+

WO2000053166A3 - Utilisation de derives de 2,3-benzodiazepine pour le traitement et la prevention de maladies liees a l'inhibition de peroxydation lipidique - Google Patents

Utilisation de derives de 2,3-benzodiazepine pour le traitement et la prevention de maladies liees a l'inhibition de peroxydation lipidique Download PDF

Info

Publication number
WO2000053166A3
WO2000053166A3 PCT/HU2000/000011 HU0000011W WO0053166A3 WO 2000053166 A3 WO2000053166 A3 WO 2000053166A3 HU 0000011 W HU0000011 W HU 0000011W WO 0053166 A3 WO0053166 A3 WO 0053166A3
Authority
WO
WIPO (PCT)
Prior art keywords
prophylaxis
treatment
lipid peroxidation
benzodiazepine derivatives
condensed
Prior art date
Application number
PCT/HU2000/000011
Other languages
English (en)
Other versions
WO2000053166A2 (fr
Inventor
Bajnogel Judit Raczne
Gabor Szenasi
Gabor Gigler
Gyoergy Levay
Geza Szabo
Karoly Tihanyi
Andras Egyed
Jozsef Barkoczy
Zoltan Ratkai
Zoltan Greff
Geza Schneider
Gyula Simig
Laszlo Balazs
Imre Doman
Nagy Peter Kotay
Peter Seres
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Bajnogel Judit Raczne
Gabor Szenasi
Gabor Gigler
Gyoergy Levay
Geza Szabo
Karoly Tihanyi
Andras Egyed
Jozsef Barkoczy
Zoltan Ratkai
Zoltan Greff
Geza Schneider
Gyula Simig
Laszlo Balazs
Imre Doman
Nagy Peter Kotay
Peter Seres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Bajnogel Judit Raczne, Gabor Szenasi, Gabor Gigler, Gyoergy Levay, Geza Szabo, Karoly Tihanyi, Andras Egyed, Jozsef Barkoczy, Zoltan Ratkai, Zoltan Greff, Geza Schneider, Gyula Simig, Laszlo Balazs, Imre Doman, Nagy Peter Kotay, Peter Seres filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to AU28194/00A priority Critical patent/AU2819400A/en
Publication of WO2000053166A2 publication Critical patent/WO2000053166A2/fr
Publication of WO2000053166A3 publication Critical patent/WO2000053166A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne l'utilisation de dérivés de 9H-1,3-dioxolo(4,5-h)(2,3)benzodiazepine 8-substituée de formule générale (I) (dans laquelle X, R1, ou X, R2, R3, Y sont tels que définis dans le descriptif) et des sels d'addition acide pharmaceutiquement acceptables ainsi que leurs dérivés d'ammoniac quaternaire pour la préparation de compositions pharmaceutiques indiquées pour le traitement ou la prévention de maladies ou de pathologies liées à une peroxydation lipidique (pathologique).
PCT/HU2000/000011 1999-02-15 2000-02-15 Utilisation de derives de 2,3-benzodiazepine pour le traitement et la prevention de maladies liees a l'inhibition de peroxydation lipidique WO2000053166A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU28194/00A AU2819400A (en) 1999-02-15 2000-02-15 Use of condensed 2,3-benzodiazepine derivatives for the treatment and prophylaxis of diseases related to the inhibition of lipid peroxidation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9900354A HUP9900354A3 (en) 1999-02-15 1999-02-15 Use of condensed 2,3-benzodiazepine derivatives for the preparation of pharmaceutical compositions treating and preventing diseases related with the inhibition of lipide peroxidation
HUP9900354 1999-02-15

Publications (2)

Publication Number Publication Date
WO2000053166A2 WO2000053166A2 (fr) 2000-09-14
WO2000053166A3 true WO2000053166A3 (fr) 2000-12-21

Family

ID=89997786

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2000/000011 WO2000053166A2 (fr) 1999-02-15 2000-02-15 Utilisation de derives de 2,3-benzodiazepine pour le traitement et la prevention de maladies liees a l'inhibition de peroxydation lipidique

Country Status (3)

Country Link
AU (1) AU2819400A (fr)
HU (1) HUP9900354A3 (fr)
WO (1) WO2000053166A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201536795A (zh) 2013-05-31 2015-10-01 Medeia Therapeutics Ltd 作為細胞保護劑用之芳基噻嗪化合物

