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WO2000053252A1 - Dispositif et methode d'administration d'une matiere dans les cavites annexes des fosses nasales - Google Patents

Dispositif et methode d'administration d'une matiere dans les cavites annexes des fosses nasales Download PDF

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Publication number
WO2000053252A1
WO2000053252A1 PCT/US2000/003344 US0003344W WO0053252A1 WO 2000053252 A1 WO2000053252 A1 WO 2000053252A1 US 0003344 W US0003344 W US 0003344W WO 0053252 A1 WO0053252 A1 WO 0053252A1
Authority
WO
WIPO (PCT)
Prior art keywords
subject
body portion
pressure
distal end
tip portion
Prior art date
Application number
PCT/US2000/003344
Other languages
English (en)
Inventor
Jack M. Gwaltney, Jr.
Cameron R. Bass
Jan Helge Bohn
J. Owen Hendley
Walter F. O'brien
Birgit Winther
Original Assignee
University Of Virginia Patent Foundation
Virginia Polytechnic Institute And State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Virginia Patent Foundation, Virginia Polytechnic Institute And State University filed Critical University Of Virginia Patent Foundation
Priority to AU28762/00A priority Critical patent/AU2876200A/en
Publication of WO2000053252A1 publication Critical patent/WO2000053252A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0618—Nose

Definitions

  • the present invention relates to a device and method for treating sinus disease. More particularly, the present invention relates to a device and method for delivering a material into the middle meatus and paranasal sinus cavities.
  • Sinus disease is a common human affliction associated with substantial economic costs. In the United States alone, approximately 1 million cases of viral sinusitis, 20 million cases of bacterial sinusitis, and 200,000 cases of chronic sinusitis are reported each year. In the course of evaluating and treating these types of sinus disease, as well as cases of
  • paranasal sinuses by natural obstructions present in the nasal passages.
  • Human nasal passages are variegated and sinuous due to the presence of three turbinates and other structures projecting from the lateral wall.
  • the paranasal sinuses are air-filled cavities that drain in the nasal passages by narrow portals or ostea.
  • paranasal sinus cavities Accordingly, conventional devices are largely incapable of delivering materials into the paranasal sinus cavities. Accordingly, it is desirable to identify a
  • the device and method of the present invention addresses the several
  • device of the present invention generally includes an elongated body portion having a distal end and a proximal end, and a passage therethrough extending from the proximal end to the
  • the distal end of the body portion may have a separate or
  • the tip portion may have a spray orifice, and is anatomically curved for inserting the tip portion through the nasal passages and positioning it in the middle meatus (ostiomeatal complex).
  • the curved portion of the tip portion includes a first curve or bend, and may include a second curve or bend that is disposed orthogonally to the first curve. The first and second curves preferably are selected to ensure that the tip portion of the device will
  • the distal end of the device is coated with a low-friction, biocompatible lubricant or other material, such as Teflon® or K-Y Jelly®, to aid the comfortable insertion of the device.
  • a low-friction, biocompatible lubricant or other material such as Teflon® or K-Y Jelly®
  • the tip portion may be configured to be detachable from the body portion of
  • the tip portion is detachable, it can also be disposable, reducing the cost of
  • the entire device may be configured so as to be disposable after
  • the proximal end of the body portion is configured to receive a material to be directed through the passage in the body portion and out the tip portion of the device.
  • the device also may include a reservoir attached to the proximal end of the body portion, which
  • a pressure device may be used to hold a quantity of material for delivery.
  • a pressure device also may be operatively attached to the device of the present invention, the pressure device being configured to apply pressure sufficient to deliver a material, such as a liquid medication, through the body portion and out the tip portion (distal portion) of the device and into a
  • the pressure device may be further configured (or a separate pressure device may be employed) to apply pressure sufficient to increase the pressure in the subject's nasal passages and thereby assist the movement of the material into one or more of the subject's paranasal cavities from the middle meatus.
  • the pressure device may be formed
  • the device of the present invention may include, for example, a syringe, a flexible bulb, or a clinical pressure system of the type frequently found in physician's offices.
