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WO2000001719A3 - Peptides from varicella-zoster and other viruses for hiv-2 diagnosis and therapy - Google Patents

Peptides from varicella-zoster and other viruses for hiv-2 diagnosis and therapy Download PDF

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Publication number
WO2000001719A3
WO2000001719A3 PCT/US1999/015114 US9915114W WO0001719A3 WO 2000001719 A3 WO2000001719 A3 WO 2000001719A3 US 9915114 W US9915114 W US 9915114W WO 0001719 A3 WO0001719 A3 WO 0001719A3
Authority
WO
WIPO (PCT)
Prior art keywords
hiv
peptides
loop
varicella
therapy
Prior art date
Application number
PCT/US1999/015114
Other languages
French (fr)
Other versions
WO2000001719A2 (en
Inventor
A Mohammed Chowdhury
David Bernstein
Alexander Kozhich
Marvin Motsenbocker
Original Assignee
Peptide Solutions
A Mohammed Chowdhury
David Bernstein
Alexander Kozhich
Marvin Motsenbocker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peptide Solutions, A Mohammed Chowdhury, David Bernstein, Alexander Kozhich, Marvin Motsenbocker filed Critical Peptide Solutions
Priority to EP99932223A priority Critical patent/EP1091976A2/en
Priority to AU48577/99A priority patent/AU4857799A/en
Publication of WO2000001719A2 publication Critical patent/WO2000001719A2/en
Publication of WO2000001719A3 publication Critical patent/WO2000001719A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Viral chimeric peptides useful for HIV diagnostic testing and therapy of HIV are described which comprise a loop sequence from a Varicella-Zoster virus protein and additional portion(s) that enhance antigenic reactivity of the loop with anti-HIV antibody. The peptides typically are at least 16 amino acid residues long and advantageously contain additional portions that have some sequence identity with peptide sequences adjacent to a cystine loop of HIV-1 gp41. The peptides immunologically cross-react with protein from a wide variety of HIV-2 strains. Peptides according to some embodiments of the invention are less hydrophobic and more basic for improved water solubility compared to peptides from naturally occurring strains of HIV. These chimeric peptides differ greatly from the naturally occurring sequences and are not identified as corresponding to any particular viral species or strain.
PCT/US1999/015114 1998-07-02 1999-07-02 Peptides from varicella-zoster and other viruses for hiv-2 diagnosis and therapy WO2000001719A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99932223A EP1091976A2 (en) 1998-07-02 1999-07-02 Peptides from varicella-zoster and other viruses for hiv-2 diagnosis and therapy
AU48577/99A AU4857799A (en) 1998-07-02 1999-07-02 Peptides from (varicella-zoster) and other viruses for hiv-2 diagnosis and therapy

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US9165998P 1998-07-02 1998-07-02
US60/091,659 1998-07-02
US10468598P 1998-10-16 1998-10-16
US60/104,685 1998-10-16
US11202698P 1998-12-11 1998-12-11
US60/112,026 1998-12-11

Publications (2)

Publication Number Publication Date
WO2000001719A2 WO2000001719A2 (en) 2000-01-13
WO2000001719A3 true WO2000001719A3 (en) 2000-02-24

Family

ID=27376950

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/015114 WO2000001719A2 (en) 1998-07-02 1999-07-02 Peptides from varicella-zoster and other viruses for hiv-2 diagnosis and therapy

Country Status (3)

Country Link
EP (1) EP1091976A2 (en)
AU (1) AU4857799A (en)
WO (1) WO2000001719A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2817604B1 (en) 2000-12-01 2004-04-23 Biomerieux Sa VALVES ACTIVATED BY ELECTRO-ACTIVE POLYMERS OR BY SHAPE MEMORY MATERIALS, DEVICE CONTAINING SUCH VALVES AND METHOD FOR IMPLEMENTING

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995023973A2 (en) * 1994-03-02 1995-09-08 Abbott Laboratories Hiv immunoassay utilizing recombinant protein and synthetic peptide reagents
WO1995033206A1 (en) * 1994-05-31 1995-12-07 Abbott Laboratories Detection of different hiv genotypes utilizing a synthetic peptide-modified immunoassay
WO1999045395A1 (en) * 1998-03-04 1999-09-10 Universal Healthwatch, Inc. Rapid confirmatory test for microbial infections

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995023973A2 (en) * 1994-03-02 1995-09-08 Abbott Laboratories Hiv immunoassay utilizing recombinant protein and synthetic peptide reagents
WO1995033206A1 (en) * 1994-05-31 1995-12-07 Abbott Laboratories Detection of different hiv genotypes utilizing a synthetic peptide-modified immunoassay
WO1999045395A1 (en) * 1998-03-04 1999-09-10 Universal Healthwatch, Inc. Rapid confirmatory test for microbial infections

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AIDS RES. HUM. RETROVIRUSES (1989), 5(5), 487-93, 1989 *
CHEMICAL ABSTRACTS, vol. 112, no. 11, 12 March 1990, Columbus, Ohio, US; abstract no. 96724, NORRBY, ERLING ET AL: "The chemistry of site-directed serology for HIV infections" XP002126794 *
CHEMICAL ABSTRACTS, vol. 122, no. 23, 5 June 1995, Columbus, Ohio, US; abstract no. 288341, TANCHOU, V. ET AL: "B-cell continuous epitopes of the SIVmac-251 envelope protein in experimentally infected macaques" XP002126793 *
RES. VIROL. (1995), 146(1), 19-32, 1995 *

Also Published As

Publication number Publication date
AU4857799A (en) 2000-01-24
EP1091976A2 (en) 2001-04-18
WO2000001719A2 (en) 2000-01-13

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