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WO2000028575A1 - Dispositif d'irradiation destine a des fins therapeutique et cosmetique - Google Patents

Dispositif d'irradiation destine a des fins therapeutique et cosmetique Download PDF

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Publication number
WO2000028575A1
WO2000028575A1 PCT/DE1999/002364 DE9902364W WO0028575A1 WO 2000028575 A1 WO2000028575 A1 WO 2000028575A1 DE 9902364 W DE9902364 W DE 9902364W WO 0028575 A1 WO0028575 A1 WO 0028575A1
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WO
WIPO (PCT)
Prior art keywords
irradiation device
gallium
radiation source
optical radiation
designed
Prior art date
Application number
PCT/DE1999/002364
Other languages
German (de)
English (en)
Inventor
Rolf Stirner
Original Assignee
Spectrometrix Optoelectronic Systems Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spectrometrix Optoelectronic Systems Gmbh filed Critical Spectrometrix Optoelectronic Systems Gmbh
Priority to EP99952241A priority Critical patent/EP1135791A1/fr
Priority to AU64602/99A priority patent/AU6460299A/en
Publication of WO2000028575A1 publication Critical patent/WO2000028575A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0616—Skin treatment other than tanning
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/67—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing refractory metals
    • C09K11/671—Chalcogenides
    • C09K11/673—Chalcogenides with alkaline earth metals
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/77—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals
    • C09K11/7728—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals containing europium
    • C09K11/7737—Phosphates
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/08—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials
    • C09K11/77—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals
    • C09K11/7728—Luminescent, e.g. electroluminescent, chemiluminescent materials containing inorganic luminescent materials containing rare earth metals containing europium
    • C09K11/7737—Phosphates
    • C09K11/7738—Phosphates with alkaline earth metals
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J61/00—Gas-discharge or vapour-discharge lamps
    • H01J61/02—Details
    • H01J61/12—Selection of substances for gas fillings; Specified operating pressure or temperature
    • H01J61/125—Selection of substances for gas fillings; Specified operating pressure or temperature having an halogenide as principal component
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J61/00—Gas-discharge or vapour-discharge lamps
    • H01J61/02—Details
    • H01J61/30—Vessels; Containers
    • H01J61/34—Double-wall vessels or containers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J61/00—Gas-discharge or vapour-discharge lamps
    • H01J61/02—Details
    • H01J61/30—Vessels; Containers
    • H01J61/35—Vessels; Containers provided with coatings on the walls thereof; Selection of materials for the coatings
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J61/00—Gas-discharge or vapour-discharge lamps
    • H01J61/02—Details
    • H01J61/38—Devices for influencing the colour or wavelength of the light
    • H01J61/40—Devices for influencing the colour or wavelength of the light by light filters; by coloured coatings in or on the envelope
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J61/00—Gas-discharge or vapour-discharge lamps
    • H01J61/02—Details
    • H01J61/38—Devices for influencing the colour or wavelength of the light
    • H01J61/42—Devices for influencing the colour or wavelength of the light by transforming the wavelength of the light by luminescence
    • H01J61/44—Devices characterised by the luminescent material
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J61/00—Gas-discharge or vapour-discharge lamps
    • H01J61/02—Details
    • H01J61/52—Cooling arrangements; Heating arrangements; Means for circulating gas or vapour within the discharge space
    • H01J61/523—Heating or cooling particular parts of the lamp
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J65/00—Lamps without any electrode inside the vessel; Lamps with at least one main electrode outside the vessel
    • H01J65/04—Lamps in which a gas filling is excited to luminesce by an external electromagnetic field or by external corpuscular radiation, e.g. for indicating plasma display panels
    • H01J65/042—Lamps in which a gas filling is excited to luminesce by an external electromagnetic field or by external corpuscular radiation, e.g. for indicating plasma display panels by an external electromagnetic field
    • H01J65/044—Lamps in which a gas filling is excited to luminesce by an external electromagnetic field or by external corpuscular radiation, e.g. for indicating plasma display panels by an external electromagnetic field the field being produced by a separate microwave unit
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/065—Light sources therefor
    • A61N2005/0654—Lamps
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J61/00—Gas-discharge or vapour-discharge lamps
    • H01J61/70—Lamps with low-pressure unconstricted discharge having a cold pressure < 400 Torr
    • H01J61/72—Lamps with low-pressure unconstricted discharge having a cold pressure < 400 Torr having a main light-emitting filling of easily vaporisable metal vapour, e.g. mercury
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J61/00—Gas-discharge or vapour-discharge lamps
    • H01J61/82—Lamps with high-pressure unconstricted discharge having a cold pressure > 400 Torr
    • H01J61/827—Metal halide arc lamps

Definitions

  • the invention relates to an irradiation device for therapeutic and cosmetic purposes.