  • a clinical pressure system may be utilized, the device of the present invention may include an adaptor to attach to such a
  • the device also may include a guide attached to the body portion of the device, the guide being designed to assist in properly inserting the distal end of the body
  • the guide may include one or more of an
  • the method of the present invention includes two steps.
  • the first step of the method of the present invention includes delivering a material into the subject's - ' . middle meatus.
  • the second step of the method includes applying pressure in the subject's
  • nasal passages sufficient to deliver the material into one or more of the subject's paranasal
  • the first step of the method of the present invention may further include providing a device, such as the device of the present invention, for delivering the material
  • the second step of the method of the present invention may be performed, for
  • FIG. 1 is an elevational side view of one embodiment of the device of the present invention.
  • FIG. 2A is a cross-sectional side view of one embodiment of a tip portion of the device of the present invention.
  • FIG. 2B is an elevational top view of the tip portion of the embodiment of the device of FIG. 2A.
  • FIG. 3 is a partial orthogonal representation of the human nasal passages, illustrating the preferred insertion of the embodiment of the device of FIG. 1.
  • FIG. 4 is a partial cross-sectional representation of the human nasal passages, illustrating the insertion of another embodiment of the device of the present invention.
  • FIG. 5 is a graph illustrating the intranasal pressure time history for a human
  • FIG. 6 is a graph illustrating the effect of the application of an external
  • FIG. 7 is a graph illustrating the effect of an external pressure transient on total
  • aqueous fluid flow in a typical human maxillary sinus in a typical human maxillary sinus.
  • the present invention includes a method and device for delivering a material
  • the device and method of the present invention can be designed to
  • FIG. 1 One embodiment of the device of the present invention is illustrated in FIG. 1.
  • the device 10 generally includes an elongated body portion 12 having a proximal end 13 and a distal end 15.
  • Body portion 12 defines a passage therein extending from proximal end 13 to distal end 15.
  • Body portion 12 may be constructed in various lengths as appropriate to the needs and circumstances of use.
  • body portion 12 is
  • Body portion 12 for insertion into a human nose, and extension into the middle meatus at distal end 15. Such a body portion 12 may be further refined to custom-fit a particular human subject.
  • Body portion 12 may be constructed of any suitable material or combination of materials, including
  • thermoplastics or other materials which are biocompatible, sufficiently soft to be comfortable to a human or other subject, and sufficiently rigid to retain their shape, yet not so rigid as to be uncomfortably unyielding when being positioned in a subject's nasal passages. It may have a cross-section that is cylindrical, or any other shape that is advantageous for
  • the cross-section of device 10 preferably is as small as
  • Proximal end 13 is configured to receive a material to be directed into the passage in body portion 12.
  • proximal end 13 may include a reservoir 14, as in
  • FIG. 1 or otherwise be connected to a reservoir 14, containing a material to be delivered to
  • Reservoir 14 may be any type of device
  • reservoir 14 may be constructed as a flexible bulb such as that used in connection
  • conventional blood pressure measurement devices as illustrated in FIG. 1, or may comprise a conventional syringe or any other device capable of containing the material to be
  • the volume of reservoir 14 must be large enough to contain a volume of a chosen
  • the reservoir should be capable of holding a volume of the chosen material which is
  • distal end 15 of body portion 12 incorporates a first curve 17 which, for use in connection with human subjects, is in the range
  • curve 17 is designed to facilitate the insertion of device 10 through a subject's nasal vestibule
  • distal end 15 of device 10 will be positioned in line-of sight of the space between the inferior turbinate and the middle turbinate bone, and therefore in line of sight with the
  • first curve 17 distal end 15 of device 10 is able, when so positioned, to maintain a spray direction ensuring an optimum spray pattern for the delivery of material into the anterior portion of the middle meatus.
  • distal end 15 of body portion 12 may have an integral
  • tip portion 16 contains first curve 17, provides the desirably elliptical shape for distal end 15 of body portion 12 (as is discussed in greater detail
  • Tip portion 16 may be constructed from any suitable material, such as one or more thermoplastics.
