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WO2001047576A3 - Compositions pour fluide de remplacement et systemes et procedes associes utilisables dans l'execution d'une hemofiltration frequente - Google Patents

Compositions pour fluide de remplacement et systemes et procedes associes utilisables dans l'execution d'une hemofiltration frequente Download PDF

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Publication number
WO2001047576A3
WO2001047576A3 PCT/US2000/042357 US0042357W WO0147576A3 WO 2001047576 A3 WO2001047576 A3 WO 2001047576A3 US 0042357 W US0042357 W US 0042357W WO 0147576 A3 WO0147576 A3 WO 0147576A3
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WO
WIPO (PCT)
Prior art keywords
replacement fluid
frequent hemofiltration
hemofiltration
compositions
performance
Prior art date
Application number
PCT/US2000/042357
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English (en)
Other versions
WO2001047576A2 (fr
Inventor
Jeffrey Burbank
Charles D Finch
Dennis M Treu
John Moran
Brigitte Moran
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Nxstage Medical Inc
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Publication date
Application filed by Nxstage Medical Inc filed Critical Nxstage Medical Inc
Priority to AU54426/01A priority Critical patent/AU5442601A/en
Publication of WO2001047576A2 publication Critical patent/WO2001047576A2/fr
Publication of WO2001047576A3 publication Critical patent/WO2001047576A3/fr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/367Circuit parts not covered by the preceding subgroups of group A61M1/3621
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3401Cassettes therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403Regulation parameters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403Regulation parameters
    • A61M1/3406Physical characteristics of the filtrate, e.g. urea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3441Substitution rate control as a function of the ultrafiltration rate
    • A61M1/3444Substitution rate control as a function of the ultrafiltration rate in which the collected ultra-filtrate expels an equal volume of substitution fluid from a reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3607Regulation parameters
    • A61M1/3609Physical characteristics of the blood, e.g. haematocrit, urea
    • A61M1/361Physical characteristics of the blood, e.g. haematocrit, urea before treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3607Regulation parameters
    • A61M1/3609Physical characteristics of the blood, e.g. haematocrit, urea
    • A61M1/3612Physical characteristics of the blood, e.g. haematocrit, urea after treatment
    • AHUMAN NECESSITIES
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    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36222Details related to the interface between cassette and machine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36224Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with sensing means or components thereof
    • AHUMAN NECESSITIES
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    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36225Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with blood pumping means or components thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362265Details of valves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3643Priming, rinsing before or after use
    • A61M1/3644Mode of operation
    • A61M1/3646Expelling the residual body fluid after use, e.g. back to the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226Constructional details of cassettes, e.g. specific details on material or shape
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3622Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
    • A61M1/36226Constructional details of cassettes, e.g. specific details on material or shape
    • A61M1/362266Means for adding solutions or substances to the blood
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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    • A61M1/3626Gas bubble detectors
    • AHUMAN NECESSITIES
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    • A61M1/36Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3621Extra-corporeal blood circuits
    • A61M1/3639Blood pressure control, pressure transducers specially adapted therefor
    • AHUMAN NECESSITIES
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    • A61M2205/00General characteristics of the apparatus
    • A61M2205/12General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/125General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated filters
    • A61M2205/126General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated filters with incorporated membrane filters
    • AHUMAN NECESSITIES
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    • A61M2205/00General characteristics of the apparatus
    • A61M2205/12General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
    • A61M2205/128General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit with incorporated valves
    • AHUMAN NECESSITIES
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    • A61M2205/00General characteristics of the apparatus
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    • A61M2205/3331Pressure; Flow
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    • A61M2205/3375Acoustical, e.g. ultrasonic, measuring means
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    • A61M2205/00General characteristics of the apparatus
    • A61M2205/50General characteristics of the apparatus with microprocessors or computers
    • A61M2205/502User interfaces, e.g. screens or keyboards
    • A61M2205/505Touch-screens; Virtual keyboard or keypads; Virtual buttons; Soft keys; Mouse touches

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • External Artificial Organs (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention se rapporte à un fluide de remplacement spécialement formulé pour être utilisé en association avec les modalités d'une hémofiltration devant être exécutée au moins quatre fois par semaine, appelée hémofiltration fréquente. Ce fluide de remplacement pour hémofiltration fréquente comprend une solution saline équilibrée qui contient du sodium, du calcium, du potassium, du chlorure et soit du bicarbonate soit un anion pouvant être métabolisé en bicarbonate. Ces modalités d'hémofiltration fréquente réduisent au minimum l'appauvrissement des électrolytes sanguins lors de chaque session thérapeutique, de telle sorte qu'il n'est pas nécessaire que le fluide de remplacement contienne des électrolytes. De plus, en raison des effets physiologiques modérés engendrés lors de chaque session d'hémofiltration fréquente, les concentrations de sodium, calcium, potassium et chlorure dans le fluide de remplacement sont telles qu'elles rendent possible l'utilisation de solutions de produit relativement peu coûteuses, par exemple une solution saline normale ou du lactate de Ringer, comme fluide de remplacement.
PCT/US2000/042357 1999-11-29 2000-11-29 Compositions pour fluide de remplacement et systemes et procedes associes utilisables dans l'execution d'une hemofiltration frequente WO2001047576A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU54426/01A AU5442601A (en) 1999-11-29 2000-11-29 Compositions for replacement fluid and associated systems and methods usable in the performance of frequent hemofiltration

