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WO2000010995A1 - Nouvelle forme de sel de pantoprazole - Google Patents

Nouvelle forme de sel de pantoprazole Download PDF

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Publication number
WO2000010995A1
WO2000010995A1 PCT/EP1999/005928 EP9905928W WO0010995A1 WO 2000010995 A1 WO2000010995 A1 WO 2000010995A1 EP 9905928 W EP9905928 W EP 9905928W WO 0010995 A1 WO0010995 A1 WO 0010995A1
Authority
WO
WIPO (PCT)
Prior art keywords
pantoprazoie
magnesium
magnesium dihydrate
dihydrate
sodium sesquihydrate
Prior art date
Application number
PCT/EP1999/005928
Other languages
English (en)
Inventor
Bernhard Kohl
Original Assignee
Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7881823&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2000010995(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to CA002341031A priority Critical patent/CA2341031C/fr
Priority to JP2000566268A priority patent/JP2002523411A/ja
Priority to IL14132899A priority patent/IL141328A0/xx
Priority to HU0103257A priority patent/HU226618B1/hu
Priority to BR9914288-0A priority patent/BR9914288A/pt
Priority to PL345993A priority patent/PL198801B1/pl
Priority to IL14115799A priority patent/IL141157A0/xx
Priority to US09/762,303 priority patent/US6410569B1/en
Priority to EA200100208A priority patent/EA004431B1/ru
Priority to EP99941605A priority patent/EP1105386B1/fr
Priority to SI9930096T priority patent/SI1105386T1/xx
Priority to DK99941605T priority patent/DK1105386T3/da
Priority to AU55156/99A priority patent/AU761715B2/en
Priority to MXPA01001758A priority patent/MXPA01001758A/es
Priority to MEP-847/08A priority patent/ME00562A/xx
Priority to SK236-2001A priority patent/SK285105B6/sk
Priority to EEP200100054A priority patent/EE04278B1/xx
Priority to AT99941605T priority patent/ATE219074T1/de
Priority to NZ509761A priority patent/NZ509761A/en
Priority to DE1999601840 priority patent/DE122005000049I2/de
Priority to DE69901840T priority patent/DE69901840T2/de
Application filed by Byk Gulden Lomberg Chemische Fabrik Gmbh filed Critical Byk Gulden Lomberg Chemische Fabrik Gmbh
Priority to UA2001021133A priority patent/UA58605C2/uk
Publication of WO2000010995A1 publication Critical patent/WO2000010995A1/fr
Priority to IL141157A priority patent/IL141157A/en
Priority to NO20010718A priority patent/NO319782B1/no
Priority to HR20010117A priority patent/HRP20010117B1/xx
Priority to HK01108172A priority patent/HK1037616A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Definitions