  • tip portion 16 is a heat-shrunk thermoplastic sheath 19 over a looped stainless steel spring wire 20.
  • tip portion 16 may be fabricated without wire 20 to define its shape, for example, by blow
  • tip portion 16 is injection molding, extrusion or injection molding.
  • tip portion 16 is injection molding, extrusion or injection molding.
  • biocompatible material or lubricant such as Teflon® or K-Y Jelly®, to aid the insertion of device 10 through the subject's nasal vestibule and into the anterior portion of the subject's
  • Tip portion 16 preferably has an elliptical shape. In the embodiment of
  • FIGS. 2A and 2B this shape is formed by the looped stainless steel wire previously
  • tip portion 16 has a cross-section measuring approximately 2 millimeters by 4
  • first curve 17 lies in the plane of the 2 millimeter
  • the overall length of device 10 in the embodiment of FIG. 1 is between 8 and 12 centimeters and the length from the distal end 18 of tip portion 16 to the start of first curve 17
  • Distal end 15 of body portion 12 preferably includes a second curve 19 in an
  • Second curve 19 is generally less than or equal to approximately 30 degrees, and preferably is approximately 20 degrees. The magnitude of
  • second curve 19 may be optimized, like first curve 17, in accordance with the anatomy of a particular subject. Although not essential to the efficacy of device 10, second curve 19 may operate in conjunction with orthogonal curve 17 to further facilitate the insertion of device 10 through the nasal vestibule and into the anterior portion of the middle meatus.
  • Device 10 may include, or be adapted for use with, a pressure device
  • device 10 operatively attached to device 10 to apply pressure sufficient to deliver a material from proximal end 13, through the passage in body portion 12, out tip portion 16 and into a subject's middle meatus.
  • the same pressure device, or an additional pressure or flow device, is operatively attached to device 10 to apply pressure sufficient to deliver a material from proximal end 13, through the passage in body portion 12, out tip portion 16 and into a subject's middle meatus.
  • Such a device include a common syringe or flexible bulb, both of which may
  • the flexible bulb serving as reservoir 14 in FIG. 1 could be manually compressed to create a pressure, forcing a
  • the pressure device and reservoir 14 need not be so combined, as the pressure device may
  • the pressure device must be capable of delivering a level of pressure which is effective to drive a sufficient volume of medicines or other selected materials into the middle meatus, or better still, the paranasal sinuses. As is discussed in greater detail below, a pressure of approximately 66 mm-Hg has been found to be sufficient to drive material from
  • a pressure regulator preferably is used in
  • Hg are generally safe for use in human nasal passages, although pressures as high as 176 mm-
  • device 10 may include a guide 22 configured to assist a user in comfortably and effectively positioning distal end 15 of body portion 12 into a
  • guide 22 is designed to include an insertion limiting portion 24 that, by having a cross section larger than the vestibule of a subject's nose, prevents device 10 from extending into a subject's nasal
  • Guide 22 also may be constructed to include a
  • vestibule locating portion 28 which may serve the same function as an insertion limiting
  • abutment portion 26 configured to
  • the abutment portion 26 of guide 22 shown in FIG. 4 is configured to comfortably abut a human subject's upper lip.
  • guide 22 may be separate from device 10 and placed in the vestibule of a subj ect' s nose prior to use of the device.
  • Guide 22 may be attached to, or integrally formed with, device 10. Alternatively, guide 22 may be configured so that, once guide 22 is in place in the vestibule
  • body portion 12 of device 10 may be inserted through a passage in guide
  • guide 22 preferably includes a manually operable cam (not shown) or other device for selectively fixing guide 22
  • body portion 12 so that the position of guide 22 relative to distal end 15 of body portion 12 may be adjusted as needed.
  • the present invention also includes a non-invasive method for delivering a material into one or more of a subject's paranasal sinus cavities.