  • T-cell-mediated skin diseases such as atopic dermatitis (neurodermatitis), cutane T-cell lymphoma, alopecia areata, Lieben ruber and psoriasis are based on a skin infiltrate of activated T-lymphocytes of the own body.
  • Neurodermatitis in particular is increasingly affecting newborns and children. Due to the inflamed areas of the skin and the associated itching, this disease is a heavy burden both physiologically and psychologically.
  • the previously known therapies for the treatment of neurodermatitis can essentially be divided into two classes, namely chemotherapy and UVA1 or UVB light therapy.
  • UVA 1 light therapy has proven to be effective for the treatment of acute episodes of neurodermatitis, urticaria pigmentosa and localized scleroderma.
  • Two types of devices are currently available for UVA 1 therapy according to Meffert and UVA 1 therapy according to Krutmann.
  • UVA 1 therapy according to Meffert works in a fire band between 340 and 500 nm
  • UVA therapy according to Krutmann at 340 - 400 nm.
  • UVA 1 therapy A very good overview of the state of the art in UVA 1 therapy is provided by "Position on quality assurance in UVA 1 phototherapy, version of the subgroup photo (chemo) therapy and diagnostics of the subcommittee on physical procedures in dermatology, May 1998” , as well as the “Guidelines for Quality Assurance in Photo (Chemo) Therapy and Diagnostics", which can be found in "Krutmann, S., Hönigsmann, H .: Manual of Dermatological Phototherapy and Diagnostics, Springer-Verlag, Heidelberg, pp. 392 - 395 "is published. Premature skin aging and carcinogenicity are listed as long-term risks. Because of this situation, it is explicitly stated that the use of medium and high doses of UVA1 in the children's string is not recommended. However, the largest affected group of neurodermatitis is excluded.
  • the long-wave absorption band of the porphyrins is 630 nm with a penetration depth of 4 mm, which is the most favorable and also used for photodynamic follicle treatment.
  • the invention is therefore based on the technical problem of creating an irradiation device for the treatment of primarily T-cell-mediated skin diseases which has fewer side effects and is also particularly suitable for the treatment of children.
  • an irradiance level of greater than 20 mW / cm 2 is preferably used for the wavelength range between 400 -440 nm selected. In general, however, it is tried to shorten the treatment times, with the highest possible irradiance in the Wavelength range of 400-440 nm to work. Tests with irradiance levels greater than 60 mW / cm 2 and greater than 100 mW / cm 2 have already been carried out. Conversely, attempts are made to suppress the irradiance levels of the other wavelengths as far as possible.
  • Gallium plasma lamps are currently used, which usually have an intensity ratio of 400-440 nm: UVA: UVB of 100: 20: 0.5.
  • the irradiance in the wavelength range of 300-400 nm is essentially caused by the spectral lines at 313 nm and 364 nm, the irradiance in
  • Range of 313 nm is less than 0.5% in relation to the irradiance in the wavelength range 400-440 nm.
  • the ratio of the intensities can be shifted by active filter measures, so that one is currently in operation
  • Irradiation device in the wavelength range from 400-440 nm has an irradiance of 58 mW / cm 2 , in the UVA range of 3 mW / cm 2 and in the UVB range of 140 ⁇ W / cm 2 , which has an intensity ratio of 100: 5.2: Corresponds to 0.25.
  • the radiation dose fluctuated in the UVB range between 25-150 mJ.
  • the UVB doses thus administered are considerably lower than the radiation doses of classic UVB therapies, which start with starting doses of 200 mJ and change over the course of several weeks
  • the radiation device can also be used for cosmetic purposes and can also replace the known UV devices there with the problems relating to the risk of skin cancer. Further advantageous embodiments of the invention result from the subclaims.
  • the optical radiation source of the radiation device is at least one
  • the effective irradiance can be increased even more, which in principle also applies to the subsequent optical radiation sources.
  • the optical radiation source is designed as a high-pressure mercury discharge lamp with metal halide additives gallium indium iodide and / or gallium iodide, the weight ratio between the mercury and the metal halide additives being 10-100.
  • the quartz bulb is partially mirrored with zirconium oxide in the area of the electrodes.
  • the radiation device is assigned a UVB filter, which in the simplest case consists of a glass pane.
