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WO2000021612A1 - Procede d'epilation et appareil correspondant - Google Patents

Procede d'epilation et appareil correspondant Download PDF

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Publication number
WO2000021612A1
WO2000021612A1 PCT/IL1999/000533 IL9900533W WO0021612A1 WO 2000021612 A1 WO2000021612 A1 WO 2000021612A1 IL 9900533 W IL9900533 W IL 9900533W WO 0021612 A1 WO0021612 A1 WO 0021612A1
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WO
WIPO (PCT)
Prior art keywords
hair
mhz
frequency
intensity
duration
Prior art date
Application number
PCT/IL1999/000533
Other languages
English (en)
Inventor
Emanuel Segal
Yoni Iger
David Shalhevet
Dmitry Elman
Original Assignee
Ultra Cure Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ultra Cure Ltd. filed Critical Ultra Cure Ltd.
Priority to JP2000575583A priority Critical patent/JP2002527162A/ja
Priority to AU61190/99A priority patent/AU6119099A/en
Priority to CA002346703A priority patent/CA2346703A1/fr
Publication of WO2000021612A1 publication Critical patent/WO2000021612A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A45—HAND OR TRAVELLING ARTICLES
    • A45D—HAIRDRESSING OR SHAVING EQUIPMENT; EQUIPMENT FOR COSMETICS OR COSMETIC TREATMENTS, e.g. FOR MANICURING OR PEDICURING
    • A45D26/00—Hair-singeing apparatus; Apparatus for removing superfluous hair, e.g. tweezers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00752—Hair removal or transplantation

Definitions

  • the present invention concerns ultrasonic methods, processes and devices for hair removal.
  • Hair removal is carried out mostly for cosmetic purposes, in order to remove undesired hair from different skin regions of the body.
  • the main methods for hair removal currently used include methods based on hair cutting such as shaving, methods based on plucking out hair from its root either by mechanical devices or by use of sticky substances such as wax, methods for chemically dissolving hair such as chemicals used for depilation and methods for the supposed permanent destruction of hair roots such as by use of electrical currents (electrolysis), or laser beams (thermolysis).
  • Cutting of hair, such as by shaving affects only the part of the hair shaft that is outside the skin. The living part of the hair, in the hair papillae continues to grow and therefore the hair removal effect is short lasting.
  • Waxing takes out most of the hair adhered to wax and tears apart the hair or disconnects the hair from its papillae.
  • the papillae itself remains at least partialh' vital and the living cells will establish a new hair germination zone subsequently leading to renewed hair growth.
  • Waxing can leave hair papillae and skin pores sore and open to infections, and cannot be used over varicose veins, moles or warts.
  • Depilation by chemical agents is carried out by using gels or creams that contain highly alkaline chemicals, usually calcium thioglycolate, that dissolve the protein structure of the hair, leading to it its separation from the papillae.
  • the concentration of the chemical is kept as low as possible so as to allow hair lysis, while avoiding skin irritation.
  • the effects of depilation by chemical substances is also relatively short termed and is occasionally accompanied by skin irritation.
  • Electrolysis is performed by transmitting a direct current to the hair root in order to form hydroxyl ions that electrochemically destroy the germinative cells of the hair follicles.
  • Thermolysis is performed using high frequency currents to heat the water of the hair follicle and electrocoagulate the germinative hair cells (Richards R and Meharg GE Electrolysis: observations from 13 years and 140,000 hours of experience. J. Am. Acad. Dermatol. 33:662-666, (1995)).
  • Both electro- and thermo-lysis are considered permanent methods for hair removal, even though the regrowth after treatment is 15-50%. These methods are carried out by using a needle inserted into the hair follicle, a rather painful and infection-prone process. The results of this procedure are heavily dependent on the skill of the person operating the electrolysis or thermolysis devices, and unskilled treatment may cause pigmentation, scarring of the skin, infection and small electrical shocks.
  • Laser hair removal is carried out by transmitting a focused laser beam
  • the "acoustic focal point” is determined as to the region of the beam where the area is smallest and the density of the energy is highest.
  • Ultrasonic Longitudinal Waves ' ''' - A manner of propagation of ultrasound through solids or liquids is due to the compressions and decompression along the direction of wave propagation, leading to compression or tension stress. The movement of the particles in these waves is essentially parallel to the direction of the propagation of the waves.