  • the method of the present invention involves two principle steps. The first step is to deliver a quantity of
  • the second step is to apply a pressure to the
  • subject's nasal passages sufficient to deliver the material into one or more of the subject's
  • the first step of the method of the present invention may be carried out with the subject's head positioned parallel to the floor or in another inclined or reclined position,
  • the second step also may be performed while the subject's head is in same position, or in another position provided that the second step of the method is
  • the material preferably is delivered to the middle meatus in the first step using a device, such as those illustrated in the
  • FIGS. 1-4 configured to consistently deposit a selected amount of material in the middle meatus with maximum efficacy and comfort.
  • the second step of the present invention may be performed by applying a pressure in the subject's
  • This application of pressure may be accomplished in any suitable manner.
  • the subject may be asked to blow the
  • second step of the method of the present invention uses the air that is naturally present in the subject's sinus cavities as a "surge tank" that contracts under the application of fluid pressure
  • paranasal sinus cavities through natural passages present in the subject's nasal passageway.
  • the device and method of the present invention represent a non-invasive technique by which to ensure that
  • the invention greatly increases the user's ability to ensure that an effective dosage of medication or other material will be deposited in the middle meatus, and not merely be deposited on one or more of the various nasal surfaces leading to the middle meatus and thereby wasted.
  • the device of the present invention may be made of any material that has more of the paranasal sinuses.
  • the device of the present invention may be made of any material having more of the paranasal sinuses.
  • the device of the present invention may be made of any material having more of the paranasal sinuses.
  • Example 1 Materials and Methods Healthy adult volunteers with no history of nasal symptoms for one month
  • Intranasal pressures were measured during nose blowing, sneezing, and coughing with a Millar SP-524 catheter pressure transducer (catheter diameter 2.5 French, transducer diameter 3.0 French) positioned above the inferior turbinate and a DSP Traq-Q data acquisition system. Data was sampled at
  • FIG. 5 A graph of the increase in intranasal pressure measured with a transducer in the nasal passages of one of the human volunteers performing a voluntary nose blow is shown in FIG 5.
  • the graph of FIG. 5 illustrates an increase in intranasal pressure of
  • intranasal pressure from 18 voluntary coughing bouts was 6.6 ( ⁇ 2.6) mm-Hg, and that from 1 minute of tidal breathing by each of 4 subjects was 0.9 ( ⁇ 0.4) mm-Hg.
  • intranasal pressure transients were characterized by sinusoidal waves of long duration and very small amplitude.
  • the maxillary sinus cavity had a volume of 14.25 mL and the cylindrical infundibulum
  • the graph of FIG. 6 was developed by modeling the measured parameters as
  • the pressure transient changes the amount of material that flows from the nasal passages into

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un dispositif et une méthode d'administration de matières telles que des médicaments ou autres matières thérapeutiques ou diagnostiques utiles dans le traitement de la maladie du sinus, dans le méat moyen, et dans les cavités annexes des fosses nasales (figure). Le dispositif présente une partie de corps allongé ayant une extrémité distale (15), une extrémité proximale (13), ainsi qu'un passage s'étendant à partir de l'extrémité proximale jusqu'à l'extrémité distale de la partie de corps (12) à travers celles-ci.
