WO2000023429A3 - Procede stereoselectif de production d'agents antineoplasiques - Google Patents
Procede stereoselectif de production d'agents antineoplasiques Download PDFInfo
- Publication number
- WO2000023429A3 WO2000023429A3 PCT/US1999/024410 US9924410W WO0023429A3 WO 2000023429 A3 WO2000023429 A3 WO 2000023429A3 US 9924410 W US9924410 W US 9924410W WO 0023429 A3 WO0023429 A3 WO 0023429A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stereoselective process
- cryptophycins
- producing
- producing cryptophycins
- stereoselective
- Prior art date
Links
- 229930188224 Cryptophycin Natural products 0.000 title 1
- 108010002156 Depsipeptides Proteins 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- PSNOPSMXOBPNNV-VVCTWANISA-N cryptophycin 1 Chemical class C1=C(Cl)C(OC)=CC=C1C[C@@H]1C(=O)NC[C@@H](C)C(=O)O[C@@H](CC(C)C)C(=O)O[C@H]([C@H](C)[C@@H]2[C@H](O2)C=2C=CC=CC=2)C/C=C/C(=O)N1 PSNOPSMXOBPNNV-VVCTWANISA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrrole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU0104027A HUP0104027A3 (en) | 1998-10-16 | 1999-10-15 | Stereoselective process for producing cryptophycin |
BR9916051-0A BR9916051A (pt) | 1998-10-16 | 1999-10-15 | Processo estereosseletivo para produzir agentes antineoplásticos |
KR1020017004775A KR20010099699A (ko) | 1998-10-16 | 1999-10-15 | 크립토피신의 입체선택적 제조 방법 |
EP99955034A EP1127055A2 (fr) | 1998-10-16 | 1999-10-15 | Procede stereoselectif de production d'agents antineoplasiques |
AU11232/00A AU1123200A (en) | 1998-10-16 | 1999-10-15 | Stereoselective process for producing antineoplastic agents |
CA002347246A CA2347246A1 (fr) | 1998-10-16 | 1999-10-15 | Procede stereoselectif de production d'agents antineoplasiques |
JP2000577157A JP2002527509A (ja) | 1998-10-16 | 1999-10-15 | 抗腫瘍剤を製造するための立体選択的な方法 |
IL14256599A IL142565A0 (en) | 1998-10-16 | 1999-10-15 | Stereoselective process for producing antineoplastic agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10466498P | 1998-10-16 | 1998-10-16 | |
US60/104,664 | 1998-10-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2000023429A2 WO2000023429A2 (fr) | 2000-04-27 |
WO2000023429A3 true WO2000023429A3 (fr) | 2000-07-27 |
Family
ID=22301706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1999/024410 WO2000023429A2 (fr) | 1998-10-16 | 1999-10-15 | Procede stereoselectif de production d'agents antineoplasiques |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1127055A2 (fr) |
JP (1) | JP2002527509A (fr) |
KR (1) | KR20010099699A (fr) |
AU (1) | AU1123200A (fr) |
BR (1) | BR9916051A (fr) |
CA (1) | CA2347246A1 (fr) |
HU (1) | HUP0104027A3 (fr) |
IL (1) | IL142565A0 (fr) |
TR (1) | TR200101084T2 (fr) |
WO (1) | WO2000023429A2 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2414320A1 (fr) * | 2009-04-01 | 2012-02-08 | LEK Pharmaceuticals d.d. | Procédé de diméthylation de groupes méthylène actifs |
FR2947269B1 (fr) | 2009-06-29 | 2013-01-18 | Sanofi Aventis | Nouveaux composes anticancereux |
CN102140068B (zh) * | 2010-01-30 | 2015-03-11 | 浙江华海药业股份有限公司 | 阿利吉仑中间体3-氨基-2,2-二甲基丙酰胺的制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996040184A1 (fr) * | 1995-03-07 | 1996-12-19 | University Of Hawaii | Nouvelles cryptophycines obtenues par synthese |
EP0792875A1 (fr) * | 1996-02-27 | 1997-09-03 | Eli Lilly And Company | Dérivés de cryptophycine et leur utilisation comme agents antimicrotubules |
WO1998009974A1 (fr) * | 1996-09-06 | 1998-03-12 | Eli Lilly And Company | Procede et nouveaux intermediaires |
EP0861838A2 (fr) * | 1997-02-26 | 1998-09-02 | Eli Lilly And Company | Procédés et intermédiaires pour la préparation de composés de cryptophycine |
-
1999
- 1999-10-15 BR BR9916051-0A patent/BR9916051A/pt not_active Application Discontinuation
- 1999-10-15 TR TR2001/01084T patent/TR200101084T2/xx unknown
- 1999-10-15 WO PCT/US1999/024410 patent/WO2000023429A2/fr not_active Application Discontinuation
- 1999-10-15 KR KR1020017004775A patent/KR20010099699A/ko not_active Withdrawn
- 1999-10-15 IL IL14256599A patent/IL142565A0/xx unknown
- 1999-10-15 HU HU0104027A patent/HUP0104027A3/hu unknown
- 1999-10-15 CA CA002347246A patent/CA2347246A1/fr not_active Abandoned
- 1999-10-15 EP EP99955034A patent/EP1127055A2/fr not_active Withdrawn
- 1999-10-15 JP JP2000577157A patent/JP2002527509A/ja not_active Withdrawn
- 1999-10-15 AU AU11232/00A patent/AU1123200A/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996040184A1 (fr) * | 1995-03-07 | 1996-12-19 | University Of Hawaii | Nouvelles cryptophycines obtenues par synthese |
EP0792875A1 (fr) * | 1996-02-27 | 1997-09-03 | Eli Lilly And Company | Dérivés de cryptophycine et leur utilisation comme agents antimicrotubules |
WO1998009974A1 (fr) * | 1996-09-06 | 1998-03-12 | Eli Lilly And Company | Procede et nouveaux intermediaires |
EP0861838A2 (fr) * | 1997-02-26 | 1998-09-02 | Eli Lilly And Company | Procédés et intermédiaires pour la préparation de composés de cryptophycine |
Non-Patent Citations (2)
Title |
---|
BARROW R A ET AL: "TOTAL SYNTHESIS OF CRYPTOPHYCINS. REVISION OF THE STRUCTURES OF CRYPTOPHYCINS A AND C", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, vol. 117, no. 9, 8 March 1995 (1995-03-08), pages 2479 - 2490, XP002066281, ISSN: 0002-7863 * |
SALAMONCZYK G ET AL: "TOTAL SYNTHESIS OF CRYPTOPHYCINS VIA A CHEMOENZYMATIC APPROACH", JOURNAL OF ORGANIC CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. EASTON, vol. 61, no. 20, 1 October 1996 (1996-10-01), pages 6893 - 6900, XP000674616, ISSN: 0022-3263 * |
Also Published As
Publication number | Publication date |
---|---|
WO2000023429A2 (fr) | 2000-04-27 |
BR9916051A (pt) | 2001-08-14 |
JP2002527509A (ja) | 2002-08-27 |
TR200101084T2 (tr) | 2001-09-21 |
EP1127055A2 (fr) | 2001-08-29 |
AU1123200A (en) | 2000-05-08 |
CA2347246A1 (fr) | 2000-04-27 |
HUP0104027A3 (en) | 2002-08-28 |
KR20010099699A (ko) | 2001-11-09 |
HUP0104027A2 (hu) | 2002-03-28 |
IL142565A0 (en) | 2002-03-10 |
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