  • the UVB filter is preferably designed as a cladding tube which is arranged around the optical radiation source and the area between the cladding tube and the quartz bulb is evacuated to a gas pressure of 10-500 torr.
  • UV-opaque transparent plastics are preferably used to suppress the UVA components Application, which are preferably designed as films and filter out not only the UVA but also the UVB range. Appropriate doping of the plastics can largely change their filtering capacity, so that different intensity distributions can be set. This is of particular interest if it should turn out that certain UVB and / or UVA components or intensities enhance a therapeutic effect.
  • the optical radiation source is designed as an electrodeless high-pressure mercury discharge lamp, as a result of which the metal halides gallium chloride and / or bromide which are preferred on account of their higher vapor pressure are then used primarily as doping.
  • the electromagnetic energy for the discharge is then coupled into a resonator formed by a metallic shield by means of a magnetron with an associated antenna.
  • an IR filter is preferably provided in order to suppress the undesired heat radiation.
  • a cooling unit with liquid cooling is assigned to the optical radiation sources, the liquid being designed as an IR filter.
  • the cooling unit preferably consists of two radiation cooler sockets with integrated inlets and outlets between which a transparent cladding tube is arranged. The advantage of this arrangement is that the radiation cooler detachments are detachably connected to the optical radiation source, which means that they can be reused in the case of defective optical sources
  • Water is particularly suitable as the coolant and silicone oil for the electrodeless high-pressure lamp.
  • the silicone oil has a number of other advantages. In addition to a large, stable temperature range, cooling down to 4 ° C is possible. Silicone oil has a low absorption of microwave energy and at the same time acts as an IR filter.
  • FIG. 2 shows a cross section through a high-pressure mercury discharge lamp with integrated water cooling
  • FIG. 3 vapor pressure curves of gallium and gallium halides
  • FIG.5 shows a cross section through an electrodeless
  • FIG. 6 a spectrum of a gallium plasma radiator
  • Fig.10 is a spectrum of a known gallium-indium effect lamp
  • Fig.11 is a schematic cross-sectional view of a
  • FIG. 12 shows a schematic cross section through an irradiation arrangement with a high-power plasma emitter.
  • the optical radiation source of the radiation device for the treatment of primarily T-cell-mediated skin diseases can be designed as a low-pressure as well as a high-pressure discharge lamp.
  • a high-pressure mercury discharge lamp 1 has some advantages in the spectrum over the known low-pressure discharge lamps for the spectral region of interest.
  • the high-pressure mercury discharge lamp 1 comprises a quartz bulb 2, in which two electrodes 3 are arranged. Electrical connecting lines 4 for the voltage supply are connected to the electrodes 3, which lead to a screw socket 5.
  • a quartz bulb 2 Around the quartz bulb 2 is a cladding tube 6 arranged, which is closed at one end and is hermetically sealed to the screw socket 5 at its other end. The space between cladding tube 6 and quartz bulb 2 is evacuated to a gas pressure of 10-500 torr.
  • the quartz bulb 2 contains mercury, argon and a metal halide additive such as gallium iodide and / or gallium indium iodide, which preferably emits in the wavelength range from 400-440 nm. The irradiance and the spectra will be discussed in more detail later.
  • the weight ratio of mercury to the metal halide additives is 10-100. In the power range of 400 W there is preferably a mixing ratio of 1-5 mg
  • the quartz bulb 2 is also partially mirrored in the area 8 of the electrodes 3 by means of zirconium oxide in order to increase the temperature in the area of the quartz bulb 2 near the electrodes.
  • the cladding tube 6 essentially has two functions. On the one hand, it serves as a UVB filter to reduce this unwanted spectral component as much as possible. On the other hand, the cladding tube 6 is used for thermal insulation, since the surface of the quartz bulb 2 becomes very hot during operation. Another advantage of the cladding tube 6 is the protection of the actual high-pressure discharge lamp against external temperature changes.
  • the coolant unit comprises a first and a second radiation cooler detection 9, 10 and a transparent cladding tube 11. In the two
  • Radiation cooler sockets 9, 10 each have an inlet or outlet 12, 13 to which a hose can then be connected.
  • the first radiation cooler 9 is simply pushed onto the screw 5.
  • the transparent cladding tube 11 is then inserted into the radiation cooler holder 9 and is closed on the opposite side by the second radiation cooler holder 10 on the screw holder 5.
  • a hermetically sealed circuit for the coolant 17 is formed between the inlet 12 and the outlet 13 by means of O-shaped sealing rings 14, 15, 16.