PCT/US2000/003344 1999-03-08 2000-02-10 Dispositif et methode d'administration d'une matiere dans les cavites annexes des fosses nasales WO2000053252A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU28762/00A AU2876200A (en) 1999-03-08 2000-02-10 Device and method for delivering a material into the paranasal sinus cavities

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12323899P 1999-03-08 1999-03-08
US60/123,238 1999-03-08
US12568599P 1999-03-23 1999-03-23
US60/125,685 1999-03-23

Publications (1)

Publication Number Publication Date
WO2000053252A1 true WO2000053252A1 (fr) 2000-09-14

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WO (1) WO2000053252A1 (fr)

Cited By (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002062269A1 (fr) * 2001-02-06 2002-08-15 Goepferich Achim Dispositif de maintien d'espace pour liberation d'un principe actif dans le sinus nasal
JP2009500051A (ja) * 2005-06-10 2009-01-08 アクラレント インコーポレイテッド 副鼻腔炎を治療する装置及びシステム
US7559925B2 (en) 2006-09-15 2009-07-14 Acclarent Inc. Methods and devices for facilitating visualization in a surgical environment
US7654997B2 (en) 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat
US8109981B2 (en) 2005-01-25 2012-02-07 Valam Corporation Optical therapies and devices
US8852143B2 (en) 2004-04-21 2014-10-07 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US8864787B2 (en) 2004-04-21 2014-10-21 Acclarent, Inc. Ethmoidotomy system and implantable spacer devices having therapeutic substance delivery capability for treatment of paranasal sinusitis
US8894614B2 (en) 2004-04-21 2014-11-25 Acclarent, Inc. Devices, systems and methods useable for treating frontal sinusitis
US8932276B1 (en) 2004-04-21 2015-01-13 Acclarent, Inc. Shapeable guide catheters and related methods
US8945088B2 (en) 2004-04-21 2015-02-03 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US8951225B2 (en) 2005-06-10 2015-02-10 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US8961398B2 (en) 2004-04-21 2015-02-24 Acclarent, Inc. Methods and apparatus for treating disorders of the ear, nose and throat
US8968269B2 (en) 2005-09-23 2015-03-03 Acclarent, Inc. Multi-conduit balloon catheter
US8979888B2 (en) 2008-07-30 2015-03-17 Acclarent, Inc. Paranasal ostium finder devices and methods
US9039680B2 (en) 2004-08-04 2015-05-26 Acclarent, Inc. Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
US9072626B2 (en) 2009-03-31 2015-07-07 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US9089258B2 (en) 2004-04-21 2015-07-28 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9101384B2 (en) 2004-04-21 2015-08-11 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, Nose and/or throat
US9155492B2 (en) 2010-09-24 2015-10-13 Acclarent, Inc. Sinus illumination lightwire device
US9198736B2 (en) 2006-05-17 2015-12-01 Acclarent, Inc. Adapter for attaching electromagnetic image guidance components to a medical device
US9265407B2 (en) 2004-04-21 2016-02-23 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9308361B2 (en) 2005-01-18 2016-04-12 Acclarent, Inc. Implantable devices and methods for treating sinusitis and other disorders
US9351750B2 (en) 2004-04-21 2016-05-31 Acclarent, Inc. Devices and methods for treating maxillary sinus disease
US9399121B2 (en) 2004-04-21 2016-07-26 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US9433437B2 (en) 2013-03-15 2016-09-06 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US9457175B2 (en) 2002-09-30 2016-10-04 Acclarent, Inc. Balloon catheters and methods for treating paranasal sinuses
US9463068B2 (en) 2007-05-08 2016-10-11 Acclarent, Inc. Methods and devices for protecting nasal turbinates
US9468362B2 (en) 2004-04-21 2016-10-18 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9615775B2 (en) 2007-04-30 2017-04-11 Acclarent, Inc. Methods and devices for ostium measurements
US9629684B2 (en) 2013-03-15 2017-04-25 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US9636258B2 (en) 2009-03-31 2017-05-02 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US9649477B2 (en) 2004-04-21 2017-05-16 Acclarent, Inc. Frontal sinus spacer
US9820688B2 (en) 2006-09-15 2017-11-21 Acclarent, Inc. Sinus illumination lightwire device
