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WO2000020586A3 - Antigenes associes au cancer du rein et leurs utilisations - Google Patents

Antigenes associes au cancer du rein et leurs utilisations Download PDF

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Publication number
WO2000020586A3
WO2000020586A3 PCT/US1999/022865 US9922865W WO0020586A3 WO 2000020586 A3 WO2000020586 A3 WO 2000020586A3 US 9922865 W US9922865 W US 9922865W WO 0020586 A3 WO0020586 A3 WO 0020586A3
Authority
WO
WIPO (PCT)
Prior art keywords
associated antigens
molecules
cancer associated
peptides
cancer
Prior art date
Application number
PCT/US1999/022865
Other languages
English (en)
Other versions
WO2000020586A2 (fr
Inventor
Sergei Nedospasov
Ekaterina Koroleva
Maria Lagarkova
Alexander Kuimov
Regina L Turetskaya
Andrei Mescheryakov
Mikhail Litchinitser
Alexei Tumanov
Lloyd J Old
Matthew J Scanlan
Original Assignee
Ludwig Inst Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ludwig Inst Cancer Res filed Critical Ludwig Inst Cancer Res
Priority to AU62824/99A priority Critical patent/AU6282499A/en
Publication of WO2000020586A2 publication Critical patent/WO2000020586A2/fr
Publication of WO2000020586A3 publication Critical patent/WO2000020586A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Des antigènes associés au cancer du rein ont pu être identifiés par criblage à l'aide d'anticorps autologues de bibliothèques d'acides nucléiques exprimés par les cellules cancéreuses du rein en utilisant des antisérums de patients cancéreux. L'invention porte sur des acides nucléiques et les polypeptides codés par eux qui sont des antigènes associés au cancer exprimés par des patients atteints du cancer du rein. L'invention porte notamment sur des molécules isolées d'acide nucléique, sur des vecteurs d'expression contenant ces molécules, et sur des cellules hôtes transfectées par ces molécules. L'invention porte également sur des protéines et des peptides isolés anticorps des protéines et des peptides et des lymphocytes T cytotoxiques qui reconnaissent lesdites protéines et lesdits peptides. L'invention porte en outre sur de leurs fragments dont des fragments fonctionnels et leurs variantes. Elle porte enfin sur des trousses contenant les susdites molécules. Les molécules de l'invention peuvent servir au diagnostic, au suivi, à la recherche ou au traitement d'états caractérisés par l'expression d'un ou plusieurs antigènes associés au cancer.
PCT/US1999/022865 1998-10-05 1999-10-04 Antigenes associes au cancer du rein et leurs utilisations WO2000020586A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU62824/99A AU6282499A (en) 1998-10-05 1999-10-04 Renal cancer associated antigens and uses therefor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16632198A 1998-10-05 1998-10-05
US09/166,321 1998-10-05

Publications (2)

Publication Number Publication Date
WO2000020586A2 WO2000020586A2 (fr) 2000-04-13
WO2000020586A3 true WO2000020586A3 (fr) 2000-07-20

Family

ID=22602764

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/022865 WO2000020586A2 (fr) 1998-10-05 1999-10-04 Antigenes associes au cancer du rein et leurs utilisations

Country Status (2)

Country Link
AU (1) AU6282499A (fr)
WO (1) WO2000020586A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029409A2 (fr) * 1995-03-21 1996-09-26 Ludwig Institute For Cancer Research Antigenes de rejet de tumeurs de la famille rage

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996029409A2 (fr) * 1995-03-21 1996-09-26 Ludwig Institute For Cancer Research Antigenes de rejet de tumeurs de la famille rage

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL - EMEST25 22 July 1997 (1997-07-22), STRAUSBERG, R.: "ng39g01.s1 NCI_CGAP_Co3 Homo sapiens CDNA clone 937200 similar to TR:E242679 E242679 D1545.", XP002135193 *
DATABASE EMBL - EMEST27 22 November 1995 (1995-11-22), HILLIER, L. ET AL.: "ys95a08.s1 Homo sapiens cDNA clone 222518 3' similar to contains TAR1 repetitive element.", XP002128710 *
DATABASE EMBL - EMEST6 8 September 1998 (1998-09-08), STRAUSBERG, R.: "qa49d07.x1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE:1690093 3', mRNA sequence.", XP002135198 *
DATABASE EMBL - EMHUM1 15 June 1998 (1998-06-15), WATERSTON, R.H.: "Homo sapiens clone 82F9, complete sequence.", XP002128709 *
NAGASE ET AL: "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro", DNA RESEARCH,JP,UNIVERSAL ACADEMY PRESS, vol. 5, no. 5, 28 February 1998 (1998-02-28), pages 31 - 39-9, XP002103187, ISSN: 1340-2838 *
SCANLAN, M. ET AL.: "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.", INTERNATIONAL JOURNAL OF CANCER, vol. 83, 12 November 1999 (1999-11-12), pages 456 - 64, XP000867569 *

Also Published As

Publication number Publication date
AU6282499A (en) 2000-04-26
WO2000020586A2 (fr) 2000-04-13

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