+

WO2000007728A3 - Micro-systeme a multiples points d'analyse chimique ou biologique - Google Patents

Micro-systeme a multiples points d'analyse chimique ou biologique Download PDF

Info

Publication number
WO2000007728A3
WO2000007728A3 PCT/FR1999/001900 FR9901900W WO0007728A3 WO 2000007728 A3 WO2000007728 A3 WO 2000007728A3 FR 9901900 W FR9901900 W FR 9901900W WO 0007728 A3 WO0007728 A3 WO 0007728A3
Authority
WO
WIPO (PCT)
Prior art keywords
micro
cup
chemical
multiple points
electrode
Prior art date
Application number
PCT/FR1999/001900
Other languages
English (en)
Other versions
WO2000007728A2 (fr
Inventor
Patrice Caillat
Jean-Frederic Clerc
Original Assignee
Commissariat Energie Atomique
Patrice Caillat
Clerc Jean Frederic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat Energie Atomique, Patrice Caillat, Clerc Jean Frederic filed Critical Commissariat Energie Atomique
Priority to US09/744,252 priority Critical patent/US6630359B1/en
Priority to EP99936658A priority patent/EP1101102A2/fr
Priority to JP2000563399A priority patent/JP4562914B2/ja
Publication of WO2000007728A2 publication Critical patent/WO2000007728A2/fr
Publication of WO2000007728A3 publication Critical patent/WO2000007728A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00709—Type of synthesis
    • B01J2219/00713—Electrochemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

L'invention concerne un micro-système à multiples points d'analyse chimique ou biologique constitué par une structure pourvue de micro-cuvettes (7), chaque micro-cuvette étant destinée à recevoir un réactif (14a, 15a, 16a) couplé à un polymère conducteur, chaque micro-cuvette possédant une électrode de réception (9a) sur laquelle est fixé le réactif par l'intermédiaire du polymère conducteur auquel il est couplé, chaque micro-cuvette possédant une contre-électrode (9b) disposée de façon à pouvoir appliquer, dans un volume de la micro-cuvette, un champ électrique entre sa contre-électrode et son électrode de réception, la structure possédant des moyens permettant de relier simultanément toutes les électrodes de réception à un premier potentiel électrique et des moyens permettant de relier simultanément toutes les contre-électrodes à un deuxième potentiel électrique pour pouvoir établir ledit champ électrique.
PCT/FR1999/001900 1998-07-31 1999-07-30 Micro-systeme a multiples points d'analyse chimique ou biologique WO2000007728A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US09/744,252 US6630359B1 (en) 1998-07-31 1999-07-30 Micro-system with multiple points for chemical or biological analysis
EP99936658A EP1101102A2 (fr) 1998-07-31 1999-07-30 Micro-systeme a multiples points d'analyse chimique ou biologique
JP2000563399A JP4562914B2 (ja) 1998-07-31 1999-07-30 化学的または生物学的分析マルチポイントマイクロシステム

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR98/09868 1998-07-31
FR9809868A FR2781886B1 (fr) 1998-07-31 1998-07-31 Micro-systeme a multiple points d'analyse chimique ou biologique

Publications (2)

Publication Number Publication Date
WO2000007728A2 WO2000007728A2 (fr) 2000-02-17
WO2000007728A3 true WO2000007728A3 (fr) 2000-05-11

Family

ID=9529280

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1999/001900 WO2000007728A2 (fr) 1998-07-31 1999-07-30 Micro-systeme a multiples points d'analyse chimique ou biologique

Country Status (5)

