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WO2000027874A3 - Nucleic acids encoding transferrin receptor-like proteins and products related thereto - Google Patents

Nucleic acids encoding transferrin receptor-like proteins and products related thereto Download PDF

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Publication number
WO2000027874A3
WO2000027874A3 PCT/US1999/026205 US9926205W WO0027874A3 WO 2000027874 A3 WO2000027874 A3 WO 2000027874A3 US 9926205 W US9926205 W US 9926205W WO 0027874 A3 WO0027874 A3 WO 0027874A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
acids encoding
proteins
transferrin receptor
tfr2
Prior art date
Application number
PCT/US1999/026205
Other languages
French (fr)
Other versions
WO2000027874A2 (en
Inventor
Hiroshi Kawabata
H Phillip Koeffler
Original Assignee
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cedars Sinai Medical Center filed Critical Cedars Sinai Medical Center
Priority to EP99971816A priority Critical patent/EP1044218A1/en
Priority to JP2000581051A priority patent/JP3920573B2/en
Priority to AU14696/00A priority patent/AU1469600A/en
Publication of WO2000027874A2 publication Critical patent/WO2000027874A2/en
Publication of WO2000027874A3 publication Critical patent/WO2000027874A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70582—CD71
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention provides isolated nucleic acids encoding TfR2 polypeptides, or fragments thereof, and isolated TfR2 polypeptides encoded thereby. Further provided are vectors containing the nucleic acids of the present invention, host cells transformed therewith, antisense oligonucleotides thereto and compositions containing antibodies that specifically bind to invention polypeptides. Methods of detecting TfR2 protein in a cell are also provided.
PCT/US1999/026205 1998-11-06 1999-11-04 Nucleic acids encoding transferrin receptor-like proteins and products related thereto WO2000027874A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP99971816A EP1044218A1 (en) 1998-11-06 1999-11-04 Nucleic acids encoding transferrin receptor-like proteins and products related thereto
JP2000581051A JP3920573B2 (en) 1998-11-06 1999-11-04 Nucleic acids encoding transferrin receptor-like proteins and related products
AU14696/00A AU1469600A (en) 1998-11-06 1999-11-04 Nucleic acids encoding transferrin receptor-like proteins and products related thereto

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10750298P 1998-11-06 1998-11-06
US60/107,502 1999-07-22
US09/358,755 US6891028B1 (en) 1998-11-06 1999-07-22 Nucleic acids encoding transferrin receptor-like proteins
US09/358,755 1999-07-22

Publications (2)

Publication Number Publication Date
WO2000027874A2 WO2000027874A2 (en) 2000-05-18
WO2000027874A3 true WO2000027874A3 (en) 2000-08-03

Family

ID=26804853

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026205 WO2000027874A2 (en) 1998-11-06 1999-11-04 Nucleic acids encoding transferrin receptor-like proteins and products related thereto

Country Status (5)

Country Link
US (3) US6891028B1 (en)
EP (1) EP1044218A1 (en)
JP (1) JP3920573B2 (en)
AU (1) AU1469600A (en)
WO (1) WO2000027874A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT411999B (en) * 2001-08-17 2004-08-26 Viennalab Labordiagnostika Gmb METHOD FOR THE GENETIC DIAGNOSIS OF HEMOCHROMATOSIS AND PROBE FOR THE GENETIC DIAGNOSIS OF HEMOCHROMATOSIS
EP3208282A1 (en) 2010-11-30 2017-08-23 F. Hoffmann-La Roche AG Low affinity anti transferrin receptor and their use to transfer therapeutic scfv across the blood brain barrier
EP3415527A1 (en) * 2017-06-14 2018-12-19 Technische Universität Dresden Use of the extracellular domain of the transferrin receptor 2 for diagnosis and treatment of primary and secondary sclerosing diseases
US10349638B2 (en) 2017-07-14 2019-07-16 Tai-Jay Chang Human ARCAP transgenic mouse
US12011489B2 (en) * 2022-03-30 2024-06-18 Christopher Key Compositions and methods for treating inflammatory disease

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
BROOKS, D. ET AL.: "Phase Ia trial of murine immunoglobulin A antitransferrin receptor antitransferrin receptor antibody 42/6", CLIN. CANCER RES., vol. 1, no. 11, November 1995 (1995-11-01), pages 1259 - 1265, XP000887102 *
DATABASE EMBL 1 November 1998 (1998-11-01), "Transferrin-Receptor2" *
DATABASE EMBL 13 June 1998 (1998-06-13), "Homo sapiens chromosome 7q22 sequence, complete sequence" *
DATABASE EMBL 3 September 1998 (1998-09-03), "Homo sapiens full length insert cDNA clone YR50H04", XP002135481 *
DATABASE EMBL 7 November 1985 (1985-11-07), "Human mRNA for transferrin receptor" *
GLÖCKNER, G. ET AL.: "Large-scale sequencing of two regions in human chromosome 7q22: Analysis of ...", GENOME RES, vol. 8, October 1998 (1998-10-01), pages 1060 - 1073, XP002135480 *
NIKINMAA, B. ET AL.: "Monoclonal antibodies to a purified human transferrin receptor", SCAND. J. IMMUNOL., vol. 20, no. 5, November 1984 (1984-11-01), pages 441 - 447, XP000885620 *
SCHNEIDER, C. ET AL.: "Primary structure of human transferrin receptor deduced from the mRNA sequence", NATURE, vol. 311, 1984, pages 675 - 678, XP000887104 *
TRINDER, D. ET AL.: "Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expression", HEPATOLOGY, vol. 23, no. 6, June 1996 (1996-06-01), pages 1512 - 1520, XP000885687 *

Also Published As

Publication number Publication date
JP3920573B2 (en) 2007-05-30
US20060216758A1 (en) 2006-09-28
US20050233385A1 (en) 2005-10-20
WO2000027874A2 (en) 2000-05-18
US6891028B1 (en) 2005-05-10
AU1469600A (en) 2000-05-29
JP2002530056A (en) 2002-09-17
US7211251B2 (en) 2007-05-01
US7083934B2 (en) 2006-08-01
EP1044218A1 (en) 2000-10-18

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