WO2001051067A1 - Composition anticoagulante a facteurs sanguins inactives multiples - Google Patents
Composition anticoagulante a facteurs sanguins inactives multiples Download PDFInfo
- Publication number
- WO2001051067A1 WO2001051067A1 PCT/US2000/034734 US0034734W WO0151067A1 WO 2001051067 A1 WO2001051067 A1 WO 2001051067A1 US 0034734 W US0034734 W US 0034734W WO 0151067 A1 WO0151067 A1 WO 0151067A1
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- Prior art keywords
- anticoagulant
- composition
- factors
- anticoagulant composition
- inactivated
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- 238000011321 prophylaxis Methods 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 229940024790 prothrombin complex concentrate Drugs 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
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- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 201000002282 venous insufficiency Diseases 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne une composition anticoagulante comprenant au moins deux facteurs sanguins inactivés dans un vecteur acceptable du point de vue pharmaceutique, les facteurs sanguins inactivés de ce type étant présents en un dosage efficace du point de vue pharmaceutique. Cette invention concerne également des procédés d'utilisation des compositions anticoagulantes de l'invention, comprenant l'administration à un patient d'une quantité desdites compositions permettant d'inhiber la coagulation, ainsi que des procédés de préparation de ces compositions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2001257893A AU2001257893A1 (en) | 2000-01-13 | 2000-12-20 | Multiple inactivated blood factor anticoagulant composition |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17582100P | 2000-01-13 | 2000-01-13 | |
| US60/175,821 | 2000-01-13 | ||
| US74023900A | 2000-12-18 | 2000-12-18 | |
| US09/740,239 | 2000-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2001051067A1 true WO2001051067A1 (fr) | 2001-07-19 |
Family
ID=26871605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2000/034734 WO2001051067A1 (fr) | 2000-01-13 | 2000-12-20 | Composition anticoagulante a facteurs sanguins inactives multiples |
Country Status (2)
| Country | Link |
|---|---|
| AU (1) | AU2001257893A1 (fr) |
| WO (1) | WO2001051067A1 (fr) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002061428A3 (fr) * | 2001-02-01 | 2003-04-17 | Magnetic Biosolutions Sweden A | Procede |
| WO2008145989A1 (fr) * | 2007-05-30 | 2008-12-04 | Nhs Blood And Transplant | Procédé de préparation de facteur x, facteur x activé, facteur x inactivé et facteur xa désactivé, et compositions pharmaceutiques comportant de tels facteurs |
| US9956272B2 (en) | 2007-05-30 | 2018-05-01 | Bio Products Laboratory Limited | Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same |
| CN112941143A (zh) * | 2021-01-28 | 2021-06-11 | 南京可诺医疗技术有限公司 | 一种简单便捷的检测凝血和血小板功能的试剂及其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120537A (en) * | 1989-06-14 | 1992-06-09 | Oklahoma Medical Research Foundation | Factor xa based anticoagulant compositions |
| US5770699A (en) * | 1994-10-28 | 1998-06-23 | Cor Therapeutics, Inc. | Process for production of inhibited forms of activated blood factors |
-
2000
- 2000-12-20 WO PCT/US2000/034734 patent/WO2001051067A1/fr active Application Filing
- 2000-12-20 AU AU2001257893A patent/AU2001257893A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120537A (en) * | 1989-06-14 | 1992-06-09 | Oklahoma Medical Research Foundation | Factor xa based anticoagulant compositions |
| US5770699A (en) * | 1994-10-28 | 1998-06-23 | Cor Therapeutics, Inc. | Process for production of inhibited forms of activated blood factors |
Non-Patent Citations (1)
| Title |
|---|
| KJALKE ET AL.: "Active site-inactivated factors VIIa, Xa and IXa inhibit individual steps in a cell-based model of tissue factor-intiated coagulation", THROMB HAEMOST., vol. 80, no. 4, October 1998 (1998-10-01), pages 578 - 584, XP002938760 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002061428A3 (fr) * | 2001-02-01 | 2003-04-17 | Magnetic Biosolutions Sweden A | Procede |
| US7279285B2 (en) | 2001-02-01 | 2007-10-09 | Magnetic Biosolutions Ab | Method of reversibly disrupting a conjugate comprising a biotin compound and a biotin-binding compound |
| WO2008145989A1 (fr) * | 2007-05-30 | 2008-12-04 | Nhs Blood And Transplant | Procédé de préparation de facteur x, facteur x activé, facteur x inactivé et facteur xa désactivé, et compositions pharmaceutiques comportant de tels facteurs |
| JP2010528096A (ja) * | 2007-05-30 | 2010-08-19 | エヌエイチエス ブラッド アンド トランスプラント | 第Ｘ因子，活性化第Ｘ因子，不活性第Ｘ因子および不活性化第Ｘａ因子の調製方法、ならびに該因子を含む医薬組成物 |
| US8906366B2 (en) | 2007-05-30 | 2014-12-09 | Nhs Blood And Transplant | Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same |
| US9956272B2 (en) | 2007-05-30 | 2018-05-01 | Bio Products Laboratory Limited | Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same |
| CN112941143A (zh) * | 2021-01-28 | 2021-06-11 | 南京可诺医疗技术有限公司 | 一种简单便捷的检测凝血和血小板功能的试剂及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001257893A1 (en) | 2001-07-24 |
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