  • Ultrasonic Shear Waves Another manner of propagation of ultrasound through solids, is a wave of shear stress along the waves' propagation. Its velocity is smaller that than of the longitudinal wave. Shear waves are created all over the irradiated solid, but their effects are noticeable in particular in the interfaces between different types of solid materials causing shear stress. The movement of the particles in the solid substance with shear waves is essentially perpendicular to the propagation of the wave.
  • “Cavitation” is the effect of the rapid creation of gas bubbles in liquid due to ultrasonic irradiate, pulsation of these bubbles and their final collapse. This phenomenon is caused by rapid transduction from super-pressure to sub-pressure which the ultrasonic force produces on the bubbles.
  • the bubbles are created around "nuclei of cavitation” which may be particles (for example pre-existing gas bubbles in the liquids), non-homogeneity in the liquid and the like.
  • Resonance A phenomenon where the ultrasonic field acts on a substance or body at the self frequency of to substance/body. At such a condition, a relatively low ultrasonic field can impact high energy. This phenomenon is amplified for example when standing waves are created i.e. when the reflected wave has the same phase and opposite direction as the incident wave. Resonance may be created by several types of ultrasonic waves, such as shear waves or longitudinal waves. Since the velocity of shear waves under the same conditions is about half of that of longitudinal waves, the resonance frequency created by theses waves will also be about half.
  • Resonator A device having a size (i.e. geometrical factors) enabling creation of resonance effect, namely the effect of incident waves is amplified b y the subsequent incident waves.
  • Transmission waves A manner of propagation of ultrasound through solids where particle movement is circular.
  • the present invention concerns novel cosmetic methods, devices and systems used therefor, allowing the removal of undesired hair. This, in accordance with the invention is achieved by utilizing ultrasonic forces.
  • the present invention concerns a cosmetic method for removal of hair from a desired body zone using ultrasonic force.
  • hair in the context of the present invention refers not only to the hair shaft but also to hair root, the hair follicle, the hair papillae and the blood supply to the hair.
  • the term “removal” in the context of the present invention refers to destruction of any of the above components, to the cease, inhibition or to the decrease in proliferation rate of cells in those components leading to cessation or to reduced rate of hair growth for example as manifested by force- free epilation.
  • the present invention provides a method and device for the removal of hair using a focused ultrasonic beam.
  • the focused ultrasonic assembly is applied for example in accordance with co-pending Patent Application PCT/IL97/00406 incorporated herein by reference. Briefly, this application refers to an ultrasonic system having an ultrasound transmitter element capable of producing a focused ultrasonic beam, the latter referring to a beam which area is becoming progressively smaller, and its intensity per area progressively higher as the beam is further away from the ultrasound transmitter. At the acoustic focal point the area of the beam is smallest and the intensity of the beam is the highest.
  • Such a beam is produced by an ultrasonic transmitter and focusing means, such as acoustic lenses or focusing transducer.
  • the system of this application also comprises a container holding a liquid medium coupled at one end to the ultrasound transmitter element for guiding the focused ultrasonic beam to the desired hair removal region of the skin, the container or "the guide " having such parameter that the ultrasound beam propagates therein without bouncing on the side walls of the container.
  • the focused beam is preferably produced with such parameters so that most of the energy is absorbed by the dense hair and not by the skin.
  • the ultrasonic beam can penetrate through the skin layers above the hair papillae, without destroying said skin layers, and only at the focal point, or the regions close to the focal point, is the ultrasonic energy high enough in order to destroy living cells, and thus, while the skin above and around the papillae or blood supply to the hair remains essentially intact, the papillae or blood supply is destroyed by ultrasonic force. Areas above the focal point are essentially not effected..
  • ultrasonic parameters to perform this aspect are as follows: Frequency: 20 kHz to 25 MHz, preferably 1 MHz to 10 MHz, most preferably 3 MHz to 7 MHz. Intensity: 5 W/cm 2 to 750 W/cm 2 , preferably 30 W/cm 2 to 500 W/cm 2 , most preferably 100 W/cm 2 to 300 W/cm 2
  • Duration 1 millisecond to 10 seconds, preferably 0.01 second to 2 seconds, most preferably 0.1 second to 0.5 second.
  • the present invention provides a method for removal of hair, wherein the ultrasonic energy is delivered via the hair shaft itself, which serves as a wave guide.
  • the ultrasonic beam may be in the form of longitudinal waves, sheer waves, torsion or bending waves and is targetically transmitted via the hair shaft into the hair papillae.
