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WO2000061774A3 - Proteines morphogeniques osseuses bmp - Google Patents

Proteines morphogeniques osseuses bmp Download PDF

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Publication number
WO2000061774A3
WO2000061774A3 PCT/US2000/009028 US0009028W WO0061774A3 WO 2000061774 A3 WO2000061774 A3 WO 2000061774A3 US 0009028 W US0009028 W US 0009028W WO 0061774 A3 WO0061774 A3 WO 0061774A3
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WO
WIPO (PCT)
Prior art keywords
polypeptides
human bmp
bone morphogenic
morphogenic proteins
novel human
Prior art date
Application number
PCT/US2000/009028
Other languages
English (en)
Other versions
WO2000061774A2 (fr
Inventor
Steven M Ruben
Jian Ni
George Komatsoulis
Craig A Rosen
Yanggu Shi
Original Assignee
Human Genome Sciences Inc
Steven M Ruben
Jian Ni
George Komatsoulis
Craig A Rosen
Yanggu Shi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Human Genome Sciences Inc, Steven M Ruben, Jian Ni, George Komatsoulis, Craig A Rosen, Yanggu Shi filed Critical Human Genome Sciences Inc
Priority to JP2000611697A priority Critical patent/JP2003527076A/ja
Priority to AU40736/00A priority patent/AU4073600A/en
Priority to CA002365917A priority patent/CA2365917A1/fr
Publication of WO2000061774A2 publication Critical patent/WO2000061774A2/fr
Priority to US10/067,422 priority patent/US6743613B2/en
Publication of WO2000061774A3 publication Critical patent/WO2000061774A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/02—Immunomodulators
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Communicable Diseases (AREA)

Abstract

L'invention concerne des nouveaux polypeptides BMP humains et des acides nucléiques contenant les régions codantes des gène codant pour lesdits polypeptides. Elle porte également sur des vecteurs, sur des cellules hôtes, sur des anticorps et sur des méthodes de recombinaison pour la production de polypeptides BMP humains. Elle se rapporte encore à des méthodes diagnostiques et thérapeutiques utiles pour le diagnostic et le traitement de troubles liés à ces nouveaux polypeptides BMP humains.
PCT/US2000/009028 1999-04-09 2000-04-06 Proteines morphogeniques osseuses bmp WO2000061774A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2000611697A JP2003527076A (ja) 1999-04-09 2000-04-06 骨形態形成タンパク質
AU40736/00A AU4073600A (en) 1999-04-09 2000-04-06 Bone morphogenic proteins
CA002365917A CA2365917A1 (fr) 1999-04-09 2000-04-06 Proteines morphogeniques osseuses bmp
US10/067,422 US6743613B2 (en) 1999-04-23 2002-02-07 Lysyl-oxidase HOHEC84 polynucleotides

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US12870199P 1999-04-09 1999-04-09
US60/128,701 1999-04-09
US13069399P 1999-04-23 1999-04-23
US60/130,693 1999-04-23
US13167299P 1999-04-29 1999-04-29
US60/131,672 1999-04-29
US13863299P 1999-06-11 1999-06-11
US60/138,632 1999-06-11
US14702099P 1999-08-03 1999-08-03
US60/147,020 1999-08-03
US15293399P 1999-09-09 1999-09-09
US60/152,933 1999-09-09

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US68589900A Continuation-In-Part 1999-04-23 2000-10-11

Publications (2)

Publication Number Publication Date
WO2000061774A2 WO2000061774A2 (fr) 2000-10-19
WO2000061774A3 true WO2000061774A3 (fr) 2004-12-29

Family

ID=27558086

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/009028 WO2000061774A2 (fr) 1999-04-09 2000-04-06 Proteines morphogeniques osseuses bmp

Country Status (4)

Country Link
JP (1) JP2003527076A (fr)
AU (1) AU4073600A (fr)
CA (1) CA2365917A1 (fr)
WO (1) WO2000061774A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061774A2 (fr) * 1999-04-09 2000-10-19 Human Genome Sciences, Inc. Proteines morphogeniques osseuses bmp
US20020068322A1 (en) * 2000-05-26 2002-06-06 Rachel Meyers 47765, a novel human lysyl oxidase and uses thereof
US7208300B2 (en) * 2000-08-08 2007-04-24 Wyeth Member of the lysyl oxidase gene family
WO2002039118A1 (fr) * 2000-11-06 2002-05-16 Thrasos, Inc. Procedes de criblage de mimetiques morphogenetiques osseux
JP2002272470A (ja) * 2001-03-21 2002-09-24 Takashi Nakamura リジルオキシダーゼ関連タンパク質をコードする核酸
KR100996226B1 (ko) * 2001-10-31 2010-11-24 유니버시티 오브 노스 텍사스 헬스 사이언스 센터 뼈 형태발생 단백질(ｂｍｐ), ｂｍｐ 수용체 및 ｂｍｐ결합 단백질 및 녹내장 진단 및 치료에서 그의 용도
EP1738767A1 (fr) * 2001-10-31 2007-01-03 Alcon, Inc. Protéines morphogéniques osseuses (BMP), récepteurs desdites protéines et protéines de liaison de ces protéines, et leur utilisation pour le diagnostic et le traitement du glaucome
WO2003083079A2 (fr) * 2002-03-28 2003-10-09 Tissuegene, Inc. Generation d'os par therapie genique
CN112574293B (zh) * 2020-12-11 2022-12-16 浙江万里学院 一种利用超声辅助从鳖背甲中脱钙提取胶原蛋白的工艺

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716834A (en) * 1994-08-19 1998-02-10 National University Of Singapore Cloned factor C cDNA of the Singapore horseshoe crab, Carcinoscorpius rotundicauda and purification of factor C proenzyme
US6054293A (en) * 1997-07-08 2000-04-25 The Regents Of The University Of California Semaphorin receptors
WO2000061774A2 (fr) * 1999-04-09 2000-10-19 Human Genome Sciences, Inc. Proteines morphogeniques osseuses bmp

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716834A (en) * 1994-08-19 1998-02-10 National University Of Singapore Cloned factor C cDNA of the Singapore horseshoe crab, Carcinoscorpius rotundicauda and purification of factor C proenzyme
US6054293A (en) * 1997-07-08 2000-04-25 The Regents Of The University Of California Semaphorin receptors
WO2000061774A2 (fr) * 1999-04-09 2000-10-19 Human Genome Sciences, Inc. Proteines morphogeniques osseuses bmp

Also Published As

Publication number Publication date
WO2000061774A2 (fr) 2000-10-19
CA2365917A1 (fr) 2000-10-19
JP2003527076A (ja) 2003-09-16
AU4073600A (en) 2000-11-14

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