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WO2000029109A1 - Support d'echantillon pour realiser des analyses en serie d'echantillons de liquides - Google Patents

Support d'echantillon pour realiser des analyses en serie d'echantillons de liquides Download PDF

Info

Publication number
WO2000029109A1
WO2000029109A1 PCT/EP1999/007281 EP9907281W WO0029109A1 WO 2000029109 A1 WO2000029109 A1 WO 2000029109A1 EP 9907281 W EP9907281 W EP 9907281W WO 0029109 A1 WO0029109 A1 WO 0029109A1
Authority
WO
WIPO (PCT)
Prior art keywords
sample carrier
carrier according
substrate part
sample
measuring chambers
Prior art date
Application number
PCT/EP1999/007281
Other languages
German (de)
English (en)
Inventor
Hermann Leistner
Dieter Schimkat
Gerhard Hotz
Heiner KÖHLER
Original Assignee
Stratec Biomedical Systems Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stratec Biomedical Systems Ag filed Critical Stratec Biomedical Systems Ag
Publication of WO2000029109A1 publication Critical patent/WO2000029109A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves

Definitions

  • the invention relates to a sample carrier for carrying out series analyzes on liquid samples with a substrate part which has a multiplicity of cavities for receiving liquid samples and optionally reagents.
  • sample analyzes In immunological diagnostics, gene analysis, microbiology, environmental analysis, clinical chemistry and other areas, it is often necessary to carry out a large number of sample analyzes automatically, using optical measurement methods such as photometry or luminometry in particular.
  • optical measurement methods such as photometry or luminometry in particular.
  • microtiter or microtest plates as sample carriers, in which a large number of samples can be placed in cavities or cells arranged in a matrix. It is usually necessary to align the individual cavities sequentially by means of a positioning device with respect to a measuring or processing station.
  • devices have already been developed that enable parallel processing through a large number of addition and measuring stations. However, the expenditure on equipment for this is considerable, especially if uniform sample processing is to be ensured.
  • the object of the invention is to develop a sample carrier of the type mentioned at the outset in such a way that a time and space-optimized process and measurement sequence with the possibility of simplified automation is ensured. Extensive miniaturization should also be made possible, in particular for processing small amounts of samples.
  • the invention is based on the idea of simultaneously distributing a liquid from a central feed chamber into a multiplicity of radially surrounding measuring chambers or reaction chambers. Accordingly, it is proposed according to the invention that the cavities are arranged as measuring chambers in an annular zone of the substrate part at an angular distance from one another, that in a central region of the substrate part a feed chamber to which a liquid sample is applied is arranged concentrically with the ring zone, and that the feed chamber with the Measuring chambers communicated via a connecting channel. This allows a test liquid to be easily divided into many
  • the substrate part is formed by a circular-cylindrical substrate disk, that the feed chamber and the measuring chambers are arranged coaxially to the central axis of the substrate disk, and that the connecting channels in the substrate disk extend radially. It is also advantageous if the measuring chambers are arranged symmetrically distributed with respect to the central axis of the substrate wafer.
  • the feed chamber is advantageously formed by a central recess in the substrate part which is designed as a cylindrical blind hole. To completely fill the measuring chambers, it should be ensured that the volume of the feed chamber is greater than or equal to the total volume of the measuring chambers.
  • the feed chamber, the connecting channels and the measuring chambers are open at the edges as recesses on a planar surface of the substrate part, and if at least the connecting channels and the measuring chambers are covered in a liquid-tight manner by a cover element on the planar surface which is firmly connected to the substrate part.
  • a cover element is formed by a flat material which forms a piercing membrane for sample injection in the area of the feed chamber.
  • the cover element it is advantageous for the cover element to be formed by a cover plate, which in the region of the feed chamber preferably faces the opening of the Feed chamber has widening breakthrough for sample application.
  • the substrate part has an engagement part which can be positively connected to a rotary drive for rotation about its central axis.
  • the sample liquid can thus be distributed in a metered manner under the influence of centrifugal force, and the measuring chambers can be positioned in a simple manner with only one degree of freedom.
  • the engagement part is formed by a toothed ring region toothed on the circumferential side or by an axial gear wheel extension of the substrate part.
  • the engagement part is formed by a recess designed for the engagement of a rotary driver.
  • the connecting channels have a mouth opening which widens towards the measuring chamber and preferably opens into the upper region thereof.
  • the measuring chambers are connected to an associated additional chamber via an additional channel.
  • the cover plate on its broad side facing away from the substrate part, separates an optionally sector-wise te ring recess, which opens into the additional chambers via an axial opening.
  • a controllable flow through the measuring chambers can be made possible in that the measuring chambers each have an outlet channel, which is preferably siphon-like and opens out on a lateral surface of the substrate part.
  • the substrate part advantageously consists of plastic, glass or a semiconductor material as a molded part.
  • FIG. 1 shows a disk-shaped sample carrier for performing series analyzes in a first embodiment with the cover part removed in an axial plan view;