US9826999B2 (en) 2004-04-21 2017-11-28 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US9861793B2 (en) 2008-03-10 2018-01-09 Acclarent, Inc. Corewire design and construction for medical devices
US10188413B1 (en) 2004-04-21 2019-01-29 Acclarent, Inc. Deflectable guide catheters and related methods
US10206821B2 (en) 2007-12-20 2019-02-19 Acclarent, Inc. Eustachian tube dilation balloon with ventilation path
US10524814B2 (en) 2009-03-20 2020-01-07 Acclarent, Inc. Guide system with suction
US10631756B2 (en) 2004-04-21 2020-04-28 Acclarent, Inc. Guidewires for performing image guided procedures
WO2020197995A1 (fr) 2019-03-28 2020-10-01 The Board Of Trustees Of The Leland Stanford Junior University Système d'administration par voie nasale de médicament
US10874838B2 (en) 2004-04-21 2020-12-29 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US11065061B2 (en) 2004-04-21 2021-07-20 Acclarent, Inc. Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses
US11529502B2 (en) 2004-04-21 2022-12-20 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US12303154B2 (en) 2021-11-12 2025-05-20 Acclarent, Inc. Guide system with suction

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3871373A (en) * 1972-10-30 1975-03-18 Richard R Jackson Humidifying gas
US5512045A (en) * 1993-12-22 1996-04-30 Gurchumelidze; Teimuraz P. Surgical decompression and irrigation apparatus and method

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3871373A (en) * 1972-10-30 1975-03-18 Richard R Jackson Humidifying gas
US5512045A (en) * 1993-12-22 1996-04-30 Gurchumelidze; Teimuraz P. Surgical decompression and irrigation apparatus and method

Cited By (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002062269A1 (fr) * 2001-02-06 2002-08-15 Goepferich Achim Dispositif de maintien d'espace pour liberation d'un principe actif dans le sinus nasal
US9457175B2 (en) 2002-09-30 2016-10-04 Acclarent, Inc. Balloon catheters and methods for treating paranasal sinuses
US11511090B2 (en) 2004-04-21 2022-11-29 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US9167961B2 (en) 2004-04-21 2015-10-27 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US7771409B2 (en) 2004-04-21 2010-08-10 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US7803150B2 (en) 2004-04-21 2010-09-28 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US10188413B1 (en) 2004-04-21 2019-01-29 Acclarent, Inc. Deflectable guide catheters and related methods
US10098652B2 (en) 2004-04-21 2018-10-16 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US8852143B2 (en) 2004-04-21 2014-10-07 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US8858586B2 (en) 2004-04-21 2014-10-14 Acclarent, Inc. Methods for enlarging ostia of paranasal sinuses
US8864787B2 (en) 2004-04-21 2014-10-21 Acclarent, Inc. Ethmoidotomy system and implantable spacer devices having therapeutic substance delivery capability for treatment of paranasal sinusitis
US8870893B2 (en) 2004-04-21 2014-10-28 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US8894614B2 (en) 2004-04-21 2014-11-25 Acclarent, Inc. Devices, systems and methods useable for treating frontal sinusitis
US8905922B2 (en) 2004-04-21 2014-12-09 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US8932276B1 (en) 2004-04-21 2015-01-13 Acclarent, Inc. Shapeable guide catheters and related methods
US8945088B2 (en) 2004-04-21 2015-02-03 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US10034682B2 (en) 2004-04-21 2018-07-31 Acclarent, Inc. Devices, systems and methods useable for treating frontal sinusitis
US8961398B2 (en) 2004-04-21 2015-02-24 Acclarent, Inc. Methods and apparatus for treating disorders of the ear, nose and throat
US8961495B2 (en) 2004-04-21 2015-02-24 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US11864725B2 (en) 2004-04-21 2024-01-09 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US11589742B2 (en) 2004-04-21 2023-02-28 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US10492810B2 (en) 2004-04-21 2019-12-03 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US10500380B2 (en) 2004-04-21 2019-12-10 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US11957318B2 (en) 2004-04-21 2024-04-16 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US9055965B2 (en) 2004-04-21 2015-06-16 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US11529502B2 (en) 2004-04-21 2022-12-20 Acclarent, Inc. Apparatus and methods for dilating and modifying ostia of paranasal sinuses and other intranasal or paranasal structures
