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WO2000029002A3 - Transplantation intra-uterine de cellules embryonnaires mesenchymateuses humaines - Google Patents

Transplantation intra-uterine de cellules embryonnaires mesenchymateuses humaines Download PDF

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Publication number
WO2000029002A3
WO2000029002A3 PCT/US1999/026927 US9926927W WO0029002A3 WO 2000029002 A3 WO2000029002 A3 WO 2000029002A3 US 9926927 W US9926927 W US 9926927W WO 0029002 A3 WO0029002 A3 WO 0029002A3
Authority
WO
WIPO (PCT)
Prior art keywords
stem cells
mesenchymal stem
human mesenchymal
transplantation
utero transplantation
Prior art date
Application number
PCT/US1999/026927
Other languages
English (en)
Other versions
WO2000029002A2 (fr
Inventor
Mark Thiede
Alan Flake
Original Assignee
Osiris Therapeutics Inc
Mark Thiede
Alan Flake
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Osiris Therapeutics Inc, Mark Thiede, Alan Flake filed Critical Osiris Therapeutics Inc
Priority to CA002348514A priority Critical patent/CA2348514A1/fr
Priority to EP99972103A priority patent/EP1128836A2/fr
Priority to AU14780/00A priority patent/AU1478000A/en
Priority to JP2000582048A priority patent/JP2002529509A/ja
Publication of WO2000029002A2 publication Critical patent/WO2000029002A2/fr
Publication of WO2000029002A3 publication Critical patent/WO2000029002A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention se rapporte à des cellules embryonnaires mésenchymateuses destinées à une transplantation intra-utérine. Ces cellules embryonnaires mésenchymateuses peuvent être utilisées dans une méthode de traitement d'un foetus, ou dans une méthode de greffe de cellules embryonnaires mésenchymateuses, ou encore dans une méthode de préparation d'un organe en vue de sa transplantation.
PCT/US1999/026927 1998-11-13 1999-11-12 Transplantation intra-uterine de cellules embryonnaires mesenchymateuses humaines WO2000029002A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002348514A CA2348514A1 (fr) 1998-11-13 1999-11-12 Transplantation intra-uterine de cellules embryonnaires mesenchymateuses humaines
EP99972103A EP1128836A2 (fr) 1998-11-13 1999-11-12 Transplantation intra-uterine de cellules embryonnaires mesenchymateuses humaines
AU14780/00A AU1478000A (en) 1998-11-13 1999-11-12 (in utero) transplantation of human mesenchymal stem cells
JP2000582048A JP2002529509A (ja) 1998-11-13 1999-11-12 ヒト間葉幹細胞の子宮内移植で胎児を処置し間葉幹細胞を移植し移植器官を調製する方法と調製された雑種器官

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10835798P 1998-11-13 1998-11-13
US60/108,357 1998-11-13

Publications (2)

Publication Number Publication Date
WO2000029002A2 WO2000029002A2 (fr) 2000-05-25
WO2000029002A3 true WO2000029002A3 (fr) 2000-10-05

Family

ID=22321740

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026927 WO2000029002A2 (fr) 1998-11-13 1999-11-12 Transplantation intra-uterine de cellules embryonnaires mesenchymateuses humaines

Country Status (5)

Country Link
EP (1) EP1128836A2 (fr)
JP (1) JP2002529509A (fr)
AU (1) AU1478000A (fr)
CA (1) CA2348514A1 (fr)
WO (1) WO2000029002A2 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020012905A1 (en) 2000-06-14 2002-01-31 Snodgrass H. Ralph Toxicity typing using liver stem cells
AU2001268399A1 (en) * 2000-06-14 2001-12-24 Vistagen, Inc. Toxicity typing using mesenchymal stem cells
WO2002040061A2 (fr) * 2000-11-15 2002-05-23 Osiris Therapeutics, Inc. Animaux immunocompetents, y compris sous forme d'implants xenogeniques de cellules embryonnaires mesenchymateuses
TW200301132A (en) * 2001-12-06 2003-07-01 Sankyo Co Pharmaceutical compositions containing cells derived from human caul
US20090186004A1 (en) * 2006-04-24 2009-07-23 Stemcell Institute Inc. Method For Preparing An Organ For Transplantation
WO2012048298A2 (fr) 2010-10-08 2012-04-12 Caridianbct, Inc. Procédés et systèmes de culture et de récolte de cellules dans un système de bioréacteur à fibres creuses avec conditions de régulation
EP3068866B1 (fr) 2013-11-16 2018-04-25 Terumo BCT, Inc. Expansion de cellules dans un bioréacteur
EP3122866B1 (fr) 2014-03-25 2019-11-20 Terumo BCT, Inc. Remplacement passif de milieu
CN106715676A (zh) 2014-09-26 2017-05-24 泰尔茂比司特公司 按计划供养
WO2017004592A1 (fr) 2015-07-02 2017-01-05 Terumo Bct, Inc. Croissance cellulaire à l'aide de stimuli mécaniques
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
CN106806947A (zh) * 2017-01-13 2017-06-09 宁夏医科大学总医院 一种低免疫原性组织工程皮肤构建方法
US11702634B2 (en) 2017-03-31 2023-07-18 Terumo Bct, Inc. Expanding cells in a bioreactor
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
US12234441B2 (en) 2017-03-31 2025-02-25 Terumo Bct, Inc. Cell expansion
CA3073665A1 (fr) * 2017-08-23 2019-02-28 Wake Forest University Health Sciences Transplantation in utero de cellules exprimant le facteur viii pour le traitement de l'hemophilie
JP2022519951A (ja) * 2019-04-02 2022-03-25 ザ ジェネラル ホスピタル コーポレイション Ｔ細胞の再生を増強する方法
CN113941032B (zh) * 2020-07-16 2023-04-07 北京中卫医正科技有限公司 一种间充质干细胞复合补片及其制备方法与应用
US12043823B2 (en) 2021-03-23 2024-07-23 Terumo Bct, Inc. Cell capture and expansion
CN113215084B (zh) * 2021-06-11 2023-04-07 中国农业科学院兰州兽医研究所 一种羊胎儿皮肤成纤维细胞、其分离方法与应用
US12209689B2 (en) 2022-02-28 2025-01-28 Terumo Kabushiki Kaisha Multiple-tube pinch valve assembly

