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WO2000016811A3 - Agent de contraste pour irm - Google Patents

Agent de contraste pour irm Download PDF

Info

Publication number
WO2000016811A3
WO2000016811A3 PCT/EP1999/007090 EP9907090W WO0016811A3 WO 2000016811 A3 WO2000016811 A3 WO 2000016811A3 EP 9907090 W EP9907090 W EP 9907090W WO 0016811 A3 WO0016811 A3 WO 0016811A3
Authority
WO
WIPO (PCT)
Prior art keywords
contrast agent
imaging
complex
mri contrast
mri
Prior art date
Application number
PCT/EP1999/007090
Other languages
English (en)
Other versions
WO2000016811A2 (fr
Inventor
Toshihiro Akaike
Naoto Miwa
Masahito Mikawa
Atsushi Maruyama
Original Assignee
Schering Ag
Toshihiro Akaike
Naoto Miwa
Masahito Mikawa
Atsushi Maruyama
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Toshihiro Akaike, Naoto Miwa, Masahito Mikawa, Atsushi Maruyama filed Critical Schering Ag
Priority to AU59815/99A priority Critical patent/AU5981599A/en
Publication of WO2000016811A2 publication Critical patent/WO2000016811A2/fr
Publication of WO2000016811A3 publication Critical patent/WO2000016811A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1803—Semi-solid preparations, e.g. ointments, gels, hydrogels

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

L'invention concerne un agent de contraste pour IRM. La capacité de mise en images est exprimée uniquement dans les cellules anormales cibles, telles que des tumeurs. La mise en images n'est par réalisée sur le site ou elle n'est pas nécessaire, ce qui permet d'améliorer considérablement la sensibilité de détection des cellules anormales, telles que des tumeurs. L'invention concerne également un agent de contraste pour IRM comprenant un complexe constitué d'un agent de contraste polyanionique du type gadolinium (Gd) et d'un polymère cationique ou comprenant un complexe constitué d'un agent de contraste polycationique du type gadolinium (Gd) et d'un polymère anionique, ces deux complexes étant capables de former un complexe de polyions. En outre, cet agent de contraste pour IRM exprime une capacité d'IRM à un pH neutre et en présence d'un électrolyte polymérique.
PCT/EP1999/007090 1998-09-17 1999-09-16 Agent de contraste pour irm WO2000016811A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU59815/99A AU5981599A (en) 1998-09-17 1999-09-16 Mri contrast agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10/263757 1998-09-17
JP10263757A JP2000086538A (ja) 1998-09-17 1998-09-17 Ｍｒｉ用造影剤

Publications (2)

Publication Number Publication Date
WO2000016811A2 WO2000016811A2 (fr) 2000-03-30
WO2000016811A3 true WO2000016811A3 (fr) 2000-11-23

Family

ID=17393868

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/007090 WO2000016811A2 (fr) 1998-09-17 1999-09-16 Agent de contraste pour irm

Country Status (3)

Country Link
JP (1) JP2000086538A (fr)
AU (1) AU5981599A (fr)
WO (1) WO2000016811A2 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030100830A1 (en) * 2001-11-27 2003-05-29 Sheng-Ping Zhong Implantable or insertable medical devices visible under magnetic resonance imaging
DE10311628B4 (de) * 2003-03-14 2006-04-13 Siemens Ag Bildgebungsverfahren
EP1684723A4 (fr) * 2003-11-21 2007-06-20 Fujifilm Corp Milieu de contraste comprenant des liposomes contenant un compose de chelate hydrophobe
EP2189167A4 (fr) 2007-09-03 2012-08-01 Univ Kyoto Agent de contraste contenant du silsesquioxane
JP2012197323A (ja) * 2009-07-21 2012-10-18 Univ Of Tokyo Ｍｒｉ造影用高分子ミセル複合体
KR101398214B1 (ko) * 2011-04-06 2014-05-23 주식회사 바이오리더스 음이온성 고분자와 양이온성 고분자 이온복합체 기반 고감도 자기공명영상 나노조영제 및 이의 제조방법
FR3043330B1 (fr) * 2015-11-05 2019-06-21 Centre National De La Recherche Scientifique (Cnrs) Agents de constrate pour imagerie medicale
RU2639390C2 (ru) * 2016-04-12 2017-12-21 Юрий Викторович Гольтяпин Лекарственная контрастная композиция
IT201900007647A1 (it) * 2019-05-30 2020-11-30 Univ Degli Studi Di Torino Nuovi agenti di contrasto per risonanza magnetica per immagini
WO2023003409A1 (fr) * 2021-07-21 2023-01-26 경북대학교 산학협력단 Composé à base de gadolinium et agent de contraste irm le comprenant
WO2023003408A1 (fr) * 2021-07-21 2023-01-26 경북대학교 산학협력단 Composé à base de gadolinium et agent de contraste irm le comprenant
KR102667904B1 (ko) * 2021-07-21 2024-05-21 경북대학교 산학협력단 가돌리늄계 화합물, 이를 포함하는 mri 조영제
KR102646267B1 (ko) * 2021-07-21 2024-03-11 경북대학교 산학협력단 가돌리늄계 화합물, 이를 포함하는 mri 조영제

