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WO2001061360A3 - Identification of modulators of gpr31 activity - Google Patents

Identification of modulators of gpr31 activity Download PDF

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Publication number
WO2001061360A3
WO2001061360A3 PCT/GB2001/000693 GB0100693W WO0161360A3 WO 2001061360 A3 WO2001061360 A3 WO 2001061360A3 GB 0100693 W GB0100693 W GB 0100693W WO 0161360 A3 WO0161360 A3 WO 0161360A3
Authority
WO
WIPO (PCT)
Prior art keywords
gpr
activity
identification
protein
gpr31
Prior art date
Application number
PCT/GB2001/000693
Other languages
French (fr)
Other versions
WO2001061360A2 (en
Inventor
Alan Wise
Original Assignee
Glaxo Group Ltd
Alan Wise
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Alan Wise filed Critical Glaxo Group Ltd
Priority to AU33895/01A priority Critical patent/AU3389501A/en
Publication of WO2001061360A2 publication Critical patent/WO2001061360A2/en
Publication of WO2001061360A3 publication Critical patent/WO2001061360A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention provides a method for identification of an agent that modulates activity of G-protein coupled receptor 31 (GPR 31). The method comprises: (i) contacting a test agent with GPR 31 or a variant thereof which is capable of coupling to a G-protein; and (ii) monitoring for GPR 31 activity in the presence of a G-protein; thereby determining whether the test agent modulates GPR 31 activity. The invention also provides activators of GPR 31, inhibitors of lipolysis and GPR 31 polynucleotides which can be used in the treatment of dyslipidaemia, coronary heart disease, atheroscloresis, thrombosis or obesity, angina, chronic renal failure, peripheral vascular disease, stroke, type I diabetes or metabolic syndrome (syndrome X).
PCT/GB2001/000693 2000-02-18 2001-02-19 Identification of modulators of gpr31 activity WO2001061360A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU33895/01A AU3389501A (en) 2000-02-18 2001-02-19 Assay

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0003898.4A GB0003898D0 (en) 2000-02-18 2000-02-18 Assay
GB0003898.4 2000-02-18

Publications (2)

Publication Number Publication Date
WO2001061360A2 WO2001061360A2 (en) 2001-08-23
WO2001061360A3 true WO2001061360A3 (en) 2002-03-28

Family

ID=9885980

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/000693 WO2001061360A2 (en) 2000-02-18 2001-02-19 Identification of modulators of gpr31 activity

Country Status (3)

Country Link
AU (1) AU3389501A (en)
GB (1) GB0003898D0 (en)
WO (1) WO2001061360A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1377834A2 (en) * 2001-04-11 2004-01-07 Glaxo Group Limited Medicaments which are modulators of hm74 and/or hm74a activity
WO2005059561A2 (en) * 2003-12-12 2005-06-30 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor 31 (gpr31)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000022129A1 (en) * 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human g protein-coupled receptors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000022129A1 (en) * 1998-10-13 2000-04-20 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human g protein-coupled receptors

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 21 August 2000 (2000-08-21), BEHAN D P ET AL: "Non-endogenous constitutively activated human G protein-coupled receptors, useful for identifying agonists for use as pharmaceutical agents", XP002174049 *
SOEDER KURT J ET AL: "The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 17, 23 April 1999 (1999-04-23), pages 12017 - 12022, XP002174047, ISSN: 0021-9258 *
WALSTON J ET AL: "The beta3-adrenergic receptor in the obesity and diabetes prone rhesus monkey is very similar to human and contains arginine at codon 64", GENE: AN INTERNATIONAL JOURNAL ON GENES AND GENOMES,GB,ELSEVIER SCIENCE PUBLISHERS, BARKING, vol. 188, no. 2, 1 April 1997 (1997-04-01), pages 207 - 213, XP004059301, ISSN: 0378-1119 *
ZINGONI ALESSANDRA ET AL: "Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor.", GENOMICS, vol. 42, no. 3, 1997, pages 519 - 523, XP002174048, ISSN: 0888-7543 *

Also Published As

Publication number Publication date
AU3389501A (en) 2001-08-27
WO2001061360A2 (en) 2001-08-23
GB0003898D0 (en) 2000-04-05

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