  • the delivery of these energy waves through the hair shaft into deeper, living parts of the hair causes sufficient mechanical distortion, vibration, bending and torsion-created torque, or thermal elevation for the destruction of hair notably the hair root follicle and/or papillae.
  • the procedure can be carried out on untreated skin, as well as skin and hair pretreated for example by drying and trimming of the hair.
  • Hair serves best as a wave guide when it is dry so that during treatment hair should preferably be as dry as possible.
  • the hair should preferably be as short as possible and should preferably be trimmed for example by shaving prior to treatment. Dry hair also minimizes leakage of energy from the hair to the surrounding skin.
  • geometrical parameters of the hair such as (length and width), the angle between the hair and the ultrasonic probe, the air gap between the probe and the skin surface, are all important parameters to be taken into consideration in connection with the yield of the process.
  • hair should be preferably cut, to reduce attenuation along the hair shaft since the longer the hair the greater the attenuation.
  • the placement of the hair in respect to the emitter of energy itself should provide required angle between transducer surface and hair surface, preferably the transducer should be perpendicular to the hair so that the wave propagates in the hair itself without bouncing off the hair wall and losing energy.
  • nl/2 ⁇ horn to achieve maximal velocity at the root or papillae
  • n ⁇ horn to achieve maximal intensity at the desired site. This means to cut the hair so that the length of the hair will be an integer number of half wavelengths and therefore the amplitude of the signal, and the desired effect, at the hair root will be maximized. For example if the wave length is 3mm the horn will be multiples of this number (3,6,9 etc.) and the hair will be trimmed to have similar sizes
  • the frequency to receive the maximum effect will be about 21 MHz, while for shear waves or torsion waves having about half velocity, will be about 10.5MHz or less.
  • the frequency may be reduced to a frequency of about half of shear waves, for example to about 5MHz.
  • Bending waves may be produced using a single transducer, preferably perpendicular to the hair, or two transducers either one above the other or one opposite the other.
  • the ultrasonic parameters to perform this aspect may be for example:
  • Frequency for longitudinal waves 1 MHz to 50 MHz, preferably 10 MHz to 30
  • MHz most preferably 15 MHz to 25 MHz.
  • the frequency depends on the specific hair diameter of the treated subject.
  • Intensity 0.5 W/cm 2 to 500 W/cm 2 , preferably 3 W/cm 2 to 50 W/cm 2 , most preferably 10 W/cm 2 to 20 W/cm 2 Duration: 0.01 second to 10 minutes, preferably 1 second to 5 minutes, most preferably few seconds.
  • the damage and transfer of energy will be most efficient when the ultrasonic wave will be in resonance with the follicle and papilla.
  • the frequency that will cause resonance will be about 17MHz for longitudinal waves, about 8MHz for shear waves and about 4MHz for bending waves.
  • the intensity of the wave may be reduced.
  • the present invention provides in accordance with a third aspect thereof a method for the destruction of at least one component of the hair, the hair root, hair follicle papillae or capillary blood supply to the hair, using cavitation.
  • the present invention provides a method and procedure for creating cavitation bubbles in the hair follicle, preferably at its inner side, for the destruction of at least one component of the hair follicle, root, papillae or blood supply.
  • the effect of cavitation may be achieved by the production of bubbles and their collapse which, due to mechanical disruption elevated temperature ,pressure and micro-streaming that destructs the surrounding regions.
  • the effect of cavitation can be achieved also using oscillating cavitation bubbles where the desired damage to the tissue is achieved not by explosion of transient bubbles but by oscillation of stable ones.
  • the stable oscillating bubbles produce heat having just a local thermal effect which leads to destruction by surrounding tissue.
  • temperature gradient reduces about 90 times (for 1 MHz frequency and bubble of 10 ⁇ m radius).
  • the bubble is present on the cell membrane and most bubbles are on cell membrane or close to it since the space between the hair shaft and the follicle is about 10 microns, it produces enough heat to destroy the components of the tissue adjacent thereto.
  • T 0 surrounding temperature
  • po-acoustic pressure po-acoustic pressure
  • ⁇ o-resonant frequency for given bubble radius
  • K' - gas thermal conductivity K' - gas thermal conductivity
  • ⁇ vis, ⁇ th, ⁇ tot energy dissipation for viscosity, temperature and total energy dissipation as shown in the formula:
  • T b T 0 +8.12* 10 "12 *po 2 , acoustic pressure in dyn/cm .
