+

WO2000023429A3 - Procede stereoselectif de production d'agents antineoplasiques - Google Patents

Procede stereoselectif de production d'agents antineoplasiques Download PDF

Info

Publication number
WO2000023429A3
WO2000023429A3 PCT/US1999/024410 US9924410W WO0023429A3 WO 2000023429 A3 WO2000023429 A3 WO 2000023429A3 US 9924410 W US9924410 W US 9924410W WO 0023429 A3 WO0023429 A3 WO 0023429A3
Authority
WO
WIPO (PCT)
Prior art keywords
stereoselective process
cryptophycins
producing
producing cryptophycins
stereoselective
Prior art date
Application number
PCT/US1999/024410
Other languages
English (en)
Other versions
WO2000023429A2 (fr
Inventor
James Abraham Aikins
Barbara Shreve Briggs
Tony Yantao Zhang
Milton Joseph Junior Zmijewski
Original Assignee
Lilly Co Eli
Univ Wayne State
Univ Hawaii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli, Univ Wayne State, Univ Hawaii filed Critical Lilly Co Eli
Priority to IL14256599A priority Critical patent/IL142565A0/xx
Priority to HU0104027A priority patent/HUP0104027A3/hu
Priority to AU11232/00A priority patent/AU1123200A/en
Priority to KR1020017004775A priority patent/KR20010099699A/ko
Priority to CA002347246A priority patent/CA2347246A1/fr
Priority to BR9916051-0A priority patent/BR9916051A/pt
Priority to EP99955034A priority patent/EP1127055A2/fr
Priority to JP2000577157A priority patent/JP2002527509A/ja
Publication of WO2000023429A2 publication Critical patent/WO2000023429A2/fr
Publication of WO2000023429A3 publication Critical patent/WO2000023429A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/08—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and more than one oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrane Compounds (AREA)

Abstract

L'invention concerne des procédés de préparation de composés de cryptophycine.
PCT/US1999/024410 1998-10-16 1999-10-15 Procede stereoselectif de production d'agents antineoplasiques WO2000023429A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
IL14256599A IL142565A0 (en) 1998-10-16 1999-10-15 Stereoselective process for producing antineoplastic agents
HU0104027A HUP0104027A3 (en) 1998-10-16 1999-10-15 Stereoselective process for producing cryptophycin
AU11232/00A AU1123200A (en) 1998-10-16 1999-10-15 Stereoselective process for producing antineoplastic agents
KR1020017004775A KR20010099699A (ko) 1998-10-16 1999-10-15 크립토피신의 입체선택적 제조 방법
CA002347246A CA2347246A1 (fr) 1998-10-16 1999-10-15 Procede stereoselectif de production d'agents antineoplasiques
BR9916051-0A BR9916051A (pt) 1998-10-16 1999-10-15 Processo estereosseletivo para produzir agentes antineoplásticos
EP99955034A EP1127055A2 (fr) 1998-10-16 1999-10-15 Procede stereoselectif de production d'agents antineoplasiques
JP2000577157A JP2002527509A (ja) 1998-10-16 1999-10-15 抗腫瘍剤を製造するための立体選択的な方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10466498P 1998-10-16 1998-10-16
US60/104,664 1998-10-16

Publications (2)

Publication Number Publication Date
WO2000023429A2 WO2000023429A2 (fr) 2000-04-27
WO2000023429A3 true WO2000023429A3 (fr) 2000-07-27

Family

ID=22301706

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/024410 WO2000023429A2 (fr) 1998-10-16 1999-10-15 Procede stereoselectif de production d'agents antineoplasiques

Country Status (10)

Country Link
EP (1) EP1127055A2 (fr)
JP (1) JP2002527509A (fr)
KR (1) KR20010099699A (fr)
AU (1) AU1123200A (fr)
BR (1) BR9916051A (fr)
CA (1) CA2347246A1 (fr)
HU (1) HUP0104027A3 (fr)
IL (1) IL142565A0 (fr)
TR (1) TR200101084T2 (fr)
WO (1) WO2000023429A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010230260A1 (en) * 2009-04-01 2011-11-10 Lek Pharmaceuticals D.D. A process for dimethylation of active methylene groups
FR2947269B1 (fr) 2009-06-29 2013-01-18 Sanofi Aventis Nouveaux composes anticancereux
CN102140068B (zh) * 2010-01-30 2015-03-11 浙江华海药业股份有限公司 阿利吉仑中间体3-氨基-2,2-二甲基丙酰胺的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040184A1 (fr) * 1995-03-07 1996-12-19 University Of Hawaii Nouvelles cryptophycines obtenues par synthese
EP0792875A1 (fr) * 1996-02-27 1997-09-03 Eli Lilly And Company Dérivés de cryptophycine et leur utilisation comme agents antimicrotubules
WO1998009974A1 (fr) * 1996-09-06 1998-03-12 Eli Lilly And Company Procede et nouveaux intermediaires
EP0861838A2 (fr) * 1997-02-26 1998-09-02 Eli Lilly And Company Procédés et intermédiaires pour la préparation de composés de cryptophycine

