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WO2000037429A3 - INHIBITORS OF α4β1 MEDIATED CELL ADHESION - Google Patents

INHIBITORS OF α4β1 MEDIATED CELL ADHESION Download PDF

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Publication number
WO2000037429A3
WO2000037429A3 PCT/US1999/030665 US9930665W WO0037429A3 WO 2000037429 A3 WO2000037429 A3 WO 2000037429A3 US 9930665 W US9930665 W US 9930665W WO 0037429 A3 WO0037429 A3 WO 0037429A3
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WO
WIPO (PCT)
Prior art keywords
inhibitors
cell adhesion
mediated cell
adhesion
mediated
Prior art date
Application number
PCT/US1999/030665
Other languages
French (fr)
Other versions
WO2000037429A2 (en
Inventor
Bradley R Teegarden
Honnappa Jayakumar
Kenji Matsuki
Robert A Chrusciel
Jed F Fisher
Steven P Tanis
Edward W Thomas
James R Blinn
Original Assignee
Tanabe Seiyaku Co
Upjohn Co
Bradley R Teegarden
Honnappa Jayakumar
Kenji Matsuki
Robert A Chrusciel
Jed F Fisher
Steven P Tanis
Edward W Thomas
James R Blinn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co, Upjohn Co, Bradley R Teegarden, Honnappa Jayakumar, Kenji Matsuki, Robert A Chrusciel, Jed F Fisher, Steven P Tanis, Edward W Thomas, James R Blinn filed Critical Tanabe Seiyaku Co
Priority to EP99966584A priority Critical patent/EP1144365B1/en
Priority to JP2000589501A priority patent/JP2003524614A/en
Priority to DE69915692T priority patent/DE69915692T2/en
Priority to AU22095/00A priority patent/AU2209500A/en
Priority to AT99966584T priority patent/ATE261932T1/en
Publication of WO2000037429A2 publication Critical patent/WO2000037429A2/en
Publication of WO2000037429A3 publication Critical patent/WO2000037429A3/en

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
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    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
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    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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Abstract

The present invention relates to small molecules according to formula (I) which are potent inhibitors of a α4β1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing α4β1 adhesion mediated conditions in a mammal such as a human.
PCT/US1999/030665 1998-12-22 1999-12-20 INHIBITORS OF α4β1 MEDIATED CELL ADHESION WO2000037429A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP99966584A EP1144365B1 (en) 1998-12-22 1999-12-20 Inhibitors of alpha-4 beta-1 mediated cell adhesion
JP2000589501A JP2003524614A (en) 1998-12-22 1999-12-20 Inhibitors of α4β1-mediated cell adhesion
DE69915692T DE69915692T2 (en) 1998-12-22 1999-12-20 INHIBITORS OF ALPHA-4 BETA-1 MEDIATED CELL ADHESION
AU22095/00A AU2209500A (en) 1998-12-22 1999-12-20 Inhibitors of alpha4beta1 mediated cell adhesion
AT99966584T ATE261932T1 (en) 1998-12-22 1999-12-20 INHIBITORS OF ALPHA-4 BETA-1-MEDIATED CELL ADHESION

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11350198P 1998-12-22 1998-12-22
US60/113,501 1998-12-22

Publications (2)

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WO2000037429A2 WO2000037429A2 (en) 2000-06-29
WO2000037429A3 true WO2000037429A3 (en) 2003-05-22

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JP (1) JP2003524614A (en)
AT (1) ATE261932T1 (en)
AU (1) AU2209500A (en)
DE (1) DE69915692T2 (en)
DK (1) DK1144365T3 (en)
ES (1) ES2220140T3 (en)
PT (1) PT1144365E (en)
WO (1) WO2000037429A2 (en)

