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WO2000000593A3 - Sphingolipide-denaturase - Google Patents

Sphingolipide-denaturase Download PDF

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Publication number
WO2000000593A3
WO2000000593A3 PCT/DE1999/001859 DE9901859W WO0000593A3 WO 2000000593 A3 WO2000000593 A3 WO 2000000593A3 DE 9901859 W DE9901859 W DE 9901859W WO 0000593 A3 WO0000593 A3 WO 0000593A3
Authority
WO
WIPO (PCT)
Prior art keywords
enzymes
sphingolipids
capnoids
sphingobase
dna sequences
Prior art date
Application number
PCT/DE1999/001859
Other languages
German (de)
English (en)
Other versions
WO2000000593A2 (fr
Inventor
Ernst Heinz
Ulrich Zaehringer
Petra Sperling
Hermann Schmidt
Original Assignee
Gvs Ges Fuer Erwerb Und Verwer
Ernst Heinz
Ulrich Zaehringer
Petra Sperling
Hermann Schmidt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gvs Ges Fuer Erwerb Und Verwer, Ernst Heinz, Ulrich Zaehringer, Petra Sperling, Hermann Schmidt filed Critical Gvs Ges Fuer Erwerb Und Verwer
Priority to AU54075/99A priority Critical patent/AU5407599A/en
Publication of WO2000000593A2 publication Critical patent/WO2000000593A2/fr
Publication of WO2000000593A3 publication Critical patent/WO2000000593A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0083—Miscellaneous (1.14.99)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Birds (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des enzymes qui introduisent de manière sélective une double liaison dans la sphingobase du reste céramide de sphingolipides et de capnoïdes. Elle concerne également des séquences d'ADN codant pour ces enzymes. L'invention concerne en outre l'utilisation de ces enzymes et des séquences d'ADN pour modifier la teneur et/ou la structure de sphingolipides, leurs catabolismes et/ou leur produits secondaires synthétiques dans des cellules et/ou des organismes transgéniques. Elle concerne aussi un procédé de production de sphingolipides et de capnoïdes avec une sphingobase non saturée.
PCT/DE1999/001859 1998-06-27 1999-06-25 Sphingolipide-denaturase WO2000000593A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU54075/99A AU5407599A (en) 1998-06-27 1999-06-25 Sphingolipid-desaturase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19828850A DE19828850A1 (de) 1998-06-27 1998-06-27 Sphingolipid-Desaturase
DE19828850.6 1998-06-27

Publications (2)

Publication Number Publication Date
WO2000000593A2 WO2000000593A2 (fr) 2000-01-06
WO2000000593A3 true WO2000000593A3 (fr) 2000-08-10

Family

ID=7872312

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/001859 WO2000000593A2 (fr) 1998-06-27 1999-06-25 Sphingolipide-denaturase

Country Status (3)

Country Link
AU (1) AU5407599A (fr)
DE (1) DE19828850A1 (fr)
WO (1) WO2000000593A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106754769A (zh) * 2016-12-01 2017-05-31 中国科学院华南植物园 一种番茄抗冷害基因及应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10030976A1 (de) 2000-06-30 2002-01-10 Basf Ag DELTA6-Desaturasegene exprimierende Pflanzen und PUFAS enthaltende Öle aus diesen Pflanzen und ein Verfahren zur Herstellung ungesättigter Fettsäuren
US6858383B2 (en) 2000-12-22 2005-02-22 Medlyte, Inc. Compositions and methods for the treatment and prevention of cardiovascular diseases and disorders, and for identifying agents therapeutic therefor
JP4737531B2 (ja) * 2005-12-05 2011-08-03 サントリーホールディングス株式会社 形質転換酵母を用いるセラミドの製造方法
US9274129B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Methods and reagents for detecting bioactive lipids
US9217749B2 (en) 2006-05-31 2015-12-22 Lpath, Inc. Immune-derived moieties reactive against lysophosphatidic acid
US9274130B2 (en) 2006-05-31 2016-03-01 Lpath, Inc. Prevention and treatment of pain using antibodies to lysophosphatidic acid
BRPI0718118A2 (pt) 2006-10-27 2017-05-30 Lpath Inc composições e métodos para ligação de sphingosine-1-fosfato
US8871202B2 (en) 2008-10-24 2014-10-28 Lpath, Inc. Prevention and treatment of pain using antibodies to sphingosine-1-phosphate
US10045499B2 (en) 2012-05-24 2018-08-14 Iowa State University Research Foundation, Inc. Arabidopsis nonhost resistance gene(s) and use thereof to engineer disease resistant plants

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021022A2 (fr) * 1994-12-30 1996-07-11 Rhone-Poulenc Agrochimie Production d'acide linoleique gamma au moyen d'une δ6-desaturase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996021022A2 (fr) * 1994-12-30 1996-07-11 Rhone-Poulenc Agrochimie Production d'acide linoleique gamma au moyen d'une δ6-desaturase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
NAPIER, J. A. (1) ET AL: "Cytochrome b5 fusion proteins: A new class of higher plant fatty acid desaturases.", JOURNAL OF EXPERIMENTAL BOTANY, (MAY, 1998) VOL. 49, NO. SUPPL., PP. 15. MEETING INFO.: THE SOCIETY FOR EXPERIMENTAL BIOLOGY ANNUAL MEETING LONDON, ENGLAND, UK MARCH 22-27, 1998 SOCIETY FOR EXPERIMENTAL BIOLOGY., XP002132573 *
SCHMIDT, HERMANN (1) ET AL: "Purification and PCR-based cDNA cloning of a plastidial n-6 desaturase.", PLANT MOLECULAR BIOLOGY, (1994) VOL. 26, NO. 2, PP. 631-642., XP002132574 *
SPERLING, PETRA ET AL: "A cytochrome-b5-containing fusion protein similar to plant acyl lipid desaturases", EUR. J. BIOCHEM. (1995), 232(3), 798-805, XP002132571 *
SPERLING, PETRA ET AL: "A sphingolipid desaturase from higher plants. Identification of a new cytochrome b5 fusion protein", J. BIOL. CHEM., 273(44), 28590-28596, 30 October 1998 (1998-10-30), XP002132572 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106754769A (zh) * 2016-12-01 2017-05-31 中国科学院华南植物园 一种番茄抗冷害基因及应用
CN106754769B (zh) * 2016-12-01 2019-08-23 中国科学院华南植物园 一种番茄抗冷害基因及应用

Also Published As

Publication number Publication date
AU5407599A (en) 2000-01-17
DE19828850A1 (de) 1999-12-30
WO2000000593A2 (fr) 2000-01-06

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