+

WO2000050565A3 - Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs - Google Patents

Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs Download PDF

Info

Publication number
WO2000050565A3
WO2000050565A3 PCT/US2000/004950 US0004950W WO0050565A3 WO 2000050565 A3 WO2000050565 A3 WO 2000050565A3 US 0004950 W US0004950 W US 0004950W WO 0050565 A3 WO0050565 A3 WO 0050565A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
tumor suppressor
kits
compositions
methods relating
Prior art date
Application number
PCT/US2000/004950
Other languages
English (en)
Other versions
WO2000050565A2 (fr
Inventor
Carlo M Croce
Hideshi Ishii
Original Assignee
Univ Jefferson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Jefferson filed Critical Univ Jefferson
Priority to EP00912007A priority Critical patent/EP1163252A4/fr
Priority to JP2000601129A priority patent/JP2003508011A/ja
Priority to CA002361396A priority patent/CA2361396A1/fr
Publication of WO2000050565A2 publication Critical patent/WO2000050565A2/fr
Publication of WO2000050565A3 publication Critical patent/WO2000050565A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des homologues de polynucléotides isolés avec une partie d'un brin du gène suppresseur de tumeur de l'homme, le gène FEZ1. L'invention traite également de la protéine suppresseur de tumeur ainsi codée, Fezl. Ces polynucléotides présentent un grand intérêt, par exemple, comme sondes, comme amorces, comme parties de vecteurs d'expression et similaires. L'invention traite également de procédés de diagnostique, de thérapie, de prolifération cellulaire et de dosage utilisant ces polynucléotides et ces protéines. L'invention a également pour objet des kits permettant de mettre en oeuvre les procédés selon l'invention.
PCT/US2000/004950 1999-02-25 2000-02-25 Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs WO2000050565A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP00912007A EP1163252A4 (fr) 1999-02-25 2000-02-25 Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs
JP2000601129A JP2003508011A (ja) 1999-02-25 2000-02-25 ヒトｆｅｚ１遺伝子である新規ガン抑制遺伝子に関する組成物、キットおよび方法
CA002361396A CA2361396A1 (fr) 1999-02-25 2000-02-25 Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12153799P 1999-02-25 1999-02-25
US60/121,537 1999-02-25

Publications (2)

Publication Number Publication Date
WO2000050565A2 WO2000050565A2 (fr) 2000-08-31
WO2000050565A3 true WO2000050565A3 (fr) 2000-12-07

Family

ID=22397335

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/004950 WO2000050565A2 (fr) 1999-02-25 2000-02-25 Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs

Country Status (4)

Country Link
EP (1) EP1163252A4 (fr)
JP (1) JP2003508011A (fr)
CA (1) CA2361396A1 (fr)
WO (1) WO2000050565A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911998B2 (en) 2007-10-26 2014-12-16 The Ohio State University Methods for identifying fragile histidine triad (FHIT) interaction and uses thereof
US9125923B2 (en) 2008-06-11 2015-09-08 The Ohio State University Use of MiR-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141417B1 (en) 1999-02-25 2006-11-28 Thomas Jefferson University Compositions, kits, and methods relating to the human FEZ1 gene, a novel tumor suppressor gene
CA2690749A1 (fr) 2007-06-15 2008-12-24 The Ohio State University Research Foundation Proteines de fusion all-1 oncogenes pour cibler le traitement de micro-arn regule par drosha
CN103866008B (zh) 2007-08-03 2016-06-29 俄亥俄州立大学研究基金会 编码ncrna的超保守区域
CA2781547A1 (fr) 2009-11-23 2011-05-26 The Ohio State University Substances et procedes pouvant s'utiliser pour agir sur la croissance, la migration, et l'invasion de cellules tumorales
ES2606146T3 (es) 2010-11-12 2017-03-22 The Ohio State University Research Foundation Métodos relacionados con microARN-21 y reparación de desapareamiento en cáncer colorrectal
JP2014500258A (ja) 2010-11-15 2014-01-09 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 制御放出粘膜付着システム
CA2828772A1 (fr) 2011-03-07 2012-09-13 The Ohio State University Activite mutatrice induite par l'inflammation des liaisons au microarn-155 (mir-155) et le cancer
EP2766500A4 (fr) 2011-10-14 2015-10-14 Univ Ohio State Méthodes et matériaux relatifs au cancer des ovaires
EP2790735A4 (fr) 2011-12-13 2015-12-09 Ohio State Innovation Foundation Procédés et compositions se rapportant à mir-21 et mir-29a, à l'inhibition d'exosome, et à la métastase cancéreuse
AU2013209477B2 (en) 2012-01-20 2016-12-08 The Ohio State University Breast cancer biomarker signatures for invasiveness and prognosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055300A2 (fr) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps
WO2001055314A2 (fr) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Acides nucleiques, proteines et anticorps