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3724985A1 (de) * 1986-07-29 1988-02-11 Univ Ramot Kontrastmittel fuer die abbildung durch nmr
FR2667072A1 (fr) * 1990-09-24 1992-03-27 Bioetica Sa Complexe ternaire de chitosane, d'ions calcium et de lipides, procede de preparation et leurs applications.
WO1994003155A1 (fr) * 1992-08-07 1994-02-17 The General Hospital Corporation Compositions d'hydrogel et procedes d'utilisation
WO1996010359A1 (fr) * 1994-10-03 1996-04-11 The Trustees Of The University Of Pennsylvania Complexe de chelates a perceptibilite elevee pour l'imagerie par resonance magnetique
EP0707857A1 (fr) * 1994-10-21 1996-04-24 Nihon Medi-Physics Co., Ltd. Dérivés d'oligomères du chitosane, marqués au Gd-DTPA, utiles comme agent de contraste pour l'imagerie à résonance magnétique
US5534241A (en) * 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use
US5554748A (en) * 1989-04-07 1996-09-10 Nycomed Salutar, Inc. Adducts of macrocyclic chelants
WO1996040274A2 (fr) * 1995-06-07 1996-12-19 Nycomed Imaging A/S Polymeres chelateurs servant d'agents de contraste pour l'imagerie medicale
US5679810A (en) * 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
WO1998031712A2 (fr) * 1997-01-21 1998-07-23 The B.F. Goodrich Company Conjugues de chitosan comportant des agents acides de constitution de complexes de chelates
WO1998041241A1 (fr) * 1997-03-18 1998-09-24 Nihon Schering K. K. Milieux de contraste pour irm, reconnaissant les modifications de l'environnement

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3724985A1 (de) * 1986-07-29 1988-02-11 Univ Ramot Kontrastmittel fuer die abbildung durch nmr
US5554748A (en) * 1989-04-07 1996-09-10 Nycomed Salutar, Inc. Adducts of macrocyclic chelants
US5679810A (en) * 1990-01-19 1997-10-21 Salutar, Inc. Linear oligomeric polychelant compounds
FR2667072A1 (fr) * 1990-09-24 1992-03-27 Bioetica Sa Complexe ternaire de chitosane, d'ions calcium et de lipides, procede de preparation et leurs applications.
WO1994003155A1 (fr) * 1992-08-07 1994-02-17 The General Hospital Corporation Compositions d'hydrogel et procedes d'utilisation
US5534241A (en) * 1993-07-23 1996-07-09 Torchilin; Vladimir P. Amphipathic polychelating compounds and methods of use
WO1996010359A1 (fr) * 1994-10-03 1996-04-11 The Trustees Of The University Of Pennsylvania Complexe de chelates a perceptibilite elevee pour l'imagerie par resonance magnetique
EP0707857A1 (fr) * 1994-10-21 1996-04-24 Nihon Medi-Physics Co., Ltd. Dérivés d'oligomères du chitosane, marqués au Gd-DTPA, utiles comme agent de contraste pour l'imagerie à résonance magnétique
WO1996040274A2 (fr) * 1995-06-07 1996-12-19 Nycomed Imaging A/S Polymeres chelateurs servant d'agents de contraste pour l'imagerie medicale
WO1998031712A2 (fr) * 1997-01-21 1998-07-23 The B.F. Goodrich Company Conjugues de chitosan comportant des agents acides de constitution de complexes de chelates
WO1998041241A1 (fr) * 1997-03-18 1998-09-24 Nihon Schering K. K. Milieux de contraste pour irm, reconnaissant les modifications de l'environnement

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MIKAWA, MASAHITO ET AL: "A pH-sensitive contrast agent for functional magnetic resonance imaging (MRI)", CHEM. LETT. (1998), (7), 693-694, July 1998 (1998-07-01), XP002134101 *
TRUBETSKOY V S ET AL: "NEW APPROACHES IN THE CHEMICAL DESIGN OG GD-CONTAINING LIPOSOMES FOR USE IN MAGNETIC RESONANCE IMAGING OF LYMPH NODES", JOURNAL OF LIPOSOME RESEARCH,US,MARCEL DEKKER, NEW YORK, vol. 4, no. 2, 1 January 1994 (1994-01-01), pages 961 - 980, XP000619021, ISSN: 0898-2104 *

Also Published As

Publication number Publication date
AU5981599A (en) 2000-04-10
JP2000086538A (ja) 2000-03-28
WO2000016811A2 (fr) 2000-03-30

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