  • the present invention relates to a novel salt form of the active compound pantoprazoie.
  • the novel salt form can be employed in the pharmaceutical industry for the preparation of medicaments.
  • Pyridin-2-ylmethylsulfinyl-1 H-benzimidazoles such as are disclosed, for example, in EP-A-0005129, EP-A-0166287, EP-A-0174726 and EP-A-0268956, have, on account of their H + /K + ATPase-inhibiting action, considerable importance in the therapy of diseases which are due to increased gastric acid secretion.
  • Examples of commercially available active compounds from this group are 5-methoxy- 2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylsulfinyl]-1 H-benzimidazole (INN: omeprazole),
  • a common property of the abovementioned pyridin-2-ylmethylsulfinyl-1 H-benzimidazoles is the acid sensitivity - which is in the end indispensable for their efficacy - of these active compounds, which is seen in their strong tendency to decompose in a neutral and, in particular, acidic environment, strongly colored decomposition products being formed.
  • the International Patent Application W097/41114 describes a specific process for the preparation of magnesium salts of pyridin-2-ylmethylsulfinyl-1 H-benzimidazoles.
  • the preparation of the magnesium salt of pantoprazoie is also described by way of example. According to the analysis data indicated, the salt prepared is pantoprazoie magnesium in anhydrous form. Description of the invention
  • the dihydrate of the magnesium salt of pantoprazoie has very surprising stability properties which make it appear to be particularly suitable for use in solid or oral administration forms. It exhibits very considerably improved stability properties both in comparison with pantoprazoie itself and in comparison to pantoprazoie sodium sesquihydrate (the active compound form on the market since 1994, European Patent 0 589 981 ), or in comparison to pantoprazoie sodium monohydrate (the intermediate form used in the industrial preparation, European Patent 0 533 790).
  • pantoprazoie magnesium dihydrate is completely stable for 4 days at 90°C and exhibits almost no discoloration or decomposition, while pantoprazoie sodium sesquihydrate and monohydrate turn brown-red in the same period with formation of considerable amounts of decomposition products.
  • the invention thus relates to the dihydrate of the magnesium salt of pantoprazoie (pantoprazoie magnesium dihydrate).
  • Pantoprazoie magnesium dihydrate can be employed for the treatment and prevention of all the diseases which are considered to be treatable or avoidable by the use of pyridin-2-ylmethylsulfinyl- 1 H-benzimidazoles.
  • pantoprazoie magnesium dihydrate can be employed in the treatment of disorders of the stomach.
  • pantoprazoie magnesium dihydrate On account of its solubility properties, possibilities of application for pantoprazoie magnesium dihydrate are conceivable for whose realization resort had to be made up to now to particular pharmaceutical preparations. Thus use of pantoprazoie magnesium dihydrate is particularly suitable, inter alia, where the active compound is to be released and absorbed over a relatively long period (see, for example, European Patent Application 0 841 903).
  • pantoprazoie magnesium dihydrate is prepared in a manner known per se by reaction of pantoprazoie or a readily soluble pantoprazoie salt (e.g. pantoprazoie sodium) with a magnesium salt in water or in mixtures of water with polar organic solvents (e.g. alcohols, preferably ethanol or isopropanol, or ketones, for example acetone or butanone).
  • a readily soluble pantoprazoie salt e.g. pantoprazoie sodium
  • a magnesium salt e.g. pantoprazoie sodium
  • polar organic solvents e.g. alcohols, preferably ethanol or isopropanol, or ketones, for example acetone or butanone.
  • Suitable magnesium salts which can be employed according to the process are, for example, magnesium chloride, bromide, fluoride, iodide, formate, acetate, propionate, sulfate, gluconate or carbonate.
  • Alkoxides of magnesium e.g. magnesium methoxide, ethoxide, (iso)propoxide, butoxide, hexoxide or phenoxide
  • magnesium hydroxide can also be reacted with pantoprazoie or pantoprazoie sodium in aqueous medium.
  • pantoprazoie Na sesquihydrate [sodium [5-[difluoromethoxy]-2-[[3,4-dimethoxy- 2-pyridinyl]methyl]sulfinyl]-1 H-benzimidazolide]sesquihydrate] are dissolved at 20-25°C in 38.5 1 of purified water in a stirring vessel.
  • a solution of 1.0 kg (4.90 mol) of magnesium dichloride hexahydrate in 8 I of purified water is added with stirring at 20-30°C in the course of 3 to 4 h.
  • the precipitated solid is centrifuged, washed with 23 I of purified water, stirred at 20-30°C for 1 to 2 h in 35 I of purified water, centrifuged again and washed again with 30-50 I of purified water.
  • the solid product is dried at 50°C in vacuo (30-50 mbar) until a residual water content of ⁇ 4.8% is achieved. The product is then ground.
  • the title compound is obtained as a white to beige powder, which is employed directly for further pharmaceutical processing.
  • the title compound can be produced using mixtures of organic solvents with water.
  • pantoprazoie Na sesquihydrate is dissolved in an organic solvent at 50-60°C.
  • 0.5 mole equivalents of the magnesium salt e. g. magnesium chloride hexahydrate
  • the solution is allowed to cool with stirring.
  • the precipitated solid is filtered off, washed with the corresponding organic solvent and is dried in vacuo at 50°C to constant weight.
  • the title compound is obtained as a colourless powder. Examples for different solvents are given in the following table 1.
  • the title compound can be produced by reacting pantoprazoie with a basic magnesium salt, such as magnesium methylate, for example in the following manner: 90 g of pantoprazoie are dissolved in 700 ml of 2-propanol at 60-70°C. 13.4 g (0.5 moles) of solid magnesium methylate are added, the solution is allowed to cool with stirring and filtered. After addition of 36 ml of water the crystalline solid formed is filtered off, washed with water and dried in vacuo at 50°C to constant weight. The title compound of melting point 194-196°C (water content 4.8 %) is obtained as beige solid.
  • a basic magnesium salt such as magnesium methylate