  • Fig. 2 is a partially sectioned side view of the closed sample holder along the line 2-2 of Fig. 1;
  • FIG. 3 shows a further exemplary embodiment of a sample carrier with the cover plate shown partially broken off in plan view
  • FIG. 4 shows an axial section of the sample carrier along the section line 4 - 4 of FIG. 3; 5 and 6 show the sample carrier according to FIG. 3 equipped with a gear extension in a side view and an end view from below;
  • FIG. 7 shows a further exemplary embodiment of a sample carrier in a partial plan view with the cover part removed.
  • FIG. 8 shows an embodiment of a sample carrier with a recess designed for the engagement of a rotary driver in accordance with the illustration according to FIG. 6.
  • the sample carriers shown in the drawing are formed by a disk-shaped molded part or substrate part 10, which on its planar upper side 12 is firmly connected or can be connected to a cover element 14, 14 '.
  • the substrate part 10 is provided in an axial central region 16 with a feed chamber or central recess 18, which can be acted upon as a cylindrical blind hole via a feed opening on the top 12 of the substrate part with a liquid sample.
  • the substrate part 10 has a peripheral ring zone 20
  • the measuring chambers 22 have a clear cross section elongated in the radial direction and are open at the edges as recesses on the upper side of the substrate part 12.
  • the feed chamber 18 is connected to the measuring chambers 22 via a connecting channel 26.
  • the connecting channels 26 run as recesses on the upper side 12 of the substrate part 10 starting from the feed chamber 18 in a straight line in the radial direction and have an opening 28 which widens towards the respective measuring chamber 22.
  • the cover element 14 for the liquid-tight covering of the feed chamber 18 as well as the measuring chambers 22 and connecting channels 26 is formed by a flat material or foil material 30, which is integrally connected flat to the top 12 of the substrate part 10 and in the opening area of the feed chamber 18 forms a piercing membrane for injecting a liquid sample.
  • the measuring chambers 22 are each connected to an associated additional chamber 34 via an additional channel 32.
  • the additional chambers 34 are arranged between the connecting channels 26 in a space-saving manner. On the one hand, they enable the air displaced when the liquid enters the measuring chambers 22 to be taken through or on the other hand, and on the other hand allow the measuring chambers 22 to be additionally charged with a washing liquid, for example, in the manner described below.
  • a disk-shaped cover plate 14 ' is provided as a cover element to close the recesses 22, 26, 32, 34. This has an opening 36, which widens conically towards the opening of the feed chamber 18, for the sample applicators.
  • the cover plate 14 is provided on its broad side 38 facing away from the substrate part 10 with an annular recess 40, which opens into an additional chamber 34 located below it via an axial opening 42 in each case.
  • a liquid can be distributed into the additional chambers 34 and from there into the measuring chambers 22 by acting on the annular recess 40.
  • the ring recess 40 it is also possible for the ring recess 40 to be separated in sectors for separate liquid distribution.
  • the connecting channels 26 and, if appropriate, the additional channels 32 are designed as capillary tubes.
  • the substrate part 10 has an engagement part which can be positively connected to a rotary drive (not shown) for rotation about its central axis 24. In this way, a liquid from the feed chamber 14 under centrifugal force, which can be adjusted via the rotational speed, can be conveyed into the measuring chambers 22 in a defined manner.
  • the engagement part can be formed by an axially toothed wheel extension 44 of the substrate part 10 that is toothed on the circumference.
  • the extension 44 can also serve to receive a bottom section of the feed chamber 18 (FIG. 4).
  • FIG. form has the substrate part 10 instead of a gear extension on an axially stepped bottom portion 46 which is provided with a transverse recess 48 for the engagement of a rotary driver, not shown.
  • the outlet channel 50 can be designed siphon-like or S-shaped in order to allow a liquid passage only when a certain centrifugal force is exceeded.
  • the substrate part 10 and the cover plate 14 ' it is expedient if they are designed as one-piece molded parts, in particular injection molded plastic parts.
  • a transparent material with the desired optical properties can be used for optical measurements, glass or quartz also being suitable.
  • the measuring chambers can, for example, have a volume of less than 100 microliters, with sufficient filling ensuring that the volume of the feed chamber is greater than or equal to the total volume of the measuring chambers.
  • Another advantageous variant can consist in that one or several antechambers are arranged for a gradual reaction process.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

L'invention concerne un support d'échantillon pour réaliser des analyses en série, comportant une partie substrat (10) qui présente une pluralité de cavités (22) servant à recevoir les échantillons de liquides et éventuellement des agents réactifs. L'invention vise à optimiser le déroulement du processus et des mesures. A cet effet, les cavités sont placées avec un écart angulaire les unes par rapport aux autres, dans une zone annulaire (20) de la partie substrat (10), sous la forme de chambres de mesure (22). De plus, une chambre de distribution (18) pouvant être alimentée avec un échantillon de liquide est placée de manière concentrique par rapport à la zone annulaire (20), dans une zone centrale (16) de la partie substrat (10). Enfin, la chambre de distribution (18) communique avec les chambres de mesure (22) par l'intermédiaire d'un canal de liaison respectif (26).
PCT/EP1999/007281 1998-11-17 1999-10-01 Support d'echantillon pour realiser des analyses en serie d'echantillons de liquides WO2000029109A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19852835.3 1998-11-17
DE1998152835 DE19852835A1 (de) 1998-11-17 1998-11-17 Probenträger

