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WO2000067779A3 - Polymerized liposomes for the delivery of mammalian growth hormone - Google Patents

Polymerized liposomes for the delivery of mammalian growth hormone Download PDF

Info

Publication number
WO2000067779A3
WO2000067779A3 PCT/US2000/012902 US0012902W WO0067779A3 WO 2000067779 A3 WO2000067779 A3 WO 2000067779A3 US 0012902 W US0012902 W US 0012902W WO 0067779 A3 WO0067779 A3 WO 0067779A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
growth hormone
mammalian growth
polymerized liposomes
present
Prior art date
Application number
PCT/US2000/012902
Other languages
French (fr)
Other versions
WO2000067779A2 (en
Inventor
Hansi J Dean
Kyle Bucher
Elijah Bolotin
Original Assignee
Endorex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endorex Corp filed Critical Endorex Corp
Priority to AU50040/00A priority Critical patent/AU5004000A/en
Publication of WO2000067779A2 publication Critical patent/WO2000067779A2/en
Publication of WO2000067779A3 publication Critical patent/WO2000067779A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1273—Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention encompasses polymerized liposomes systems for oral and/or mucosal delivery of protein drugs. In a preferred embodiment, the polymerized liposome is modified to contain mammalian growth hormone for the delivery of biologically active hormone after mucosal administration. The present invention further relates to the synthesis, preparation and use of the polymerized liposomes of the present invention as, or in, pharmaceutical compositions for oral delivery of bioactive molecules, in particular, mammalian growth hormone.
PCT/US2000/012902 1999-05-12 2000-05-11 Polymerized liposomes for the delivery of mammalian growth hormone WO2000067779A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU50040/00A AU5004000A (en) 1999-05-12 2000-05-11 Polymerized liposomes for the delivery of mammalian growth hormone

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13369699P 1999-05-12 1999-05-12
US60/133,696 1999-05-12

Publications (2)

Publication Number Publication Date
WO2000067779A2 WO2000067779A2 (en) 2000-11-16
WO2000067779A3 true WO2000067779A3 (en) 2001-01-18

Family

ID=22459889

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/012902 WO2000067779A2 (en) 1999-05-12 2000-05-11 Polymerized liposomes for the delivery of mammalian growth hormone

Country Status (2)

Country Link
AU (1) AU5004000A (en)
WO (1) WO2000067779A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110097392A1 (en) * 2008-04-17 2011-04-28 Banyan Biomarkers, Inc Antibody bound synthetic vesicle containing molecules for deliver to central and peripheral nervous system cells

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366881A (en) * 1993-02-23 1994-11-22 The United States Of America As Represented By The Secretary Of The Navy Polymerizable lipids for preparing vesicles that controllably release an encapsulant
WO1995003035A1 (en) * 1993-07-23 1995-02-02 Massachusetts Institute Of Technology Polymerized liposomes with enhanced stability for oral delivery
WO1999033940A1 (en) * 1997-12-31 1999-07-08 Orasomal Technologies, Inc. Novel polymerizable fatty acids, phospholipids and polymerized liposomes therefrom

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5366881A (en) * 1993-02-23 1994-11-22 The United States Of America As Represented By The Secretary Of The Navy Polymerizable lipids for preparing vesicles that controllably release an encapsulant
WO1995003035A1 (en) * 1993-07-23 1995-02-02 Massachusetts Institute Of Technology Polymerized liposomes with enhanced stability for oral delivery
WO1999033940A1 (en) * 1997-12-31 1999-07-08 Orasomal Technologies, Inc. Novel polymerizable fatty acids, phospholipids and polymerized liposomes therefrom

Also Published As

Publication number Publication date
AU5004000A (en) 2000-11-21
WO2000067779A2 (en) 2000-11-16

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