US9826999B2 (en) 2004-04-21 2017-11-28 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US9089258B2 (en) 2004-04-21 2015-07-28 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9101384B2 (en) 2004-04-21 2015-08-11 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, Nose and/or throat
US9107574B2 (en) 2004-04-21 2015-08-18 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US10441758B2 (en) 2004-04-21 2019-10-15 Acclarent, Inc. Frontal sinus spacer
US9220879B2 (en) 2004-04-21 2015-12-29 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US7654997B2 (en) 2004-04-21 2010-02-02 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitus and other disorders of the ears, nose and/or throat
US10631756B2 (en) 2004-04-21 2020-04-28 Acclarent, Inc. Guidewires for performing image guided procedures
US11202644B2 (en) 2004-04-21 2021-12-21 Acclarent, Inc. Shapeable guide catheters and related methods
US9241834B2 (en) 2004-04-21 2016-01-26 Acclarent, Inc. Devices, systems and methods for treating disorders of the ear, nose and throat
US9265407B2 (en) 2004-04-21 2016-02-23 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US11065061B2 (en) 2004-04-21 2021-07-20 Acclarent, Inc. Systems and methods for performing image guided procedures within the ear, nose, throat and paranasal sinuses
US9351750B2 (en) 2004-04-21 2016-05-31 Acclarent, Inc. Devices and methods for treating maxillary sinus disease
US9370649B2 (en) 2004-04-21 2016-06-21 Acclarent, Inc. Devices, systems and methods useable for treating sinusitis
US9399121B2 (en) 2004-04-21 2016-07-26 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US11019989B2 (en) 2004-04-21 2021-06-01 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US10695080B2 (en) 2004-04-21 2020-06-30 Acclarent, Inc. Devices, systems and methods for diagnosing and treating sinusitis and other disorders of the ears, nose and/or throat
US11020136B2 (en) 2004-04-21 2021-06-01 Acclarent, Inc. Deflectable guide catheters and related methods
US9468362B2 (en) 2004-04-21 2016-10-18 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9554691B2 (en) 2004-04-21 2017-01-31 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US10874838B2 (en) 2004-04-21 2020-12-29 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US10856727B2 (en) 2004-04-21 2020-12-08 Acclarent, Inc. Endoscopic methods and devices for transnasal procedures
US9610428B2 (en) 2004-04-21 2017-04-04 Acclarent, Inc. Devices, systems and methods useable for treating frontal sinusitis
US9649477B2 (en) 2004-04-21 2017-05-16 Acclarent, Inc. Frontal sinus spacer
US10806477B2 (en) 2004-04-21 2020-10-20 Acclarent, Inc. Systems and methods for transnasal dilation of passageways in the ear, nose or throat
US10779752B2 (en) 2004-04-21 2020-09-22 Acclarent, Inc. Guidewires for performing image guided procedures
US10702295B2 (en) 2004-04-21 2020-07-07 Acclarent, Inc. Methods and apparatus for treating disorders of the ear nose and throat
US9084876B2 (en) 2004-08-04 2015-07-21 Acclarent, Inc. Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
US9039657B2 (en) 2004-08-04 2015-05-26 Acclarent, Inc. Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
US9039680B2 (en) 2004-08-04 2015-05-26 Acclarent, Inc. Implantable devices and methods for delivering drugs and other substances to treat sinusitis and other disorders
US9308361B2 (en) 2005-01-18 2016-04-12 Acclarent, Inc. Implantable devices and methods for treating sinusitis and other disorders
US8109981B2 (en) 2005-01-25 2012-02-07 Valam Corporation Optical therapies and devices
US10842978B2 (en) 2005-06-10 2020-11-24 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
JP2009500051A (ja) * 2005-06-10 2009-01-08 アクラレント インコーポレイテッド 副鼻腔炎を治療する装置及びシステム
US8951225B2 (en) 2005-06-10 2015-02-10 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
