WO2001057071A3 - Glycopeptide derivatives having antibiotic activity - Google Patents
Glycopeptide derivatives having antibiotic activity Download PDFInfo
- Publication number
- WO2001057071A3 WO2001057071A3 PCT/US2001/003495 US0103495W WO0157071A3 WO 2001057071 A3 WO2001057071 A3 WO 2001057071A3 US 0103495 W US0103495 W US 0103495W WO 0157071 A3 WO0157071 A3 WO 0157071A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- derivatives
- antibiotic activity
- glycopeptide
- glycopeptide derivatives
- disclosed
- Prior art date
Links
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical class NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 title abstract 3
- 230000003115 biocidal effect Effects 0.000 title 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
- C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Disclosed are derivatives of glycopeptide antibiotic compounds having at least one substituent of the formula: -Ra-Y-Rb-(Z)x where Ra, Rb, Y, Z and x are as defined, and having a group W at the glucose C-6 position, where W is as defined; and pharmaceutical compositions containing such glycopeptide derivatives. The disclosed glycopeptide derivatives are useful as antibacterial agents.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2001238020A AU2001238020A1 (en) | 2000-02-04 | 2001-02-02 | Glycopeptide derivatives having antibiotic activity |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49908100A | 2000-02-04 | 2000-02-04 | |
| US09/499,081 | 2000-02-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2001057071A2 WO2001057071A2 (en) | 2001-08-09 |
| WO2001057071A3 true WO2001057071A3 (en) | 2003-10-30 |
Family
ID=23983731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2001/003495 WO2001057071A2 (en) | 2000-02-04 | 2001-02-02 | Glycopeptide derivatives having antibiotic activity |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2001238020A1 (en) |
| WO (1) | WO2001057071A2 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6699836B2 (en) * | 1999-04-02 | 2004-03-02 | The Trustees Of Princeton University | Vancomycin analogs |
| TWI312785B (en) | 2001-08-24 | 2009-08-01 | Theravance Inc | Process for preparing vancomycin derivatives |
| ES2384707T3 (en) * | 2002-05-24 | 2012-07-11 | Theravance, Inc. | Cross-linked antibiotics of glycopeptides and cephalosporins |
| AU2003243574A1 (en) * | 2002-06-17 | 2003-12-31 | Theravance, Inc. | PROCESS FOR PREPARING N-PROTECTED Beta-AMINO ALDEHYDE COMPOUNDS |
| CN107325159A (en) * | 2016-04-29 | 2017-11-07 | 中国科学院上海药物研究所 | One class vancomycin derivatives, its preparation method, pharmaceutical composition and purposes |
| CA3062570A1 (en) | 2017-05-22 | 2018-11-29 | Insmed Incorporated | Lipo-glycopeptide cleavable derivatives and uses thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000004044A1 (en) * | 1998-07-14 | 2000-01-27 | Princeton University | Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same |
| WO2000039156A1 (en) * | 1998-12-23 | 2000-07-06 | Advanced Medicine, Inc. | Glycopeptide derivatives and pharmaceutical compositions containing the same |
| WO2000042067A1 (en) * | 1999-01-12 | 2000-07-20 | Princeton University | Saccharides linked to compounds that bind cell-surface peptides or proteins |
| WO2000059528A1 (en) * | 1999-04-02 | 2000-10-12 | The Trustees Of Princeton University | Desleucyl glycopeptide antibiotics and methods of making same |
-
2001
- 2001-02-02 AU AU2001238020A patent/AU2001238020A1/en not_active Abandoned
- 2001-02-02 WO PCT/US2001/003495 patent/WO2001057071A2/en active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000004044A1 (en) * | 1998-07-14 | 2000-01-27 | Princeton University | Glycopeptide antibiotics, combinatorial libraries of glycopeptide antibiotics and methods of producing same |
| WO2000039156A1 (en) * | 1998-12-23 | 2000-07-06 | Advanced Medicine, Inc. | Glycopeptide derivatives and pharmaceutical compositions containing the same |
| WO2000042067A1 (en) * | 1999-01-12 | 2000-07-20 | Princeton University | Saccharides linked to compounds that bind cell-surface peptides or proteins |
| WO2000059528A1 (en) * | 1999-04-02 | 2000-10-12 | The Trustees Of Princeton University | Desleucyl glycopeptide antibiotics and methods of making same |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001057071A2 (en) | 2001-08-09 |
| AU2001238020A1 (en) | 2001-08-14 |
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