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WO2000036928A1 - Composition de complement alimentaire - Google Patents

Composition de complement alimentaire Download PDF

Info

Publication number
WO2000036928A1
WO2000036928A1 PCT/BE1999/000168 BE9900168W WO0036928A1 WO 2000036928 A1 WO2000036928 A1 WO 2000036928A1 BE 9900168 W BE9900168 W BE 9900168W WO 0036928 A1 WO0036928 A1 WO 0036928A1
Authority
WO
WIPO (PCT)
Prior art keywords
supplement composition
feed supplement
fatty acids
feed
composition
Prior art date
Application number
PCT/BE1999/000168
Other languages
English (en)
Inventor
Koen Molly
Luc Vandevoorde
Jaak Decuypere
Noel Dierick
Original Assignee
Vitamex N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vitamex N.V. filed Critical Vitamex N.V.
Priority to AU18509/00A priority Critical patent/AU1850900A/en
Publication of WO2000036928A1 publication Critical patent/WO2000036928A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides

Definitions

  • the present invention relates to a feed supplement composition as described in the preamble of the first claim.
  • a feed supplement composition which comprised one or more fatty acids containing 6-10 carbon atoms
  • the development of bacteria in the digestive tract of the young animal can be controlled. Most probably this effect can be explained by the fact that by the presence of these fatty acids in the stomach of the animal a physiological environment is created that is capable of regulating and stabilizing the gastro-intestinal microflora. It has been found that fatty acids containing 6-10 carbon atoms are capable of killing the majority of the pathological bacteria already in the stomach, so that the transit of pathological doses of bacteria towards the intestines can be prohibited and the occurrence of gastro-intestinal disorder prevented.
  • fatty acids containing 6-10 carbon atoms have unexpectedly been found capable of markedly improving the growth rate of the animal.
  • the observed growth promotion ability of fatty acids containing 6-10 carbon atoms appears to be comparable with the growth promotion effects obtainable with the known antibiotic growth promoters, without however showing the above described adverse side effects for the animal, the feed industry and the consumer.
  • the growth promoting effect of the fatty acids containing 6-10 carbon atoms can be explained by their particular absorption from the digestive tract into the portal blood circulation system, as a consequence of which they constitute an energy source that is readily available to the animal.
  • Fatty acids containing 6-10 carbon atoms namely form the main energy source for the development of mucosa and epithelial cells.
  • a mixture of different fatty acids preferably use is made of a mixture of different fatty acids, the individual fatty acids containing a different number of carbon atoms.
  • the inventors have found that such a mixture shows optimal antimicrobial properties. Also with such a mixture, the antimicrobial spectrum of the antibiotic growth promoters used in today's intensive animal production can be mimicked approximately completely. This is surprising.
  • the feed supplement composition of the present invention preferably comprises a mixture of fatty acids, which contain 6-8 carbon atoms.
  • the inventors have found that those fatty acids unexpectedly show the best antimicrobial properties and the most important growth rate enhancing effect.
  • the fatty acids are preferably present in the supplement composition in an amount of 0.01-2 percent by weight with respect to the total weight of the feed supplement composition.
  • the feed supplement composition of the present invention preferably contains an ammonium, a sodium, potassium or calcium salt of one or more of the free fatty acids, or a mixture of one or more of these salts, to prevent the composition from spreading an unpleasant odor which could restrain the animal from consuming it.
  • a calcium salt of one or more of the fatty acids the addition of lime stone as a calcium source can at least partly be dispensed with.
  • the sodium salt of the fatty acids has been found to be capable of increasing the resorption efficiency of the fatty acid by the digestive system. This allows either to lower the amount of fatty acid to be supplied or to further improve both the control of the microbial environment in the gastro-intestinal tract and the growth rate.