Country Link
US (1) US6630359B1 (fr)
EP (1) EP1101102A2 (fr)
JP (1) JP4562914B2 (fr)
FR (1) FR2781886B1 (fr)
WO (1) WO2000007728A2 (fr)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2789401B1 (fr) * 1999-02-08 2003-04-04 Cis Bio Int Procede de fabrication de matrices de ligands adresses sur un support
EP1218098A1 (fr) * 1999-09-09 2002-07-03 Ben-Gurion University Of The Negev Matrices de sondes et preparation de celles-ci
US6645359B1 (en) * 2000-10-06 2003-11-11 Roche Diagnostics Corporation Biosensor
EP1094318B1 (fr) * 1999-10-22 2007-03-28 Ngk Insulators, Ltd. Chip d'ADN et sa préparation
WO2001094666A2 (fr) * 2000-06-08 2001-12-13 Ylektra Inc. Plate-forme d'electrolyse adressable spatialement et procedes d'utilisation
WO2002016904A2 (fr) 2000-08-23 2002-02-28 Imego Ab Procede et systeme de preparation d'echantillons
US7998746B2 (en) 2000-08-24 2011-08-16 Robert Otillar Systems and methods for localizing and analyzing samples on a bio-sensor chip
US20020048821A1 (en) 2000-08-24 2002-04-25 David Storek Sample preparing arrangement and a method relating to such an arrangement
WO2002066969A1 (fr) * 2001-02-19 2002-08-29 Kyowa Medex Co., Ltd. Detecteur de composant charge, son procede d'utilisation et un panneau de detection
FR2824143B1 (fr) * 2001-04-27 2003-06-27 Commissariat Energie Atomique Utilisations d'un dispositif miniature de separation et d'isolement d'objets biologiques et procedes mis en oeuvre
FR2823999B1 (fr) * 2001-04-27 2003-06-27 Commissariat Energie Atomique Dispositif miniature de separation et d'isolement d'objets biologiques et utilisations
EP2423673B8 (fr) 2001-06-29 2020-10-28 Meso Scale Technologies, LLC. Appareil pour mesurer la luminescence à partir d'une plaque d'essai à puits multiples ayant une pluralité de puits, procédé de mesure de la luminescence à l'aide de l'appareil et système comprenant l'appareil
US7074519B2 (en) * 2001-10-26 2006-07-11 The Regents Of The University Of California Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device
FR2834299B1 (fr) * 2001-12-27 2004-05-21 Commissariat Energie Atomique Procede de fixation par electrodeposition de reactifs sur une face plane d'un substrat
DE10164358C2 (de) * 2001-12-28 2003-11-27 Advalytix Ag Charakterisierungsverfahren für funktionalisierte Oberflächen
ES2191553B2 (es) * 2002-01-22 2005-02-01 Universitat Rovira I Virgili Metodo para la fabricacion de chips para la deteccion de analitos.
FR2836071B1 (fr) * 2002-02-21 2005-02-04 Commissariat Energie Atomique Composant pour microsysteme d'analyse biologique ou biochimique
US20050100938A1 (en) * 2002-03-14 2005-05-12 Infineon Technologies Ag Vertical impedance sensor arrangement and method for producing a vertical impedance sensor arrangement
GB2386949A (en) * 2002-03-26 2003-10-01 Sensor Tech Ltd A multiwell plate for electrochemical detection
US7560269B2 (en) 2002-12-20 2009-07-14 Acea Biosciences, Inc. Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
US7468255B2 (en) * 2002-12-20 2008-12-23 Acea Biosciences Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
US7470533B2 (en) 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
WO2005047482A2 (fr) 2003-11-12 2005-05-26 Xiao Xu Systemes de detection de cellules electroniques en temps reel pour des epreuves a base de cellules
US7732127B2 (en) 2002-12-20 2010-06-08 Acea Biosciences, Inc. Dynamic monitoring of cell adhesion and spreading using the RT-CES system
DE60330022D1 (de) * 2002-07-20 2009-12-24 Acea Biosciences Inc Vorrichtungen auf impedanzbasis sowie verfahren zur verwendung in assays
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US8206903B2 (en) 2002-12-20 2012-06-26 Acea Biosciences Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses
US20040099531A1 (en) * 2002-08-15 2004-05-27 Rengaswamy Srinivasan Methods and apparatus for electrochemically testing samples for constituents
FR2843829A1 (fr) * 2002-08-26 2004-02-27 Commissariat Energie Atomique Support de garniture par voie electrochimique, systeme d'adressage d'un tel support, et procede pour un depot selectif
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
US10215748B2 (en) 2002-12-20 2019-02-26 Acea Biosciences, Inc. Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways
US10539523B2 (en) 2002-12-20 2020-01-21 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology, and electrophysiological properties