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Detergent Compositions (AREA)
  • Manufacture And Refinement Of Metals (AREA)
  • Drying Of Gases (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

L'invention porte sur un dihydrate du sel de magnésium du pantoprazole.
PCT/EP1999/005928 1998-08-18 1999-08-12 Nouvelle forme de sel de pantoprazole WO2000010995A1 (fr)

Priority Applications (26)

Application Number Priority Date Filing Date Title
MXPA01001758A MXPA01001758A (es) 1998-08-18 1999-08-12 Nueva forma de sal de patnoprasol.
AU55156/99A AU761715B2 (en) 1998-08-18 1999-08-12 Novel salt form of pantoprazole
IL14132899A IL141328A0 (en) 1998-08-18 1999-08-12 Pantoprazole magnesium dihydrat
HU0103257A HU226618B1 (en) 1998-08-18 1999-08-12 Dihidrate of the magnesium salt of pantoprazole and pharmaceutical compositions containing it
MEP-847/08A ME00562A (en) 1998-08-18 1999-08-12 Novel salt form of pantoprazole
PL345993A PL198801B1 (pl) 1998-08-18 1999-08-12 Nowa postać soli pantoprazolu
IL14115799A IL141157A0 (en) 1998-08-18 1999-08-12 Salt form of pantoprazole and pharmaceutical compositions containing the same
US09/762,303 US6410569B1 (en) 1998-08-18 1999-08-12 Salt form of pantoprazole
EA200100208A EA004431B1 (ru) 1998-08-18 1999-08-12 Новая форма соли пантопразола, ее применение и лекарственное средство (варианты)
EP99941605A EP1105386B1 (fr) 1998-08-18 1999-08-12 Nouvelle forme de sel de pantoprazole
SI9930096T SI1105386T1 (en) 1998-08-18 1999-08-12 Novel salt form of pantoprazole
DK99941605T DK1105386T3 (da) 1998-08-18 1999-08-12 Hidtil ukendt saltform af pantoprazol
DE1999601840 DE122005000049I2 (de) 1998-08-18 1999-08-12 Neue Salzform von Pantoprazol
CA002341031A CA2341031C (fr) 1998-08-18 1999-08-12 Forme de sel de pantoprazole
BR9914288-0A BR9914288A (pt) 1998-08-18 1999-08-12 Forma de sal de pantoprazol
SK236-2001A SK285105B6 (sk) 1998-08-18 1999-08-12 Dihydrát pantoprazolu horečnatého, farmaceutický prostriedok s jeho obsahom a jeho použitie
EEP200100054A EE04278B1 (et) 1998-08-18 1999-08-12 Pantoprasoolmagneesiumdihüdraat, seda sisaldav ravim ja selle kasutamine
AT99941605T ATE219074T1 (de) 1998-08-18 1999-08-12 Neue salzform von pantoprazol
NZ509761A NZ509761A (en) 1998-08-18 1999-08-12 Pantoprazole magnesium dihydrate and pharmaceuticals thereof
JP2000566268A JP2002523411A (ja) 1998-08-18 1999-08-12 パントプラゾールの新規の塩の形
DE69901840T DE69901840T2 (de) 1998-08-18 1999-08-12 Neue salzform von pantoprazol
UA2001021133A UA58605C2 (uk) 1998-08-18 1999-12-08 Дигідрат пантопразолу магнію та лікарський засіб на його основі (варіанти)
IL141157A IL141157A (en) 1998-08-18 2001-01-29 Pentoprazole Magnesium Dihydrate, Salt of Pentoprazole and Pharmaceuticals Containing It
NO20010718A NO319782B1 (no) 1998-08-18 2001-02-12 Pantoprazol-magnesiumdihydrat, medikamenter inneholdende denne og anvendelsen derav
HR20010117A HRP20010117B1 (en) 1998-08-18 2001-02-16 Novel salt form of pantoprazole
HK01108172A HK1037616A1 (en) 1998-08-18 2001-11-20 Novel salt form of pantoprazole

