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WO2000018763A3 - 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles; ligands specifiques du sous-type du recepteur de dopamine - Google Patents

2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles; ligands specifiques du sous-type du recepteur de dopamine Download PDF

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Publication number
WO2000018763A3
WO2000018763A3 PCT/US1999/022699 US9922699W WO0018763A3 WO 2000018763 A3 WO2000018763 A3 WO 2000018763A3 US 9922699 W US9922699 W US 9922699W WO 0018763 A3 WO0018763 A3 WO 0018763A3
Authority
WO
WIPO (PCT)
Prior art keywords
aminomethylimidazoles
dihydrobenzofuran
dopamine receptor
receptor subtype
specific ligands
Prior art date
Application number
PCT/US1999/022699
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English (en)
Other versions
WO2000018763A2 (fr
Inventor
Xi Chen
Xiao-Shu He
Original Assignee
Neurogen Corp
Xi Chen
He Xiao Shu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp, Xi Chen, He Xiao Shu filed Critical Neurogen Corp
Priority to AU65038/99A priority Critical patent/AU6503899A/en
Publication of WO2000018763A2 publication Critical patent/WO2000018763A2/fr
Publication of WO2000018763A3 publication Critical patent/WO2000018763A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés représentés par la formule (I) ou leurs sels d'apport acide acceptables sur le plan pharmaceutique, dans laquelle: n est un entier; R1 représente un groupe organique ou inorganique; R2 représente halogène ou alkyle C1-C6; RN représente un alkylène portant une pipérazine, pipéridine ou tétrahydropyridine substituées; R4 représente hydrogène ou alkyle C1-C6. Ces composés sont utiles pour le traitement et/ou la prévention de maladies neuropsychologiques, y compris, mais non exclusivement, la schizophrénie, la manie, la démence, la dépression, l'anxiété, les comportements compulsifs, l'abus de drogues, les troubles moteurs de type Parkinson et les troubles moteurs associés à l'utilisation d'agents neuroleptiques.
PCT/US1999/022699 1998-09-29 1999-09-29 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles; ligands specifiques du sous-type du recepteur de dopamine WO2000018763A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU65038/99A AU6503899A (en) 1998-09-29 1999-09-29 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16286198A 1998-09-29 1998-09-29
US09/162,861 1998-09-29

Publications (2)

Publication Number Publication Date
WO2000018763A2 WO2000018763A2 (fr) 2000-04-06
WO2000018763A3 true WO2000018763A3 (fr) 2000-05-25

Family

ID=22587429

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/022699 WO2000018763A2 (fr) 1998-09-29 1999-09-29 2-(2,3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles; ligands specifiques du sous-type du recepteur de dopamine

Country Status (2)

Country Link
AU (1) AU6503899A (fr)
WO (1) WO2000018763A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002223968A1 (en) * 2000-12-21 2002-07-01 Warner Lambert Company Llc Piperidine derivatives as subtype selective n-methyl-d-aspartate antagonists

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2061515A1 (de) * 1969-12-15 1971-06-24 Merck & Co Ine, Rahway, N J (V St A) 2,5 disubstituierte Imidazole und Ver fahren zur Herstellung derselben
WO1992012134A2 (fr) * 1990-12-28 1992-07-23 Neurogen Corporation Certains derives de phenylimidazole aminomethyle; nouvelle classe de ligands a specificite de sous-type de recepteur de dopamine
WO1996010018A1 (fr) * 1994-09-27 1996-04-04 Neurogen Corporation Derives de l'aminomethylphenylimidazole et nouvelle categorie de ligands specifiques du sous-type du recepteur de la dopamine
WO1996016040A1 (fr) * 1994-11-23 1996-05-30 Neurogen Corporation Certains derives 4-aminomethyl 2-substitues de l'imidazole et derives 2-aminomethyl 4-substitues de l'imidazole, nouvelles categories de ligands specifiques du sous-type du recepteur de la dopamine
WO1996016057A1 (fr) * 1994-11-23 1996-05-30 Neurogen Corporation Certains derives d'aminoethyl imidazole et pyrrole substitues en 1; nouveaux ligands specifiques d'un sous-type de recepteur dopaminergique
WO1997043279A1 (fr) * 1996-05-10 1997-11-20 Janssen Pharmaceutica N.V. Derives de la 2,4-diaminopyrimidine utilises comme antagonistes du recepteur d4 de la dopamine