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026884A1 (fr) * 1993-05-14 1994-11-24 Biotechnology Research And Development Corporation Cellules souches embryonnaires destinees a la reproduction d'ongules chimeres et transgeniques
WO1997010348A1 (fr) * 1995-09-14 1997-03-20 The Regents Of The University Of California Procedes d'induction de types cellulaires selectionnes
WO1999046366A1 (fr) * 1998-03-13 1999-09-16 Osiris Therapeutics, Inc. Utilisations de cellules souches humaines mesenchymateuses non autologues

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996028967A1 (fr) * 1995-03-17 1996-09-26 Chihiro Koike Mammiferes transgeniques autres que des primates, ou des serotypes de primates superieurs ont ete exprimes par un transfert de genes etrangers et procede pour creer ceux-ci

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026884A1 (fr) * 1993-05-14 1994-11-24 Biotechnology Research And Development Corporation Cellules souches embryonnaires destinees a la reproduction d'ongules chimeres et transgeniques
WO1997010348A1 (fr) * 1995-09-14 1997-03-20 The Regents Of The University Of California Procedes d'induction de types cellulaires selectionnes
WO1999046366A1 (fr) * 1998-03-13 1999-09-16 Osiris Therapeutics, Inc. Utilisations de cellules souches humaines mesenchymateuses non autologues

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
ALMEIDA-PORADA G ET AL: "Human bone marrow stromal cell progenitors are able to induce donor specific tolerance after in utero transplantation.", BLOOD, vol. 94, no. 10 SUPPL. 1 PART 1, 15 November 1999 (1999-11-15), 41th annual meeting of the American Society of Hematology, 3-7/12-1999, pages 40a, XP002139877 *
DEVINE S ET AL.: "Studies of mesenchymal stem cells in non-human primates: Evaluation of toxicity and engraftment", BLOOD, vol. 94, no. 10 Suppl. 1, 15 November 1999 (1999-11-15), 41th annual meeting of the American Society of Hematology, 3-7/12/1999, pages 391a, XP002139790 *
LIECHTY K W ET AL.: "Distribution and engraftment of human mesenchymal stem cells (MSC) after in utero transplantation in fetal sheep.", BLOOD, vol. 92, no. 10 Suppl. 1, 15 November 1998 (1998-11-15), 40th annual meeting of the American Society of Hematology, 4-8/12/1998, pages 117A, XP000914604 *
PEREIRA R F ET AL.: "Cultured adherent cells from marrow can serve as long-lasting precursor cells for bone, cartilage, and lung in irradiated mice", PROC. NAT'L. ACAD. SCI. USA, vol. 92, May 1995 (1995-05-01), pages 4857 - 4861, XP002139789 *
PROCKOP D J: "Marrow stromal cells as stem cells for nonhematopoietic tissues", SCIENCE, vol. 276, no. 5309, 4 April 1997 (1997-04-04), pages 71 - 74, XP002139788 *
SROUR E F ET AL.: "Sustained human hematopoiesis in sheep transplanted in utero during early gestation with fractionated adult human bone marrow cells", BLOOD, vol. 79, no. 6, 15 March 1992 (1992-03-15), pages 1404 - 1412, XP000569644 *

Also Published As

Publication number Publication date
CA2348514A1 (fr) 2000-05-25
WO2000029002A2 (fr) 2000-05-25
EP1128836A2 (fr) 2001-09-05
JP2002529509A (ja) 2002-09-10
AU1478000A (en) 2000-06-05

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