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US45123899A 1999-11-29 1999-11-29
US09/451,238 1999-11-29
US51344600A 2000-02-25 2000-02-25
US09/513,446 2000-02-25

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WO2001047576A2 WO2001047576A2 (fr) 2001-07-05
WO2001047576A3 true WO2001047576A3 (fr) 2002-02-28

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Cited By (4)

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US8834719B2 (en) 2007-10-24 2014-09-16 Baxter International Inc. Personal hemodialysis system
US8858488B2 (en) 2003-11-05 2014-10-14 Baxter International Inc. Dialysis system including blood and dialysate cassette
US8882692B2 (en) 2003-11-05 2014-11-11 Baxter International Inc. Hemodialysis system with multiple cassette interference
US8920362B2 (en) 2007-07-05 2014-12-30 Baxter International Inc. Dialysis system having disposable cassette

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Publication number Priority date Publication date Assignee Title
GB0123115D0 (en) 2001-09-26 2001-11-14 Pharma Sol Int Ltd Saline solutions for clinical use
US7241272B2 (en) 2001-11-13 2007-07-10 Baxter International Inc. Method and composition for removing uremic toxins in dialysis processes
JP4890761B2 (ja) 2002-07-19 2012-03-07 バクスター・インターナショナル・インコーポレイテッド 腹膜透析を実施するためのシステムおよび方法
US9415150B2 (en) 2007-11-09 2016-08-16 Baxter Healthcare S.A. Balanced flow dialysis machine
US8062513B2 (en) 2008-07-09 2011-11-22 Baxter International Inc. Dialysis system and machine having therapy prescription recall
US8057679B2 (en) 2008-07-09 2011-11-15 Baxter International Inc. Dialysis system having trending and alert generation
DE102009036101A1 (de) * 2009-08-04 2011-02-24 Fresenius Medical Care Deutschland Gmbh Verbindungsvorrichtung zum Verbinden wenigstens einer externen Funktionseinrichtung mit einer Anordnung, Anordnung umfassend eine solche Verbindungsvorrichtung sowie Verfahren zum Verbinden
CA2985719C (fr) 2015-06-25 2024-03-26 Gambro Lundia Ab Systeme et procede de dispositif medical comprenant une base de donnees distribuee
JP7153017B2 (ja) 2016-12-21 2022-10-13 ガンブロ・ルンディア・エービー 外部ドメインをサポートするセキュアクラスタドメインを有する情報技術インフラストラクチャを含む医療機器システム
EP3505200B1 (fr) 2017-12-29 2020-09-09 Gambro Lundia AB Appareil pour traitement sanguin extracorporel

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US4468329A (en) * 1980-06-27 1984-08-28 Gambro Lundia Ab Hemofiltration system and safety system therefor
US5032615A (en) * 1989-10-31 1991-07-16 The Regents Of The University Of California Continuous hemodialysis using citrate
US5211849A (en) * 1991-10-11 1993-05-18 Children's Hospital Medical Center Hemofiltration system and method
US5252213A (en) * 1989-06-20 1993-10-12 University Of Washington Dry dialysate composition
US5277820A (en) * 1992-02-06 1994-01-11 Hemocleanse, Inc. Device and method for extracorporeal blood treatment
US5919369A (en) * 1992-02-06 1999-07-06 Hemocleanse, Inc. Hemofiltration and plasmafiltration devices and methods
US5945449A (en) * 1996-11-01 1999-08-31 Dialysis Solutions Inc. Sterile bicarbonate concentrate

Patent Citations (8)

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Publication number Priority date Publication date Assignee Title
US4468329A (en) * 1980-06-27 1984-08-28 Gambro Lundia Ab Hemofiltration system and safety system therefor
US5252213A (en) * 1989-06-20 1993-10-12 University Of Washington Dry dialysate composition
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US9364602B2 (en) 2003-11-05 2016-06-14 Baxter International Inc. Systems and methods for priming sorbent-based hemodialysis using dialysis fluid
US9480784B2 (en) 2003-11-05 2016-11-01 Baxter International Inc. Dialysis system with balance chamber prime and rinseback
US8920362B2 (en) 2007-07-05 2014-12-30 Baxter International Inc. Dialysis system having disposable cassette
US8834719B2 (en) 2007-10-24 2014-09-16 Baxter International Inc. Personal hemodialysis system
US8932469B2 (en) 2007-10-24 2015-01-13 Baxter International Inc. Personal hemodialysis system including priming sequence and methods of same

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