  • the coolant 17th can be water in the simplest case.
  • the coolant 17 mainly serves to dissipate the heat generated on the evacuated cladding tube 6 in order to keep it at a temperature of 40-60 ° C.
  • an irradiation device is advantageous in which the circulating coolant 17 is significantly cooler than the skin temperature . Then the cooled cladding tube 11 can be placed directly on the affected skin, in which case irradiations of the order of magnitude of approximately 1-2 W / cm 2 can be applied with an electrical connected load of 1000 W, since higher irradiations lead to a shorter treatment time .
  • the preferred coolant 17 for electrode lamps is water.
  • the coolant 17 serves as an IR absorber.
  • the inside of the cladding tube 6 can be coated with the phosphors known from the low-pressure discharge lamps, in order to transform additional portions of the UVC radiation emitted by the mercury into the interesting wavelength range of 400-440 nm. Since the phosphor itself has only a low absorption in the 400-440 nm range, an effective increase in the emission in this wavelength range is thus possible. Cooling of the phosphor is a prerequisite for the use of blue phosphors in the evacuated cladding tube, which may be filled with noble gas. Under normal operating conditions without cooling, the cladding tube reaches up to 600 ° C.
  • the efficiency of the blue phosphors drops sharply at temperatures above 100 ° C that their use only makes sense when using thermostatting to below 100 ° C, as can be achieved by the coolant unit described above.
  • the efficiency of the optical radiation source can be increased further by using phosphors in connection with other doping in the quartz burner, which preferably emit in the UV range.
  • Halide compounds of the metals selenium, antimony, zinc and cadmium are suitable for this.
  • gallium iodide shows the vapor pressure curves in torr versus the absolute temperature for the pure metal gallium and its halide salts gallium iodide, gallium chloride and gallium bromide.
  • the pure gallium is inferior to the halides by several orders of magnitude, so that efficient discharge with gallium can only be achieved at extremely high wall temperatures, which in turn requires more cooling with silicone oil, for example.
  • gallium halides shows gallium iodide has the lowest vapor pressure.
  • Gallium bromide is an order of magnitude better from this point of view. However, these bromides or chlorides are so aggressive that they would quickly destroy the electrodes 3 in the exemplary embodiments according to FIGS. 1 and 2.
  • the irradiation device 1 comprises a quartz bulb 2 in which the gallium or gallium halides are distributed.
  • the cooling unit already described is arranged around the quartz piston 2.
  • a magnetron 18 with an associated antenna 19 is arranged on at least one end face of a radiation cooler detection 9.
  • a metallic shield 20 is arranged around the cooling unit, which forms a resonator for the electromagnetic waves emitted by the antenna 19.
  • Electrode-free lamps have a useful life of 10,000 - 20,000 hours and a better efficiency than conventional light sources with electrodes 3.
  • the emission of these lamps is influenced by temperature differences within the lamp. If parts of the quartz bulb 2 (plasma ampoule) are not heated uniformly, dark bands result which are caused by self-absorption of the plasma.
  • the temperature differences within the plasma source are often the result of an uneven field distribution of the microwave energy in the resonator. This leads to an uneven discharge and a deterioration in the lamp output.
  • control over the electromagnetic field distribution is achieved by a resonance cylinder which supports the E 01 mode.
  • the field distribution is such that the electric field in the resonator axis has its highest value and the electric field vector points in the radial direction.
  • the field strength drops to the conductive walls of the resonator to disappear on the conductive surface of the cylindrical shield 20.
  • the required power depends on the achievable plasma density.
  • the plasma is concentrated in the middle of the discharge vessel.
  • the entire cylinder jacket of the quartz piston 2 is in the region of the same field strength, so that irregularities in this regard are excluded.
  • the resonant waveguide has a diameter of 9.37 cm in the E 01 mode and the preferred excitation frequency of 2450 MHz. Under these conditions, any length is permissible for the resonator without the E 01 resonance condition being changed, as a result of which the resonator can be easily adapted to different powers by changing the length.
  • E 01 mode Another advantage of the E 01 mode is that, due to the symmetry, electromagnetic energy can be coupled in from two sides, as shown in FIG. 5, which is particularly the case with longer lengths of the quartz piston 2 important is. Because of the standing wave, only the diameter of the waveguide must be strictly observed. The distance between the two magnetrons 18 is comparatively uncritical. It is only necessary to ensure that the energy absorption in the plasma is sufficiently high that no undamped waves hit the other magnetron 18, since this could lead to destruction.