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19843413A DE19843413C1 (de) 1998-08-18 1998-08-18 Neue Salzform von Pantoprazol
DE19843413.8 1998-08-18

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/762,303 A-371-Of-International US6410569B1 (en) 1998-08-18 1999-08-12 Salt form of pantoprazole
US10/135,528 Continuation US6686379B2 (en) 1998-08-18 2002-05-01 Salt form of pantoprazole

Publications (1)

Publication Number Publication Date
WO2000010995A1 true WO2000010995A1 (fr) 2000-03-02

Family

ID=7881823

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/005928 WO2000010995A1 (fr) 1998-08-18 1999-08-12 Nouvelle forme de sel de pantoprazole

Country Status (33)

Country Link
US (2) US6410569B1 (fr)
EP (1) EP1105386B1 (fr)
JP (1) JP2002523411A (fr)
KR (1) KR100657835B1 (fr)
CN (1) CN1146558C (fr)
AT (1) ATE219074T1 (fr)
AU (1) AU761715B2 (fr)
BG (1) BG65255B1 (fr)
BR (1) BR9914288A (fr)
CA (1) CA2341031C (fr)
CZ (1) CZ293734B6 (fr)
DE (3) DE19843413C1 (fr)
DK (1) DK1105386T3 (fr)
EA (1) EA004431B1 (fr)
EE (1) EE04278B1 (fr)
ES (1) ES2178896T3 (fr)
HK (1) HK1037616A1 (fr)
HR (1) HRP20010117B1 (fr)
HU (1) HU226618B1 (fr)
IL (3) IL141328A0 (fr)
ME (1) ME00562A (fr)
MX (1) MXPA01001758A (fr)
NO (1) NO319782B1 (fr)
NZ (1) NZ509761A (fr)
PL (1) PL198801B1 (fr)
PT (1) PT1105386E (fr)
RS (1) RS50071B (fr)
SI (1) SI1105386T1 (fr)
SK (1) SK285105B6 (fr)
TR (1) TR200100287T2 (fr)
UA (1) UA58605C2 (fr)
WO (1) WO2000010995A1 (fr)
ZA (1) ZA200100934B (fr)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004013126A1 (fr) * 2002-07-29 2004-02-12 Altana Pharma Ag Sel de (s)-pantoprazole et ses hydrates
WO2005012289A1 (fr) * 2003-07-17 2005-02-10 Altana Pharma Ag Nouveau sel de (r) - pantoprazole
WO2005074898A2 (fr) * 2004-01-28 2005-08-18 Altana Pharma Ag Nouvelle combinaison pour le traitement d'helicobacter pylori
WO2005074929A2 (fr) * 2004-01-28 2005-08-18 Altana Pharma Ag Nouveaux sels de pantoprazole et de (s)-pantoprazole
WO2005077936A1 (fr) * 2004-02-11 2005-08-25 Ulkar Kimya Sanayii Ve Ticaret A.S. Sulfoxydes pyridine benzimidazole d'une grande purete
WO2005082888A1 (fr) * 2004-03-01 2005-09-09 Milen Merkez Ilac Endustrisi A.S. Procede de preparation d'un sel magnesique d'omeprazole
US7351723B2 (en) * 2000-11-22 2008-04-01 Nycomed Gmbh Freeze-dried pantoprazole preparation and pantoprazole injection
WO2008057559A1 (fr) * 2006-11-06 2008-05-15 Teva Pharmaceutical Industries Ltd. Procédés de préparation de pantoprazole magnésium sensiblement pur
AU2004237363B2 (en) * 2003-05-08 2009-12-10 Takeda Gmbh Dosage form containing pantoprazole as active ingredient
AU2004237364B2 (en) * 2003-05-08 2010-02-18 Takeda Gmbh Dosage form containing (S)-pantoprazole as active ingredient
US7683177B2 (en) 2003-06-10 2010-03-23 Teva Pharmaceutical Industries Ltd Process for preparing 2-[(pyridinyl)methyl]sulfinyl-substituted benzimidazoles and novel chlorinated derivatives of pantoprazole
US7915423B2 (en) 2002-12-19 2011-03-29 Teva Pharmaceutical Industries, Ltd. Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
DE10234617B4 (de) * 2002-07-29 2013-04-04 Nycomed Gmbh Neues Salz von (S)-Pantoprazol