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992011262A1 (fr) * 1990-12-21 1992-07-09 Gyógyszerkutató Intézet K.V. Derives de 1-(4-acylaminophenyl)-7,8-methylenedioxy-5h-2,3-benzo-diazepine, leurs sels d'addition d'acides, compositions pharmaceutiques les contenant, et leur procede de preparation
US5519019A (en) * 1990-12-21 1996-05-21 Gyogyszerkutato Intezet N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
WO1998030229A1 (fr) * 1997-01-10 1998-07-16 Massachusetts Institute Of Technology TRAITEMENTS RELATIFS A LA NEUROTOXICITE DANS LA MALADIE D'ALZHEIMER PROVOQUEE PAR DES PEPTIDES β-AMYLOIDES
WO1999007708A1 (fr) * 1997-08-12 1999-02-18 EGIS Gyógyszergyár Rt. Derives de 1,3-dioxolo/4,5-h//2,3/benzodiazepine utilises comme inhibiteurs des recepteurs ampa/kainate
WO1999007707A1 (fr) * 1997-08-12 1999-02-18 EGIS Gyógyszergyár Rt. DERIVES DE 9H-1,3-DIOXOLO/4,5-h//2,3/BENZODIAZEPINE SUBSTITUEE EN HUIT UTILISES COMME INHIBITEURS DES RECEPTEURS D'AMPA/KAINATE

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992011262A1 (fr) * 1990-12-21 1992-07-09 Gyógyszerkutató Intézet K.V. Derives de 1-(4-acylaminophenyl)-7,8-methylenedioxy-5h-2,3-benzo-diazepine, leurs sels d'addition d'acides, compositions pharmaceutiques les contenant, et leur procede de preparation
US5519019A (en) * 1990-12-21 1996-05-21 Gyogyszerkutato Intezet N-acyl-2,3-benzoidazepine derivatives, pharmaceutical compositions containing them and process for preparing same
US5639751A (en) * 1990-12-21 1997-06-17 Cyogyszerkutato Intezet Kft N-acyl-2,3-benzodiazepine derivatives for treating acute and chronic neurodegenerative disorders
WO1998030229A1 (fr) * 1997-01-10 1998-07-16 Massachusetts Institute Of Technology TRAITEMENTS RELATIFS A LA NEUROTOXICITE DANS LA MALADIE D'ALZHEIMER PROVOQUEE PAR DES PEPTIDES β-AMYLOIDES
WO1999007708A1 (fr) * 1997-08-12 1999-02-18 EGIS Gyógyszergyár Rt. Derives de 1,3-dioxolo/4,5-h//2,3/benzodiazepine utilises comme inhibiteurs des recepteurs ampa/kainate
WO1999007707A1 (fr) * 1997-08-12 1999-02-18 EGIS Gyógyszergyár Rt. DERIVES DE 9H-1,3-DIOXOLO/4,5-h//2,3/BENZODIAZEPINE SUBSTITUEE EN HUIT UTILISES COMME INHIBITEURS DES RECEPTEURS D'AMPA/KAINATE

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
BARTHA, E. ET AL: "Neuroprotective effect of GYKI 52466 on AMPA-induced neurotoxicity in rat striatum", NEUROBIOLOGY (BUDAPEST) (1998), 6(2), 127-139, 1998, XP000900705 *
BLOCK, F. ET AL: "The b-wave of the electroretinogram as an index of retinal ischemia", GEN. PHARMACOL. (1998), 30(3), 281-287, 1998, XP000900438 *
KOVACS, A.D. ET AL: "Protection against non-NMDA receptor-mediated excitotoxicity by GYKI 52466 in mature telencephalic cultures of the rat", NEUROBIOLOGY (BUDAPEST) (1996), 4(1-2), 59-72, 1996, XP000900714 *
KOVACS, ATTILA D. ET AL: "GYKI 53655, a 2,3-benzodiazepine, non-competitively protects cultured neurons against AMPA toxicity", EUR. J. PHARMACOL. (1997), 331(1), 93-96, 1997, XP000900425 *
LIU, X.-H. ET AL: "The non-competitive AMPA antagonist LY 300168 (GYKI 53655) attenuates AMPA-induced hippocampal injury in neonatal rodents", NEUROSCI. LETT. (1997), 235(1,2), 93-97, 1997, XP000861801 *
LOMBARDI, GRAZIA ET AL: "Glutamate receptor antagonists protect against ischemia-induced retinal damage", EUR. J. PHARMACOL. (1994), 271(2/3), 489-95, 1994, XP000900421 *
MAY, PATRICK C. ET AL: "GYKI 52466 protects against non-NMDA receptor-mediated excitotoxicity in primary rat hippocampal cultures", NEUROSCI. LETT. (1993), 152(1-2), 169-72, 1993, XP000900419 *
MENG, CHARLES Q.: "Talampanel Eli Lilly & Co", CURR. OPIN. CENT. PERIPHER. NERV. SYST. INVEST. DRUGS (1999), 1(5), 637-643, 1999, XP000900416 *
ROTHSTEIN J D ET AL: "NEUROPROTECTIVE STRATEGIES IN A MODEL OF CHRONIC GLUTAMATE-MEDIATEDMOTOR NEURON TOXICITY", JOURNAL OF NEUROCHEMISTRY,US,NEW YORK, NY, vol. 65, no. 2, 1995, pages 643 - 651, XP000910839, ISSN: 0022-3042 *
SLUSHER, B. STAUCH ET AL: "Centrally-administered AMPA antagonists increase locomotion in Parkinsonian rats", J. NEURAL TRANSM.: PARKINSON'S DIS. DEMENTIA SECT. (1995), 9(2-3), 145-9, 1995, XP000900426 *
SZEKELY J I ET AL: "APPARENT ANTINOCICEPTIVE AND ANTI-INFLAMMATORY EFFECTS OF GYKI 52466", EUROPEAN JOURNAL OF PHARMACOLOGY,NL,AMSTERDAM, vol. 336, no. 2/03, 1997, pages 143 - 154, XP000878685, ISSN: 0014-2999 *
TARNAWA, ISTVAN ET AL: "2,3-Benzodiazepine AMPA antagonists", RESTOR. NEUROL. NEUROSCI. (1998), 13(1,2), 41-57, 1998, XP000900422 *

