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WO2000065090A3 - The insulin receptor-related receptor gene sequence for diagnosis of human obesity and diabetic disorders - Google Patents

The insulin receptor-related receptor gene sequence for diagnosis of human obesity and diabetic disorders Download PDF

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Publication number
WO2000065090A3
WO2000065090A3 PCT/US2000/010644 US0010644W WO0065090A3 WO 2000065090 A3 WO2000065090 A3 WO 2000065090A3 US 0010644 W US0010644 W US 0010644W WO 0065090 A3 WO0065090 A3 WO 0065090A3
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WO
WIPO (PCT)
Prior art keywords
diagnosis
gene sequence
human obesity
diabetic disorders
receptor
Prior art date
Application number
PCT/US2000/010644
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French (fr)
Other versions
WO2000065090A2 (en
Inventor
Si Lok
Theodore E Whitmore
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU46498/00A priority Critical patent/AU4649800A/en
Publication of WO2000065090A2 publication Critical patent/WO2000065090A2/en
Publication of WO2000065090A3 publication Critical patent/WO2000065090A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides methods for identifying abnormalities in human chromosome 1q that are linked to defects in glucose metabolism. The present invention also provides methods for identifying polymorphisms in an insulin receptor-related receptor gene that resides on chromosome 1q21-q24, and more specifically, 1q21-q23, a locus linked with a heritable form of Type II diabetes.
PCT/US2000/010644 1999-04-22 2000-04-19 The insulin receptor-related receptor gene sequence for diagnosis of human obesity and diabetic disorders WO2000065090A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU46498/00A AU4649800A (en) 1999-04-22 2000-04-19 The insulin receptor-related receptor gene sequence for diagnosis of human obesity and diabetic disorders

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US29690699A 1999-04-22 1999-04-22
US09/296,906 1999-04-22
US33797699A 1999-06-22 1999-06-22
US09/337,976 1999-06-22

Publications (2)

Publication Number Publication Date
WO2000065090A2 WO2000065090A2 (en) 2000-11-02
WO2000065090A3 true WO2000065090A3 (en) 2001-10-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/010644 WO2000065090A2 (en) 1999-04-22 2000-04-19 The insulin receptor-related receptor gene sequence for diagnosis of human obesity and diabetic disorders

Country Status (2)

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AU (1) AU4649800A (en)
WO (1) WO2000065090A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2151502A1 (en) * 2008-07-30 2010-02-10 Lohmann Tierzucht GmbH Genetic variations associated with feather pecking behaviour in avians

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023591A2 (en) * 1998-10-21 2000-04-27 Zymogenetics, Inc. Secreted protein zsig49

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000023591A2 (en) * 1998-10-21 2000-04-27 Zymogenetics, Inc. Secreted protein zsig49

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ELBEIN S C ET AL: "GENOME-WIDE SEARCH FOR TYPE 2 DIABETES SUSCEPTIBILITY GENES IN CAUCASIANS: EVIDENCE FOR A RECESSIVE LOCUS ON CHROMOSOME 1", DIABETES,NEW YORK, NY,US, 13 June 1998 (1998-06-13), pages 1278b, XP000906839, ISSN: 0012-1797 *
ELBEIN S.C. ET AL.: "A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians", DIABETES, vol. 48, no. 5, May 1999 (1999-05-01), pages 1175 - 1182, XP000944793 *
HANSON R L ET AL: "AN AUTOSOMAL GENOMIC SCAN FOR LOCI LINKED TO TYPE II DIABETES MELLITUS AND BODY-MASS INDEX IN PIMA INDIANS", AMERICAN JOURNAL OF HUMAN GENETICS,US,UNIVERSITY OF CHICAGO PRESS, CHICAGO,, vol. 63, no. 4, 1998, pages 1130 - 1138, XP000909507, ISSN: 0002-9297 *
ITOH N. ET AL.: "Two truncated forms of rat insulin receptor-related receptor", J. BIOL. CHEM., vol. 268, no. 24, 25 August 1993 (1993-08-25), pages 17983 - 17986, XP002154781 *
SHIER P. AND WATT V.M.: "Primary structure of a putative receptor for a ligand of the insulin family", J. BIOL. CHEM., vol. 264, no. 25, 5 September 1989 (1989-09-05), pages 14605 - 14608, XP002154780 *
SHIER P. ET AL.: "Localization of the insulin receptor-related receptor gene on human chromosome 1", CYTOGENET CELL GENET, vol. 54, 1990, pages 80 - 81, XP000944567 *
WHITMORE T.E. ET AL.: "The assignment of the human insulin receptor-related receptor gene (INSRR) tp chromosome 1q21-q23 by the use of radiation hybrid mapping", CYTOGENET CELL GENET, vol. 87, no. 1-2, 1999, pages 93 - 94, XP000944566 *

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Publication number Publication date
AU4649800A (en) 2000-11-10
WO2000065090A2 (en) 2000-11-02

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