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WO2000067788A3 - Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires - Google Patents

Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires Download PDF

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Publication number
WO2000067788A3
WO2000067788A3 PCT/US2000/012435 US0012435W WO0067788A3 WO 2000067788 A3 WO2000067788 A3 WO 2000067788A3 US 0012435 W US0012435 W US 0012435W WO 0067788 A3 WO0067788 A3 WO 0067788A3
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WO
WIPO (PCT)
Prior art keywords
immune responses
costimulatory molecules
enhance immune
soluble costimulatory
molecules
Prior art date
Application number
PCT/US2000/012435
Other languages
English (en)
Other versions
WO2000067788A2 (fr
Inventor
Knut Sturmhoefel
Stanley F Wolf
Margot O'toole
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP00930437A priority Critical patent/EP1181053A2/fr
Priority to IL14610600A priority patent/IL146106A0/xx
Priority to JP2000616813A priority patent/JP2002544170A/ja
Priority to PL36091500A priority patent/PL360915A1/xx
Priority to KR1020017014170A priority patent/KR20020001865A/ko
Priority to CA002373256A priority patent/CA2373256A1/fr
Application filed by Genetics Inst filed Critical Genetics Inst
Priority to BR0010711-5A priority patent/BR0010711A/pt
Priority to AU48257/00A priority patent/AU4825700A/en
Publication of WO2000067788A2 publication Critical patent/WO2000067788A2/fr
Publication of WO2000067788A3 publication Critical patent/WO2000067788A3/fr
Priority to NO20015396A priority patent/NO20015396L/no
Priority to HK02102335.8A priority patent/HK1041810A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5152—Tumor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Cette invention concerne des méthodes propres à favoriser des réponses immunitaires, selon lesquelles on administre des formes solubles de molécules de co-stimulation, telles que des molécules B7, pour accroître les réponses immunitaires à des antigènes tels que des cellules tumorales ou des agents infectieux. Les méthodes selon l'invention conviennent à titre tant prophylactique et thérapeutique pour l'immunisation de sujets.
PCT/US2000/012435 1999-05-06 2000-05-05 Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires WO2000067788A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
IL14610600A IL146106A0 (en) 1999-05-06 2000-05-05 Use of soluble costimulatory molecules to enhance immune responses
JP2000616813A JP2002544170A (ja) 1999-05-06 2000-05-05 免疫応答を高めるための可溶性同時刺激分子の使用
PL36091500A PL360915A1 (en) 1999-05-06 2000-05-05 Use of soluble costimulatory molecules to enhance immune responses
KR1020017014170A KR20020001865A (ko) 1999-05-06 2000-05-05 면역반응을 증강시키기 위한 가용성 공동자극 분자의 용도
CA002373256A CA2373256A1 (fr) 1999-05-06 2000-05-05 Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires
EP00930437A EP1181053A2 (fr) 1999-05-06 2000-05-05 Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires
BR0010711-5A BR0010711A (pt) 1999-05-06 2000-05-05 Uso de moléculas co-estimulatórias solúveis para intensificar respostas imunes
AU48257/00A AU4825700A (en) 1999-05-06 2000-05-05 Use of soluble costimulatory molecules to enhance immune responses
NO20015396A NO20015396L (no) 1999-05-06 2001-11-05 Anvendelse av löselige kostimulerende molekyler for å forsterke immunresponser
HK02102335.8A HK1041810A1 (zh) 1999-05-06 2002-03-26 增加免疫反應的可溶性共同刺激分子的用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13294499P 1999-05-06 1999-05-06
US60/132,944 1999-05-06

Publications (2)

Publication Number Publication Date
WO2000067788A2 WO2000067788A2 (fr) 2000-11-16
WO2000067788A3 true WO2000067788A3 (fr) 2001-04-05

Family

ID=22456295

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/012435 WO2000067788A2 (fr) 1999-05-06 2000-05-05 Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires

Country Status (15)

