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WO2001051523A3 - Proteines et fragments de proteines anti-angiogeniques et leurs procede d'utilisation - Google Patents

Proteines et fragments de proteines anti-angiogeniques et leurs procede d'utilisation Download PDF

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Publication number
WO2001051523A3
WO2001051523A3 PCT/US2001/000565 US0100565W WO0151523A3 WO 2001051523 A3 WO2001051523 A3 WO 2001051523A3 US 0100565 W US0100565 W US 0100565W WO 0151523 A3 WO0151523 A3 WO 0151523A3
Authority
WO
WIPO (PCT)
Prior art keywords
fragments
methods
angiogenic proteins
proteins
angiogenic
Prior art date
Application number
PCT/US2001/000565
Other languages
English (en)
Other versions
WO2001051523A2 (fr
Inventor
Raghuram Kalluri
Original Assignee
Beth Israel Hospital
Raghuram Kalluri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/625,191 external-priority patent/US6962974B1/en
Application filed by Beth Israel Hospital, Raghuram Kalluri filed Critical Beth Israel Hospital
Priority to JP2001551107A priority Critical patent/JP2003519630A/ja
Priority to AU26356/01A priority patent/AU783662B2/en
Priority to EP01900949A priority patent/EP1337633A2/fr
Priority to CA002396235A priority patent/CA2396235A1/fr
Publication of WO2001051523A2 publication Critical patent/WO2001051523A2/fr
Priority to US10/032,221 priority patent/US7387779B2/en
Publication of WO2001051523A3 publication Critical patent/WO2001051523A3/fr
Priority to AU2006200751A priority patent/AU2006200751A1/en
Priority to US12/127,193 priority patent/US20090054344A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des protéines et des fragments de celles-ci possédant des propriétés anti-angiogéniques, ainsi que des méthodes d'utilisation de ces protéines et de ces fragments permettant d'inhiber ou de promouvoir l'angiogénèse.
PCT/US2001/000565 1998-06-17 2001-01-08 Proteines et fragments de proteines anti-angiogeniques et leurs procede d'utilisation WO2001051523A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2001551107A JP2003519630A (ja) 2000-01-07 2001-01-08 抗血管新生タンパク質およびその断片ならびに使用方法
AU26356/01A AU783662B2 (en) 2000-01-07 2001-01-08 Anti-angiogenic proteins and fragments and methods of use thereof
EP01900949A EP1337633A2 (fr) 2000-01-07 2001-01-08 Proteines et fragments de proteines anti-angiogeniques et leurs procede d'utilisation
CA002396235A CA2396235A1 (fr) 2000-01-07 2001-01-08 Proteines et fragments de proteines anti-angiogeniques et leurs procede d'utilisation
US10/032,221 US7387779B2 (en) 1998-06-17 2001-12-21 Anti-angiogenic proteins and fragments and methods of use thereof
AU2006200751A AU2006200751A1 (en) 2000-01-07 2006-02-23 Anti-Angiogenic Proteins and Fragments and Methods of Use Thereof
US12/127,193 US20090054344A1 (en) 1998-06-17 2008-05-27 Anti-angiogenic proteins and fragments and methods of use thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US47911800A 2000-01-07 2000-01-07
US09/479,118 2000-01-07
US54337100A 2000-04-04 2000-04-04
US09/543,371 2000-04-04
US09/625,191 2000-07-21
US09/625,191 US6962974B1 (en) 1998-06-17 2000-07-21 Anti-angiogenic proteins and fragments and methods of use thereof

Related Parent Applications (3)

Application Number Title Priority Date Filing Date
US47911800A Continuation-In-Part 1998-06-17 2000-01-07
US54337100A Continuation-In-Part 1998-06-17 2000-04-04
US09/625,191 Continuation-In-Part US6962974B1 (en) 1998-06-17 2000-07-21 Anti-angiogenic proteins and fragments and methods of use thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/032,221 Continuation-In-Part US7387779B2 (en) 1998-06-17 2001-12-21 Anti-angiogenic proteins and fragments and methods of use thereof