US10551371B2 (en) 2003-11-10 2020-02-04 Acea Biosciences, Inc. System and method for monitoring cardiomyocyte beating, viability and morphology and for screening for pharmacological agents which may induce cardiotoxicity or modulate cardiomyocyte function
US9709548B2 (en) 2008-05-05 2017-07-18 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
US9612234B2 (en) 2008-05-05 2017-04-04 Acea Biosciences, Inc. Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments
FR2855269B1 (fr) 2003-05-21 2007-06-08 Commissariat Energie Atomique Dispositif et procedes d'accrochage/decrochage d'une cible ou d'un objet present dans un echantillon
US20080070803A1 (en) * 2003-10-15 2008-03-20 Egeland Ryan D Electrochemical Treatment Of Substrates
DE102004024364A1 (de) * 2004-05-17 2005-12-15 Apibio Sas Verfahren zur Herstellung von Polymeren
US8940143B2 (en) 2007-06-29 2015-01-27 Intel Corporation Gel-based bio chip for electrochemical synthesis and electrical detection of polymers
US8053774B2 (en) 2005-06-06 2011-11-08 Intel Corporation Method and apparatus to fabricate polymer arrays on patterned wafers using electrochemical synthesis
AU2006350566B2 (en) 2005-12-21 2012-02-09 Meso Scale Technologies, Llc Assay apparatuses, methods and reagents
US8246910B2 (en) * 2006-03-16 2012-08-21 Universal Nanosensor Technologies Inc. Dielectric sensing method and system
US20120284921A9 (en) * 2006-03-17 2012-11-15 Monica Blake Ross Sheet set for a sofa
FR2901884B1 (fr) * 2006-05-31 2008-09-05 Commissariat Energie Atomique Procede, dispositif et systeme de microanalyse d'ions
US8041515B2 (en) * 2006-09-20 2011-10-18 Acea Biosciences, Inc. Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents
FR2916367B1 (fr) * 2007-05-25 2009-07-31 Commissariat Energie Atomique Procede de fixation sur un microsysteme de composes a liaisons peptidiques, tels que des proteines, et microsysteme incorporant ces composes.
JP4914403B2 (ja) * 2008-05-29 2012-04-11 日本電信電話株式会社 細胞外マイクロ電極及びその製造方法
JP6586884B2 (ja) * 2013-11-07 2019-10-09 コニカミノルタ株式会社 チップおよび表面プラズモン増強蛍光測定方法
US12066428B2 (en) 2015-11-20 2024-08-20 Agilent Technologies, Inc. Cell-substrate impedance monitoring of cancer cells
WO2018161063A1 (fr) 2017-03-03 2018-09-07 Acea Biosciences, Inc. Procédés et systèmes pour la maturation fonctionnelle de cardiomyocytes dérivés de cspi et de cellule se
US10498001B2 (en) 2017-08-21 2019-12-03 Texas Instruments Incorporated Launch structures for a hermetically sealed cavity
US10775422B2 (en) 2017-09-05 2020-09-15 Texas Instruments Incorporated Molecular spectroscopy cell with resonant cavity
US10589986B2 (en) 2017-09-06 2020-03-17 Texas Instruments Incorporated Packaging a sealed cavity in an electronic device
US10444102B2 (en) 2017-09-07 2019-10-15 Texas Instruments Incorporated Pressure measurement based on electromagnetic signal output of a cavity
US10424523B2 (en) 2017-09-07 2019-09-24 Texas Instruments Incorporated Hermetically sealed molecular spectroscopy cell with buried ground plane
US10131115B1 (en) 2017-09-07 2018-11-20 Texas Instruments Incorporated Hermetically sealed molecular spectroscopy cell with dual wafer bonding
US10551265B2 (en) 2017-09-07 2020-02-04 Texas Instruments Incorporated Pressure sensing using quantum molecular rotational state transitions
US10549986B2 (en) 2017-09-07 2020-02-04 Texas Instruments Incorporated Hermetically sealed molecular spectroscopy cell
US10544039B2 (en) * 2017-09-08 2020-01-28 Texas Instruments Incorporated Methods for depositing a measured amount of a species in a sealed cavity
CN110743643B (zh) * 2019-11-27 2021-11-30 南京轩世琪源软件科技有限公司 一种培养基制备机的试管架
USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
US20210301245A1 (en) 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402917A2 (fr) * 1989-06-15 1990-12-19 Biocircuits Corporation Biocapteurs utilisant des signaux électriques, optiques et mécaniques
WO1993006237A1 (fr) * 1991-09-13 1993-04-01 Allage Associates, Inc. Procede analytique pour dispositifs chimiques et biodetecteurs formes a partir de films minces polymeres electroactifs
WO1996028538A1 (fr) * 1995-03-10 1996-09-19 Meso Scale Technologies, Llc Essai par electrochimioluminescence multispecifique et multirangee
US5653939A (en) * 1991-11-19 1997-08-05 Massachusetts Institute Of Technology Optical and electrical methods and apparatus for molecule detection
US5776791A (en) * 1995-11-17 1998-07-07 Commissariat A L'energie Atomique Process for collective manufacture of chips with electrodes selectively covered by a deposit