  • the ultrasonic parameters to the cavitational aspect of the invention may be, for example, as follows:
  • Frequency 1 kHz to 5 MHz, preferably 10 kHz to 2 MHz, most preferably 100 kHz to 1 MHz.
  • Intensity 0.3 W/cm 2 to 500 W/cm 2 , preferably 0.5 W/cm 2 to 50 W/cm 2 , most preferably 1 W/cm 2 to 10 W/cm 2 Duration: 0.01 second to 10 minutes, preferably 1 second to 5 minutes, most preferably less than 7 sec.
  • the present invention provides in accordance with a fourth aspect thereof a method for the destruction of at least one component of the hair, root, papillae or capillary blood supply to the hair, using ultrasound either to activate hair degenerative agents naturally present or externally administered to the hair papillae and/or to facilitate intrafollicular delivery of follicle degenerative agents.
  • the present invention provides a method and procedure for the active and/or delivery of different natural or artificial chemical degenerative agents into the hair follicle for altering the cell cycle of papillae, root or follicle cells, and for the destruction of at least one component of the hair, the hair root, hair follicle, papillae or capillary blood supply to the hair.
  • this embodiment may take advantage of natural compounds of the skin which may be used to destroy hair, i.e. use compounds already present in the skin as degenerative agents.
  • epilation can be performed by irradiating the skin surface using ultrasound of preferably high frequency so as to heat the desired zone with the hair with minimum penetration into deeper layers.
  • the irradiation affects differentially the different components of the skin.
  • the follicle is partially filled with sebum and is attached to the sebaceous gland.
  • the sebum is actually fat having attenuation of 0.5 db/cm., i.e. ten times more than the skin. Therefore when irradiated, the sebum will accumulate heat and elevate its temperature about 10 times more than the surrounding tissue, causing localized lysis and destructure of the living part of the hair.
  • Tweezers can be used to finally force free epilate the hair after the process.
  • the intrafollicular delivery of follicle degenerative agents is facilitated by ultrasound.
  • the delivery itself is a modified version of the method stipulated in co-pending PCT/IL 97/00405.
  • the tissue surface is exposed to a first irradiated stimulus having such parameters as to enlarge the space between the hair shaft and the follicle itself and to remove from said space wax (fat) and debris, without causing any irreversible damage; and within a time period where a substantial portion of said openings remain open, a second driving ultrasound stimulus is administered in the presence of at least one follicle-degenerative agent.
  • the opening pulse is at generally low frequencies, preferably 100 kHz- 1 MHz.
  • the driving pulse is of higher frequency, preferably 1-10 MHz.
  • the duration of both pulses is preferably several seconds and intensity of several w/cm .
  • the skin is wiped to remove remnants of the compound from the skin surface itself and the ultrasound is used to activate the degenerative agent.
  • the degenerative agent itself used to cause the desired epilation effect can be of the following groups: sonosensitizable agents capable of undergoing exothermic reactions upon ultrasonic irradiation or exposure to light, such as gallium porphyrins, dimethylsulfoxide, dimethylforma and adramycin, NaN 3 , nitrocellulose and the like according to co pending PCT/IL98/00203 of the inventors, optionally with helper agents used to facilitate the destructive effect such as 0 2 , chloride, kalium permanganate and the like, capable of contributing to the effect, for example, by the releasing of radicals or other oxidative moieties.
  • sonosensitizable agents capable of undergoing exothermic reactions upon ultrasonic irradiation or exposure to light
  • helper agents used to facilitate the destructive effect such as 0 2 , chloride, kalium permanganate and the like, capable of contributing to the effect, for example, by the releasing of radicals or other oxidative moie
  • Examples of degenerative compounds which act by mechanisms other than oxidative or exothermic mechanisms are: oil that causes pore clogging and malnutrition of the hair root thus facilitating destruction of hair roots by heat; natural substances capable of affecting the cell cycle of the root, papillae or blood vessel cell, including cytokines such as epidermal growth factors or tumor necrosis factors, or Interleukin-1 capable of shifting the growth cycle from the anagen to the catagen phase (the latter phase is the phase where the hair separates from its root); androgen hormones in particular dihydrotestosterone or 5-alpha-reductase that converts testosterone to its active form dihydrotestosterone. The latter compete for a place on the hair follicle's receptor sites and when succeeded start shrinking the follicle and root death in different body zones.
