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WO2001066568A3 - Use of recombinant antigens to determine the immune status of an animal - Google Patents

Use of recombinant antigens to determine the immune status of an animal Download PDF

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Publication number
WO2001066568A3
WO2001066568A3 PCT/US2001/007251 US0107251W WO0166568A3 WO 2001066568 A3 WO2001066568 A3 WO 2001066568A3 US 0107251 W US0107251 W US 0107251W WO 0166568 A3 WO0166568 A3 WO 0166568A3
Authority
WO
WIPO (PCT)
Prior art keywords
animal
recombinant
infectious agent
antigen
immune status
Prior art date
Application number
PCT/US2001/007251
Other languages
French (fr)
Other versions
WO2001066568A2 (en
Inventor
Wayne A Jensen
Michael R Lappin
David K Rosen
Janet S Andrews
Original Assignee
Heska Corp
Univ Colorado State Res Found
Wayne A Jensen
Michael R Lappin
David K Rosen
Janet S Andrews
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Heska Corp, Univ Colorado State Res Found, Wayne A Jensen, Michael R Lappin, David K Rosen, Janet S Andrews filed Critical Heska Corp
Priority to AU49103/01A priority Critical patent/AU783559B2/en
Priority to JP2001565733A priority patent/JP2003527584A/en
Priority to CA002399202A priority patent/CA2399202A1/en
Priority to EP01922286A priority patent/EP1294749A2/en
Publication of WO2001066568A2 publication Critical patent/WO2001066568A2/en
Publication of WO2001066568A3 publication Critical patent/WO2001066568A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14311—Parvovirus, e.g. minute virus of mice
    • C12N2750/14322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14311—Parvovirus, e.g. minute virus of mice
    • C12N2750/14341—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention includes a method to determine the immune status of an animal that includes the steps of (a) contacting a biological specimen of the animal with a recombinant infectious agent antigen that is specific for detecting an antibody selective for that infectious agent, under conditions suitable for formation of a complex between the recombinant antigen and the antibody and (b) detecting the presence or absence of the complex, wherein presence or absence of a complex is indicative of the immune status of the animal. Preferably such a method indicates whether the animal should be vaccinated. The present invention also includes an assay comprising (a) a recombinant infectious agent antigen that is specific for detecting an antibody selective for that infectious agent; and (b) a means to detect an antibody that selectively binds to the recombinant antigen. Also included in the present invention are recombinant antigens and nucleic acid molecules encoding such antigens as well as methods to produce and use such nucleic acid molecule and recombinant antigens.
PCT/US2001/007251 2000-03-09 2001-03-07 Use of recombinant antigens to determine the immune status of an animal WO2001066568A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU49103/01A AU783559B2 (en) 2000-03-09 2001-03-07 Use of recombinant antigens to determine the immune status of an animal
JP2001565733A JP2003527584A (en) 2000-03-09 2001-03-07 Use of recombinant antigens to determine the immune status of animals
CA002399202A CA2399202A1 (en) 2000-03-09 2001-03-07 Use of recombinant antigens to determine the immune status of an animal
EP01922286A EP1294749A2 (en) 2000-03-09 2001-03-07 Use of recombinant antigens to determine the immune status of an animal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52173800A 2000-03-09 2000-03-09
US09/521,738 2000-03-09

Publications (2)

Publication Number Publication Date
WO2001066568A2 WO2001066568A2 (en) 2001-09-13
WO2001066568A3 true WO2001066568A3 (en) 2003-01-23

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/007251 WO2001066568A2 (en) 2000-03-09 2001-03-07 Use of recombinant antigens to determine the immune status of an animal

Country Status (6)