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4886625A (en) * 1987-10-29 1989-12-12 Miles Inc. Functionalized conducting polymers and their use in diagnostic devices
GB9325946D0 (en) * 1993-12-18 1994-02-23 Japat Ltd Protein absorbed shapable electroconductive polymer film
US6103552A (en) * 1998-08-10 2000-08-15 Lin; Mou-Shiung Wafer scale packaging scheme

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0402917A2 (fr) * 1989-06-15 1990-12-19 Biocircuits Corporation Biocapteurs utilisant des signaux électriques, optiques et mécaniques
WO1993006237A1 (fr) * 1991-09-13 1993-04-01 Allage Associates, Inc. Procede analytique pour dispositifs chimiques et biodetecteurs formes a partir de films minces polymeres electroactifs
US5653939A (en) * 1991-11-19 1997-08-05 Massachusetts Institute Of Technology Optical and electrical methods and apparatus for molecule detection
WO1996028538A1 (fr) * 1995-03-10 1996-09-19 Meso Scale Technologies, Llc Essai par electrochimioluminescence multispecifique et multirangee
US5776791A (en) * 1995-11-17 1998-07-07 Commissariat A L'energie Atomique Process for collective manufacture of chips with electrodes selectively covered by a deposit

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
COSNIER, S.: "Electropolymerization of amphiphilic monomers for designing amperometric biosensors.", ELECTROANALYSIS, vol. 9, no. 12, 1997, pages 894 - 902, XP002101569 *

Also Published As

Publication number Publication date
FR2781886B1 (fr) 2001-02-16
WO2000007728A2 (fr) 2000-02-17
EP1101102A2 (fr) 2001-05-23
US6630359B1 (en) 2003-10-07
FR2781886A1 (fr) 2000-02-04
JP4562914B2 (ja) 2010-10-13
JP2002522749A (ja) 2002-07-23

Similar Documents

Publication Publication Date Title
WO2000007728A3 (fr) Micro-systeme a multiples points d'analyse chimique ou biologique
Figeys et al. Nanoflow solvent gradient delivery from a microfabricated device for protein identifications by electrospray ionization mass spectrometry
US8864967B2 (en) Device for moving and treating volumes of liquid
PT988533E (pt) Biossensor compreendendo uma membrana lipidica contendo canais ionicos de abertura controlada
GB0116384D0 (en) Microfluidic chemical assay apparatus and method
WO2005059513A3 (fr) Systeme et procede de detection electrochimique multiplexe
ATE297551T1 (de) Mikroelektrodensystem
CA2329564A1 (fr) Cellule pour l'analyse electrochimique d'un echantillon et methode connexe
AU3150895A (en) Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
WO2000049385A3 (fr) Procede et appareil d'analyse des globules dans un echantillon de sang entier
CA2199515A1 (fr) Systeme de diagnostic automatise de biologie moleculaire
CA2150791A1 (fr) Biocapteur et son mode de production
WO2004061418A3 (fr) Cartouches d'essai et procedes d'utilisation
ATE223498T1 (de) Elektrochemische erkennung von nukleinsäurehybridation
WO2000071742A3 (fr) Genomique fonctionnelle a fort rendement
ATE419527T1 (de) Mikrovorrichtung zum screening von biomolekülen
WO2003019139A3 (fr) Dispositif de separation d'analyte multicanal utilisant une excitation d'entree laterale
Kang et al. High-throughput comprehensive peptide mapping of proteins by multiplexed capillary electrophoresis
WO2003098661A3 (fr) Systeme de detection de risques chimiques et biologiques et leurs procedes
WO2004011144A3 (fr) Support polymere transparent pour l'electrophorese et procedes associes
JP2002031617A5 (fr)
Yang et al. Two-dimensional capillary electrophoresis involving capillary isoelectric focusing and capillary zone electrophoresis
WO2001077658A3 (fr) Cassette destine a l'electrophorese en gel sans tampon
WO2003087771A3 (fr) Procede de fabrication d'une surface lisse au niveau moleculaire
WO2004012585A3 (fr) Procedes de tests electrophysiologiques

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

WWE Wipo information: entry into national phase

Ref document number: 1999936658

Country of ref document: EP

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 563399

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 09744252

Country of ref document: US

WWP Wipo information: published in national office

Ref document number: 1999936658

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载