Publications (2)

Publication Number Publication Date
WO2001051523A2 WO2001051523A2 (fr) 2001-07-19
WO2001051523A3 true WO2001051523A3 (fr) 2002-08-08

Family

ID=27413473

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/000565 WO2001051523A2 (fr) 1998-06-17 2001-01-08 Proteines et fragments de proteines anti-angiogeniques et leurs procede d'utilisation

Country Status (6)

Country Link
EP (1) EP1337633A2 (fr)
JP (1) JP2003519630A (fr)
CN (1) CN1420926A (fr)
AU (2) AU783662B2 (fr)
CA (1) CA2396235A1 (fr)
WO (1) WO2001051523A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7387779B2 (en) 1998-06-17 2008-06-17 Beth Israel Deaconess Medical Center Anti-angiogenic proteins and fragments and methods of use thereof
US20040105857A1 (en) * 2000-10-02 2004-06-03 Anthony Montgomery Methods and compositions for enhancing angiogenesis
US7122517B2 (en) 2001-07-27 2006-10-17 Kansas University Medical Center Crystallized structure of type IV collagen NC1 domain hexamer
US7893033B2 (en) 2002-05-06 2011-02-22 Board Of Regents, The University Of Texas System Targeting proteins to deliver therapeutic or diagnostic reagents
WO2004067762A2 (fr) * 2003-01-27 2004-08-12 University Of Kansas Medical Center Structure cristallisee hexamere a domaine nc1 de collagene de type iv
JP4843767B2 (ja) * 2005-08-31 2011-12-21 国立大学法人 岡山大学 がん細胞特異的遺伝子発現法を用いた血管新生阻害薬
US8227419B2 (en) 2006-02-03 2012-07-24 Crc For Asthma And Airways Ltd. Method of treating conditions associated with airway tissue remodeling
FR2898895B1 (fr) * 2006-03-23 2012-04-06 Univ Reims Champagne Ardenne Cyclopeptide a activite anti-cancereuse derive du collagene de type iv
EP2649095B1 (fr) 2010-12-10 2021-10-06 Aleksander S. Popel Peptides mimétiques dérivés de collagène de type iv et leur utilisation pour traiter des maladies dépendantes de l'angiogenèse et de la lymphangiogenèse
CN102145161A (zh) * 2011-04-07 2011-08-10 中国药科大学 整合素阻断剂在制备治疗肿瘤药物中的应用
GB201721387D0 (en) * 2017-12-20 2018-01-31 Nordic Bioscience As Tumstatin assay
CN113735966B (zh) * 2021-09-29 2022-11-01 陕西巨子生物技术有限公司 一种抗肿瘤重组胶原蛋白及其制备方法和应用
CN114931665B (zh) * 2021-12-14 2024-09-27 广州医科大学 六型胶原α2亚基在神经修复产品中的应用
CN117720619B (zh) * 2023-05-16 2024-10-29 杭州禾泰健宇生物科技有限公司 一种多肽、抗光老化多肽及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049885A2 (fr) * 1998-03-27 1999-10-07 University Of Kansas Medical Center Utilisation de domaines isoles de collagene du type iv pour modifier des interactions cellulaires et tissulaires
WO1999065940A1 (fr) * 1998-06-17 1999-12-23 Beth Israel Deaconess Medical Center Proteines anti-angiogeniques et methodes d'utilisation de ces proteines
WO2000059532A1 (fr) * 1999-04-01 2000-10-12 Biostratum, Inc. Utilisation de domaine de collagene de type iv permettant d'inhiber l'angiogenese et la croissance tumorale

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999049885A2 (fr) * 1998-03-27 1999-10-07 University Of Kansas Medical Center Utilisation de domaines isoles de collagene du type iv pour modifier des interactions cellulaires et tissulaires
WO1999065940A1 (fr) * 1998-06-17 1999-12-23 Beth Israel Deaconess Medical Center Proteines anti-angiogeniques et methodes d'utilisation de ces proteines
WO2000059532A1 (fr) * 1999-04-01 2000-10-12 Biostratum, Inc. Utilisation de domaine de collagene de type iv permettant d'inhiber l'angiogenese et la croissance tumorale

