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WO2000066787A3 - Growth hormone-regulatable liver genes and proteins, and uses thereof - Google Patents

Growth hormone-regulatable liver genes and proteins, and uses thereof Download PDF

Info

Publication number
WO2000066787A3
WO2000066787A3 PCT/US2000/012366 US0012366W WO0066787A3 WO 2000066787 A3 WO2000066787 A3 WO 2000066787A3 US 0012366 W US0012366 W US 0012366W WO 0066787 A3 WO0066787 A3 WO 0066787A3
Authority
WO
WIPO (PCT)
Prior art keywords
regulatable
proteins
growth hormone
liver genes
liver
Prior art date
Application number
PCT/US2000/012366
Other languages
French (fr)
Other versions
WO2000066787A2 (en
Inventor
John Joseph Kopchick
Jean Tiong
Original Assignee
Univ Ohio
John Joseph Kopchick
Jean Tiong
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ohio, John Joseph Kopchick, Jean Tiong filed Critical Univ Ohio
Priority to CA002370134A priority Critical patent/CA2370134A1/en
Priority to US09/959,716 priority patent/US6858389B1/en
Publication of WO2000066787A2 publication Critical patent/WO2000066787A2/en
Publication of WO2000066787A3 publication Critical patent/WO2000066787A3/en
Priority to US11/032,232 priority patent/US7309572B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Growth hormone-regulatable liver genes and proteins are described. These may be used as diagnostic markers of liver pathology.
PCT/US2000/012366 1999-05-05 2000-05-05 Growth hormone-regulatable liver genes and proteins, and uses thereof WO2000066787A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002370134A CA2370134A1 (en) 1999-05-05 2000-05-05 Growth hormone-regulatable liver genes and proteins, and uses thereof
US09/959,716 US6858389B1 (en) 1999-05-05 2000-05-05 Growth hormone-regulatable liver genes and proteins, and uses thereof
US11/032,232 US7309572B2 (en) 1999-05-05 2005-01-11 Growth hormone-regulatable liver genes and proteins, and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13266399P 1999-05-05 1999-05-05
US60/132,663 1999-05-05

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09959716 A-371-Of-International 2000-05-05
US11/032,232 Continuation US7309572B2 (en) 1999-05-05 2005-01-11 Growth hormone-regulatable liver genes and proteins, and uses thereof

Publications (2)

Publication Number Publication Date
WO2000066787A2 WO2000066787A2 (en) 2000-11-09
WO2000066787A3 true WO2000066787A3 (en) 2002-01-31

Family

ID=22455037

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/012366 WO2000066787A2 (en) 1999-05-05 2000-05-05 Growth hormone-regulatable liver genes and proteins, and uses thereof

Country Status (2)

Country Link
CA (1) CA2370134A1 (en)
WO (1) WO2000066787A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2831890B1 (en) * 2001-10-31 2006-06-23 Agronomique Inst Nat Rech USE OF THE GENE OF CBG AS A GENETIC MARKER FOR HYPERCORTISOLEMIA AND ASSOCIATED PATHOLOGIES
AU2005216922A1 (en) * 2004-02-26 2005-09-09 Icoria, Inc. Diagnosis of hyperinsulinemia and type II diabetes and protection against same based on genes differentially expressed in muscle cells

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0158973A2 (en) * 1984-04-12 1985-10-23 The General Hospital Corporation Multisite immunometric assay

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0158973A2 (en) * 1984-04-12 1985-10-23 The General Hospital Corporation Multisite immunometric assay

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
ADAN L ET AL: "Diagnostic markers of permanent idiopathic growth hormone deficiency.", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 78, no. 2, 1994, pages 353 - 358, XP000971698, ISSN: 0021-972X *
COSTA CRISTINA ET AL: "Transgenic rabbits overexpressing growth hormone develop acromegaly and diabetes mellitus.", FASEB JOURNAL, vol. 12, no. 14, November 1998 (1998-11-01), pages 1455 - 1460, XP002161567, ISSN: 0892-6638 *
HERMANSSON MAJLIS ET AL: "Measurement of human growth hormone receptor messenger ribonucleic acid by a quantitative polymerase chain reaction-based assay: Demonstration of reduced expression after elective surgery.", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 82, no. 2, 1997, pages 421 - 428, XP000971696, ISSN: 0021-972X *
KOPCHICK JOHN J ET AL: "Transgenic models of growth hormone action.", ANNUAL REVIEW OF NUTRITION, vol. 19, 1999, 1999 Annual Reviews Inc. P.O. Box 10139, 4139 El Camino Way, Palo Alto, California 94306, USA, pages 437 - 461, XP000971266, ISBN: 0-8243-2819-1 *
LE STUNFF CATHERINE ET AL: "Growth hormone stimulates interferon regulatory factor-1 gene expression in the liver.", ENDOCRINOLOGY, vol. 139, no. 3, March 1998 (1998-03-01), pages 859 - 866, XP000971253, ISSN: 0013-7227 *
LEMMEY A B ET AL: "Differential regulation of tissue insulin-like growth factor-binding protein (IGFBP)-3, IGF-I and IGF type 1 receptor mRNA levels, and serum IGF-I and IGFBP concentrations by growth hormone and IGF-I.", JOURNAL OF ENDOCRINOLOGY, vol. 154, no. 2, 1997, pages 319 - 328, XP000971284, ISSN: 0022-0795 *
MALHOTRA KHUSHBEER ET AL: "Identification of differentially expressed mRNAs in human fetal liver across gestation.", NUCLEIC ACIDS RESEARCH, vol. 27, no. 3, 1 February 1999 (1999-02-01), pages 839 - 847, XP002161562, ISSN: 0305-1048 *
PANDURO A ET AL: "LIVER-SPECIFIC GENE EXPRESSION IN VARIOUS PATHOPHYSIOLOGIC STATES", HEPATOLOGY, vol. 7, no. 1 SUPPL., 1987, pages 10S - 18S, XP000971276, ISSN: 0270-9139 *
SAGGESE G ET AL: "Diagnosis and treatment of growth hormone deficiency in children and adolescents: Towards a consensus: Ten years after the availability of recombinant human growth hormone: (Pisa, Italy;March 1998).", HORMONE RESEARCH (BASEL), vol. 50, no. 6, December 1998 (1998-12-01), pages 320 - 340, XP002161600, ISSN: 0301-0163 *

Also Published As

Publication number Publication date
CA2370134A1 (en) 2000-11-09
WO2000066787A2 (en) 2000-11-09

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