661401P 2001-02-05 2001-02-05
US60/266,614 2001-02-05

Publications (3)

Publication Number Publication Date
WO2001077169A2 WO2001077169A2 (fr) 2001-10-18
WO2001077169A3 true WO2001077169A3 (fr) 2002-07-04
WO2001077169A9 WO2001077169A9 (fr) 2002-12-19

Family

ID=27499020

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/011208 WO2001077169A2 (fr) 2000-04-05 2001-04-05 Methodes et materiaux relatifs a de nouveaux polypeptides et polynucleotides du type facteur de croissance des cellules-souches

Country Status (5)

Country Link
EP (1) EP1268543A2 (fr)
JP (1) JP2003530124A (fr)
AU (1) AU5904101A (fr)
CA (1) CA2405104A1 (fr)
WO (1) WO2001077169A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7411052B2 (en) 2001-03-05 2008-08-12 Nuvelo, Inc. Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
EP1434796A2 (fr) * 2001-10-03 2004-07-07 Incyte Genomics, Inc. Proteines secretees
WO2005040418A2 (fr) 2003-10-10 2005-05-06 Deutsches Krebsforschungszentrum Compositions pour le diagnostic et le traitement de maladies associees a l'expression aberrante des futrins (r-spondins) et/ou wnt
US20050256044A1 (en) 2004-01-27 2005-11-17 Boyle Bryan J Gastrointestinal proliferative factor and uses thereof
US7541431B2 (en) 2005-09-07 2009-06-02 Maine Medical Center Cristin/R-spondin ligands active in the Wnt signaling pathway and methods, compositions and kits relating thereto
US20090118176A1 (en) * 2005-10-07 2009-05-07 Emtage Peter C R Stem Cell Factor-Like Protein Scfa1 and Uses Thereof
ES2557953T3 (es) 2006-09-29 2016-01-29 Oncomed Pharmaceuticals, Inc. Composiciones y métodos para diagnosticar y tratar cáncer
HUE027179T2 (en) 2006-10-20 2016-10-28 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts Angiogenesis and vasculogenesis modulator for Rspond
WO2008075796A1 (fr) * 2006-12-21 2008-06-26 Kyowa Hakko Kirin Co., Ltd. Agent pour encourager la récupération après une déplétion de globule sanguin
PL2173379T3 (pl) 2007-07-02 2016-02-29 Oncomed Pharm Inc Kompozycje oraz sposoby leczenia i diagnozowania nowotworu
KR101904224B1 (ko) 2009-02-03 2018-10-04 코닌클리즈케 네덜란드세 아카데미 반 베텐샤펜 상피 줄기 세포용 배양 배지 및 상기 줄기 세포를 포함하는 오르가노이드
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
EP2412800A1 (fr) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Organoïde du foie, ses utilisations et son procédé de culture pour l'obtenir
EP2419133A1 (fr) 2009-04-15 2012-02-22 Deutsches Krebsforschungszentrum Inhibition de la rspondine-3 dans des troubles osseux
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
MX349198B (es) 2011-07-15 2017-07-18 Oncomed Pharmaceuticals Inc * Agentes que se unen a las proteinas de r-espondinas (rspo) y usos de los mismos.
US10420801B2 (en) 2012-03-21 2019-09-24 The General Hospital Corporation Isolation and use of human lymphoid organ-derived suppressive stromal cells
EP2872175A4 (fr) 2012-07-13 2016-04-20 Oncomed Pharm Inc Agents de liaison des protéines rspo3 et leurs utilisations
MA40574A (fr) 2014-09-16 2016-03-24 Oncomed Pharm Inc Traitement de maladies fibrotiques
CN108607101A (zh) * 2018-05-04 2018-10-02 广西中医药大学附属瑞康医院 Zip1基因在制备抑制骨髓间充质干细胞凋亡的产品中的应用
CN111420034A (zh) * 2019-01-08 2020-07-17 上海莱馥医疗科技有限公司 一种用于治疗银屑病的混合干细胞制剂及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998049302A1 (fr) * 1997-04-25 1998-11-05 Genetics Institute, Inc. Proteines secretees et polynucleotides les codant
WO2000056755A1 (fr) * 1999-03-19 2000-09-28 Human Genome Sciences, Inc. Proteines humaines secretees (49)
WO2001040294A1 (fr) * 1999-11-29 2001-06-07 Bioroad Gene Development Ltd. Shanghai Nouveau polypeptide, thrombospondine humaine 30, et polynucleotide codant pour ce polypeptide
WO2001057190A2 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Acides nucleiques et polypeptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998049302A1 (fr) * 1997-04-25 1998-11-05 Genetics Institute, Inc. Proteines secretees et polynucleotides les codant
WO2000056755A1 (fr) * 1999-03-19 2000-09-28 Human Genome Sciences, Inc. Proteines humaines secretees (49)
WO2001040294A1 (fr) * 1999-11-29 2001-06-07 Bioroad Gene Development Ltd. Shanghai Nouveau polypeptide, thrombospondine humaine 30, et polynucleotide codant pour ce polypeptide
WO2001057190A2 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Acides nucleiques et polypeptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 200142, Derwent World Patents Index; Class B04, AN 2001-397948, XP002183188 *
See also references of EP1268543A2 *
SZILVASSY S J ET AL: "LEUKEMIA INHIBITORY FACTOR UPREGULATES CYTOKINE EXPRESSION BY A MURINE STROMAL CELL LINE ENABLING THE MAINTENANCE OF HIGHLY ENRICHED COMPETITIVE REPOPULATING STEM CELLS", BLOOD, W.B. SAUNDERS, PHILADELPHIA, VA, US, vol. 87, no. 11, 1 June 1996 (1996-06-01), pages 4618 - 4628, XP000971084, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
WO2001077169A9 (fr) 2002-12-19
JP2003530124A (ja) 2003-10-14
EP1268543A2 (fr) 2003-01-02
WO2001077169A2 (fr) 2001-10-18
AU5904101A (en) 2001-10-23
CA2405104A1 (fr) 2001-10-18

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