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
COLORADO P.C. ET AL.: "Anti-angiogenic cues from vascular basement membrane Collagen", CANCER RESEARCH, vol. 60, 1 May 2000 (2000-05-01), pages 2520 - 2526, XP001019102 *
COLORADO P.C. ET AL.: "Arresten: Angiogenesis and Renal Cell Carcinoma Tumor Inhibiting Matrix Protein", J. OF THE AMERICAN SOC. OF NEPHROLOGY, vol. 10, 1999, pages 489A, XP001018558 *
HAN J ET AL: "A cell binding domain from the alpha3 chain of type IV collagen inhibits proliferation of melanoma cells", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 33, 15 August 1997 (1997-08-15), pages 20395 - 20401, XP002118639, ISSN: 0021-9258 *
J.A. VARNER: "The Role of Vascular Integrins alpha v beta 3 and alpha v beta 5 in angiogenesis", 1997, BIRKHÄUSER, BASEL, XP002924175 *
KAMPHAUS G.D. ET AL.: "Canstatin, a novel matrix-derived inhibitor of angiogenesis and tumor growth", J. BIOL. CHEM., vol. 275, no. 2, 14 January 2000 (2000-01-14), pages 1209 - 1215, XP002177916 *
KAMPHAUS G.D. ET AL.: "Canstatin: A novel matrix derived inhibitor of Angiogenesis and Renal Cell Carcinoma", J. OF THE AMERICAN SOC. OF NEPHROLOGY, vol. 10, 1999, pages 495A, XP001018557 *
KEFALIDES N A ET AL: "SUPPRESSION OF TUMOR CELL GROWTH BY TYPE IV COLLAGEN AND A PEPTIDE FROM THE NC1 DOMAIN OF THE ALPAH3(IV) CHAIN", MEDICINA, BUENOS AIRES, AR, vol. 59, no. 5-2, 1999, pages 553, XP002144122, ISSN: 0025-7680 *
MAESHIMA Y. ET AL.: "Two RGD-independent alpha v beta 3 Integrin binding sites on Tumstatin regulate Distinct anti-tumor properties", J. BIOL. CHEM., vol. 275, no. 31, 4 August 2000 (2000-08-04), pages 23745 - 23750, XP002177918 *
NICKOLS A ET AL: "ANTIANGIOGENIC AND ANTICANCER ACTIVITIES OF ANTAGONISTS OF INTEGRINALPHAVBETA3", PROCEEDINGS OF THE 88TH. ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. SAN DIEGO, APR. 12 - 16, 1997, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, AACR, US, vol. 38, 1 March 1997 (1997-03-01), pages 206, XP002071773 *
PETITCLERC ET AL.: "New functions for non-collagenous domains of human collagen type IV", J. BIOL. CHEM., vol. 275, no. 11, 17 March 2000 (2000-03-17), pages 8051 - 8061, XP002144125 *
PRESTAYKO ET AL: "Type IV collagen domains inhibit adhesion and migration of tumor cells and block angiogenesis", PROCEEDINGS OF THE 89TH. ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH. NEW ORLEANS, LA, MARCH 28 - APRIL 1, 1998, PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, PHILADELPHIA, PA: AACR, US, vol. 39, 28 March 1998 (1998-03-28), pages 45, XP002118641 *

Also Published As

Publication number Publication date
JP2003519630A (ja) 2003-06-24
AU2635601A (en) 2001-07-24
CN1420926A (zh) 2003-05-28
CA2396235A1 (fr) 2001-07-19
EP1337633A2 (fr) 2003-08-27
WO2001051523A2 (fr) 2001-07-19
AU2006200751A1 (en) 2006-03-16
AU783662B2 (en) 2005-11-24

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