+

WO2001052817A3 - Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles - Google Patents

Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles Download PDF

Info

Publication number
WO2001052817A3
WO2001052817A3 PCT/US2001/002299 US0102299W WO0152817A3 WO 2001052817 A3 WO2001052817 A3 WO 2001052817A3 US 0102299 W US0102299 W US 0102299W WO 0152817 A3 WO0152817 A3 WO 0152817A3
Authority
WO
WIPO (PCT)
Prior art keywords
biologically relevant
cochleate
relevant molecules
delivering biologically
cochleates
Prior art date
Application number
PCT/US2001/002299
Other languages
English (en)
Other versions
WO2001052817A2 (fr
Inventor
Leila Zarif
Tuo Jin
Ignacio Segarra
Raphael J Mannino
Original Assignee
Biodelivery Sciences Inc
Univ New Jersey Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2000/001684 external-priority patent/WO2000042989A2/fr
Application filed by Biodelivery Sciences Inc, Univ New Jersey Med filed Critical Biodelivery Sciences Inc
Priority to EP01903273A priority Critical patent/EP1259224A2/fr
Priority to CA002397792A priority patent/CA2397792A1/fr
Priority to JP2001552865A priority patent/JP2003529557A/ja
Priority to AU31114/01A priority patent/AU3111401A/en
Publication of WO2001052817A2 publication Critical patent/WO2001052817A2/fr
Publication of WO2001052817A3 publication Critical patent/WO2001052817A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Manufacturing Of Micro-Capsules (AREA)

Abstract

L'invention concerne un procédé de production d'une structure cochléaire de petite taille à base de lipide. Les structures cochléaires sont obtenues à partir de liposomes qui sont mis en suspension dans une solution aqueuse polymère à deux phases, ce qui permet de séparer de manière différentielle les structures à base de molécules polaires par séparation de phases. La solution polymère à deux phases contenant des liposomes, traitée à l'aide de molécules chargées positivement telles que Ca?2+ ou Zn2+¿, forme un précipité de structures cochléaires présentant des dimensions de particules inférieures à un micron. Le procédé peut être utilisé pour produire des structures cochléaires contenant des molécules biologiquement utiles.
PCT/US2001/002299 2000-01-24 2001-01-24 Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles WO2001052817A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP01903273A EP1259224A2 (fr) 2000-01-24 2001-01-24 Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles
CA002397792A CA2397792A1 (fr) 2000-01-24 2001-01-24 Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles
JP2001552865A JP2003529557A (ja) 2000-01-24 2001-01-24 コクリエート製剤、その調製方法および生物学的関連分子投与のための用途
AU31114/01A AU3111401A (en) 2000-01-24 2001-01-24 New cochleate formulations, process of preparation and their use for the delivery of biologically relevant molecules

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/US2000/001684 WO2000042989A2 (fr) 1999-01-22 2000-01-24 Nouvelles formulations de structures cochleaires isolees dans des hydrogels, procede de preparation et utilisation de celles-ci pour administrer des molecules biologiquement utiles
USPCT/US00/01684 2000-01-24
US09/613,840 US6592894B1 (en) 1999-01-22 2000-07-11 Hydrogel-isolated cochleate formulations, process of preparation and their use for the delivery of biologically relevant molecules
US09/613,840 2000-07-11

Publications (2)

Publication Number Publication Date
WO2001052817A2 WO2001052817A2 (fr) 2001-07-26
WO2001052817A3 true WO2001052817A3 (fr) 2002-02-21

Family

ID=26680118

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/002299 WO2001052817A2 (fr) 2000-01-24 2001-01-24 Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles

Country Status (5)

Country Link
EP (1) EP1259224A2 (fr)
JP (1) JP2003529557A (fr)
AU (1) AU3111401A (fr)
CA (1) CA2397792A1 (fr)
WO (1) WO2001052817A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030219473A1 (en) * 2002-03-26 2003-11-27 Leila Zarif Cochleates made with purified soy phosphatidylserine
US20050008686A1 (en) * 2003-01-15 2005-01-13 Mannino Raphael J. Cochleate preparations of fragile nutrients
EP1624858B1 (fr) 2003-04-09 2018-06-06 Rutgers, the State University of New Jersey Nouveaux procédés de formation de structures cochléaires
EP1631669A2 (fr) 2003-04-09 2006-03-08 Biodelivery Sciences International, Inc. Compositions contenant des structures cochleaires, dirigees contre l'expression de proteines
US20070258926A1 (en) * 2003-10-15 2007-11-08 Ltt Bio-Pharma Co., Ltd. Composition containing retinoic acid nanoparticles coated with inorganic salt of polyvalent metal
CN1859905A (zh) * 2003-10-15 2006-11-08 日本株式会社Ltt生物医药 多价金属无机盐包覆的视黄酸纳米颗粒的粒径的调节方法和由该调节方法得到的纳米颗粒
AR064359A1 (es) 2006-12-15 2009-04-01 Ca Nat Research Council Agregados de lipidos polares de arqueas para administracion a animales
JP6347743B2 (ja) * 2011-05-05 2018-06-27 マティナス バイオファーマ ナノテクノロジーズ，インコーポレーテッド コクリエート組成物およびその製造および使用方法
CA2982259A1 (fr) * 2015-04-22 2016-10-27 Matinas Biopharma Nanotechnologies, Inc. Compositions et methodes pour le traitement d'infections et de maladies pulmonaires a mycobacteries
CA2987798A1 (fr) * 2015-06-18 2016-12-22 Matinas Biopharma Nanotechnologies, Inc. Compositions et procedes pour le traitement de maladies ou de troubles inflammatoires
CN114053417A (zh) * 2016-07-12 2022-02-18 马丁尼斯生物制药纳米技术公司 用于中枢神经系统递送和治疗隐球菌感染的脂质卷包封的抗真菌化合物
KR101989789B1 (ko) * 2017-11-30 2019-06-18 (주) 에이치엔에이파마켐 포스파티딜세린/음이온계면활성제/염화칼슘을 이용한 코킬레이트