Publications (1)

Publication Number Publication Date
WO2000029109A1 true WO2000029109A1 (fr) 2000-05-25

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ID=7887982

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/007281 WO2000029109A1 (fr) 1998-11-17 1999-10-01 Support d'echantillon pour realiser des analyses en serie d'echantillons de liquides

Country Status (2)

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DE (1) DE19852835A1 (fr)
WO (1) WO2000029109A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004504828A (ja) * 2000-07-28 2004-02-19 ジェネシステム 標的核酸配列の熱依存性連鎖増幅のための装置
EP1325306A4 (fr) * 2001-04-24 2004-08-11 Dade Behring Inc Dispositif de test d'identification dans un analyseur microbiologique a acces direct

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10036174B4 (de) * 2000-07-25 2006-12-07 Axaron Bioscience Ag Verfahren und Vorrichtung zum Analysieren von chemischen oder biologischen Proben
US7297531B2 (en) 2003-04-17 2007-11-20 Idexx Laboratories, Inc. Apparatus and method for testing liquid samples
US7582472B2 (en) 2003-08-26 2009-09-01 Smith Kenneth E Apparatus and method for liquid sample testing
DE102004041965B4 (de) 2004-08-31 2009-08-13 Leica Mikrosysteme Gmbh Vorrichtung und Verfahren zur Gefriersubstitution und Einbettung von biologischen Proben
EP1854541A1 (fr) * 2006-05-12 2007-11-14 F. Hoffmann-la Roche AG Plaque à puits multiples
EP1864715A1 (fr) * 2006-05-12 2007-12-12 F. Hoffmann-La Roche AG Plaque multipuits
DE102008003979B3 (de) 2008-01-11 2009-06-10 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Fluidikvorrichtung, Fluidikmodul und Verfahren zum Handhaben einer Flüssigkeit
FR2955268B1 (fr) * 2010-01-20 2019-06-28 Apex Biosolutions Dispositif de repartition, notamment pour un echantillon biologique
DE102017123249A1 (de) * 2017-10-06 2019-04-11 Hamilton Bonaduz Ag Vorrichtung zur Bestimmung des Volumens einer Flüssigkeit
KR102401909B1 (ko) 2018-08-30 2022-05-24 주식회사 엘지화학 반응 최적화를 위한 고속 스크리닝 분석 시스템

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0106536A2 (fr) * 1982-09-15 1984-04-25 Ortho Diagnostic Systems Inc. Dispositif centrifuge de séparation, de lavage et d'examen de microparticules et méthode d'utilisation
US4720465A (en) * 1985-05-14 1988-01-19 Fisher Scientific Company Centrifugal kinetic agglutination assay
US5077013A (en) * 1988-07-28 1991-12-31 Jean Guigan Miniature laboratory for performing biological analyses by chemical reaction on a sample of blood
WO1997021090A1 (fr) * 1995-12-05 1997-06-12 Gamera Bioscience Dispositifs et procedes d'utilisation de l'acceleration centripete pour commander le deplacement de liquides dans le traitement de laboratoire automatise

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0106536A2 (fr) * 1982-09-15 1984-04-25 Ortho Diagnostic Systems Inc. Dispositif centrifuge de séparation, de lavage et d'examen de microparticules et méthode d'utilisation
US4720465A (en) * 1985-05-14 1988-01-19 Fisher Scientific Company Centrifugal kinetic agglutination assay
US5077013A (en) * 1988-07-28 1991-12-31 Jean Guigan Miniature laboratory for performing biological analyses by chemical reaction on a sample of blood
WO1997021090A1 (fr) * 1995-12-05 1997-06-12 Gamera Bioscience Dispositifs et procedes d'utilisation de l'acceleration centripete pour commander le deplacement de liquides dans le traitement de laboratoire automatise

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004504828A (ja) * 2000-07-28 2004-02-19 ジェネシステム 標的核酸配列の熱依存性連鎖増幅のための装置
JP2011200245A (ja) * 2000-07-28 2011-10-13 Pall Genesystems Sa 酸素反応及び／又は分子生物学反応を実施するための装置および核酸を増幅するための方法および充填のためのプロセス
EP1325306A4 (fr) * 2001-04-24 2004-08-11 Dade Behring Inc Dispositif de test d'identification dans un analyseur microbiologique a acces direct

Also Published As

Publication number Publication date
DE19852835A1 (de) 2000-05-18

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