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19843413C1 (de) * 1998-08-18 2000-03-30 Byk Gulden Lomberg Chem Fab Neue Salzform von Pantoprazol
CA2524268A1 (fr) * 2003-05-06 2004-11-18 Altana Pharma Ag Agents pour le traitement de troubles du bas-ventre
WO2004100949A2 (fr) * 2003-05-19 2004-11-25 Pliva-Istrazivanje I Razvoj D.O.O. Nouvelles formes a l'etat solide de complexes eau/sodium de 5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]sulfinyl]-1h-benzimidazole
CN100457104C (zh) * 2003-07-23 2009-02-04 尼科梅德有限责任公司 质子泵抑制剂的碱性盐
ATE386522T1 (de) * 2003-07-23 2008-03-15 Nycomed Gmbh Alkalisalze von protonenpumpen-hemmern
WO2005074931A1 (fr) * 2004-01-28 2005-08-18 Altana Pharma Ag Produits composes pharmaceutiques comprenant (s)-pantoprazole
WO2005074932A1 (fr) * 2004-01-28 2005-08-18 Altana Pharma Ag Utilisation de (s)-pantoprazole magnesium pour le traitement de troubles des voies respiratoires
WO2005074930A1 (fr) * 2004-01-28 2005-08-18 Altana Pharma Ag Combinaisons pharmaceutiques de (s) -pantoprazole avec nsaid ou des corticosteroides
WO2005107721A2 (fr) * 2004-05-07 2005-11-17 Altana Pharma Ag Forme galenique pharmaceutique et procede de fabrication de celle-ci
WO2007041790A1 (fr) * 2005-10-14 2007-04-19 Jon Pty Limited Sels d'inhibiteurs de la pompe à protons et procédé servant à préparer ceux-ci
US20080139623A1 (en) 2006-06-12 2008-06-12 Lilach Hedvati Amorphous and crystalline forms of pantoprazole magnesium salt
EP3187494A1 (fr) * 2015-12-30 2017-07-05 KRKA, tovarna zdravil, d.d., Novo mesto Procede de preparation de pantoprazole sodium sesquihdrate
SI3397630T1 (sl) * 2015-12-30 2021-11-30 Krka, tovarna zdravil, d.d., Novo mesto, Postoek za pripravo natrijevega pantoprazolata seskvihidrata

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EP0166287A1 (fr) * 1984-06-16 1986-01-02 Byk Gulden Lomberg Chemische Fabrik GmbH Dialcoxypyridines, procédé pour leur préparation, leur application et médicaments les contenant
WO1991019710A1 (fr) * 1990-06-11 1991-12-26 Byk Gulden Lomberg Chemische Fabrik Gmbh Nouvelle forme de sel
WO1995001977A1 (fr) * 1993-07-09 1995-01-19 Astra Aktiebolag Omeprazole de magnesium
EP0589981B1 (fr) * 1991-06-17 1996-10-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Formes de presentation d'un medicament contenant du pantoprazol et administre par voie orale
WO1997041114A1 (fr) * 1996-04-26 1997-11-06 Astra Aktiebolag Procede de preparation d'un sel de magnesium d'un heterocycle sulfinyl substitue