  • the present invention provides in accordance with a fifth aspect thereof a method for the detachment and destruction of at least one component of the hair, hair follicle, hair root, papillae or capillary blood supply to the plaque, using stretching and relaxation effects of resonance produced by ultrasonic energy in a resonator. Therefore in accordance with a firth aspect of the invention termed "resonator epilation ", the present invention provides a method and device for stretching and relaxing hair by transmitting an ultrasonic resonance energy which matches the natural resonance of a resonator so as to cause fatigue effects in the hair follicle lending to the detachment and destruction of at least one component of the hair, hair root, hair follicle, papillae or capillary blood supply.
  • the present provides in accordance with a sixth aspect thereof a method for the destruction of the blood supply to the hair, using aggregation of blood cells. Therefore in accordance with a sixth aspect of the invention termed " aggregational epilation ", the present invention provides a method and device for causing aggregation of blood cells in the papillae blood vessel for hampering papillary blood supply to the hair, thus causing cessation or substantial reduction of supply of nutrients to the hair root and hair papillae leading to the detachment of hair due to the destruction of the hair root or papillae.
  • Aggregation is created when the wave is transmitted in aquatic medium containing particles. It is created (among other factors) due to Bernoulli attraction force formed between particles caused by acoustic streaming, and due to disturbance of the oscillating movements of particles caused by the movement of the liquid in the acoustic field.
  • the ultrasonic parameters to perform this aspect may be as follows:
  • Frequency for longitudinal waves 10 kHz to 15 MHz, preferably 500 kHz to 10 MHz, most preferably 1 MHz to 5 MHz.
  • Intensity 0.1 W/cm 2 to 50 W/cm 2 , preferably 0.5 W/cm 2 to 10 W/cm 2 , most preferably 1 W/cm to 3 W/cm Duration: 1 second to 10 minutes, preferably 10 seconds to 5 minutes, most preferably 30 seconds to 2 minutes.
  • aggregation can be carried out with the hair serving as a hair guide and/or by direct irradiation through the skin directly.
  • the different aspects of hair removal may be carried out separately or in combination.
  • focal beam epilation is suitable for removal of hair in non-sensitive skin regions such as the legs.
  • Hair-guide epilation is suitable for treatment of sensitive regions such as the face. Cavitational epilation after mechanical hair removal.
  • the present invention further concerns devices and systems for use in any of the above methods .
  • the system is composed of wave signal generator attached to an amplifier and appropriate transducer and attachment devices.
  • focal beam epilation focusing means such as acoustic lenses should be supplied as well as a conical wave guide.
  • hair-guide epilation means for holding the hair should be supplied.
  • resonator epilation a resonator should be supplied.
  • cavitational epilation and epilation with degenerative agents the system should contain components for supplying the cavitational helper agents or the degenerative agents to the skin.
  • Fig. 1 shows a schematic drawing of an epilation device using focused ultrasonic beam
  • Fig. 2 shows a schematic drawing of transducer cover used to grasp a hair shaft end for epilation and using the hair shaft as wave-guide;
  • Fig. 3 shows a schematic drawing of transducer used for epilation using bending wave
  • Fig. 3a shows a schematic drawing with two transducers used to remove hair
  • Fig. 3b shows a schematic drawing with one transducer.
  • Fig. 3c shows schematically the effect achieved by ultrasonic irradiation on hair when leading to its distortion and eventual breaking
  • Fig. 4 shows a schematic drawing of cavitation effect caused by ultrasonic irradiation in the hair follicle around the hair shaft
  • Fig. 5 shows a schematic drawing of destruction of an empty hair papillae with cavitation after hair was previously removed therefrom (for example, by plucking) where the bubbles are created in the empty hair follicle;
  • Fig. 6 shows a schematic drawing of agglutination of blood cells in the blood capillaries around the hair root leading to cessation of blood and nutrient supply to the root;
  • Fig. 7A shows a schematic drawing of an ultrasonic device capable of providing energy resources used for resonator epilation
  • Fig. 7B shows a schematic drawing of an ultrasonic system for hair removal
  • Fig. 8 shows a permanent epilation effect created at the hairy side of a rabbit's ear using focal beam epilation.
  • Sonicator 720 (Mettler electronics, California, USA) for frequencies of 1 MHz and 3 MHz, power output up to 2.2 W/cm , pulse mode of continuous mode.
  • Focused beam ultrasound (Imasonic, Besancon, France) for frequencies of 3.9 MHz to 7.4 MHz, power up to 300 W/cm 2 .
  • Fig. 1 shows system 1 used for focal beam epilation. Focused ultrasound beam emitted from transducer 2 to skin 12.
