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WO2000077041A3 - Peptides essentiels a proteine de liaison de la decorine et procedes d'utilisation - Google Patents

Peptides essentiels a proteine de liaison de la decorine et procedes d'utilisation Download PDF

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Publication number
WO2000077041A3
WO2000077041A3 PCT/US2000/016713 US0016713W WO0077041A3 WO 2000077041 A3 WO2000077041 A3 WO 2000077041A3 US 0016713 W US0016713 W US 0016713W WO 0077041 A3 WO0077041 A3 WO 0077041A3
Authority
WO
WIPO (PCT)
Prior art keywords
dbpa
decorin
peptides
binding
binding protein
Prior art date
Application number
PCT/US2000/016713
Other languages
English (en)
Other versions
WO2000077041A2 (fr
Inventor
Magnus Hoeoek
Eric L Brown
Original Assignee
Texas A & M Univ Sys
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A & M Univ Sys filed Critical Texas A & M Univ Sys
Priority to AU54955/00A priority Critical patent/AU5495500A/en
Publication of WO2000077041A2 publication Critical patent/WO2000077041A2/fr
Publication of WO2000077041A3 publication Critical patent/WO2000077041A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1207—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0225—Spirochetes, e.g. Treponema, Leptospira, Borrelia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Borrelia burgdorferi, l'agent étiologique de la maladie de Lyme exprime sur sa surface une protéine de liaison de la décorine, DbpA et DbpB. L'invention concerne des résidus de lysine nécessaires pour la DbpA se liant à la décorine et des peptides DbpA contenant ces résidus vitaux essentiels pour la liaison de la décorine. L'invention concerne également le fait que la vaccination utilisant les peptides qui comprennent ces domaines de liaison de Dbpa vitaux peut conférer une réaction d'hypersensibilité de type différé à la DbpA et réduire le nombre d'organismes Borrelia burgdorferi, présents chez les animaux infectés.
PCT/US2000/016713 1999-06-16 2000-06-16 Peptides essentiels a proteine de liaison de la decorine et procedes d'utilisation WO2000077041A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU54955/00A AU5495500A (en) 1999-06-16 2000-06-16 Decorin binding protein essential peptides and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13952399P 1999-06-16 1999-06-16
US60/139,523 1999-06-16

Publications (2)

Publication Number Publication Date
WO2000077041A2 WO2000077041A2 (fr) 2000-12-21
WO2000077041A3 true WO2000077041A3 (fr) 2001-05-25

Family

ID=22487071

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/016713 WO2000077041A2 (fr) 1999-06-16 2000-06-16 Peptides essentiels a proteine de liaison de la decorine et procedes d'utilisation

Country Status (2)

Country Link
AU (1) AU5495500A (fr)
WO (1) WO2000077041A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI112544B (fi) * 2001-11-26 2003-12-15 Bortech Oy Menetelmä varhais- ja myöhäisvaiheen Lymen borrelioosin diagnosoimiseksi
EP1853289A4 (fr) * 2005-01-31 2008-04-09 Vaxinnate Corp Nouveaux ligands de polypeptides destines a un recepteur de type toll 2 (tlr2)
PE20211279A1 (es) 2018-10-23 2021-07-19 Dragonfly Therapeutics Inc Proteinas heterodimericas fusionadas con fc
CA3175809A1 (fr) 2020-04-22 2021-10-28 Dragonfly Therapeutics, Inc. Formulation, schema posologique et procede de fabrication de proteines fusionnees avec fc heterodimeres

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997027301A1 (fr) * 1996-01-22 1997-07-31 The Texas A & M University System Compositions de proteines de liaison de la decorine et modes d'utilisation
DE19632862A1 (de) * 1996-08-14 1998-02-19 Mikrogen Molekularbiol Entw Immunologisch aktive Proteine von Borrelia burgdorferi, dafür kodierende Nukleinsäuren sowie deren Verwendung in Testkits und als Impfstoffe

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997027301A1 (fr) * 1996-01-22 1997-07-31 The Texas A & M University System Compositions de proteines de liaison de la decorine et modes d'utilisation
DE19632862A1 (de) * 1996-08-14 1998-02-19 Mikrogen Molekularbiol Entw Immunologisch aktive Proteine von Borrelia burgdorferi, dafür kodierende Nukleinsäuren sowie deren Verwendung in Testkits und als Impfstoffe

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
D. CASSATT. ET AL.: "DbpA but not OspA is expressed by B. bergdorfii during spirochetemia and is a target for protecive antibodies", INF. IMMUN., vol. 66, no. 11, 1998, pages 5379 - 5387, XP002154989 *
M. HANSON ET AL.: "Active and passive immunity against Borrelia berdorfii DbpA protects agains infection", INF. IMMUN., vol. 66, no. 5, 1998, pages 2143 - 2153, XP002154988 *
W. ROBERTS ET AL.: "Molecular analysis of sequence heterogeneity among genes encoding decorin binding proteins A and B of B. bergdorfii sensu lato", INF. IMMUN., vol. 66, no. 11, 1998, pages 5275 - 5285, XP002154990 *

Also Published As

Publication number Publication date
WO2000077041A2 (fr) 2000-12-21
AU5495500A (en) 2001-01-02

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