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WO2000063351A3 - Enzymes modifiant les hydrates de carbone - Google Patents

Enzymes modifiant les hydrates de carbone Download PDF

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Publication number
WO2000063351A3
WO2000063351A3 PCT/US2000/010882 US0010882W WO0063351A3 WO 2000063351 A3 WO2000063351 A3 WO 2000063351A3 US 0010882 W US0010882 W US 0010882W WO 0063351 A3 WO0063351 A3 WO 0063351A3
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WO
WIPO (PCT)
Prior art keywords
cme
carbohydrate
modifying enzymes
provides
expression
Prior art date
Application number
PCT/US2000/010882
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English (en)
Other versions
WO2000063351A2 (fr
Inventor
Preeti Lal
Henry Yue
Y Tom Tang
Jennifer L Hillman
Mariah R Baughn
Junming Yang
Original Assignee
Incyte Genomics Inc
Preeti Lal
Henry Yue
Y Tom Tang
Jennifer L Hillman
Mariah R Baughn
Junming Yang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Preeti Lal, Henry Yue, Y Tom Tang, Jennifer L Hillman, Mariah R Baughn, Junming Yang filed Critical Incyte Genomics Inc
Priority to CA002369342A priority Critical patent/CA2369342A1/fr
Priority to EP00923579A priority patent/EP1173552A2/fr
Priority to AU43679/00A priority patent/AU4367900A/en
Priority to JP2000612430A priority patent/JP2002541836A/ja
Publication of WO2000063351A2 publication Critical patent/WO2000063351A2/fr
Publication of WO2000063351A3 publication Critical patent/WO2000063351A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01113—Mannosyl-oligosaccharide 1,2-alpha-mannosidase (3.2.1.113), i.e. alpha-1,2-mannosidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1241—Nucleotidyltransferases (2.7.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01017—Glucuronosyltransferase (2.4.1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07043—N-Acylneuraminate cytidylyltransferase (2.7.7.43)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01021—Beta-glucosidase (3.2.1.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention concerne des enzymes humaines modifiant les hydrates de carbone (CME), et des polynucléotides qui identifient et codent ces enzymes. L'invention concerne également des vecteurs d'expression, des cellules hôtes, des anticorps, des agonistes et des antagonistes. Elle concerne en outre des méthodes pour le diagnostic, le traitement et ou la prévention de troubles associés à l'expression de CME.
PCT/US2000/010882 1999-04-21 2000-04-20 Enzymes modifiant les hydrates de carbone WO2000063351A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002369342A CA2369342A1 (fr) 1999-04-21 2000-04-20 Enzymes modifiant les hydrates de carbone
EP00923579A EP1173552A2 (fr) 1999-04-21 2000-04-20 Enzymes modifiant les hydrates de carbone
AU43679/00A AU4367900A (en) 1999-04-21 2000-04-20 Carbohydrate-modifying enzymes
JP2000612430A JP2002541836A (ja) 1999-04-21 2000-04-20 炭水化物修飾酵素

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13038399P 1999-04-21 1999-04-21
US60/130,383 1999-04-21

Publications (2)

Publication Number Publication Date
WO2000063351A2 WO2000063351A2 (fr) 2000-10-26
WO2000063351A3 true WO2000063351A3 (fr) 2001-08-09

Family

ID=22444456

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/010882 WO2000063351A2 (fr) 1999-04-21 2000-04-20 Enzymes modifiant les hydrates de carbone

Country Status (5)

Country Link
EP (1) EP1173552A2 (fr)
JP (1) JP2002541836A (fr)
AU (1) AU4367900A (fr)
CA (1) CA2369342A1 (fr)
WO (1) WO2000063351A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6987014B2 (en) * 2000-08-30 2006-01-17 Applera Corporation Isolated nucleic acid molecules encoding human drug metabolizing proteins
EP1366162A2 (fr) * 2000-12-06 2003-12-03 Curagen Corporation Proteines putatives et acides nucleiques codant celles-ci
WO2002061059A2 (fr) * 2000-12-20 2002-08-08 Incyte Genomics, Inc. Enzymes du metabolisme des glucides
US7033790B2 (en) 2001-04-03 2006-04-25 Curagen Corporation Proteins and nucleic acids encoding same

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007573A1 (fr) * 1988-12-23 1990-07-12 Genzyme Corporation Glucosyl-ceramidase de recombinaison a action enzymatique
WO1994014472A1 (fr) * 1992-12-22 1994-07-07 The Regents Of The University Of California Procede pour inhiber l'adhesion cellulaire a des recepteurs renfermant des selectines
WO1994023070A1 (fr) * 1993-03-26 1994-10-13 New York Blood Center, Inc. α-N-ACETYLGALACTOSAMINIDASE RECOMBINEE ET ADNc CODANT CETTE ENZYME
WO1994025061A1 (fr) * 1993-04-23 1994-11-10 Glyko, Inc. Procedes et compositions permettant de traiter des maladies au moyen d'enzymes de modification d'hydrates de carbone
EP0737745A1 (fr) * 1993-12-24 1996-10-16 The Institute Of Physical & Chemical Research Nouvelle synthetase a chaine de sucres, et procede pour produire cette derniere
EP0893506A1 (fr) * 1996-04-05 1999-01-27 Seikagaku Corporation Polypeptide d'hyaluronate synthetase d'origine humaine et adn codant celui-ci

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990007573A1 (fr) * 1988-12-23 1990-07-12 Genzyme Corporation Glucosyl-ceramidase de recombinaison a action enzymatique
WO1994014472A1 (fr) * 1992-12-22 1994-07-07 The Regents Of The University Of California Procede pour inhiber l'adhesion cellulaire a des recepteurs renfermant des selectines
WO1994023070A1 (fr) * 1993-03-26 1994-10-13 New York Blood Center, Inc. α-N-ACETYLGALACTOSAMINIDASE RECOMBINEE ET ADNc CODANT CETTE ENZYME
WO1994025061A1 (fr) * 1993-04-23 1994-11-10 Glyko, Inc. Procedes et compositions permettant de traiter des maladies au moyen d'enzymes de modification d'hydrates de carbone
EP0737745A1 (fr) * 1993-12-24 1996-10-16 The Institute Of Physical & Chemical Research Nouvelle synthetase a chaine de sucres, et procede pour produire cette derniere
EP0893506A1 (fr) * 1996-04-05 1999-01-27 Seikagaku Corporation Polypeptide d'hyaluronate synthetase d'origine humaine et adn codant celui-ci

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MÜNSTER ANJA-K ET AL: "Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: A nuclear protein with evolutionarily conserved structural motifs.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES, vol. 95, no. 16, 4 August 1998 (1998-08-04), pages 9140 - 9145, XP002153786, ISSN: 0027-8424 *
NEHES V L ET AL: "HUMAN LYSOSOMAL ALPHA-MANNOSIDASE: ISOLATION AND NUCLEOTIDE SEQUENCE OF THE FULL-LENGTH CDNA1", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,US,ACADEMIC PRESS INC. ORLANDO, FL, vol. 200, no. 1, 15 April 1994 (1994-04-15), pages 239 - 245, XP000647751, ISSN: 0006-291X *

Also Published As

Publication number Publication date
CA2369342A1 (fr) 2000-10-26
AU4367900A (en) 2000-11-02
JP2002541836A (ja) 2002-12-10
WO2000063351A2 (fr) 2000-10-26
EP1173552A2 (fr) 2002-01-23

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