  • the feed supplement composition of the present invention preferably comprises slowly fermentable sugars (called prebiotics), preferably in an amount of 0.5 to 1.5 percent by weight with respect to the total weight of the composition.
  • prebiotics include slowly fermentable sugars for example galactomannans, for example guar gum, ⁇ -glucanes, transoligosaccharides, fructo- oligosaccharides and galacto-oligo-saccharides, but ⁇ -glucanes and galactomannans are preferred.
  • Prebiotics have been found capable of inhibiting the attachment sites of pathogenic bacteria in the small and large intestine and in that way of lowering the pathogenic bacterial population at the end of the small intestine. Simultaneously they have been found capable of enhancing the development of bacteria in support of the well functioning of the large intestine, by counteracting reflux of pathogenic bacteria into the small intestine to a large extent.
  • the fatty acids that can be used in the feed supplement of this invention include both fatty acids with an even and an odd number of carbon atoms, for example C6 (caproic acid, hexanoic acid), C7 (heptanoic acid), C8 (caprylic acid, octanoic acid), C9 (nonanoic or pelargonic acid) and C10 (capric acid, decanoic acid).
  • C6 caproic acid, hexanoic acid
  • C7 heptanoic acid
  • C8 caprylic acid, octanoic acid
  • C9 nonanoic or pelargonic acid
  • C10 capric acid, decanoic acid
  • the mechanism according to which the fatty acids exert antimicrobial activity has been well documented in literature.
  • the currently accepted theory is that the lipid microbial cell membrane is permeable for the undissociated fatty acid, as a consequence of which the fatty acid is capable of passing across the microbial cell membrane towards the more alkaline interior.
  • the fatty acid is dissociated, thus involving a decrease of the intracellular pH below the survival level.
  • the fatty acid thus in fact acts as a protonophore, which increases inward leak of H + and involves that efflux of H + is too slow to allow the intracellular pH to be increased again.
  • the physicochemical properties of the fatty acids which allow them to act as protonophores may vary and depend on numerous parameters.
  • the feed supplement composition of the present invention is preferably used as a supplement for the feed of early weaned piglets, but is not limited thereto.
  • the feed supplement composition of this invention is also suitable for use with other animals for example poultry or other types of animals, as well as other age categories of animals.
  • the feed supplement composition of this invention can for example also be administered to sows, shortly before weaning of the piglets. In that way the fatty acids are administered to the piglets in an indirect manner and allow to prevent the development of pathogenic microorganisms in the stomach already before weaning.
  • coccidioses which may involve Clos di ⁇ m spp. and necrotic enteritis, can be treated.
  • the invention also relates to a feed composition
  • a feed composition comprising the above described feed supplement composition, preferably in an amount of 10-30 percent by weight with respect to the total weight of the feed composition. Administration of such an amount allows to achieve an optimum growth performance .
  • Example 1 Feed composition.
  • a mixture according to this invention was prepared which contained approximately 40 parts by weight of barley, 14 parts by weight of wheat, 10 parts by weight of maize products, 11 parts by weight of Soya products and 20 parts by weight of a feed supplement composition containing 0.8 parts by weight of fatty acids with 8-10 carbon atoms.
  • a control feed was prepared which contained the same components as the above described mixture, with the exception that the control feed did not contain fatty acids.
  • Example 2 In vivo test with early weaned pigs.
  • a group of 10 pigs have been weaned after a period of 21 days. All pigs had free access to water and feed.
  • a first control group (group 1 ) was fed with the control feed.
  • 10 8 pathogenic bacteria (E. coli K88) were added per g of feed.
  • a second group (group 2) was fed with the feed composition of this invention as described in example 1.
  • 10 8 pathogenic bacteria (E. coli K88) were added per g of feed.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Fodder In General (AREA)

