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WO2000066105A3 - Treatment of epilepsy with imino sugars - Google Patents

Treatment of epilepsy with imino sugars Download PDF

Info

Publication number
WO2000066105A3
WO2000066105A3 PCT/US2000/011584 US0011584W WO0066105A3 WO 2000066105 A3 WO2000066105 A3 WO 2000066105A3 US 0011584 W US0011584 W US 0011584W WO 0066105 A3 WO0066105 A3 WO 0066105A3
Authority
WO
WIPO (PCT)
Prior art keywords
epilepsy
treatment
imino sugars
imino
sugars
Prior art date
Application number
PCT/US2000/011584
Other languages
French (fr)
Other versions
WO2000066105A9 (en
WO2000066105A2 (en
Inventor
Thomas N Seyfried
Mariana T Tran
Original Assignee
Trustees Boston College
Thomas N Seyfried
Mariana T Tran
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Boston College, Thomas N Seyfried, Mariana T Tran filed Critical Trustees Boston College
Publication of WO2000066105A2 publication Critical patent/WO2000066105A2/en
Publication of WO2000066105A3 publication Critical patent/WO2000066105A3/en
Publication of WO2000066105A9 publication Critical patent/WO2000066105A9/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Imino sugars, in particular N-nonyl deoxymojirimycin (N-nonyl DNJ), and derivatives thereof are used for the treatment of epilepsy.
PCT/US2000/011584 1999-04-30 2000-04-28 Treatment of epilepsy with imino sugars WO2000066105A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13212599P 1999-04-30 1999-04-30
US60/132,125 1999-04-30

Publications (3)

Publication Number Publication Date
WO2000066105A2 WO2000066105A2 (en) 2000-11-09
WO2000066105A3 true WO2000066105A3 (en) 2001-07-19
WO2000066105A9 WO2000066105A9 (en) 2001-08-09

Family

ID=22452594

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/011584 WO2000066105A2 (en) 1999-04-30 2000-04-28 Treatment of epilepsy with imino sugars

Country Status (1)

Country Link
WO (1) WO2000066105A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009103953A1 (en) * 2008-02-18 2009-08-27 Summit Corporation Plc Treatment of energy utilization disease

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0350012A2 (en) * 1988-07-08 1990-01-10 Meiji Seika Kaisha Ltd. Antiviral composition
WO1994021230A1 (en) * 1993-03-19 1994-09-29 Cellegy Pharmaceuticals, Inc. Method and compositions for disrupting the epithelial barrier function
US5798366A (en) * 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
WO2000062780A1 (en) * 1999-04-20 2000-10-26 Oxford Glycosciences (Uk) Limited Use of glucosylceramide synthesis inhibitors in therapy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0350012A2 (en) * 1988-07-08 1990-01-10 Meiji Seika Kaisha Ltd. Antiviral composition
WO1994021230A1 (en) * 1993-03-19 1994-09-29 Cellegy Pharmaceuticals, Inc. Method and compositions for disrupting the epithelial barrier function
US5798366A (en) * 1993-05-13 1998-08-25 Monsanto Company Method for treatment of CNS-involved lysosomal storage diseases
WO2000062780A1 (en) * 1999-04-20 2000-10-26 Oxford Glycosciences (Uk) Limited Use of glucosylceramide synthesis inhibitors in therapy

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CLAEYSSENS, MARC ET AL: "Amine derivatives of.beta.-D-xylopyranose as reversible and irreversible inhibitors of.beta.-D-xylosidases", MECH. SACCHARIDE POLYM. DEPOLYM., [PROC. SYMP.] (1980), MEETING DATE 1978 355-69. EDITOR(S): MARSHALL, JAMES JOHN. PUBLISHER: ACADEMIC, NEW YORK, N. Y., XP000980308 *
HELLWIG B.: "[New drugs in 1998]. NEUE ARZNEIMITTEL 1998.", DEUTSCHE APOTHEKER ZEITUNG, (17 DEC 1998) 138/51-52 SUPPL. (11-27), XP000867043 *
P.B. GOVE: "Webster's Third New Internatinal Dictionary", 1993, MERRIAM-WEBSTER INC., SPRINGFIELD MASS., XP002158035 *
WINCHESTER, FLEET: "Amino-sugar glycosidase inhibitors: Versatile tools for glycobiologists", GLYCOBIOLOGY, vol. 2, no. 3, June 1992 (1992-06-01), pages 199 - 210, XP000978578 *

Also Published As

Publication number Publication date
WO2000066105A9 (en) 2001-08-09
WO2000066105A2 (en) 2000-11-09

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