Country Link
US (2) US20040058316A1 (en)
EP (1) EP1294749A2 (en)
JP (1) JP2003527584A (en)
AU (1) AU783559B2 (en)
CA (1) CA2399202A1 (en)
WO (1) WO2001066568A2 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6916626B1 (en) * 2001-04-25 2005-07-12 Rockeby Biomed Ltd. Detection of Candida
KR100531760B1 (en) * 2003-04-28 2005-11-29 대한민국(관리부서 : 농림부 국립수의과학검역원) Method of Diagnosis of Foot and Mouth Disease and The Diagnotic kit
EP1843158A1 (en) * 2006-04-05 2007-10-10 Micronas Holding GmbH Pathogen detection system
WO2009108170A2 (en) * 2007-11-16 2009-09-03 Invitrogen Corporation Compositions and methods for determining immune status
CA2646944A1 (en) * 2007-11-30 2009-05-30 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Serum components that bind to threat agents
ES2609847T3 (en) 2010-08-31 2017-04-24 Merial, Inc. Herpesvirus vaccines based on Newcastle disease virus vectors
US20150004623A1 (en) * 2011-07-05 2015-01-01 Abdul Rani Bahaman Diagnostic kit for the detection of early acute leptospirosis
US20140141410A1 (en) * 2011-07-08 2014-05-22 Universitat Zurich Feline leukemia virus trans-membrane protein p15e for diagnosis of felv infection
EP3031820A1 (en) 2014-12-08 2016-06-15 Life Science Inkubator JC Polyomavirus VLP (virus-like particle) with a targeting peptide
US11311616B2 (en) 2017-11-06 2022-04-26 Intervet Inc. Feline leukemia virus vaccine
US11167027B2 (en) 2017-11-06 2021-11-09 Intervet Inc. Multivalent feline vaccine
WO2019110213A1 (en) * 2017-12-08 2019-06-13 Intervet International B.V. Feline calicivirus vaccine
JP7427585B2 (en) * 2017-12-15 2024-02-05 インターベット インターナショナル ベー． フェー． polyvalent feline vaccine
CN109298175A (en) * 2018-09-21 2019-02-01 中国农业科学院哈尔滨兽医研究所（中国动物卫生与流行病学中心哈尔滨分中心） A kind of feline parvovirus antibody ELISA kit and detection method thereof
CN110845582B (en) * 2019-12-23 2021-07-23 杭州贤至生物科技有限公司 Preparation of feline parvovirus recombinant protein and monoclonal antibody thereof
JP2023549377A (en) * 2020-11-13 2023-11-24 ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー Novel feline herpesvirus vaccine
CN113956362B (en) * 2021-09-01 2022-09-06 中国农业科学院上海兽医研究所(中国动物卫生与流行病学中心上海分中心) Recombinant feline parvovirus VP2 protein antigen and application thereof in antibody diagnosis and vaccine preparation
CN116754766B (en) * 2023-06-30 2024-10-25 深圳赫兹生命科学技术有限公司 Kit for detecting feline calicivirus
CN116735873B (en) * 2023-08-09 2023-10-31 北京纳百生物科技有限公司 Application of monoclonal antibody specifically binding to canine parvovirus VP2 protein in detection reagent