Also Published As

Publication number Publication date
HUP9900354A3 (en) 2001-02-28
AU2819400A (en) 2000-09-28
HUP9900354A2 (hu) 2001-01-29
HU9900354D0 (en) 1999-04-28
WO2000053166A2 (fr) 2000-09-14

Similar Documents

Publication Publication Date Title
WO1998025930A3 (fr) Utilisation des derives de la pyridone bi- et tricyclique pour traiter la maladie d'alzheimer
CA2290918A1 (fr) Derives bicycliques heteroaromatiques utiles comme agents anticancereux
WO2000061568A3 (fr) Derives de 1,4-benzothiazepin-1,1-dioxyde substitues par des residus de sucre, leur procede de production, des medicaments contenant ces composes et leur utilisation
WO1997020823A3 (fr) Antagonistes de recepteurs
CA2401229A1 (fr) Composes azapolycycliques a fusion aryle
HUP9602215A2 (hu) 4-Klór-5-(imidazolin-2-il-amino)-6-metoxi-2-metil-pirimidin alkalmazása megvonási tünetek kezelésére alkalmas gyógyszerkészítmény előállítására
CA2191871A1 (fr) Derives de piperazine utilises comme antagonistes de 5ht1a
CA2333703A1 (fr) Derives isothiazole utiles en tant qu'agents anticancereux
WO2001041768A3 (fr) Utilisation d'hymenialdisine ou de ses derives pour la fabrication de medicaments
IS6042A (is) Fjölbreytileg kristalform af celecoxib
WO2001027111A3 (fr) Derives d'imidazo-3-yl-amine bicycliques
HUT61022A (en) Process for producing 8-substituted purine derivatives functioning as selective adenosine receptor, as well as pharmaceutical compositions comprising same as active ingredient
WO2001019797A3 (fr) HYDROXYALKANOYL AMINOLACTAMES ET STRUCTURES ASSOCIEES, INHIBITEURS DE LA PRODUCTION DE LA PROTEINE A$g(b)
DK0411534T3 (da) Derivater af 1,2,3,4-tetrahydro-9-acridinamin
BR9801157A (pt) Derivados de adamantano substituìdos por flúor.
FR2801587B1 (fr) Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DK1181024T3 (da) Anvendelse af glycosaminoglycaner til behandling af senil demens
TR200101163T2 (tr) Safra suyu ikameli fenil-alkenoilguanidinler, üretim yöntemleri, kullanımları
WO2002026732A1 (fr) Derive de benzodiazepine
EP1101769A3 (fr) Dérivés de l'érythromycine contenant de l'azote
WO2000053166A3 (fr) Utilisation de derives de 2,3-benzodiazepine pour le traitement et la prevention de maladies liees a l'inhibition de peroxydation lipidique
WO2003040086A1 (fr) Derives de 5-amidino-2-hydroxybenzene-sulfonamide, composition medicinales les contenant, leur utilisation medicale et produits intermediaires utilises dans le cadre de leur production
EP1123923A4 (fr) Derives de dihydropyridine et compositions medicamenteuses contenant ces derives
SE9702716D0 (sv) Substituted phenylazacycloalkanes in the treatment of cognitive disorders
WO1999005103A3 (fr) Derives d'amidino-camptothecine

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AL AM AT AU AZ BA BB BG BR BY CA CH CN CR CU CZ DE DK DM EE ES FI GB GD GE GH GM HR ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

122 Ep: pct application non-entry in european phase
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载