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WO2001060848A3 - Conjugues cibles sur des recepteurs cibles - Google Patents

Conjugues cibles sur des recepteurs cibles Download PDF

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Publication number
WO2001060848A3
WO2001060848A3 PCT/US2001/005225 US0105225W WO0160848A3 WO 2001060848 A3 WO2001060848 A3 WO 2001060848A3 US 0105225 W US0105225 W US 0105225W WO 0160848 A3 WO0160848 A3 WO 0160848A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
cell
chemical agent
target
conjugate
Prior art date
Application number
PCT/US2001/005225
Other languages
English (en)
Other versions
WO2001060848A2 (fr
Inventor
Ramesh K Prakash
Christopher G Anderson
Original Assignee
Watson Pharmaceuticals Inc
Ramesh K Prakash
Christopher G Anderson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Watson Pharmaceuticals Inc, Ramesh K Prakash, Christopher G Anderson filed Critical Watson Pharmaceuticals Inc
Priority to CA002398395A priority Critical patent/CA2398395A1/fr
Priority to AU2001241549A priority patent/AU2001241549A1/en
Priority to EP01912804A priority patent/EP1255568A2/fr
Publication of WO2001060848A2 publication Critical patent/WO2001060848A2/fr
Publication of WO2001060848A3 publication Critical patent/WO2001060848A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Un conjugué d'apport intracellulaire d'un agent chimique dans un récepteur cible tel qu'une cellule porteuse de récepteur d'interleukine-2, par exemple un lymphocyte T activé et une cellule cancéreuse, comprend un agent chimique, au moins une copie du ligand fixant le récepteur cible et induisant une endocytose, couplé à un polymère hydrosoluble. Le ligand se fixe à un récepteur cible tel qu'un récepteur d'Il-2 sur la cellule portant le récepteur cible et il met en lumière une endocytose du conjugué. Le conjugué comprend aussi facultativement un espaceur biodégradable destiné à coupler l'agent chimique et le ligand au polymère. Les agents chimiques peuvent comprendre des cytotoxines, des acides nucléiques transformants, des régulateurs de gènes, des étiquettes, des antigènes, des médicaments et analogues. Le polymère hydrosoluble préféré est un oxyde de polyalkylène, tel qu'un polyéthylène glycol et un oxyde de polyéthylène, ainsi que leurs dérivés activés. L'invention concerne également des procédés d'utilisation de ces compositions pour administrer un agent chimique in vivo ou in vitro. L'invention concerne aussi des méthodes de détection d'une maladie, telle que le cancer, la leucémie lymphoïde à cellules T, la leucémie aiguë lymphoblastique à cellules T, le lymphome malin à cellules T périphériques, la maladie de Hodgkin, ainsi que l'hématosarcome non Hodgkinien, associée à des niveaux élevés de récepteur cible soluble et/ou de récepteur d'IL-2.
PCT/US2001/005225 2000-02-18 2001-02-15 Conjugues cibles sur des recepteurs cibles WO2001060848A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002398395A CA2398395A1 (fr) 2000-02-18 2001-02-15 Conjugues cibles sur des recepteurs cibles
AU2001241549A AU2001241549A1 (en) 2000-02-18 2001-02-15 Conjugates targeted to target receptors
EP01912804A EP1255568A2 (fr) 2000-02-18 2001-02-15 Conjugues cibles sur des recepteurs cibles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50714000A 2000-02-18 2000-02-18
US09/507,140 2000-02-18

Publications (2)

Publication Number Publication Date
WO2001060848A2 WO2001060848A2 (fr) 2001-08-23
WO2001060848A3 true WO2001060848A3 (fr) 2002-04-25

Family

ID=24017414

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/005225 WO2001060848A2 (fr) 2000-02-18 2001-02-15 Conjugues cibles sur des recepteurs cibles

Country Status (4)

Country Link
EP (1) EP1255568A2 (fr)
AU (1) AU2001241549A1 (fr)
CA (1) CA2398395A1 (fr)
WO (1) WO2001060848A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2351967T3 (es) * 2002-04-29 2011-02-14 Biotesys Gmbh Lípidos polimerizados modificados con péptidos como sistemas de transporte biológico para micronutrientes.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997038011A1 (fr) * 1996-04-03 1997-10-16 Pepresearch A/S Porteur peptidique non-dendritique d'ossature
CZ283008B6 (cs) * 1993-07-20 1997-12-17 Ústav Makromolekulární Chemie Av Čr Polymerní konjugát cyklosporinu A, způsob jeho přípravy a použití v in vitro diagnostických testech, způsob stanovení volného cyklosporinu A a jeho metabolitů in vitro v lidských tělních tekutinách
WO1999007324A2 (fr) * 1997-08-05 1999-02-18 Watson Pharmaceuticals, Inc. Conjugues cibles apportes au recepteur de l'interleukine-2
WO2000007543A2 (fr) * 1998-08-04 2000-02-17 Watson Laboratories, Inc.-Utah Conjugues cibles apportes aux recepteurs cibles et/ou aux recepteurs de l'interleukine 2

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ283008B6 (cs) * 1993-07-20 1997-12-17 Ústav Makromolekulární Chemie Av Čr Polymerní konjugát cyklosporinu A, způsob jeho přípravy a použití v in vitro diagnostických testech, způsob stanovení volného cyklosporinu A a jeho metabolitů in vitro v lidských tělních tekutinách
WO1997038011A1 (fr) * 1996-04-03 1997-10-16 Pepresearch A/S Porteur peptidique non-dendritique d'ossature
WO1999007324A2 (fr) * 1997-08-05 1999-02-18 Watson Pharmaceuticals, Inc. Conjugues cibles apportes au recepteur de l'interleukine-2
WO2000007543A2 (fr) * 1998-08-04 2000-02-17 Watson Laboratories, Inc.-Utah Conjugues cibles apportes aux recepteurs cibles et/ou aux recepteurs de l'interleukine 2

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; ULBRICH, KAREL ET AL: "Polymeric conjugate of cyclosporin A, process of its preparation and use for in vitro diagnostic tests, method of determining free cyclosporin A and its metabolites in vitro in human body fluids", XP002187324, retrieved from STN Database accession no. 130:335013 CA *

Also Published As

Publication number Publication date
AU2001241549A1 (en) 2001-08-27
EP1255568A2 (fr) 2002-11-13
WO2001060848A2 (fr) 2001-08-23
CA2398395A1 (fr) 2001-08-23

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