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US552276A (en) * 1895-12-31 Condensing-guide for drawing or slubbing machines
US5622871A (en) * 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
NL7807532A (en) * 1978-07-13 1980-01-15 Akzo Nv METAL IMMUNO TEST.
US4366241A (en) * 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4469787A (en) * 1982-05-14 1984-09-04 Mallinckrodt Inc. Immunoassay involving soluble complex of second antibody and labeled binding protein
GB8331514D0 (en) * 1983-11-25 1984-01-04 Janssen Pharmaceutica Nv Visualization method
US4632901A (en) * 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
US4623461A (en) * 1985-05-31 1986-11-18 Murex Corporation Transverse flow diagnostic device
US4693834A (en) * 1986-05-05 1987-09-15 Murex Corporation Transverse flow diagnostic kit
JPS6228128A (en) * 1985-07-31 1987-02-06 Shimano & Co Ltd Manufacture of oval gear
US4939096A (en) * 1986-09-10 1990-07-03 Idexx, Corp. Method and apparatus for assaying whole blood
US4965187A (en) * 1986-09-10 1990-10-23 Idexx Corporation Method and apparatus for assaying whole blood
CA1303983C (en) * 1987-03-27 1992-06-23 Robert W. Rosenstein Solid phase assay
US4855240A (en) * 1987-05-13 1989-08-08 Becton Dickinson And Company Solid phase assay employing capillary flow
US4962023A (en) * 1987-06-22 1990-10-09 Louisiana State University, Agricultural And Mechanical College Single incubation immuno sorbent assay method using particle labels to detect test antigen specific antibodies in presence of other antibodies
US5120643A (en) * 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
US4923680A (en) * 1987-09-18 1990-05-08 Eastman Kodak Company Test device containing an immunoassay filter with a flow-delaying polymer
US4853335A (en) * 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
US5006464A (en) * 1987-10-01 1991-04-09 E-Y Laboratories, Inc. Directed flow diagnostic device and method
US5571667A (en) * 1987-10-01 1996-11-05 Chu; Albert E. Elongated membrane flow-through diagnostic device and method
US4859612A (en) * 1987-10-07 1989-08-22 Hygeia Sciences, Inc. Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite
US4999163A (en) * 1987-10-29 1991-03-12 Hygeia Sciences, Inc. Disposable, pre-packaged device for conducting immunoassay procedures
US5256372A (en) * 1987-11-06 1993-10-26 Idexx Corporation Dipstick test device including a removable filter assembly
DE3878167T2 (en) * 1987-11-16 1993-05-27 Janssen Pharmaceutica Nv GENERAL APPLICABLE DETECTING SYSTEM BASED ON ULTRA-SMALL COLLOIDAL METAL PARTICLES.
CA1339723C (en) * 1988-01-19 1998-03-17 Philip Mcmahon Immunoassay with multiple test spots
US5202267A (en) * 1988-04-04 1993-04-13 Hygeia Sciences, Inc. Sol capture immunoassay kit and procedure
US5137804A (en) * 1988-05-10 1992-08-11 E. I. Du Pont De Nemours And Company Assay device and immunoassay
US5759774A (en) * 1988-05-18 1998-06-02 Cobe Laboratories, Inc. Method of detecting circulating antibody types using dried or lyophilized cells
AU2684488A (en) * 1988-06-27 1990-01-04 Carter-Wallace, Inc. Test device and method for colored particle immunoassay
US5202268A (en) * 1988-12-30 1993-04-13 Environmental Diagnostics, Inc. Multi-layered test card for the determination of substances in liquids
US5028535A (en) * 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
US5555276A (en) * 1990-01-18 1996-09-10 Norand Corporation Method of and apparatus for controlling modulation of digital signals in frequency-modulated transmissions
US5766933A (en) * 1989-04-26 1998-06-16 Diagnostic Products Corporation Method and element for measuring analytes in biological fluids using immobilized binder--analyte labeled complex
US5141850A (en) * 1990-02-07 1992-08-25 Hygeia Sciences, Inc. Porous strip form assay device method
US5223220A (en) * 1990-03-27 1993-06-29 Pacific Biotech, Inc. Solid phase immunoassay device and method of making same
US5418171A (en) * 1991-03-28 1995-05-23 Meiji Seika Kabushiki Kaisha Method for detecting a target analyte in a sample
JP3290988B2 (en) * 1991-04-11 2002-06-10 バイオサイト・ダイアグノスティックス・インコーポレイテッド Novel conjugates and assays for simultaneous detection of multiple ligands
US5726010A (en) * 1991-07-31 1998-03-10 Idexx Laboratories, Inc. Reversible flow chromatographic binding assay
US5391272A (en) * 1992-03-06 1995-02-21 Andcare, Inc. Electrochemical immunoassay methods
US5391372A (en) * 1993-06-28 1995-02-21 Campbell; Elizabeth Methods of treating colic and founder in horses
US5541059A (en) * 1993-12-29 1996-07-30 Chu; Albert E. Immunoassay device having an internal control of protein A and methods of using same
US5888826A (en) * 1994-06-30 1999-03-30 Dade Behring Inc. Combination reagent holding and test device
US5561049A (en) * 1994-09-21 1996-10-01 Behringwerke Ag Method for detecting antibodies
US5821073A (en) * 1996-05-09 1998-10-13 Syntron Bioresearch, Inc. Method and apparatus for single step assays of whole blood

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BOUCHE ET AL: "A simplified immunoassay based on measles virus recombinant hemagglutinin protein for testing the immune status o vaccinees", JOURNAL OF VIROLOGICAL METHODS, AMSTERDAM, NL, vol. 74, no. 1, 1 September 1998 (1998-09-01), pages 77 - 87, XP002091976, ISSN: 0166-0934 *
KNAPP B ET AL: "A recombinant hybrid outer membrane protein for vaccination against Pseudomonas aeruginosa", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 17, no. 13-14, January 1999 (1999-01-01), pages 1663 - 1666, XP004158302, ISSN: 0264-410X *
SPATZ S J ET AL: "Immunological characterization of the feline herpesvirus-1 glycoprotein B and analysis of its deduced amino acid sequence.", VIROLOGY. UNITED STATES NOV 1993, vol. 197, no. 1, November 1993 (1993-11-01), pages 125 - 136, XP002213501, ISSN: 0042-6822 *
WILD T F ET AL: "VACCINATION OF MICE AGAINST CANINE DISTEMPER VIRUS-INDUCED ENCEPHALITIS WITH VACCINIA VIRUS RECOMBINANTS ENCODING MEASLES OR CANINE DISTEMPER VIRUS ANTIGENS", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 11, no. 4, 1993, pages 438 - 444, XP002905640, ISSN: 0264-410X *

Also Published As

Publication number Publication date
JP2003527584A (en) 2003-09-16
EP1294749A2 (en) 2003-03-26
WO2001066568A2 (en) 2001-09-13
US20080286295A1 (en) 2008-11-20
CA2399202A1 (en) 2001-09-13
AU783559B2 (en) 2005-11-10
AU4910301A (en) 2001-09-17
US20040058316A1 (en) 2004-03-25

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