  • the ultrasound transducer 2 is encased by the focusing apparatus cone which includes a sheath 3 and container 4.
  • the container fits over the sheath thread (not shown) thus by turning the container, the distance between the transducer face 14 and cover opening 13 can be continuously changed to any required length .
  • the focused ultrasonic beam 5 in prefocal point regions propagates through the container 4 which opening 13 rests on the skin epidermis 7.
  • the apparatus is typically set so that the beam 5 converges into a focal zone 9 at or near the opening 13 either at the apparatus-epidermis interface or in the skin itself.
  • the beam then widens into the post focal zone 11 and the ultrasound energy dissipates as it travels further through the dermis 6.
  • the "destructive zone " or "effective zone” 10 is a part of the beam path proximate to the focal area 9 where the energy is concentrated enough to cause temperature elevation, denaturation and destruction of the irradiated area.
  • the length of area 10 depends on the ultrasonic frequency. Frequencies in the MHz region, cause formation of destruction zones of few millimeters, similar to that of the hair follicle. Therefore according to this, the ultrasonic focus beam is used directly to heat and destroy the follicle papilla from outside, i.e. without using the hair as a wave guide.
  • Example 2 Epilation using the hair as a wave guide Braids of hair were fabricated by placing hairs obtained from natural hair obtained from humans in a sleeve made of rubber. The sleeve was heat-shrunk so that it tightened around the hairs which protruded out of the sleeve from both sides. Each sleeve contained about 10,000 hairs. The length of the braids, were 5 mm to 3 cm long and the diameters of the braids were 2 to 9 mm. A contact "Through Transmission" ultrasonic measurements were executed using Ultrasonic Flaw Detector - EPOCH 3 manufactured by Panametrics, USA.
  • the higher frequency here e.g., 5 MHz
  • the higher frequency will be accompanied by pre-treatment trimming of the hair to reduce attenuation and energy loss along the hair length when the hair is used as a wave guide.
  • Another reason to use high frequency transducers is the rapid decrease in attenuation when the wave length decreases (frequency increases) and becomes of the same order as the hair diameter.
  • the transmitted wave has to pass from the hair to the skin, i.e., from an area of certain velocity into an area of other wave velocity, it is partially reflected and elevated the temperature at the transition location of the hair root (transition between the hair shaft and the skin tissue). The elevated temperature is the most effective parameter here.
  • the wire was placed in a drop of coupling medium at each side.
  • the measured voltage was 20mV which means that 0.4% of the acoustic energy was transferred from one transducer to the other.
  • the experiment was carried out again under the same procedure but with one hair shaft between the transducers. Hair properties were 15-mm length and 0.12-mm diameter.
  • the measured voltage was 7mV, which indicates that 0.14% of the emitted ultrasonic energy reached its desired location after passing in the hair shaft.
  • Fig 2 shows the hair used as wave-guide from transducer or acoustic horn 20 into hair root 26 and papillae 21.
  • Solid transducer or acoustic horn 20 is used to grasp the hair shaft 28 end for the epilation treatment.
  • the transducer or acoustic horns a single mass with a hole or holes of a size capable of containing a hair shaft widths or is composed of two units that grasp the hair in a similar manner to tweezers.
  • the grasping area can be also holes in horn attached to the transducer.
  • the hairs may be directly attached to the transducer via acoustic coupling medium such as gel (not shown).
  • the hair shaft 28 recedes into the skin, past the stratum corneum 23, epidermis 27, through the sebum partially-filled gap 22 within the follicle 29 and ends in the epidermal invagination in dermal layer 25 at the hair root 26, which covers the follicle bulbous area 24.
  • the hair root is fed from nurturing capillaries 21 via the papilla.
  • the ultrasonic wave emitted from transducer 20 propagates through the hair shaft and dissipates into the follicle at its inner side, where the hair root 26 is in close contact with the bulbous follicle 24 and the papillae 21.
  • the diffusion of the ultrasonic energy at that location destroys the hair root and papillae causing epilation.
  • the wave itself can be in the form of longitudinal or bending waves which cause thermal elevation and thermal destruction.
  • a single hair shaft was placed at focal point of focusing transducer attached to delivery cone.
  • the opening of the cone was covered by paraffin, on top of which a drop of acoustic gel was placed.
  • Ends of hair shafts obtained from human arms were placed in the gel and an ultrasonic wave was emitted from transducer via aquatic medium of the cone, parafilm, and acoustic gel and hair shaft into the hair follicle and hair root.
