WO2001057073A3 - Clone infectieux genetiquement modifie du genome du virus de l'hepatite b (vhe), production et utilisations de ce dernier - Google Patents
Clone infectieux genetiquement modifie du genome du virus de l'hepatite b (vhe), production et utilisations de ce dernier Download PDFInfo
- Publication number
- WO2001057073A3 WO2001057073A3 PCT/IN2001/000015 IN0100015W WO0157073A3 WO 2001057073 A3 WO2001057073 A3 WO 2001057073A3 IN 0100015 W IN0100015 W IN 0100015W WO 0157073 A3 WO0157073 A3 WO 0157073A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hev
- clone
- hepatitis
- virus
- viral proteins
- Prior art date
Links
- 241000724675 Hepatitis E virus Species 0.000 title abstract 10
- 208000015181 infectious disease Diseases 0.000 title abstract 3
- 230000002458 infectious effect Effects 0.000 title abstract 2
- 108010067390 Viral Proteins Proteins 0.000 abstract 3
- 108091026890 Coding region Proteins 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 101000768957 Acholeplasma phage L2 Uncharacterized 37.2 kDa protein Proteins 0.000 abstract 1
- 101000823746 Acidianus ambivalens Uncharacterized 17.7 kDa protein in bps2 3'region Proteins 0.000 abstract 1
- 101000916369 Acidianus ambivalens Uncharacterized protein in sor 5'region Proteins 0.000 abstract 1
- 101000769342 Acinetobacter guillouiae Uncharacterized protein in rpoN-murA intergenic region Proteins 0.000 abstract 1
- 101000823696 Actinobacillus pleuropneumoniae Uncharacterized glycosyltransferase in aroQ 3'region Proteins 0.000 abstract 1
- 101000786513 Agrobacterium tumefaciens (strain 15955) Uncharacterized protein outside the virF region Proteins 0.000 abstract 1
- 101000618005 Alkalihalobacillus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4) Uncharacterized protein BpOF4_00885 Proteins 0.000 abstract 1
- 102100020724 Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Human genes 0.000 abstract 1
- 101000967489 Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571) Uncharacterized protein AZC_3924 Proteins 0.000 abstract 1
- 101000823761 Bacillus licheniformis Uncharacterized 9.4 kDa protein in flaL 3'region Proteins 0.000 abstract 1
- 101000819719 Bacillus methanolicus Uncharacterized N-acetyltransferase in lysA 3'region Proteins 0.000 abstract 1
- 101000789586 Bacillus subtilis (strain 168) UPF0702 transmembrane protein YkjA Proteins 0.000 abstract 1
- 101000792624 Bacillus subtilis (strain 168) Uncharacterized protein YbxH Proteins 0.000 abstract 1
- 101000790792 Bacillus subtilis (strain 168) Uncharacterized protein YckC Proteins 0.000 abstract 1
- 101000819705 Bacillus subtilis (strain 168) Uncharacterized protein YlxR Proteins 0.000 abstract 1
- 101000948218 Bacillus subtilis (strain 168) Uncharacterized protein YtxJ Proteins 0.000 abstract 1
- 101000718627 Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor Proteins 0.000 abstract 1
- 101000641200 Bombyx mori densovirus Putative non-structural protein Proteins 0.000 abstract 1
- 101000947633 Claviceps purpurea Uncharacterized 13.8 kDa protein Proteins 0.000 abstract 1
- 101000948901 Enterobacteria phage T4 Uncharacterized 16.0 kDa protein in segB-ipI intergenic region Proteins 0.000 abstract 1
- 101000805958 Equine herpesvirus 4 (strain 1942) Virion protein US10 homolog Proteins 0.000 abstract 1
- 101000790442 Escherichia coli Insertion element IS2 uncharacterized 11.1 kDa protein Proteins 0.000 abstract 1
- 101000788354 Escherichia phage P2 Uncharacterized 8.2 kDa protein in gpA 5'region Proteins 0.000 abstract 1
- 101000770304 Frankia alni UPF0460 protein in nifX-nifW intergenic region Proteins 0.000 abstract 1
- 101000797344 Geobacillus stearothermophilus Putative tRNA (cytidine(34)-2'-O)-methyltransferase Proteins 0.000 abstract 1
- 101000748410 Geobacillus stearothermophilus Uncharacterized protein in fumA 3'region Proteins 0.000 abstract 1
- 101000772675 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) UPF0438 protein HI_0847 Proteins 0.000 abstract 1
- 101000631019 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Uncharacterized protein HI_0350 Proteins 0.000 abstract 1
- 101000768938 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 8.9 kDa protein in int-C1 intergenic region Proteins 0.000 abstract 1
- 101000785414 Homo sapiens Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Proteins 0.000 abstract 1
