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WO2000065091A3 - Method of identifying ligands for the peroxisome proliferator activated receptor gamma using differential gene expression - Google Patents

Method of identifying ligands for the peroxisome proliferator activated receptor gamma using differential gene expression Download PDF

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Publication number
WO2000065091A3
WO2000065091A3 PCT/US2000/010757 US0010757W WO0065091A3 WO 2000065091 A3 WO2000065091 A3 WO 2000065091A3 US 0010757 W US0010757 W US 0010757W WO 0065091 A3 WO0065091 A3 WO 0065091A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene expression
activated receptor
peroxisome proliferator
differential gene
receptor gamma
Prior art date
Application number
PCT/US2000/010757
Other languages
French (fr)
Other versions
WO2000065091A2 (en
Inventor
Bonnie Gould-Rothberg
Original Assignee
Curagen Corp
Bonnie Gould-Rothberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curagen Corp, Bonnie Gould-Rothberg filed Critical Curagen Corp
Priority to AU46526/00A priority Critical patent/AU4652600A/en
Publication of WO2000065091A2 publication Critical patent/WO2000065091A2/en
Publication of WO2000065091A3 publication Critical patent/WO2000065091A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Disclosed are methods of identifying ligands for the peroxisome proliferator activated receptor gamma (PPARη) using differential gene expression. Also disclosed are novel nucleic acid sequences whose expression is differentially regulated by PPARη ligands.
PCT/US2000/010757 1999-04-23 2000-04-21 Method of identifying ligands for the peroxisome proliferator activated receptor gamma using differential gene expression WO2000065091A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU46526/00A AU4652600A (en) 1999-04-23 2000-04-21 Method of identifying ligands for the peroxisome proliferator activated receptorgamma using differential gene expression

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US13082199P 1999-04-23 1999-04-23
US60/130,821 1999-04-23
US54603800A 2000-04-10 2000-04-10
US09/546,038 2000-04-10

Publications (2)

Publication Number Publication Date
WO2000065091A2 WO2000065091A2 (en) 2000-11-02
WO2000065091A3 true WO2000065091A3 (en) 2002-09-12

Family

ID=26828851

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/010757 WO2000065091A2 (en) 1999-04-23 2000-04-21 Method of identifying ligands for the peroxisome proliferator activated receptor gamma using differential gene expression

Country Status (2)

Country Link
AU (1) AU4652600A (en)
WO (1) WO2000065091A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002086122A2 (en) * 2001-03-14 2002-10-31 Hybrigenics Protein-protein interactions in adipocytes

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021944A1 (en) * 1994-02-14 1995-08-17 Smithkline Beecham Corporation Differentially expressed genes in healthy and diseased subjects
WO1997010813A1 (en) * 1995-09-18 1997-03-27 Ligand Pharmaceuticals Incorporated Ppar gamma antagonists for treating obesity
WO1998005331A2 (en) * 1996-08-02 1998-02-12 Ligand Pharmaceuticals Incorporated Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators
WO2000063435A2 (en) * 1999-04-15 2000-10-26 Curagen Corporation Method of identifying toxic agents using differential gene expression

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995021944A1 (en) * 1994-02-14 1995-08-17 Smithkline Beecham Corporation Differentially expressed genes in healthy and diseased subjects
WO1997010813A1 (en) * 1995-09-18 1997-03-27 Ligand Pharmaceuticals Incorporated Ppar gamma antagonists for treating obesity
WO1998005331A2 (en) * 1996-08-02 1998-02-12 Ligand Pharmaceuticals Incorporated Prevention or treatment of type 2 diabetes or cardiovascular disease with ppar modulators
WO2000063435A2 (en) * 1999-04-15 2000-10-26 Curagen Corporation Method of identifying toxic agents using differential gene expression

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BONALDO FATIMA DE M; LENNON G; SOARES M B: "NORMALIZATION AND SUBTRACTION: TWO APPROACHES TO FACILITATE GENE DISCOVERY", GENOME RESEARCH, vol. 6, no. 9, 1 September 2001 (2001-09-01), GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, US, pages 791 - 806, XP002039972 *
DATABASE EMBL 8 April 1998 (1998-04-08), "UI-R-E0-by-g-09-0-UI.s4 UI-R-E0 Rattus norvegicus cDNA clone", XP002180486 *
MARTIN ET AL: "Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthase genes by PPAR-alpha and PPAR-gamma activators", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 45, 7 November 1997 (1997-11-07), pages 28210 - 28217, XP002081439, ISSN: 0021-9258 *
SCHOONJANS K ET AL: "PPARALPHA AND PPARGAMMA ACTIVATORS DIRECT A DISTINCT TISSUE-SPECIFIC TRANSCRIPTIONAL RESPONSE VIA A PPRE IN THE LIPOPROTEIN LIPASE GENE", EMBO JOURNAL, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 15, no. 19, 1 October 1996 (1996-10-01), pages 5336 - 5348, XP000615472, ISSN: 0261-4189 *

Also Published As

Publication number Publication date
WO2000065091A2 (en) 2000-11-02
AU4652600A (en) 2000-11-10

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