  • Silicone oils such as dimethyl polysiloxane are therefore preferably used which have only a low microwave absorption of less than 0.2 W / cm per kilowatt output. Silicon oil is transparent in the visible range and absorbs a significant IR component in the wavelength range greater than 1 ⁇ m. This means that separate IR filters can either be dispensed with altogether or can be dimensioned in a less critical manner.
  • dimethyl polysiloxane can be used over a wide temperature range from -70 ° C to 250 ° C. With this arrangement it is possible to couple up to 300 W / cm 3 of plasma without melting the quartz bulb 2. Compared to the usual air cooling of a plasma source, the noises that otherwise occur with a high air flow are eliminated, which is psychologically more pleasant for the patient.
  • a rotating plasma quartz ball can be used, which is arranged on a shaft, for example, and when rotating in an E or E 112 mode resonator, an average field distribution results on average. It also increases the effective surface area for convection cooling.
  • the ball rotation preferably takes place in two planes, so that on average there is complete field mixing.
  • a so-called wobble rotation is alternatively and technically simpler to implement, ie the rod itself rotates around a cone shell during a rotation about the z-axis.
  • the irradiance in the wavelength range between 300-400 nm is essentially determined by a peak at 364 nm and a peak at 313 nm, the former forming the UVA component and the latter forming the UVB component. These peaks represent typical spectral ranges of the mercury. The characteristics of the peaks fluctuate considerably with the manufacturing tolerances, although the UVA content is less than 20% and the UVB content is less than 0.5% in relation to the irradiance of the wavelength range between 400 Is -440 nm. Due to the absolutely low irradiance in the UVA and UVB range, these ranges are not shown in the following spectra.
  • Emission in the spectral range between 400-440 nm decreases significantly. With the weight ratios 22 and 44, the yield in the spectral region of interest is much better.
  • a further increase in the emission in the range between 400-440 nm is possible by adding indium iodide in the mercury / indium iodide ratio of 20-200. With the addition of small amounts of indium iodide, an increase in indium emission in the 405 nm range is possible without the blue emission in the 500 nm range worsening the energy yield in the spectral range of interest between 400-440 nm.
  • FIG. 11 shows a schematic illustration of a whole-body irradiation device for a patient 21.
  • a large number of the optical radiation sources are arranged in an array with respect to one another, a parabolic reflector 22 being associated with each optical radiation source.
  • the cooling units described they can be connected to each other in a meandering shape.
  • only individual cooling units of the radiation sources can be combined, so that several cooling circuits with pumps are then used.
  • the upper and lower parabolic reflectors 22 and the side walls are tilted downwards or upwards by approximately 5 ° in order to obtain a more uniform radiation power over the radiation surface.
  • the optimal radiation level is obtained at a distance of 45-50 cm. Due to the high radiation output, the space between the radiation arrangement and the patient is preferably cooled with recirculating air conditioning.
  • a further preferred embodiment of the irradiation device 1 is shown in cross section in FIG. The
  • Irradiation device 1 comprises a gallium plasma emitter 20 with a quartz tube 21.
  • the quartz tube 21 has, for example, a diameter of approximately 20 mm.
  • the quartz tube 21 is preferably formed from UVC absorbing quartz to prevent the formation of ozone.
  • a first cladding tube 22 is arranged around the quartz tube 21, the cladding tube consisting for example of Duran glass.
  • the cladding tube 22 is spaced 20 mm from the quartz tube 21, for example, and is formed with a wall thickness of approximately 3 mm. There is air between the quartz tube 21 and the cladding tube 22.
  • a second outer cladding tube 23 Arranged around the first cladding tube 22 is a second outer cladding tube 23, which likewise preferably consists of Duran glass and has a wall thickness of 3 mm, the distance between the first cladding tube 22 and the second cladding tube 23 being approximately 10 mm.
  • the advantage of this indirect cooling of the quartz tube 21 is that it avoids blackening due to precipitation of mercury compounds on the quartz tube 21 and the quartz tube 21 can be operated at optimal operating temperatures between 600-900 ° C.

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Abstract

L'invention concerne un dispositif d'irradiation destiné à des fins thérapeutiques et cosmétiques pour le traitement de maladies cutanées transmises par les lymphocytes T primaires, notamment de dermatite atopique (neurodermitis), lymphome à lymphocyte T cutané, lichen ruber, Alopecia areata, lupus érythémateux systémique et psoriasis et pour le bronzage cosmétique. Ce dispositif comprend au moins une source de rayonnement optique qui produit sur une surface à irradier une intensité de rayonnement d'au moins 2 mW/cm2 dans l'intervalle de longueur d'onde de 400 à 440 nm et, dans l'intervalle de longueur d'onde de 300 à 400 nm, une intensité de rayonnement inférieure à 21 % de l'intensité de rayonnement dans la plage de longueur d'onde de 400 à 440 nm.
