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WO2001051095A3 - Derives paramagnetiques de type dota, agents pharmaceutiques les contenant, procedes permettant de les preparer et leur utilisation pour l'imagerie par resonance magnetique de necroses et de l'infarctus - Google Patents

Derives paramagnetiques de type dota, agents pharmaceutiques les contenant, procedes permettant de les preparer et leur utilisation pour l'imagerie par resonance magnetique de necroses et de l'infarctus Download PDF

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Publication number
WO2001051095A3
WO2001051095A3 PCT/EP2001/000285 EP0100285W WO0151095A3 WO 2001051095 A3 WO2001051095 A3 WO 2001051095A3 EP 0100285 W EP0100285 W EP 0100285W WO 0151095 A3 WO0151095 A3 WO 0151095A3
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WO
WIPO (PCT)
Prior art keywords
infarction
necrosis
imaging
methods
paramagnetic
Prior art date
Application number
PCT/EP2001/000285
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German (de)
English (en)
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WO2001051095A2 (fr
Inventor
Johannes Platzek
Heribert Schmitt-Willich
Ulrich Niedballa
Wolfgang Ebert
Hanns-Joachim Weinmann
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Schering Ag filed Critical Schering Ag
Priority to AU2001225150A priority Critical patent/AU2001225150A1/en
Publication of WO2001051095A2 publication Critical patent/WO2001051095A2/fr
Publication of WO2001051095A3 publication Critical patent/WO2001051095A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

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  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des composés de formule générale (I) Ar-(L-K)n dans laquelle K désigne un complexe métallique cyclique non radioactif de type DOTA, L désigne un lieur, Ar un reste aromatique contenant un composé aromatique polycondensé et n désigne les chiffres 1 ou 2. L'invention concerne en outre des agents diagnostiques contenant ces composés, leur utilisation pour l'imagerie par résonance magnétique de nécroses et de l'infarctus, ainsi que des procédés permettant de préparer lesdits composés et agents.
PCT/EP2001/000285 2000-01-13 2001-01-11 Derives paramagnetiques de type dota, agents pharmaceutiques les contenant, procedes permettant de les preparer et leur utilisation pour l'imagerie par resonance magnetique de necroses et de l'infarctus WO2001051095A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001225150A AU2001225150A1 (en) 2000-01-13 2001-01-11 Paramagnetic dota derivatives, pharmaceutical agents containing the same, methods for the production thereof and their use for the mr imaging of necrosis and infarction

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE100012939.6 2000-01-13
DE2000102939 DE10002939C1 (de) 2000-01-13 2000-01-13 Paramagnetische DOTA-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung für die Herstellung von pharmazeutischen Mitteln

Publications (2)

Publication Number Publication Date
WO2001051095A2 WO2001051095A2 (fr) 2001-07-19
WO2001051095A3 true WO2001051095A3 (fr) 2002-11-28

Family

ID=7628564

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/000285 WO2001051095A2 (fr) 2000-01-13 2001-01-11 Derives paramagnetiques de type dota, agents pharmaceutiques les contenant, procedes permettant de les preparer et leur utilisation pour l'imagerie par resonance magnetique de necroses et de l'infarctus

Country Status (3)

Country Link
AU (1) AU2001225150A1 (fr)
DE (1) DE10002939C1 (fr)
WO (1) WO2001051095A2 (fr)

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* Cited by examiner, † Cited by third party
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DE10311628B4 (de) * 2003-03-14 2006-04-13 Siemens Ag Bildgebungsverfahren
JP2008274271A (ja) * 2007-04-06 2008-11-13 Mitsubishi Chemicals Corp ビスフェニルフルオレンジカルボン酸系化合物及びポリエステル樹脂、並びにこのポリエステル樹脂を用いた位相差フィルム、液晶パネル及び画像表示機器
JP2016508507A (ja) 2013-02-12 2016-03-22 バイエル・ファルマ・アクティエンゲゼルシャフト 血小板特異的糖タンパク質ＩＩｂ／ＩＩＩａに結合するための金属キレート化合物
EP3068443B1 (fr) 2013-11-12 2019-04-10 Centre for Probe Development and Commercialization Groupes de liaison à résidualisation et leurs applications
EP3101012A1 (fr) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Nouveaux composés de chélate de gadolinium pour une utilisation dans l'imagerie par résonance magnétique
US10975060B2 (en) 2016-11-28 2021-04-13 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
CN117603148A (zh) 2017-05-05 2024-02-27 探针技术开发及商业化中心 双官能螯合物的药代动力学增强及其用途
US10093741B1 (en) 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
CN110891614A (zh) 2017-05-05 2020-03-17 融合制药公司 Igf-1r单克隆抗体及其用途
CN107456583B (zh) * 2017-06-19 2020-05-29 南京科技职业学院 一类含钆磁共振成像造影剂及其制备与应用
PE20211471A1 (es) 2018-11-23 2021-08-05 Bayer Ag Formulacion de medios de contraste y proceso para prepararlos
JP7516701B2 (ja) 2019-05-08 2024-07-17 本州化学工業株式会社 ビナフチルカルボン酸類の製造方法
EP4360660A1 (fr) 2022-10-24 2024-05-01 Bayer AG Procédé de préparation d'un agent de contraste à base de gadolinium

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EP0451824A2 (fr) * 1990-04-10 1991-10-16 Nihon Medi-Physics Co., Ltd. Composés chélatants et leur utilisation
EP0545511A2 (fr) * 1991-12-06 1993-06-09 Schering Aktiengesellschaft Procédé pour la préparation de tétraazamacrocycles mono-N-substitués
WO1998041540A1 (fr) * 1997-03-14 1998-09-24 Nycomed Imaging As Ligands radiomarques du recepteur de la somatostatine pour le diagnostic et la theraphie
WO1999016757A1 (fr) * 1997-09-26 1999-04-08 Schering Aktiengesellschaft Agents de contraste pour imagerie de necroses et d'infarctus
WO1999025389A2 (fr) * 1997-11-17 1999-05-27 Research Corporation Technologies, Inc. Agents d'imagerie par resonance magnetique permettant la detection d'agents physiologiques
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JP3878208B2 (ja) * 1994-04-08 2007-02-07 ブラッコ インターナショナル ベスローテン フェンノートシャップ 芳香族アミド化合物およびそれらのキレート

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EP0451824A2 (fr) * 1990-04-10 1991-10-16 Nihon Medi-Physics Co., Ltd. Composés chélatants et leur utilisation
EP0545511A2 (fr) * 1991-12-06 1993-06-09 Schering Aktiengesellschaft Procédé pour la préparation de tétraazamacrocycles mono-N-substitués
WO1998041540A1 (fr) * 1997-03-14 1998-09-24 Nycomed Imaging As Ligands radiomarques du recepteur de la somatostatine pour le diagnostic et la theraphie
WO1999016757A1 (fr) * 1997-09-26 1999-04-08 Schering Aktiengesellschaft Agents de contraste pour imagerie de necroses et d'infarctus
WO1999025389A2 (fr) * 1997-11-17 1999-05-27 Research Corporation Technologies, Inc. Agents d'imagerie par resonance magnetique permettant la detection d'agents physiologiques
US6056939A (en) * 1998-08-28 2000-05-02 Desreux; Jean F. Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals

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Publication number Publication date
WO2001051095A2 (fr) 2001-07-19
AU2001225150A1 (en) 2001-07-24
DE10002939C1 (de) 2001-09-20

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