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WO2000067697A3 - Conjugue acide nucleique-anticorps pour delivrer un acide nucleique etranger dans les cellules - Google Patents

Conjugue acide nucleique-anticorps pour delivrer un acide nucleique etranger dans les cellules Download PDF

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Publication number
WO2000067697A3
WO2000067697A3 PCT/FR2000/001259 FR0001259W WO0067697A3 WO 2000067697 A3 WO2000067697 A3 WO 2000067697A3 FR 0001259 W FR0001259 W FR 0001259W WO 0067697 A3 WO0067697 A3 WO 0067697A3
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WIPO (PCT)
Prior art keywords
nucleic acid
cells
antibody conjugate
delivering
foreign
Prior art date
Application number
PCT/FR2000/001259
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English (en)
Other versions
WO2000067697A2 (fr
Inventor
Francois Hirsch
Antoine Durrbach
Original Assignee
Centre Nat Rech Scient
Francois Hirsch
Antoine Durrbach
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Francois Hirsch, Antoine Durrbach filed Critical Centre Nat Rech Scient
Priority to AU44152/00A priority Critical patent/AU4415200A/en
Priority to EP00925426A priority patent/EP1175498A2/fr
Priority to IL14639900A priority patent/IL146399A0/xx
Priority to CA002373851A priority patent/CA2373851A1/fr
Priority to JP2000616728A priority patent/JP2002543810A/ja
Publication of WO2000067697A2 publication Critical patent/WO2000067697A2/fr
Publication of WO2000067697A3 publication Critical patent/WO2000067697A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3038—Kidney, bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
    • A61K47/6861—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from kidney or bladder cancer cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)

Abstract

La présente invention concerne les techniques relatives à l'introduction d'acide nucléique étranger dans des cellules. Plus particulièrement, la présente invention concerne un conjugué ADN/anticorps permettant l'expression efficace d'ADN étranger sous forme protéique dans des cellules cibles in vivo ou in vitro.
PCT/FR2000/001259 1999-05-10 2000-05-10 Conjugue acide nucleique-anticorps pour delivrer un acide nucleique etranger dans les cellules WO2000067697A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU44152/00A AU4415200A (en) 1999-05-10 2000-05-10 Nucleic acid-antibody conjugate for delivering a foreign nucleic acid in cells
EP00925426A EP1175498A2 (fr) 1999-05-10 2000-05-10 Conjugue acide nucleique-anticorps pour delivrer un acide nucleique etranger dans les cellules
IL14639900A IL146399A0 (en) 1999-05-10 2000-05-10 Nucleic acid-antibody conjugate for delivering a foreign nucleic acid in cells
CA002373851A CA2373851A1 (fr) 1999-05-10 2000-05-10 Conjugue acide nucleique-anticorps pour delivrer un acide nucleique etranger dans les cellules
JP2000616728A JP2002543810A (ja) 1999-05-10 2000-05-10 外来性核酸を細胞に送達するための核酸−抗体複合体

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR99/05943 1999-05-10
FR9905943A FR2793414B1 (fr) 1999-05-10 1999-05-10 Conjugue acide nucleique-anticorps pour delivrer un acide nucleique etranger dans les cellules

Publications (2)

Publication Number Publication Date
WO2000067697A2 WO2000067697A2 (fr) 2000-11-16
WO2000067697A3 true WO2000067697A3 (fr) 2001-06-28

Family

ID=9545418

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2000/001259 WO2000067697A2 (fr) 1999-05-10 2000-05-10 Conjugue acide nucleique-anticorps pour delivrer un acide nucleique etranger dans les cellules

Country Status (7)

Country Link
EP (1) EP1175498A2 (fr)
JP (1) JP2002543810A (fr)
AU (1) AU4415200A (fr)
CA (1) CA2373851A1 (fr)
FR (1) FR2793414B1 (fr)
IL (1) IL146399A0 (fr)
WO (1) WO2000067697A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2514536A1 (fr) * 2003-01-31 2004-08-12 Novartis Ag Regulation negative d'un gene cible a l'aide de complexes de pei/oligoribonucleotide simple brin
JP4521519B2 (ja) * 2003-05-26 2010-08-11 学校法人慶應義塾 部分ヒストンテイル型イムノポーター
FR2958645B1 (fr) * 2010-04-09 2012-08-31 Commissariat Energie Atomique Hemi-anticorps a auto-assemblage
US10540907B2 (en) 2014-07-31 2020-01-21 Intelligent Technologies International, Inc. Biometric identification headpiece system for test taking
US9959777B2 (en) 2014-08-22 2018-05-01 Intelligent Technologies International, Inc. Secure testing device, system and method
US10410535B2 (en) 2014-08-22 2019-09-10 Intelligent Technologies International, Inc. Secure testing device
WO2016073202A1 (fr) 2014-11-04 2016-05-12 Intelligent Technologies International, Inc. Carte intelligente
CN108530540B (zh) * 2018-03-30 2021-06-15 华南农业大学 抗亚精胺单克隆抗体杂交瘤细胞株4e4及其单克隆抗体和应用