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SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
SE9600070D0 (sv) * 1996-01-08 1996-01-08 Astra Ab New oral pharmaceutical dosage forms
DE19843413C1 (de) * 1998-08-18 2000-03-30 Byk Gulden Lomberg Chem Fab Neue Salzform von Pantoprazol

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0166287A1 (fr) * 1984-06-16 1986-01-02 Byk Gulden Lomberg Chemische Fabrik GmbH Dialcoxypyridines, procédé pour leur préparation, leur application et médicaments les contenant
WO1991019710A1 (fr) * 1990-06-11 1991-12-26 Byk Gulden Lomberg Chemische Fabrik Gmbh Nouvelle forme de sel
EP0589981B1 (fr) * 1991-06-17 1996-10-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Formes de presentation d'un medicament contenant du pantoprazol et administre par voie orale
WO1995001977A1 (fr) * 1993-07-09 1995-01-19 Astra Aktiebolag Omeprazole de magnesium
WO1997041114A1 (fr) * 1996-04-26 1997-11-06 Astra Aktiebolag Procede de preparation d'un sel de magnesium d'un heterocycle sulfinyl substitue

Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8754108B2 (en) 2000-11-22 2014-06-17 Takeda, GmbH Freeze-dried pantoprazole preparation and pantoprazole injection
US7351723B2 (en) * 2000-11-22 2008-04-01 Nycomed Gmbh Freeze-dried pantoprazole preparation and pantoprazole injection
CN1312150C (zh) * 2002-07-29 2007-04-25 艾塔那法玛公司 (s)－泛托派唑镁水合物及其药物和用途
DE10234617B4 (de) * 2002-07-29 2013-04-04 Nycomed Gmbh Neues Salz von (S)-Pantoprazol
US7629361B2 (en) 2002-07-29 2009-12-08 Nycomed Gmbh Salt of (S)-pantoprazole and its hydrates
WO2004013126A1 (fr) * 2002-07-29 2004-02-12 Altana Pharma Ag Sel de (s)-pantoprazole et ses hydrates
US7915423B2 (en) 2002-12-19 2011-03-29 Teva Pharmaceutical Industries, Ltd. Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates
AU2004237364B2 (en) * 2003-05-08 2010-02-18 Takeda Gmbh Dosage form containing (S)-pantoprazole as active ingredient
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CA2341031A1 (fr) 2000-03-02
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US6410569B1 (en) 2002-06-25
MXPA01001758A (es) 2002-04-17
NO20010718L (no) 2001-02-12
EP1105386A1 (fr) 2001-06-13
YU11301A (sh) 2003-12-31
DE122005000049I2 (de) 2007-03-29
NO319782B1 (no) 2005-09-12
ZA200100934B (en) 2002-03-04
EA004431B1 (ru) 2004-04-29
DE122005000049I1 (de) 2006-12-28
PT1105386E (pt) 2002-11-29
HRP20010117B1 (en) 2010-07-31
TR200100287T2 (tr) 2001-07-23
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DK1105386T3 (da) 2002-09-30
BG65255B1 (bg) 2007-10-31
EE200100054A (et) 2002-06-17
DE19843413C1 (de) 2000-03-30
US20020188008A1 (en) 2002-12-12
HUP0103257A2 (hu) 2002-02-28
CN1146558C (zh) 2004-04-21
KR20010072487A (ko) 2001-07-31
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EE04278B1 (et) 2004-04-15
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CA2341031C (fr) 2006-04-04
CN1318065A (zh) 2001-10-17
EP1105386B1 (fr) 2002-06-12
ME00562B (fr) 2011-12-20
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