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MY153569A (en) 1998-01-20 2015-02-27 Mitsubishi Tanabe Pharma Corp Inhibitors of ?4 mediated cell adhesion
CA2380817A1 (en) * 1999-08-13 2001-02-22 Biogen, Inc. Cell adhesion inhibitors
CN1196682C (en) * 1999-12-06 2005-04-13 霍夫曼-拉罗奇有限公司 4-pyridinyl-N-acyl-L-phenylalanines
US6388084B1 (en) 1999-12-06 2002-05-14 Hoffmann-La Roche Inc. 4-pyridinyl-n-acyl-l-phenylalanines
AU2224901A (en) * 1999-12-28 2001-07-09 Ajinomoto Co., Inc. Novel phenylalanine derivatives
EP1270547A4 (en) 2000-03-23 2005-07-13 Ajinomoto Kk Novel phenylalanine derivative
MY129000A (en) 2000-08-31 2007-03-30 Tanabe Seiyaku Co INHIBITORS OF a4 MEDIATED CELL ADHESION
WO2002022563A1 (en) * 2000-09-14 2002-03-21 Toray Industries, Inc. Urea derivative and adhesive-molecule inhibitor containing the same as active ingredient
DE10124041A1 (en) * 2001-05-16 2002-11-21 Graffinity Pharm Design Gmbh New peptide-type compounds, useful as protease, especially thrombin, inhibitors for treating e.g. thrombosis and cardiac infarct
MY140707A (en) 2002-02-28 2010-01-15 Mitsubishi Tanabe Pharma Corp Process for preparing a phenylalanine derivative and intermediates thereof
AU2003265398A1 (en) 2002-08-09 2004-02-25 Transtech Pharma, Inc. Aryl and heteroaryl compounds and methods to modulate coagulation
WO2005014534A1 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
US7208601B2 (en) 2003-08-08 2007-04-24 Mjalli Adnan M M Aryl and heteroaryl compounds, compositions, and methods of use
WO2005014533A2 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
ATE509941T1 (en) 2006-01-11 2011-06-15 Seikagaku Kogyo Co Ltd CYCLOALKYLCARBONYLAMINOSIC ACID ESTER DERIVATIVE AND PROCESS FOR PRODUCTION THEREOF
JP3975226B2 (en) 2006-01-11 2007-09-12 生化学工業株式会社 Cycloalkylcarbonylamino acid derivative and process for producing the same
JP4047365B2 (en) 2006-01-11 2008-02-13 生化学工業株式会社 Cycloalkanecarboxamide derivative and method for producing the same
CA2678615A1 (en) 2007-02-16 2008-08-28 Synta Pharmaceutical Corp. Substituted fused-ring compounds for inflammation and immune-related uses
WO2011094890A1 (en) * 2010-02-02 2011-08-11 Argusina Inc. Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators
CN106588690B (en) * 2016-12-19 2019-06-04 广西中医药大学 The preparation method of the hairy chicken bone herb Abrusamide

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1996022966A1 (en) * 1995-01-23 1996-08-01 Biogen, Inc. Cell adhesion inhibitors
WO1998058902A1 (en) * 1997-06-23 1998-12-30 Tanabe Seiyaku Co., Ltd. INHIBITORS OF α4β1MEDIATED CELL ADHESION

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1996022966A1 (en) * 1995-01-23 1996-08-01 Biogen, Inc. Cell adhesion inhibitors
WO1998058902A1 (en) * 1997-06-23 1998-12-30 Tanabe Seiyaku Co., Ltd. INHIBITORS OF α4β1MEDIATED CELL ADHESION

Also Published As

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EP1144365B1 (en) 2004-03-17
DE69915692D1 (en) 2004-04-22
EP1144365A2 (en) 2001-10-17
WO2000037429A2 (en) 2000-06-29
ES2220140T3 (en) 2004-12-01
ATE261932T1 (en) 2004-04-15
PT1144365E (en) 2004-06-30
AU2209500A (en) 2000-07-12
JP2003524614A (en) 2003-08-19
DK1144365T3 (en) 2004-06-28
EP1144365A3 (en) 2003-07-09
DE69915692T2 (en) 2005-02-10

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