  • the parameters of the ultrasonic beam were frequency of 3 MHz, intensity of 3 W/mm , and duration of 120 seconds.
  • Tweezers attached to dynamometer were used to measure the forced needed to epilate the hair. All of the non treated hair were epilated using force of 40 to 60 grams. For the treated hair, 70% were epilated instantly, i.e., using force of less than about 2.5 grams.
  • Example 4 Epilation using the hair as a wave-guide
  • FIGs. 3a to 3c show schematic drawings of another example of system used for epilation utilizing bending wave.
  • Figure 3a shows schematic drawing of bending wave epilation effect created with two transducers 30 and 31, with their respective centers a and b distance between centers X.
  • the distance X is an even number of half- wavelengths so that they are synchronized in creating maximum effect/ This causes the two waves to have the same phase and direction so that their effects are added.
  • transducers 30 and 31 are placed one at each side of the hair, facing each other, with an offset X of odd number of half- wavelengths to create the maximum effect
  • the hair shaft 33 is pulled taut by a holding apparatus 34 such as tweezers and the interface with the transducers is via acoustic coupling medium.
  • Holding apparatus 34 can optionally be a part of transducer or an attachment capable of emitting waves. The wave is propagated through the hair shaft until reaching the hair root 35 and papilla 36 interface, effecting the destruction of this area. Mainly through torque.
  • the hair shaft is pulled using holding apparatus 34' and the bending wave is transmitted via hair shaft 33' into the hair root 35' where it affects also the papillae 36'.
  • the effect of the bending wave is schematically described in Fig. 3c.
  • a single transducer 30" is touching the hair shaft, which is held taut by a device 34" such as tweezers and sends a wave along the hair shaft.
  • the subsequent forces working upon the hair root 35" and papillae 36" are tension (upward arrows) and vibration (side to side arrow). These two forces cause fatigue of the hair follicle, i.e., it mechanically distract the hair-follicle connection, weaken the hair root to a point of total disconnection that allows the hair shaft to be extracted by the tweezers from the follicle itself 36" with no or very little force..
  • the hair is used here as mechanical wave guide to create effect at desired location.
  • Fig. 4 shows agglutination of blood cells caused by ultrasound irradiation which leads to blockage of blood vessels.
  • the signal transmitted via the hair shaft reaches the hair root 46 and affects also blood cells 47 running in capillary 45 which enters the papillae 41.
  • Such a procedure deprives the hair root from its nutrients leading to its death.
  • the advantage of using the hair shaft as a wave guide is that only capillaries supplying the hair roots are destroyed, while other capillaries remain unharmed
  • Fig. 6 the effect of ultrasonic waves on aggregation of erythrocytes 47 is described.
  • the energy is partially dispersed into the papillae 41 and affects the capillary 45 with its flow through erythrocytes 47.
  • erythrocytes 43 aggregated in the small diameter and curved capillaries.
  • erythrocytes will also agglutinate causing the capillaries to clog, blood flow to cease and hair root 46 and papilla 41 to die through lack of nourishment.
  • irradiation of the chorio-alantoic-membrane of chick embryo was carried out with 3 MHz transducer for different durations and intensities. Irradiation for duration of more than 60-80 seconds and at intensities higher than 1.5 W/cm 2 resulted in stasis of the blood circulation of the fine capillaries whereas the bigger diameter capillaries were not affected as determined by inspection through a binocular. The stasis was permanent, probably via formation of blood occlusion at the fine blood capillaries.
  • Fig. 5 shows the follicle space, or gap 52 between the hair shaft 58 and follicle wall 50 which is used as cavitational space.
  • the acoustic beam 58 created by transducer 52 and runs into the tissue. While threshold ultrasound energy required to cause cavitation in tissue itself is high, it can be lowered by enriching the hair follicle by water or other acoustic coupling medium of low viscosity alone or together with helper agents such as gas enriched water, or cavitation-inducing agents such as silica particles or CC1 4 to enhance the appearance of cavitational bubbles 57 in the follicle.
  • the cavitation in particular the transient one exploding cavitation, destroys the adjacent tissue, i.e., the follicle wall 50, hair root 56 and papilla 51.
  • Fig. 6 shows the follicle cavitation in an empty follicle, i.e. the follicle lacks hair which was completely removed before initiating of cavitation 67 due to the irradiation of transducer 62.
  • the cavitation is created throughout the follicle, and since there is more space (due to lack of hair), more bubbles are created, they might be also of larger size, and their collapse directly affects the exposed papillae 61 its blood supply 65 and the follicle wall 63.