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DATABASE GENBANK ISHII ET AL.: "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein and its expression is altered in multiple human tumors", XP002950674 *
DATABASE GENBANK ISHII ET AL.: "The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein and its expression is altered in multiple human tumors", XP002950675 *
DATABASE GENBANK WANG ET AL.: "Large-scale indentification, mapping and genotyping of single-nucleotide polymorphiosms in the human genome", XP002950673 *
PROC. NATL. ACAD. SCI. USA, vol. 96, no. 7, 1999, pages 3928 - 3933 *
SCIENCE, vol. 280, no. 5366, 1998, pages 1077 - 1082 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911998B2 (en) 2007-10-26 2014-12-16 The Ohio State University Methods for identifying fragile histidine triad (FHIT) interaction and uses thereof
US9125923B2 (en) 2008-06-11 2015-09-08 The Ohio State University Use of MiR-26 family as a predictive marker for hepatocellular carcinoma and responsiveness to therapy

Also Published As

Publication number Publication date
EP1163252A4 (fr) 2004-04-07
WO2000050565A2 (fr) 2000-08-31
JP2003508011A (ja) 2003-03-04
CA2361396A1 (fr) 2000-08-31
EP1163252A2 (fr) 2001-12-19

Similar Documents

Publication Publication Date Title
EP1005540A4 (fr) Proteines ikk-beta, acides nucleiques et procedes
WO2004076639A8 (fr) Compositions et methodes destinees a diagnostiquer et traiter des maladies auto-immunes
EP1440981A3 (fr) ADN complementaire humaine de pleine longueur
WO2000055180A3 (fr) Sequences et polypeptides geniques associes au cancer du poumon chez l'homme
WO2000040614A3 (fr) Caracterisation d'une famille de canaux calciques
WO1999053040A3 (fr) Sequences d'acide nucleique humain provenant de tissu de tumeur ovarienne
WO2003016475A3 (fr) Sequences d'acides nucleiques et d'acides amines intervenant dans la douleur
WO2000050565A3 (fr) Compositions, kits et procedes concernant le gene fez1 de l'homme, nouveau gene suppresseur des tumeurs
AU1367095A (en) Effector proteins of rapamycin
WO2004023092A3 (fr) Analyse et authentification genetiques
WO2001055308A3 (fr) Acides nucleiques, proteines et anticorps
WO2000031235A3 (fr) Sequences nucleotidiques et proteiques de gene nogo et procedes reposant sur ces sequences
WO2002095051A3 (fr) Peptides mage-a3 presentes par des molecules hla de classe ii
WO2004048551A3 (fr) Cible destinee a la therapie d'un trouble cognitif
WO1998059040A3 (fr) Sous-unite de telomerase catalytique humaine et son utilisation therapeutique et diagnostique
WO2002061144A8 (fr) Diagnostic de tumeur cerebrale et prediction de resultat de traitement
WO1998011234A3 (fr) Proteines kinases humaines
EP1447413A3 (fr) ADN complementaire humaine de pleine longueur
WO2005058251A3 (fr) Anticorps specifiques de hla-dr, compositions et methodes associees
WO1999046374A3 (fr) Sequences d'acide nucleique humaines issues de tissus tumoraux prostatiques
WO2005019269A3 (fr) Techniques et compositions pour le diagnostic et le traitement du cancer (muc1)
WO2002010388A3 (fr) Molecules du type recepteur de complement c3b/c4b et utilisations de ces molecules
WO1998018822A3 (fr) Nouvelles proteines humaines lim
WO1997031111A3 (fr) Famille de transporteurs d'anions organiques, acides nucleiques codant ceux-ci, cellules les comprenant et procedes d'utilisation associes
WO2004047757A3 (fr) Diagnostic et traitement des cancers hematopoietiques

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE

ENP Entry into the national phase

Ref document number: 2361396

Country of ref document: CA

Ref country code: CA

Ref document number: 2361396

Kind code of ref document: A

Format of ref document f/p: F

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2000 601129

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2000912007

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2000912007

Country of ref document: EP

点击 这是indexloc提供的php浏览器服务，不要输入任何密码和下载