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WO2000007582A3 - Use of thiazolidinedione derivatives for the treatment or prevention of cataracts - Google Patents

Use of thiazolidinedione derivatives for the treatment or prevention of cataracts Download PDF

Info

Publication number
WO2000007582A3
WO2000007582A3 PCT/US1999/013810 US9913810W WO0007582A3 WO 2000007582 A3 WO2000007582 A3 WO 2000007582A3 US 9913810 W US9913810 W US 9913810W WO 0007582 A3 WO0007582 A3 WO 0007582A3
Authority
WO
WIPO (PCT)
Prior art keywords
cataracts
prevention
treatment
thiazolidinedione derivatives
derivatives
Prior art date
Application number
PCT/US1999/013810
Other languages
French (fr)
Other versions
WO2000007582A2 (en
Inventor
John Hardwick Johnson
Original Assignee
Warner Lambert Co
John Hardwick Johnson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co, John Hardwick Johnson filed Critical Warner Lambert Co
Priority to AU46949/99A priority Critical patent/AU4694999A/en
Publication of WO2000007582A2 publication Critical patent/WO2000007582A2/en
Publication of WO2000007582A3 publication Critical patent/WO2000007582A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention provides a method of using thiazolidinone derivatives to treat or prevent cataracts.
PCT/US1999/013810 1998-08-06 1999-06-18 Use of thiazolidinedione derivatives for the treatment or prevention of cataracts WO2000007582A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU46949/99A AU4694999A (en) 1998-08-06 1999-06-18 Use of thiazolidinedione derivatives for the treatment or prevention of cataracts

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9551898P 1998-08-06 1998-08-06
US60/095,518 1998-08-06

Publications (2)

Publication Number Publication Date
WO2000007582A2 WO2000007582A2 (en) 2000-02-17
WO2000007582A3 true WO2000007582A3 (en) 2000-06-22

Family

ID=22252372

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/013810 WO2000007582A2 (en) 1998-08-06 1999-06-18 Use of thiazolidinedione derivatives for the treatment or prevention of cataracts

Country Status (5)

Country Link
AR (1) AR021749A1 (en)
CO (1) CO5050324A1 (en)
PE (1) PE20000946A1 (en)
UY (1) UY25643A1 (en)
WO (1) WO2000007582A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2020124373A (en) * 2017-12-28 2022-01-28 Юниверсити Оф Фукуи PREVENTIVE AND/OR THERAPEUTIC AGENT FOR CATARACT, MEDICAL COMPOSITION FOR THE PREVENTION AND/OR TREATMENT OF CATARACT, APPLICATION OF A PPAR ACTIVATOR FOR THE SAME PURPOSE AND EYE DROPS

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0139421A1 (en) * 1983-08-30 1985-05-02 Sankyo Company Limited Thiazolidine derivatives, their preparation and compositions containing them
JPS62234085A (en) * 1985-12-18 1987-10-14 Sankyo Co Ltd Remedy for diabetic complication comprising thiazolidine derivative as active ingredient
EP0277836A1 (en) * 1987-02-04 1988-08-10 Sankyo Company Limited Thiazolidinone derivatives, their preparation and their use
WO1998010760A1 (en) * 1996-09-12 1998-03-19 Sankyo Company, Limited Glutathione reductase activity potentiator containing troglitazone
EP0869126A1 (en) * 1997-04-02 1998-10-07 Sankyo Company Limited Dithiolan derivatives, their preparation and their therapeutic effect

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0139421A1 (en) * 1983-08-30 1985-05-02 Sankyo Company Limited Thiazolidine derivatives, their preparation and compositions containing them
JPS62234085A (en) * 1985-12-18 1987-10-14 Sankyo Co Ltd Remedy for diabetic complication comprising thiazolidine derivative as active ingredient
EP0277836A1 (en) * 1987-02-04 1988-08-10 Sankyo Company Limited Thiazolidinone derivatives, their preparation and their use
WO1998010760A1 (en) * 1996-09-12 1998-03-19 Sankyo Company, Limited Glutathione reductase activity potentiator containing troglitazone
EP0869126A1 (en) * 1997-04-02 1998-10-07 Sankyo Company Limited Dithiolan derivatives, their preparation and their therapeutic effect

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
"Troglitazone, Noscal.RTM..", DRUGS OF THE FUTURE, (1995) 20/9 (974-976)., XP000853998 *
ARAKI, KAZUSI (1) ET AL: "Troglitazone suppresses diabetic nephropathy and cataract formation without decreasing plasma glucose and blood pressure in severely diabetic ZDF rats.", DIABETES, (1999) VOL. 48, NO. SUPPL. 1, PP. A138. MEETING INFO.: 59TH SCIENTIFIC SESSIONS OF THE AMERICAN DIABETES ASSOCIATION SAN DIEGO, CALIFORNIA, USA JUNE 19-22, 1999 AMERICAN DIABETES ASSOCIATION., May 1999 (1999-05-01), XP000856147 *
DATABASE CHEMABS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; HORIKOSHI, HIROYOSHI ET AL: "Pharmaceutical compositions containing thiazolidine derivatives for the treatment of diseases related to diabetes", XP002123769 *
DATABASE CHEMABS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; YOKOYAMA, TOMIHISA ET AL: "Glutathione reductase activity potentiator containing troglitazone", XP002123768 *
DATABASE CHEMABS chemical abstracts service; "Dithiolan derivatives, their preparation, and their therapeutic effect as glutathione reductase enhancers" *
MADAR Z (REPRINT) ET AL: "EFFECT OF CS-045 ON CATARACT APPEARANCE IN SAND RAT MODEL FOR DIABETES TYPE-II", DIABETES, (MAY 1993) VOL. 42, SUPP. 1, PP. A198. ISSN: 0012-1797., XP000853997 *
YOKOYAMA, TOMIHISA ET AL: "Inhibition of galactose-induced cataractogenesis by troglitazone, a new antidiabetic drug with an antioxidant property, in rat lens culture", J. OCUL. PHARMACOL. THER. (1999), 15(1), 73-83, XP000853996 *

Also Published As

Publication number Publication date
AR021749A1 (en) 2002-08-07
WO2000007582A2 (en) 2000-02-17
UY25643A1 (en) 1999-11-17
CO5050324A1 (en) 2001-06-27
PE20000946A1 (en) 2000-10-18

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