Country Link
EP (1) EP1181053A2 (fr)
JP (1) JP2002544170A (fr)
KR (1) KR20020001865A (fr)
CN (1) CN1377279A (fr)
AU (1) AU4825700A (fr)
BR (1) BR0010711A (fr)
CA (1) CA2373256A1 (fr)
CZ (1) CZ20013964A3 (fr)
HK (1) HK1041810A1 (fr)
HU (1) HUP0201222A3 (fr)
IL (1) IL146106A0 (fr)
NO (1) NO20015396L (fr)
PL (1) PL360915A1 (fr)
WO (1) WO2000067788A2 (fr)
ZA (1) ZA200109376B (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3521382B2 (ja) 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
US7112655B1 (en) 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
JP3597140B2 (ja) 2000-05-18 2004-12-02 日本たばこ産業株式会社 副刺激伝達分子ａｉｌｉｍに対するヒトモノクローナル抗体及びその医薬用途
JP4212278B2 (ja) 2001-03-01 2009-01-21 日本たばこ産業株式会社 移植片拒絶反応抑制剤
JP5214446B2 (ja) * 2005-06-30 2013-06-19 エーザイ・アール・アンド・ディー・マネジメント株式会社 免疫アジュバントの調製のための化合物
JP2009521409A (ja) 2005-12-08 2009-06-04 ユニバーシティー オブ ルーイビル リサーチ ファンデーション，インコーポレーテッド 制御性ｔ細胞を増殖する方法と組成物
WO2007067682A2 (fr) 2005-12-08 2007-06-14 University Of Louisville Research Foundation, Inc. Modification in vivo de surfaces cellulaires
US9511151B2 (en) 2010-11-12 2016-12-06 Uti Limited Partnership Compositions and methods for the prevention and treatment of cancer
WO2013019669A2 (fr) 2011-07-29 2013-02-07 Selecta Biosciences, Inc. Nanosupports synthétiques qui génèrent des réponses immunitaires humorales et de lymphocytes t cytotoxiques (ltc)
US10988516B2 (en) 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
CA2867516A1 (fr) * 2012-04-02 2013-10-10 The Arizona Board Of Regents For And On Behalf Of Arizona State University Bacterie recombinante pour induire une reponse immunitaire cellulaire
US9603948B2 (en) 2012-10-11 2017-03-28 Uti Limited Partnership Methods and compositions for treating multiple sclerosis and related disorders
US10124045B2 (en) 2013-11-04 2018-11-13 Uti Limited Partnership Methods and compositions for sustained immunotherapy
BR112017023853A2 (pt) 2015-05-06 2018-07-17 Uti Limited Partnership composições de nanopartícula para terapia sustentada.
CN110743006B (zh) * 2019-11-22 2020-08-25 北京启辰生生物科技有限公司 用于协同解除免疫细胞衰竭的组合物及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006605A2 (fr) * 1998-07-28 2000-02-10 Micromet Ag Heterominicorps

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000006605A2 (fr) * 1998-07-28 2000-02-10 Micromet Ag Heterominicorps

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEN AOSHUANG ET AL: "Non-glycosylated human B7-1(CD80) retains the capacity to bind its counter-receptors.", FEBS LETTERS, vol. 428, no. 3, 29 May 1998 (1998-05-29), pages 127 - 134, XP002154489, ISSN: 0014-5793 *
MORO MONICA ET AL: "Induction of therapeutic T-cell immunity by tumor targeting with soluble recombinant B7-immunoglobulin costimulatory molecules.", CANCER RESEARCH, vol. 59, no. 11, 1 June 1999 (1999-06-01), pages 2650 - 2656, XP002154490, ISSN: 0008-5472 *
RAO JAY B ET AL: "IL-12 is an effective adjuvant to recombinant vaccinia virus-based tumor vaccines: Enhancement by simultaneous B7-1 expression.", JOURNAL OF IMMUNOLOGY, vol. 156, no. 9, 1996, pages 3357 - 3365, XP002154488, ISSN: 0022-1767 *
RENNERT PAUL ET AL: "The IgV domain of human B7-2 (CD86) is sufficient to co-stimulate T lymphocytes and induce cytokine secretion.", INTERNATIONAL IMMUNOLOGY, vol. 9, no. 6, 1997, pages 805 - 813, XP000971089, ISSN: 0953-8178 *

Also Published As

Publication number Publication date
NO20015396D0 (no) 2001-11-05
CN1377279A (zh) 2002-10-30
NO20015396L (no) 2002-01-02
BR0010711A (pt) 2002-02-13
JP2002544170A (ja) 2002-12-24
AU4825700A (en) 2000-11-21
ZA200109376B (en) 2003-03-13
HUP0201222A3 (en) 2004-07-28
PL360915A1 (en) 2004-09-20
CA2373256A1 (fr) 2000-11-16
KR20020001865A (ko) 2002-01-09
CZ20013964A3 (cs) 2002-06-12
WO2000067788A2 (fr) 2000-11-16
IL146106A0 (en) 2002-07-25
EP1181053A2 (fr) 2002-02-27
HUP0201222A2 (en) 2002-08-28
HK1041810A1 (zh) 2002-07-26

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