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WO2000061574A3 - Method for producing thiophenyl-amidines - Google Patents

Method for producing thiophenyl-amidines Download PDF

Info

Publication number
WO2000061574A3
WO2000061574A3 PCT/EP2000/003018 EP0003018W WO0061574A3 WO 2000061574 A3 WO2000061574 A3 WO 2000061574A3 EP 0003018 W EP0003018 W EP 0003018W WO 0061574 A3 WO0061574 A3 WO 0061574A3
Authority
WO
WIPO (PCT)
Prior art keywords
amidines
producing
thiophenyl
amidoximes
reacted
Prior art date
Application number
PCT/EP2000/003018
Other languages
German (de)
French (fr)
Other versions
WO2000061574A2 (en
Inventor
Thomas Zierke
Helmut Mack
Original Assignee
Basf Ag
Thomas Zierke
Helmut Mack
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag, Thomas Zierke, Helmut Mack filed Critical Basf Ag
Priority to CA002369267A priority Critical patent/CA2369267A1/en
Priority to JP2000610848A priority patent/JP2002541252A/en
Priority to AU35590/00A priority patent/AU3559000A/en
Priority to EP00914182A priority patent/EP1169315A2/en
Publication of WO2000061574A2 publication Critical patent/WO2000061574A2/en
Publication of WO2000061574A3 publication Critical patent/WO2000061574A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B43/00—Formation or introduction of functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

The invention relates to a method for producing amidines that are not substituted on the nitrogen atom and salts thereof with inorganic or organic acids. According to said method, the corresponding carboxylic acid amidoximes are reacted with Zn in the presence of carboxylic acids.
PCT/EP2000/003018 1999-04-09 2000-04-05 Method for producing thiophenyl-amidines WO2000061574A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002369267A CA2369267A1 (en) 1999-04-09 2000-04-05 Method for producing amidines
JP2000610848A JP2002541252A (en) 1999-04-09 2000-04-05 Amidine production
AU35590/00A AU3559000A (en) 1999-04-09 2000-04-05 Method for producing amidines
EP00914182A EP1169315A2 (en) 1999-04-09 2000-04-05 Method for producing amidines

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19915930 1999-04-09
DE19915930.0 1999-04-09
DE19933873.6 1999-07-23
DE19933873 1999-07-23

Publications (2)

Publication Number Publication Date
WO2000061574A2 WO2000061574A2 (en) 2000-10-19
WO2000061574A3 true WO2000061574A3 (en) 2001-04-26

Family

ID=26052817

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2000/003018 WO2000061574A2 (en) 1999-04-09 2000-04-05 Method for producing thiophenyl-amidines

Country Status (5)

Country Link
EP (1) EP1169315A2 (en)
JP (1) JP2002541252A (en)
AU (1) AU3559000A (en)
CA (1) CA2369267A1 (en)
WO (1) WO2000061574A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1357108A4 (en) * 2001-01-29 2005-12-07 Teijin Ltd Benzamidine derivatives and process for production thereof
ATE450522T1 (en) * 2005-03-16 2009-12-15 Janssen Pharmaceutica Nv NEW THIOPHENSULFOXIMINES FOR THE TREATMENT OF COMPLEMENT-MEDIATED DISEASES AND CONDITIONS

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2375611A (en) * 1941-08-19 1945-05-08 May & Baker Ltd Production of amidines
US2851490A (en) * 1955-04-20 1958-09-09 Monsanto Chemicals Guanyl aliphatic mono-carboxylic acids
WO1998006741A1 (en) * 1996-08-14 1998-02-19 Basf Aktiengesellschaft Thrombin inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2375611A (en) * 1941-08-19 1945-05-08 May & Baker Ltd Production of amidines
US2851490A (en) * 1955-04-20 1958-09-09 Monsanto Chemicals Guanyl aliphatic mono-carboxylic acids
WO1998006741A1 (en) * 1996-08-14 1998-02-19 Basf Aktiengesellschaft Thrombin inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
F. ELOY ET AL.: "THE CHEMISTRY OF AMIDOXIMES AND RELATED COMPOUNDS", CHEMICAL REVIEWS., vol. 62, 1962, AMERICAN CHEMICAL SOCIETY. EASTON., US, pages 155 - 183, XP002151891, ISSN: 0009-2665 *

Also Published As

Publication number Publication date
EP1169315A2 (en) 2002-01-09
CA2369267A1 (en) 2000-10-19
WO2000061574A2 (en) 2000-10-19
JP2002541252A (en) 2002-12-03
AU3559000A (en) 2000-11-14

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