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040184A1 (fr) * 1995-03-07 1996-12-19 University Of Hawaii Nouvelles cryptophycines obtenues par synthese
EP0792875A1 (fr) * 1996-02-27 1997-09-03 Eli Lilly And Company Dérivés de cryptophycine et leur utilisation comme agents antimicrotubules
WO1998009974A1 (fr) * 1996-09-06 1998-03-12 Eli Lilly And Company Procede et nouveaux intermediaires
EP0861838A2 (fr) * 1997-02-26 1998-09-02 Eli Lilly And Company Procédés et intermédiaires pour la préparation de composés de cryptophycine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BARROW R A ET AL: "TOTAL SYNTHESIS OF CRYPTOPHYCINS. REVISION OF THE STRUCTURES OF CRYPTOPHYCINS A AND C", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,US,AMERICAN CHEMICAL SOCIETY, WASHINGTON, DC, vol. 117, no. 9, 8 March 1995 (1995-03-08), pages 2479 - 2490, XP002066281, ISSN: 0002-7863 *
SALAMONCZYK G ET AL: "TOTAL SYNTHESIS OF CRYPTOPHYCINS VIA A CHEMOENZYMATIC APPROACH", JOURNAL OF ORGANIC CHEMISTRY,US,AMERICAN CHEMICAL SOCIETY. EASTON, vol. 61, no. 20, 1 October 1996 (1996-10-01), pages 6893 - 6900, XP000674616, ISSN: 0022-3263 *

Also Published As

Publication number Publication date
HUP0104027A3 (en) 2002-08-28
EP1127055A2 (fr) 2001-08-29
AU1123200A (en) 2000-05-08
IL142565A0 (en) 2002-03-10
KR20010099699A (ko) 2001-11-09
TR200101084T2 (tr) 2001-09-21
JP2002527509A (ja) 2002-08-27
CA2347246A1 (fr) 2000-04-27
BR9916051A (pt) 2001-08-14
HUP0104027A2 (hu) 2002-03-28
WO2000023429A2 (fr) 2000-04-27

Similar Documents

Publication Publication Date Title
WO1999055830A3 (fr) Procede de synthese d'inhibiteurs de cox-2
EP1309547A4 (fr) Modafinil cristallin et pur et procede de preparation associe
AU2002237527A1 (en) Method of synthesizing camptothecin-relating compounds
AU695352B2 (en) Process for producing derivatives of 4a,5,9,10,11,12,-hexahydro-6h-benzofuro{3a,3,2-ef}{2} benzazepine
AU6487600A (en) Process for production of an etheralcohol
WO2001018005A8 (fr) Procede de preparation de derives de benzoxazine et de leurs intermediaires
WO2000023429A3 (fr) Procede stereoselectif de production d'agents antineoplasiques
AU6578400A (en) Novel method for preparing benzoperhydroisoindole compounds
WO1997038124A3 (fr) Procede enzymatique pour la preparation stereoselective d'amides therapeutiques
AU2003240634A1 (en) Method for producing bicalutamide
WO2000064882A3 (fr) Enantiomeres de mercaptolactones et leurs procedes de synthese
AU694653B2 (en) D4T polymorphic form I process
AU3453502A (en) A process for the preparation of paclitaxel
ZA200005110B (en) Process for preparing intermediates.
WO2001025236A3 (fr) Procede stereoselectif de preparation d'endo-3-aminoazabicycloalcanes
YU18199A (sh) Postupak za dobijanje hidroksamskih kiselina
AU3517299A (en) Method for non-oxidative production of formaldehyde from methanol
EP0928814A3 (fr) Procédé de fabrication de composés de dioxazine
MXPA02003042A (es) Proceso para prevenir formacion de incrustaciones.
CZ20011915A3 (cs) Způsob výroby cyklenu
AU2002367422A1 (en) Process for production of high-molecular compounds
ATE299147T1 (de) Verfahren zur herstellung von 3-amino-1,5- benzodiazepinderivaten
CA2272539A1 (fr) Procede de production stereoselective de composes de nitroenlamine
AU4757000A (en) Method of producing methoxyimino acetic amide
ATE253553T1 (de) Verfahren zur herstellung von 2- alkylthiobenzonitril-derivaten

Legal Events

Date Code Title Description
ENP Entry into the national phase

Ref document number: 2000 11232

Country of ref document: AU

Kind code of ref document: A

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: PA/a/2001/003776

Country of ref document: MX

Ref document number: IN/PCT/2001/415/KOL

Country of ref document: IN

ENP Entry into the national phase

Ref document number: 2347246

Country of ref document: CA

Ref document number: 2347246

Country of ref document: CA

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 142565

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 2001/01084

Country of ref document: TR

ENP Entry into the national phase

Ref document number: 2000 577157

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 1020017004775

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 1999955034

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 1999955034

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 1020017004775

Country of ref document: KR

WWW Wipo information: withdrawn in national office

Ref document number: 1999955034

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 1020017004775

Country of ref document: KR

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载