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WO2001068670A3 - Famille de canaux potassium humains mecanosensibles et actives par les acides gras polyinsatures et leur utilisation - Google Patents

Famille de canaux potassium humains mecanosensibles et actives par les acides gras polyinsatures et leur utilisation Download PDF

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Publication number
WO2001068670A3
WO2001068670A3 PCT/FR2001/000758 FR0100758W WO0168670A3 WO 2001068670 A3 WO2001068670 A3 WO 2001068670A3 FR 0100758 W FR0100758 W FR 0100758W WO 0168670 A3 WO0168670 A3 WO 0168670A3
Authority
WO
WIPO (PCT)
Prior art keywords
fatty acids
polyunsaturated fatty
family
potassium channels
mechanically sensitive
Prior art date
Application number
PCT/FR2001/000758
Other languages
English (en)
Other versions
WO2001068670A2 (fr
Inventor
Michel Lazdunski
Florian Lesage
Francois Maingret
Original Assignee
Centre Nat Rech Scient
Michel Lazdunski
Florian Lesage
Francois Maingret
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Michel Lazdunski, Florian Lesage, Francois Maingret filed Critical Centre Nat Rech Scient
Priority to AU2001242558A priority Critical patent/AU2001242558A1/en
Priority to CA002403201A priority patent/CA2403201A1/fr
Priority to EP01915465A priority patent/EP1263953A2/fr
Priority to JP2001567760A priority patent/JP2003527114A/ja
Publication of WO2001068670A2 publication Critical patent/WO2001068670A2/fr
Publication of WO2001068670A3 publication Critical patent/WO2001068670A3/fr
Priority to US10/243,035 priority patent/US20030049697A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une nouvelle famille de canaux potassium humains mécanosensibles activeés par les acides gras polyinsaturés notamment l'acide arachidonique et par le riluzole et leur utilisation pour le diagnostic, la prévention et le traitement de pathologies humaines et animales.
PCT/FR2001/000758 2000-03-14 2001-03-14 Famille de canaux potassium humains mecanosensibles et actives par les acides gras polyinsatures et leur utilisation WO2001068670A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001242558A AU2001242558A1 (en) 2000-03-14 2001-03-14 Novel family of mechanically sensitive human potassium channels activated by polyunsaturated fatty acids and use thereof
CA002403201A CA2403201A1 (fr) 2000-03-14 2001-03-14 Famille de canaux potassium humains mecanosensibles et actives par les acides gras polyinsatures et leur utilisation
EP01915465A EP1263953A2 (fr) 2000-03-14 2001-03-14 Famille de canaux potassium humains mecanosensibles et actives par les acides gras polyinsatures et leur utilisation
JP2001567760A JP2003527114A (ja) 2000-03-14 2001-03-14 機械的感受性を有し、かつ多価不飽和脂肪酸によって活性化される新規なヒトカリウムチャンネルファミリー及びその使用
US10/243,035 US20030049697A1 (en) 2000-03-14 2002-09-13 Family of mechanosensitive human potassium channels activated by polyunsaturated fatty acids and their use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0003264A FR2806411B1 (fr) 2000-03-14 2000-03-14 Nouvelle famille de canaux potassium humains mecanosensibles et actives par les acides gras polyinsatures et leur utilisation
FR00/03264 2000-03-14

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/236,530 Continuation US7285244B2 (en) 2000-03-09 2002-09-06 Automated device for biological analysis
US10/243,035 Continuation US20030049697A1 (en) 2000-03-14 2002-09-13 Family of mechanosensitive human potassium channels activated by polyunsaturated fatty acids and their use

Publications (2)

Publication Number Publication Date
WO2001068670A2 WO2001068670A2 (fr) 2001-09-20
WO2001068670A3 true WO2001068670A3 (fr) 2002-02-14

Family

ID=8848075

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2001/000758 WO2001068670A2 (fr) 2000-03-14 2001-03-14 Famille de canaux potassium humains mecanosensibles et actives par les acides gras polyinsatures et leur utilisation

Country Status (7)

Country Link
US (1) US20030049697A1 (fr)
EP (1) EP1263953A2 (fr)
JP (1) JP2003527114A (fr)
AU (1) AU2001242558A1 (fr)
CA (1) CA2403201A1 (fr)
FR (1) FR2806411B1 (fr)
WO (1) WO2001068670A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL213159B1 (pl) 2010-04-23 2013-01-31 Inst Biolog Doswiadczalnej Im Marcelego Nenckiego Pan Zmutowane szczepy Escherichia coli, sposób testowania potencjalnych zwiazków antybakteryjnych wykorzystujacy te szczepy oraz zestaw do testowania

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045108A2 (fr) * 1998-03-05 1999-09-10 Centre National De La Recherche Scientifique (Cnrs) Nouvelle famille de canaux potassium de mammiferes mecanosensibles et actives par les acides gras polyinsatures et leur utilisation notamment pour le criblage de drogues
WO2000026253A1 (fr) * 1998-11-03 2000-05-11 Smithkline Beecham P.L.C. Canal potassique humain (h-traak)

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999045108A2 (fr) * 1998-03-05 1999-09-10 Centre National De La Recherche Scientifique (Cnrs) Nouvelle famille de canaux potassium de mammiferes mecanosensibles et actives par les acides gras polyinsatures et leur utilisation notamment pour le criblage de drogues
WO2000026253A1 (fr) * 1998-11-03 2000-05-11 Smithkline Beecham P.L.C. Canal potassique humain (h-traak)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHAPMAN CONRAD G ET AL: "Cloning, localisation and functional expression of a novel human, cerebellum specific, two pore domain potassium channel.", MOLECULAR BRAIN RESEARCH, vol. 82, no. 1-2, October 2000 (2000-10-01), pages 74 - 83, XP001016191, ISSN: 0169-328X *
HILLIER L ET AL: "WashU-NCI human EST project, Schneider fetal brain Homo spiens cDNA clone, similar to TRAAK K+ channel", EMBL NUCLEOTIDE SEQUENCE ACCESSION NUMBER AI816233, 12 July 1999 (1999-07-12), XP002129766 *

Also Published As

Publication number Publication date
FR2806411B1 (fr) 2004-11-05
WO2001068670A2 (fr) 2001-09-20
CA2403201A1 (fr) 2001-09-20
AU2001242558A1 (en) 2001-09-24
JP2003527114A (ja) 2003-09-16
US20030049697A1 (en) 2003-03-13
FR2806411A1 (fr) 2001-09-21
EP1263953A2 (fr) 2002-12-11

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