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988008854A1 (fr) * 1987-05-06 1988-11-17 Egbert Oosterwijk Anticorps monoclonaux contre le carcinome des cellules renales
US5166320A (en) * 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
WO1994004696A1 (fr) * 1992-08-25 1994-03-03 Miles Inc. Apport nucleaire de macromolecules facilite par un signal de translocation
WO1994013325A2 (fr) * 1992-12-15 1994-06-23 Microprobe Corporation Sequences de liaison peptidiques pour l'amelioration de l'apport d'oligonucleotides
US5428132A (en) * 1987-10-11 1995-06-27 United States Of America Conjugate and method for integration of foreign DNA into cells
WO1995021195A1 (fr) * 1994-02-07 1995-08-10 Research Development Foundation Vecteur non viral
WO1996013599A1 (fr) * 1994-11-01 1996-05-09 Winfried Wels Systeme de transfert de l'acide nucleique
WO1998002564A1 (fr) * 1996-07-12 1998-01-22 The John P. Robarts Research Institute Vecteur hybride de virus herpetique/virus de epstein-barr
WO1998047538A2 (fr) * 1997-04-23 1998-10-29 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Colorants de synthese labiles aux acides et clivables par voie enzymatique pour le diagnostic avec de la lumiere dans le proche infrarouge et pour l'usage therapeutique
WO1998056425A1 (fr) * 1997-06-11 1998-12-17 The School Of Pharmacy, University Of London Compositions pharmaceutiques contenant des conjugues anticorps-enzymes combines a des promedicaments

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5166320A (en) * 1987-04-22 1992-11-24 University Of Connecticut Carrier system and method for the introduction of genes into mammalian cells
WO1988008854A1 (fr) * 1987-05-06 1988-11-17 Egbert Oosterwijk Anticorps monoclonaux contre le carcinome des cellules renales
US5428132A (en) * 1987-10-11 1995-06-27 United States Of America Conjugate and method for integration of foreign DNA into cells
WO1994004696A1 (fr) * 1992-08-25 1994-03-03 Miles Inc. Apport nucleaire de macromolecules facilite par un signal de translocation
WO1994013325A2 (fr) * 1992-12-15 1994-06-23 Microprobe Corporation Sequences de liaison peptidiques pour l'amelioration de l'apport d'oligonucleotides
WO1995021195A1 (fr) * 1994-02-07 1995-08-10 Research Development Foundation Vecteur non viral
WO1996013599A1 (fr) * 1994-11-01 1996-05-09 Winfried Wels Systeme de transfert de l'acide nucleique
WO1998002564A1 (fr) * 1996-07-12 1998-01-22 The John P. Robarts Research Institute Vecteur hybride de virus herpetique/virus de epstein-barr
WO1998047538A2 (fr) * 1997-04-23 1998-10-29 Institut für Diagnostikforschung GmbH an der Freien Universität Berlin Colorants de synthese labiles aux acides et clivables par voie enzymatique pour le diagnostic avec de la lumiere dans le proche infrarouge et pour l'usage therapeutique
WO1998056425A1 (fr) * 1997-06-11 1998-12-17 The School Of Pharmacy, University Of London Compositions pharmaceutiques contenant des conjugues anticorps-enzymes combines a des promedicaments

Non-Patent Citations (9)

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Title
BIOCHEMICAL PHARMACOLOGY, vol. 40, no. 2, 1990, pages 253 - 264, ISSN: 0006-2952 *
BIOCHEMISTRY AND CELL BIOLOGY, vol. 73, no. 11-12, 1995, pages 949 - 958, ISSN: 0829-8211 *
CHAKRABARTI, M. ET AL: "Transfer of DNA into lymphoma cells by DNA-bound to T101- biotinylated -avidin- polylysine antibody complex.", JOURNAL OF NUCLEAR MEDICINE, (1996) VOL. 37, NO. 5 SUPPL., PP. 62P. MEETING INFO.: 43RD ANNUAL MEETING OF THE SOCIETY OF NUCLEAR MEDICINE DENVER, COLORADO, USA JUNE 3-5, 1996, XP002133111 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1990, HUCKETT B ET AL: "EVIDENCE FOR TARGETED GENE TRANSFER BY RECEPTOR-MEDIATED ENDOCYTOSIS STABLE EXPRESSION FOLLOWING INSULIN-DIRECTED ENTRY OF NEO INTO HEPG2 CELLS", XP002155196, Database accession no. PREV199090077976 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1995, TRAUT ROBERT R ET AL: "Location and domain structure of Escherichia coli ribosomal protein L7/L12: Site specific cysteine cross-linking and attachment of fluorescent probes.", XP002155195, Database accession no. PREV199698797154 *
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; GUY J ET AL: "Delivery of DNA into mammalian cells by receptor-mediated endocytosis and gene therapy.", XP002133112, retrieved from STN Database accession no. 96031841 *
FOMINAYA J ET AL: "Target cell-specific DNA transfer mediated by a chimeric multidomain protein. Novel non-viral gene delivery system.", JOURNAL OF BIOLOGICAL CHEMISTRY, (1996 MAY 3) 271 (18) 10560-8., XP002133110 *
MOLECULAR BIOTECHNOLOGY, (1995 JUN) 3 (3) 237-48. REF: 60 *
PONCET ET AL: "ANTIFECTION: AN ANTIBODY-MEDIATED METHOD TO INTRODUCE GENES INTO LYMPHOID CELLS IN VITRO AND IN VIVO", GENE THERAPY, vol. 3, 1996, pages 731 - 738, XP000877306 *

Also Published As

Publication number Publication date
WO2000067697A2 (fr) 2000-11-16
AU4415200A (en) 2000-11-21
IL146399A0 (en) 2002-07-25
JP2002543810A (ja) 2002-12-24
FR2793414B1 (fr) 2003-05-23
CA2373851A1 (fr) 2000-11-16
EP1175498A2 (fr) 2002-01-30
FR2793414A1 (fr) 2000-11-17

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