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2061515A1 (de) * 1969-12-15 1971-06-24 Merck & Co Ine, Rahway, N J (V St A) 2,5 disubstituierte Imidazole und Ver fahren zur Herstellung derselben
WO1992012134A2 (fr) * 1990-12-28 1992-07-23 Neurogen Corporation Certains derives de phenylimidazole aminomethyle; nouvelle classe de ligands a specificite de sous-type de recepteur de dopamine
WO1996010018A1 (fr) * 1994-09-27 1996-04-04 Neurogen Corporation Derives de l'aminomethylphenylimidazole et nouvelle categorie de ligands specifiques du sous-type du recepteur de la dopamine
WO1996016040A1 (fr) * 1994-11-23 1996-05-30 Neurogen Corporation Certains derives 4-aminomethyl 2-substitues de l'imidazole et derives 2-aminomethyl 4-substitues de l'imidazole, nouvelles categories de ligands specifiques du sous-type du recepteur de la dopamine
WO1996016057A1 (fr) * 1994-11-23 1996-05-30 Neurogen Corporation Certains derives d'aminoethyl imidazole et pyrrole substitues en 1; nouveaux ligands specifiques d'un sous-type de recepteur dopaminergique
WO1997043279A1 (fr) * 1996-05-10 1997-11-20 Janssen Pharmaceutica N.V. Derives de la 2,4-diaminopyrimidine utilises comme antagonistes du recepteur d4 de la dopamine

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BARFIELD,M. ET AL.: "Conformational,Bond-Order, and Substituent Dependenciess of Orthobenzylic Coupling Constants", J.AM.CHEM.SOC., vol. 105, 1983, WASHINGTON, pages 2178 - 2186, XP000881169 *
C H ANDREWS ET AL: "Experimental chemotherapy of typhus. Anti-rickettsial action of p-sulphamylbenzamidine and related compounds", PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON,GB,THE ROYAL SOCIETY, LONDON, vol. 133, December 1946 (1946-12-01), pages 20 - 62, XP002100404, ISSN: 0080-4649 *
LIEGEOIS,J.F. ET AL.: "Dopamine D4 Receptors, A new Opportunity for Research on Schizophrenia", CURR.MED.CHEM., vol. 5, 1995, pages 77 - 100, XP002130728 *
MATSUMURA,K. ET AL.: "Studies of Nitriles. XI. Preparation and Chemistry of Schiff Bases of ADAN...", CHEM.PHARM.BULL., vol. 24, 1976, TOKYO, pages 960 - 969, XP000881165 *
THURKAUF,A. ET AL.: "2-Phenyl-4(5)-[[4-(pyrimidin-2yl-)piperazin-1-yl]methyl]imidazole. A Highly Selective Antagonist at Cloned Human D4 Receptors", J.MED.CHEM., vol. 40, no. 1, 3 January 1997 (1997-01-03), WASHINGTON, pages 1 - 3, XP000872968 *
THURKAUF,A. ET AL.: "2-Phenyl-4-(aminomethyl)imidazoles as Potential Antipsychotic Agnets. Synthesis and Dopamine D2 Receptor Binding", J.MED.CHEM., vol. 38, no. 12, 1995, WASHINGTON, pages 2251 - 2255, XP000872913 *

Also Published As

Publication number Publication date
AU6503899A (en) 2000-04-17
WO2000018763A2 (fr) 2000-04-06

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