- 101000782488 Junonia coenia densovirus (isolate pBRJ/1990) Putative non-structural protein NS2 Proteins 0.000 abstract 1
- 101000811523 Klebsiella pneumoniae Uncharacterized 55.8 kDa protein in cps region Proteins 0.000 abstract 1
- 101000818409 Lactococcus lactis subsp. lactis Uncharacterized HTH-type transcriptional regulator in lacX 3'region Proteins 0.000 abstract 1
- 101000878851 Leptolyngbya boryana Putative Fe(2+) transport protein A Proteins 0.000 abstract 1
- 101000758828 Methanosarcina barkeri (strain Fusaro / DSM 804) Uncharacterized protein Mbar_A1602 Proteins 0.000 abstract 1
- 101001122401 Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) Non-structural protein ORF3 Proteins 0.000 abstract 1
- 101001055788 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) Pentapeptide repeat protein MfpA Proteins 0.000 abstract 1
- 108091092724 Noncoding DNA Proteins 0.000 abstract 1
- 101000740670 Orgyia pseudotsugata multicapsid polyhedrosis virus Protein C42 Proteins 0.000 abstract 1
- 101000769182 Photorhabdus luminescens Uncharacterized protein in pnp 3'region Proteins 0.000 abstract 1
- 101710159752 Poly(3-hydroxyalkanoate) polymerase subunit PhaE Proteins 0.000 abstract 1
- 101710130262 Probable Vpr-like protein Proteins 0.000 abstract 1
- 101000961392 Pseudescherichia vulneris Uncharacterized 29.9 kDa protein in crtE 3'region Proteins 0.000 abstract 1
- 101000731030 Pseudomonas oleovorans Poly(3-hydroxyalkanoate) polymerase 2 Proteins 0.000 abstract 1
- 101001065485 Pseudomonas putida Probable fatty acid methyltransferase Proteins 0.000 abstract 1
- 101000711023 Rhizobium leguminosarum bv. trifolii Uncharacterized protein in tfuA 3'region Proteins 0.000 abstract 1
- 101000948156 Rhodococcus erythropolis Uncharacterized 47.3 kDa protein in thcA 5'region Proteins 0.000 abstract 1
- 101000917565 Rhodococcus fascians Uncharacterized 33.6 kDa protein in fasciation locus Proteins 0.000 abstract 1
- 101000790284 Saimiriine herpesvirus 2 (strain 488) Uncharacterized 9.5 kDa protein in DHFR 3'region Proteins 0.000 abstract 1
- 101000936719 Streptococcus gordonii Accessory Sec system protein Asp3 Proteins 0.000 abstract 1
- 101000788499 Streptomyces coelicolor Uncharacterized oxidoreductase in mprA 5'region Proteins 0.000 abstract 1
- 101001102841 Streptomyces griseus Purine nucleoside phosphorylase ORF3 Proteins 0.000 abstract 1
- 101000708557 Streptomyces lincolnensis Uncharacterized 17.2 kDa protein in melC2-rnhH intergenic region Proteins 0.000 abstract 1
- 101000649826 Thermotoga neapolitana Putative anti-sigma factor antagonist TM1081 homolog Proteins 0.000 abstract 1
- 101000827562 Vibrio alginolyticus Uncharacterized protein in proC 3'region Proteins 0.000 abstract 1
- 101000778915 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) Uncharacterized membrane protein VP2115 Proteins 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000012472 biological sample Substances 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000003255 drug test Methods 0.000 abstract 1
- 210000005229 liver cell Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/28011—Hepeviridae
- C12N2770/28111—Hepevirus, e.g. hepatitis E virus
- C12N2770/28121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/28011—Hepeviridae
- C12N2770/28111—Hepevirus, e.g. hepatitis E virus
- C12N2770/28161—Methods of inactivation or attenuation
- C12N2770/28162—Methods of inactivation or attenuation by genetic engineering
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La présente invention concerne un clone d'acide nucléique génétiquement modifié du virus de l'hépatite E (VHE) qui comprend les gènes structuraux (ORF2 et ORF3) et non structuraux (ORF1) complets, c'est à dire la séquence codante complète, du VHE, flanquée par les régions non codantes 5` et 3` avec une queue polyadénylée 3`dans la région non codante 3`, le clone précité étant capable d'infecter des cellules hépatiques en culture et de répliquer, transcrire et assembler le VHE qui s'y trouve. L'invention se rapporte également à un procédé permettant de synthétiser ce clone et à l'expression par ce dernier de protéines virales aptes à être utilisées pour détecter la présence d'anticorps dirigés contre le VHE dans des prélèvements biologiques. Le clone et les protéines virales exprimées de l'invention peuvent également être utilisés dans une trousse d'essai comprenant les protéines virales précitées, qui permet de diagnostiquer la présence d'une infection par VHE, dans un vaccin anti-VHE qui comprend des particules non infectieuses de VHE produites à partir d'une mutation du clone de l'acide nucléique du virus de l'hépatite E précité, et dans un système d'analyse qui permet de tester rapidement un médicament anti-VHE.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU44516/01A AU4451601A (en) | 2000-02-07 | 2001-02-05 | Genetically engineered clone of hepatitis e virus (hev) genome which is infectious, its production and uses |