  • the resonator epilation embodiment is described.
  • the resonator box 74 is connected to the transducer 72.
  • the resonator can be for example a hollow cylinder filled with a fluid 77 such as water, having good acoustic- wave transmission properties.
  • a fluid 77 such as water
  • the acoustic impedance Z of the liquid 77 is intermediate to that of transducer 72 and hair shaft 78.
  • the size of the resonator, between transducer 72 and end of hair shaft 78 is chosen in such way that the wave is amplified maximally in order to cause oscillation of the wall of the resonator, which is present opposite the transducer.
  • This wall is a thin elastic membrane 75 which parameters are given below.
  • a calculation can provide the intensity needed to create movement of the membrane close to or at its own resonance frequency, which should fit to the frequency of ultrasonic wave. For instance, to create vibration of membrane with amplitude of 1 mm, using aluminum round membrane with diameter of 50 mm and thickness 0.5 mm acoustic pressure of 1.1756 atom or Intensity of 1.43 W/cm 2 are needed.
  • the space between membrane 75, holder 76 and the skin surface is in fact composed of air. Alternatively, or in addition, the space can be maintained using a suitable spacer (not shown in the Fig.) composed of a non-conducting or a non- ultrasonic conducting component.
  • Frequency 1 kHz to 5 MHz preferably 1 MHz to 5 MHz, most preferably 2 MHz to 5 MHz.
  • Intensity 0.3 W/cm 2 to 50 W/cm 2 , preferably 0.5 W/cm 2 to 10 W/cm 2 , most preferably 1 W/cm 2 to 5 W/cm
  • Duration 0.01 second to 10 minutes, preferably 1 second to 5 minutes, most preferably few seconds.
  • Fig. 7B shows a schematic illustration of a system for ultrasonic removal of hair.
  • the system is schematically composed of two main parts: the first is a signal generator 102 comprising of a voltage source 104, a frequency converter 106, a signal amplifier 108.
  • the second part of the system which can be constructed as a single unit or operated as separate independent units is an ultrasonic treatment unit 110.
  • the ultrasonic treatment unit 110 may also include the following components: the transducer 112, which produces ultrasonic vibration, positioned in the treatment part 110.
  • the transducer horn 114 amplifies and transmits the vibrations to the removable tip 116, which further amplifies the vibration, for instance the resonator described in Fig. 7A.
  • Tip 116 also acts as a holder for a hair gripper element 118, which is a part intended to grip the hair and may have any configuration known in the art. However the gripper element can be also connected to other components of the system, as long as they do not interfere with its hair gripping properties.
  • These several parts 112, 114, 116 and 118 can be also arranged as one integral unit.
  • Sensor 120 monitors the ultrasonic converter and through a feedback line 124 maintains optimal driving conditions from the voltage source 104, frequency converter 106 and signal amplification 108 units. Such feedback is needed in particular for safety reasons, but might be also used for the regular course of operation.
  • the hair gripper 118 which is also the ultrasonic horn tip should preferably be kept a consistent and predetermined distance from the skin by means of a spacer device (not shown).
  • This spacer device will act as a protective mechanism, avoiding contact between irradiating elements and the skin, as well as improve energy transfer from transducer to hair.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Cosmetics (AREA)

Abstract

Cette invention, qui a trait à divers procédés d'épilation faisant appel aux ultrasons, concerne également des appareils utilisés pour mettre en oeuvre ces procédés.
PCT/IL1999/000533 1998-10-09 1999-10-08 Procede d'epilation et appareil correspondant WO2000021612A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2000575583A JP2002527162A (ja) 1998-10-09 1999-10-08 体毛除去の方法および装置
AU61190/99A AU6119099A (en) 1998-10-09 1999-10-08 A method and device for hair removal
CA002346703A CA2346703A1 (fr) 1998-10-09 1999-10-08 Procede d'epilation et appareil correspondant

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12650598A IL126505A0 (en) 1998-10-09 1998-10-09 A method and device for hair removal
IL126505 1998-10-09

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WO2000021612A1 true WO2000021612A1 (fr) 2000-04-20

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JP (1) JP2002527162A (fr)
AU (1) AU6119099A (fr)
CA (1) CA2346703A1 (fr)
IL (1) IL126505A0 (fr)
WO (1) WO2000021612A1 (fr)

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AU6119099A (en) 2000-05-01

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