PCT/DE1999/002364 1998-11-06 1999-07-29 Dispositif d'irradiation destine a des fins therapeutique et cosmetique WO2000028575A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99952241A EP1135791A1 (fr) 1998-11-06 1999-07-29 Dispositif d'irradiation destine a des fins therapeutique et cosmetique
AU64602/99A AU6460299A (en) 1998-11-06 1999-07-29 Radiation device for therapeutic and cosmetic purposes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19852524.9 1998-11-06
DE19852524A DE19852524A1 (de) 1998-11-06 1998-11-06 Bestrahlungseinrichtung für therapeutische und kosmetische Zwecke

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WO2000028575A1 true WO2000028575A1 (fr) 2000-05-18

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AU (1) AU6460299A (fr)
DE (1) DE19852524A1 (fr)
WO (1) WO2000028575A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10100662A1 (de) * 2001-01-02 2002-07-11 Optomed Optomedical Systems Gmbh Therapeutische Bestrahlungsanordnung
WO2002072200A1 (fr) 2001-03-08 2002-09-19 Optomed Optomedical Systems Gmbh Systeme d'irradiation utilise a des fins therapeutiques
DE10112289A1 (de) * 2001-03-08 2002-09-26 Optomed Optomedical Systems Gmbh Bestrahlungsanordnung und Verfahren zur Behandlung von Akne
US7381976B2 (en) * 2001-03-13 2008-06-03 Triton Thalassic Technologies, Inc. Monochromatic fluid treatment systems
US7985219B2 (en) 2001-03-08 2011-07-26 Spectrometric Optoelectronic Systems GmbH Irradiation device and method for the treatment of acne and acne scars
WO2013017190A1 (fr) * 2011-08-04 2013-02-07 Heraeus Noblelight Gmbh Dispositif permettant de durcir des revêtements ou liners en matière plastique sur la paroi intérieure de cavités allongées
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DE10100662A1 (de) * 2001-01-02 2002-07-11 Optomed Optomedical Systems Gmbh Therapeutische Bestrahlungsanordnung
EP2258446A1 (fr) 2001-03-08 2010-12-08 Spectrometrix Optoelectronic Systems GmbH Système d'irradiation à des fins thérapeutiques
DE10123926A1 (de) * 2001-03-08 2002-09-19 Optomed Optomedical Systems Gmbh Bestrahlungsanordnung
DE10112289A1 (de) * 2001-03-08 2002-09-26 Optomed Optomedical Systems Gmbh Bestrahlungsanordnung und Verfahren zur Behandlung von Akne
US6902563B2 (en) 2001-03-08 2005-06-07 Optomed Optomedical Systems Irradiation device for therapeutic treatment of skin and other ailments
WO2002072200A1 (fr) 2001-03-08 2002-09-19 Optomed Optomedical Systems Gmbh Systeme d'irradiation utilise a des fins therapeutiques
US7985219B2 (en) 2001-03-08 2011-07-26 Spectrometric Optoelectronic Systems GmbH Irradiation device and method for the treatment of acne and acne scars
US7381976B2 (en) * 2001-03-13 2008-06-03 Triton Thalassic Technologies, Inc. Monochromatic fluid treatment systems
WO2013017190A1 (fr) * 2011-08-04 2013-02-07 Heraeus Noblelight Gmbh Dispositif permettant de durcir des revêtements ou liners en matière plastique sur la paroi intérieure de cavités allongées
CN103842708A (zh) * 2011-08-04 2014-06-04 贺利氏特种光源有限责任公司 用于硬化在细长空腔的内壁上的涂层或塑料衬垫的设备
WO2015055387A1 (fr) * 2013-10-17 2015-04-23 Asml Netherlands B.V. Source de photons, appareil de métrologie, système lithographique et procédé de fabrication de dispositif
US9814126B2 (en) 2013-10-17 2017-11-07 Asml Netherlands B.V. Photon source, metrology apparatus, lithographic system and device manufacturing method
TWI620993B (zh) * 2013-10-17 2018-04-11 Ａｓｍｌ荷蘭公司 光子源、度量衡裝置、微影系統及元件製造方法

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