| EP01917440A EP1169341A1 (fr) | 2000-02-07 | 2001-02-05 | Clone infectieux genetiquement modifie du genome du virus de l'hepatite b (vhe), production et utilisations de ce dernier |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN106DE2000 | 2000-02-07 | ||
| IN106/DEL/2000 | 2000-02-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2001057073A2 WO2001057073A2 (fr) | 2001-08-09 |
| WO2001057073A3 true WO2001057073A3 (fr) | 2002-04-18 |
Family
ID=11097025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IN2001/000015 WO2001057073A2 (fr) | 2000-02-07 | 2001-02-05 | Clone infectieux genetiquement modifie du genome du virus de l'hepatite b (vhe), production et utilisations de ce dernier |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP1169341A1 (fr) |
| AU (1) | AU4451601A (fr) |
| WO (1) | WO2001057073A2 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002365931A1 (en) * | 2001-11-09 | 2003-09-02 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Healt | Hepatitis e virus clones and methods of their use |
| JP2022543668A (ja) | 2019-08-09 | 2022-10-13 | ナットクラッカー セラピューティクス， インコーポレイテッド | マイクロ流体装置およびその使用方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996010580A2 (fr) * | 1994-10-03 | 1996-04-11 | The Government Of The United States Of America, Re | Proteines de recombinaison d'une souche pakistanaise d'hepatite e et leur utilisation dans des procedes de diagnostic et des vaccins |
-
2001
- 2001-02-05 AU AU44516/01A patent/AU4451601A/en not_active Abandoned
- 2001-02-05 WO PCT/IN2001/000015 patent/WO2001057073A2/fr not_active Application Discontinuation
- 2001-02-05 EP EP01917440A patent/EP1169341A1/fr not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996010580A2 (fr) * | 1994-10-03 | 1996-04-11 | The Government Of The United States Of America, Re | Proteines de recombinaison d'une souche pakistanaise d'hepatite e et leur utilisation dans des procedes de diagnostic et des vaccins |
Non-Patent Citations (8)
| Title |
|---|
| BOYER J-C ET AL: "INFECTIOUS TRANSCRIPTS AND CDNA CLONES OF RNA VIRUSES", VIROLOGY, ACADEMIC PRESS,ORLANDO, US, vol. 198, 1994, pages 415 - 426, XP000652105, ISSN: 0042-6822 * |
| BRADLEY D W: "HEPATITIS E VIRUS: A BRIEF REVIEW OF THE BIOLOGY, MOLECULAR VIROLOGY, AND IMMUNOLOGY OF A NOVEL VIRUS", JOURNAL OF HEPATOLOGY, vol. 22, no. 1, SUPPL, 1995, COPENHAGEN DK, pages 140 - 145, XP000565565 * |
| DATABASE EM_VI [online] EMBL; 20 July 1998 (1998-07-20), PANDA, S.K. ET AL.: "Hepatitis E virus from Hyderabad, Inda, complete genome", XP002176001, retrieved from EBI accession no. AF076239 Database accession no. AF076239 * |
| JAMEEL, S. ET AL.: "Expression in animal cells and characterization of the hepatitis E virus structural proteins", JOURNAL OF VIROLOGY., vol. 70, no. 1, 1996, WASHINGTON, US, pages 207 - 216, XP002175999 * |
| PANDA S K ET AL: "THE IN VITRO-SYNTHESIZED RNA FROM A CDNA CLONE OF HEPATITIS E VIRUS IS INFECTIOUS", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 74, no. 5, March 2000 (2000-03-01), pages 2430 - 2437, XP001012211, ISSN: 0022-538X * |
| TAM A W ET AL: "HEPATITIS E VIRUS (HEV): MOLECULAR CLONING AND SEQUENCING OF THE FULL-LENGTH VIRAL GENOME", VIROLOGY, NEW YORK, NY, US, vol. 185, no. 1, November 1991 (1991-11-01), pages 120 - 131, XP001011402, ISSN: 0042-6822 * |
| TAM ALBERT W ET AL: "In vitro infection and replication of hepatitis E virus in primary cynomolgus macaque hepatocytes.", VIROLOGY., vol. 238, no. 1, 10 November 1997 (1997-11-10), ORLANDO., US, pages 94 - 102, XP002176000 * |
| UCHIDA, T. ET AL: "Hepatitis E virus: cDNA cloning and expression", MICROBIOLOGY AND IMMUNOLOGY, vol. 36, no. 1, 1992, pages 67 - 79, XP000926525 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1169341A1 (fr) | 2002-01-09 |
| AU4451601A (en) | 2001-08-14 |
| WO2001057073A2 (fr) | 2001-08-09 |
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