Abstract

La présente invention concerne une composition de complément alimentaire comprenant un ou plusieurs acides gras libres renfermant 6-10 atomes de carbone, ou des sels de ces acides gras, ou des mélanges des composés précités. Comme sel, on utilise, de préférence, un sel NH4?+Na+, K+ ou Ca2+¿. La présente invention concerne également une composition alimentaire comprenant 10-30 pour-cent en poids, par rapport au poids de la composition totale, de la composition de complément alimentaire précitée.
PCT/BE1999/000168 1998-12-22 1999-12-21 Composition de complement alimentaire WO2000036928A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU18509/00A AU1850900A (en) 1998-12-22 1999-12-21 Feed supplement composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EPPCT/EP98/08531 1998-12-22
EP9808531 1998-12-22

Publications (1)

Publication Number Publication Date
WO2000036928A1 true WO2000036928A1 (fr) 2000-06-29

Family

ID=8167179

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BE1999/000168 WO2000036928A1 (fr) 1998-12-22 1999-12-21 Composition de complement alimentaire

Country Status (2)

Country Link
AU (1) AU1850900A (fr)
WO (1) WO2000036928A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1294371A1 (fr) † 2000-06-20 2003-03-26 N.V. Seghers Nutrition Sciences S.A. Acides gras a chaines moyennes utilisables comme agents antimicrobiens
EP1314358A1 (fr) * 2001-11-21 2003-05-28 N.V. Seghers Nutrition Sciences Composition antimicrobienne pour animaux
JP2012131741A (ja) * 2010-12-22 2012-07-12 Bussan Biotech Kk 細胞性免疫活性化剤及びその利用
CN103609853A (zh) * 2013-12-12 2014-03-05 山东新希望六和集团有限公司 用于治疗猪胃溃疡的饲料及其制备方法
EP2381797B1 (fr) 2009-01-23 2017-03-08 Nutreco Nederland B.V. Additif d'aliment de bétail et aliment de bétail comprenant des esters alcoyls d'acides gras de longueur de chaîne intermédiaire, et leur utilisation dans les aliments de bétail
US10772343B2 (en) 2014-11-19 2020-09-15 Kansas State University Research Foundation Chemical mitigants in animal feed and feed ingredients

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309863A (en) * 1970-10-08 1973-03-14 Hydrierwerk Rodleben Veb Supplement foodstuff for animals
US4002775A (en) * 1973-07-09 1977-01-11 Kabara Jon J Fatty acids and derivatives of antimicrobial agents
EP0089376A1 (fr) * 1981-09-18 1983-09-28 MITSUI TOATSU CHEMICALS, Inc. Additif d'alimentation ou produit d'alimentation
EP0519458A1 (fr) * 1991-06-17 1992-12-23 Kao Corporation Additif de fourrage et fourrage
WO1997000018A1 (fr) * 1995-06-14 1997-01-03 Matforsk Norwegian Food Research Institute Aliments pour animaux

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1309863A (en) * 1970-10-08 1973-03-14 Hydrierwerk Rodleben Veb Supplement foodstuff for animals
US4002775A (en) * 1973-07-09 1977-01-11 Kabara Jon J Fatty acids and derivatives of antimicrobial agents
EP0089376A1 (fr) * 1981-09-18 1983-09-28 MITSUI TOATSU CHEMICALS, Inc. Additif d'alimentation ou produit d'alimentation
EP0519458A1 (fr) * 1991-06-17 1992-12-23 Kao Corporation Additif de fourrage et fourrage
WO1997000018A1 (fr) * 1995-06-14 1997-01-03 Matforsk Norwegian Food Research Institute Aliments pour animaux

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1294371A1 (fr) † 2000-06-20 2003-03-26 N.V. Seghers Nutrition Sciences S.A. Acides gras a chaines moyennes utilisables comme agents antimicrobiens
EP1294371B2 (fr) † 2000-06-20 2010-05-26 Nutrition Sciences Acides gras a chaines moyennes utilisables comme agents antimicrobiens
EP1314358A1 (fr) * 2001-11-21 2003-05-28 N.V. Seghers Nutrition Sciences Composition antimicrobienne pour animaux
WO2003043441A1 (fr) * 2001-11-21 2003-05-30 Nutrition Sciences N.V. Composition anti-microbienne pour animaux
EP2381797B1 (fr) 2009-01-23 2017-03-08 Nutreco Nederland B.V. Additif d'aliment de bétail et aliment de bétail comprenant des esters alcoyls d'acides gras de longueur de chaîne intermédiaire, et leur utilisation dans les aliments de bétail
EP2381797B2 (fr) † 2009-01-23 2023-05-31 Nutreco Nederland B.V. Additif d'aliment de bétail et aliment de bétail comprenant des esters alcoyls d'acides gras de longueur de chaîne intermédiaire, et leur utilisation dans les aliments de bétail
JP2012131741A (ja) * 2010-12-22 2012-07-12 Bussan Biotech Kk 細胞性免疫活性化剤及びその利用
CN103609853A (zh) * 2013-12-12 2014-03-05 山东新希望六和集团有限公司 用于治疗猪胃溃疡的饲料及其制备方法
US10772343B2 (en) 2014-11-19 2020-09-15 Kansas State University Research Foundation Chemical mitigants in animal feed and feed ingredients
US10918118B2 (en) 2014-11-19 2021-02-16 Kansas State University Research Foundation Chemical mitigants in animal feed and feed ingredients
US11896035B2 (en) 2014-11-19 2024-02-13 Kansas State University Research Foundation Chemical mitigants in animal feed and feed ingredients

Also Published As

Publication number Publication date
AU1850900A (en) 2000-07-12

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