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WO2001068069A3 - Pharmaceutical composition comprising paracetamol - Google Patents

Pharmaceutical composition comprising paracetamol Download PDF

Info

Publication number
WO2001068069A3
WO2001068069A3 PCT/GB2001/001142 GB0101142W WO0168069A3 WO 2001068069 A3 WO2001068069 A3 WO 2001068069A3 GB 0101142 W GB0101142 W GB 0101142W WO 0168069 A3 WO0168069 A3 WO 0168069A3
Authority
WO
WIPO (PCT)
Prior art keywords
paracetamol
compound
antipyretic
analgesic
relates
Prior art date
Application number
PCT/GB2001/001142
Other languages
French (fr)
Other versions
WO2001068069A2 (en
Inventor
John Anthony Henry
Seif Omar Shaheen
Original Assignee
King S College London
Imp College Innovations Ltd
John Anthony Henry
Seif Omar Shaheen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0006301A external-priority patent/GB0006301D0/en
Priority claimed from GB0026716A external-priority patent/GB0026716D0/en
Priority claimed from GB0102462A external-priority patent/GB0102462D0/en
Application filed by King S College London, Imp College Innovations Ltd, John Anthony Henry, Seif Omar Shaheen filed Critical King S College London
Priority to AU40852/01A priority Critical patent/AU4085201A/en
Publication of WO2001068069A2 publication Critical patent/WO2001068069A2/en
Publication of WO2001068069A3 publication Critical patent/WO2001068069A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to the use of a paracetamol compound in combination with a glutathione enhancing compound as an analgesic or antipyretic. In particular, the present invention relates to the use of a paracetamol compound and a glutathione enhancing compound for simultaneous, separate or sequential use as an analgesic or antipyretic by a patient suffering from or susceptible to an allergic disease or an inflammatory lung desease. The present invention also relates to the use of a paracetamol compound and a glutathione enhancing compound for simultaneous, separate or sequential use as an analgesic or antipyretic by a pregnant woman to prevent the development of wheezing and/or asthma in the offspring.
PCT/GB2001/001142 2000-03-15 2001-03-15 Pharmaceutical composition comprising paracetamol WO2001068069A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU40852/01A AU4085201A (en) 2000-03-15 2001-03-15 Pharmaceutical composition

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0006301.6 2000-03-15
GB0006301A GB0006301D0 (en) 2000-03-15 2000-03-15 Pharmaceutical composition
GB0026716.1 2000-11-01
GB0026716A GB0026716D0 (en) 2000-11-01 2000-11-01 Pharmaceutical composition
GB0102462A GB0102462D0 (en) 2001-01-31 2001-01-31 Pharmaceutical composition
GB0102462.9 2001-01-31

Publications (2)

Publication Number Publication Date
WO2001068069A2 WO2001068069A2 (en) 2001-09-20
WO2001068069A3 true WO2001068069A3 (en) 2002-04-11

Family

ID=27255599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/001142 WO2001068069A2 (en) 2000-03-15 2001-03-15 Pharmaceutical composition comprising paracetamol

Country Status (2)

Country Link
AU (1) AU4085201A (en)
WO (1) WO2001068069A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003261147A1 (en) * 2002-07-12 2004-02-02 University Of Rochester Use of amino acids for treatment of various conditions
DE10360954B3 (en) * 2003-12-23 2005-08-18 Esparma Gmbh Use of silibinin, its salts and / or its prodrugs together with α-lipoic acid for the treatment of chronic obstructive pulmonary diseases
DE102006058183A1 (en) * 2006-11-29 2008-06-05 Eberhard-Karls-Universität Tübingen Universitätsklinikum Use of substances that lower the cellular glutathione content for the manufacture of a medicament for the treatment of T-cell mediated autoimmune diseases
ITMI20080187A1 (en) * 2008-02-07 2009-08-08 Velleja Res Srl AMINO ACID FORMULATIONS FOR THE PREVENTION OF HEPATIC PARACETAMOL DAMAGE
WO2009143299A1 (en) 2008-05-20 2009-11-26 Neurogesx, Inc. Hepatoprotectant acetaminophen mutual prodrugs
CN105687177A (en) 2009-07-15 2016-06-22 小利兰·斯坦福大学托管委员会 N-acetyl cysteine compositions and methods to improve the therapeutic efficacy of acetaminophen
KR20130132496A (en) * 2010-12-09 2013-12-04 마루이시세이야쿠가부시키가이샤 Stabilizer of acetaminophen
US20140179615A1 (en) * 2012-07-12 2014-06-26 Hainan Weikang Pharmaceutical (Qianshan) Co., Ltd. Glutathione and Acetaminophen Composition and Preparation Method Thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1463505A (en) * 1973-11-21 1977-02-02 Nat Res Dev Pharmaceutical compositions
FR2401906A1 (en) * 1977-09-02 1979-03-30 Aiache Jean Marc Water soluble analgesic salts of paracetamol - with amino acids derived from proteins
WO1994020086A1 (en) * 1993-03-12 1994-09-15 British Technology Group Limited Pharmaceutical compositions comprising paracetamol and l-cysteine or a precursor thereof
GR1002731B (en) * 1996-10-21 1997-07-04 Uni-Pharma ����� ������ �.�.�.�. ������������ ���������� Medicinal solutions containing combinations of paracetamol and other active ingredients
FR2744917A1 (en) * 1996-02-16 1997-08-22 Kouchner Gerard THERAPEUTIC COMPOSITION BASED ON ACETAMINOPHENE
US6159500A (en) * 1996-12-31 2000-12-12 Antioxidant Pharmaceuticals Corporation Pharmaceutical preparations of glutathione and methods of administration thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1463505A (en) * 1973-11-21 1977-02-02 Nat Res Dev Pharmaceutical compositions
FR2401906A1 (en) * 1977-09-02 1979-03-30 Aiache Jean Marc Water soluble analgesic salts of paracetamol - with amino acids derived from proteins
WO1994020086A1 (en) * 1993-03-12 1994-09-15 British Technology Group Limited Pharmaceutical compositions comprising paracetamol and l-cysteine or a precursor thereof
FR2744917A1 (en) * 1996-02-16 1997-08-22 Kouchner Gerard THERAPEUTIC COMPOSITION BASED ON ACETAMINOPHENE
GR1002731B (en) * 1996-10-21 1997-07-04 Uni-Pharma ����� ������ �.�.�.�. ������������ ���������� Medicinal solutions containing combinations of paracetamol and other active ingredients
US6159500A (en) * 1996-12-31 2000-12-12 Antioxidant Pharmaceuticals Corporation Pharmaceutical preparations of glutathione and methods of administration thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HUITEMA, A. D. R. (1) ET AL: "A dose-dependent delayed hypersensitivity reaction to acetaminophen after repeated acetaminophen intoxications.", HUMAN & EXPERIMENTAL TOXICOLOGY, (JULY, 1998) VOL. 17, NO. 7, PP. 406-408., XP001051459 *
NUTTALL S.L. ET AL: "Frequent paracetamol use linked to asthma.", LANCET, (6 MAY 2000) 355/9215 (1648-1649)., XP001051414 *

Also Published As

Publication number Publication date
WO2001068069A2 (en) 2001-09-20
AU4085201A (en) 2001-09-24

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