JP2012192196A (ja) * 2005-06-10 2012-10-11 Acclarent Inc 副鼻腔炎を治療するシステム
US10124154B2 (en) 2005-06-10 2018-11-13 Acclarent, Inc. Catheters with non-removable guide members useable for treatment of sinusitis
US9050440B2 (en) 2005-09-23 2015-06-09 Acclarent, Inc. Multi-conduit balloon catheter
US10639457B2 (en) 2005-09-23 2020-05-05 Acclarent, Inc. Multi-conduit balloon catheter
US8968269B2 (en) 2005-09-23 2015-03-03 Acclarent, Inc. Multi-conduit balloon catheter
US9999752B2 (en) 2005-09-23 2018-06-19 Acclarent, Inc. Multi-conduit balloon catheter
US9198736B2 (en) 2006-05-17 2015-12-01 Acclarent, Inc. Adapter for attaching electromagnetic image guidance components to a medical device
US9629656B2 (en) 2006-05-17 2017-04-25 Acclarent, Inc. Adapter for attaching electromagnetic image guidance components to a medical device
US9603506B2 (en) 2006-09-15 2017-03-28 Acclarent, Inc. Methods and devices for facilitating visualization in a surgical environment
US9820688B2 (en) 2006-09-15 2017-11-21 Acclarent, Inc. Sinus illumination lightwire device
US7559925B2 (en) 2006-09-15 2009-07-14 Acclarent Inc. Methods and devices for facilitating visualization in a surgical environment
US9179823B2 (en) 2006-09-15 2015-11-10 Acclarent, Inc. Methods and devices for facilitating visualization in a surgical environment
US10716629B2 (en) 2006-09-15 2020-07-21 Acclarent, Inc. Methods and devices for facilitating visualization in a surgical environment
US9572480B2 (en) 2006-09-15 2017-02-21 Acclarent, Inc. Methods and devices for facilitating visualization in a surgical environment
US9615775B2 (en) 2007-04-30 2017-04-11 Acclarent, Inc. Methods and devices for ostium measurements
US9463068B2 (en) 2007-05-08 2016-10-11 Acclarent, Inc. Methods and devices for protecting nasal turbinates
US11311419B2 (en) 2007-12-20 2022-04-26 Acclarent, Inc. Eustachian tube dilation balloon with ventilation path
US11850120B2 (en) 2007-12-20 2023-12-26 Acclarent, Inc. Eustachian tube dilation balloon with ventilation path
US10206821B2 (en) 2007-12-20 2019-02-19 Acclarent, Inc. Eustachian tube dilation balloon with ventilation path
US9861793B2 (en) 2008-03-10 2018-01-09 Acclarent, Inc. Corewire design and construction for medical devices
US10271719B2 (en) 2008-07-30 2019-04-30 Acclarent, Inc. Paranasal ostium finder devices and methods
US8979888B2 (en) 2008-07-30 2015-03-17 Acclarent, Inc. Paranasal ostium finder devices and methods
US11116392B2 (en) 2008-07-30 2021-09-14 Acclarent, Inc. Paranasal ostium finder devices and methods
US9750401B2 (en) 2008-07-30 2017-09-05 Acclarent, Inc. Paranasal ostium finder devices and methods
US11207087B2 (en) 2009-03-20 2021-12-28 Acclarent, Inc. Guide system with suction
US10524814B2 (en) 2009-03-20 2020-01-07 Acclarent, Inc. Guide system with suction
US9636258B2 (en) 2009-03-31 2017-05-02 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US10376416B2 (en) 2009-03-31 2019-08-13 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US9072626B2 (en) 2009-03-31 2015-07-07 Acclarent, Inc. System and method for treatment of non-ventilating middle ear by providing a gas pathway through the nasopharynx
US9155492B2 (en) 2010-09-24 2015-10-13 Acclarent, Inc. Sinus illumination lightwire device
US9433437B2 (en) 2013-03-15 2016-09-06 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US9629684B2 (en) 2013-03-15 2017-04-25 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
US10524869B2 (en) 2013-03-15 2020-01-07 Acclarent, Inc. Apparatus and method for treatment of ethmoid sinusitis
WO2020197995A1 (fr) 2019-03-28 2020-10-01 The Board Of Trustees Of The Leland Stanford Junior University Système d'administration par voie nasale de médicament
EP3941561A4 (fr) * 2019-03-28 2022-12-28 The Board of Trustees of the Leland Stanford Junior University Système d'administration par voie nasale de médicament
EP4406582A3 (fr) * 2019-03-28 2024-10-09 The Board of Trustees of the Leland Stanford Junior University Système d'administration de médicament nasal
US12303154B2 (en) 2021-11-12 2025-05-20 Acclarent, Inc. Guide system with suction

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