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997030725A1 (fr) * 1996-02-22 1997-08-28 Raphael James Mannino Vecteurs d'apport de structures cochleaires
US5994318A (en) * 1993-10-04 1999-11-30 Albany Medical College Cochleate delivery vehicles
WO2000042989A2 (fr) * 1999-01-22 2000-07-27 Biodelivery Sciences, Inc. Nouvelles formulations de structures cochleaires isolees dans des hydrogels, procede de preparation et utilisation de celles-ci pour administrer des molecules biologiquement utiles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5994318A (en) * 1993-10-04 1999-11-30 Albany Medical College Cochleate delivery vehicles
WO1997030725A1 (fr) * 1996-02-22 1997-08-28 Raphael James Mannino Vecteurs d'apport de structures cochleaires
WO2000042989A2 (fr) * 1999-01-22 2000-07-27 Biodelivery Sciences, Inc. Nouvelles formulations de structures cochleaires isolees dans des hydrogels, procede de preparation et utilisation de celles-ci pour administrer des molecules biologiquement utiles

Also Published As

Publication number Publication date
WO2001052817A2 (fr) 2001-07-26
CA2397792A1 (fr) 2001-07-26
AU3111401A (en) 2001-07-31
EP1259224A2 (fr) 2002-11-27
JP2003529557A (ja) 2003-10-07

Similar Documents

Publication Publication Date Title
DK1143933T3 (da) Hidtil ukendte hydrogelisolerede cochleat-formuleringer, fremgangsmåde til fremstilling og deres anvendelse ved afgivelse af biologisk relevante molekyler
WO2001052817A3 (fr) Nouvelles formulations cochleaires, procede de preparation et utilisation de celles-ci dans l'administration de molecules biologiquement utiles
EP4509118A3 (fr) Lipides peg de haute pureté et leurs utilisations
Evans et al. Thermodynamics of solution of nonpolar gases in a fused salt. Hydrophobic bonding behavior in a nonaqueous system
WO2002096457A3 (fr) Formulations liquides stable s
CA2201120A1 (fr) Lipides du type ceramide modifies par polyethylene glycol et leurs utilisations sous forme de liposomes
EP1266959A3 (fr) Anlage und verfahren zur gewinnen von zellen
MY123675A (en) Process for conditioning substances.
IL67939A0 (en) Production of pulverulent mixture of lipidic constituents and hydrophobic constituents,hydrated lipidic lamellar phases obtained therefrom and pharmaceutical and cosmetic composition comprising such phases
WO2003037835A3 (fr) Procede d'elimination d'impuretes polarisables contenues dans des hydrocarbures et melanges d'hydrocarbures
CA2243946A1 (fr) Eau electrolytique reductrice et procede de preparation de celle-ci
IL174206A0 (en) Mahonia aquifolium extract, extraction process and pharmaceutical composition containing the same
WO2000009086A3 (fr) Formulation protegee, dans un seul flacon, pour molecules d'acide nucleique, ses procedes de fabrication par melangeage en ligne, produits et procedes associes
Lind et al. Purification of alpha-toxin from Staphylococcus aureus and application to cell permeabilization
Ito et al. Isolation of a Kinetically Stabilized 1, 3, 6-Triphosphafulvene This work was supported in part by a Grant-in-Aid for Scientific Research (No. 09239101) from the Ministry of Education, Science, Sports and Culture, Japan
WO2003094865A1 (fr) Preparations externes pour la peau
AU2003268890A1 (en) Cosmetic and dermatological agent containing magnetic particles, production thereof, and use of the same
ATE330474T1 (de) Antimikrobielles mittel
Owoseni Surfactants: Fundamental Concepts and Emerging Perspectives
Fadnavis et al. Reverse micellar extraction of antibiotics from aqueous solutions
DE4036648A1 (de) Verwendung von insbesondere magnetischen vektorpotentialen zur behandlung von materialien
WO2002094209A3 (fr) Cremes lipoproteiques contenant des filtres uv
Chavarriga et al. Polynomial inverse integrating factors
MD1951G2 (ro) Metodă de depistare a acidului hialuronic în preparatele biologice
Kartasheva et al. Polarimetric studies of the closest of the binaries with the Wolf-Rayet component CQ Cep (II)

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU CA JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AU CA JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR

WWE Wipo information: entry into national phase

Ref document number: 2397792

Country of ref document: CA

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 552865

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 31114/01

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2001903273

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001903273

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2001903273

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载